Systematic review of medication adherence in children with tic disorder_Chinese Journal of Evidence-Based Medicine

Authors：

CHENG Xiao ^1,2,3 , YANG Chunsong ^2,3 , ZHANG Chuan ^2,3 ,  ZHANG Lingli ^1,2,3

1. West China School of Pharmacy, Sichuan University, Chengdu 610041, P.R.China;
2. Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China;
3. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu 610041, P.R.China;

Corresponding?author：

ZHANG Lingli, Email: zhanglingli@scu.edu.cn

Keywords：

Tic disorder; Drug therapy; Adherence; Systematic review

DOI：

10.7507/1672-2531.202012024

Video：

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Objective To systematically review the medication adherence in children with tic disorder to assist in the selection of clinical treatment options and enhance the efficacy of medications for tic disorder.Methods Databases including Medline (Ovid), EMbase (Ovid), The Cochrane Library, PsycINFO (EBSCOhost), CINAHL Plus (EBSCOhost), CNKI, WanFang Data and VIP were searched from inception to August 2020, and original studies on medication adherence in children with tic disorder were included. Two researchers independently screened literature, extracted data on the definition of compliance, compliance rate, and factors affecting compliance, and evaluated risk bias of included studies. Systematic review was performed to analyze the status of medication adherence in children with tic disorder.Results A total of 12 studies were included, involving seven randomized controlled trials, two case series studies, and three cross-sectional studies. Most studies failed to specify the definition of compliance. The results of cross-sectional studies showed that the proportion of children with good medication compliance was 29.3% to 47.1%. The first-line treatment drugs, tiapride, risperidone, aripiprazole, and clonidine, had relatively good adherence. Medication adherence was affected by drug factors, patient and family factors, and environmental factors.Conclusions The adherence rate of medications for tic disorder varies between studies. Few studies have analyzed the factors that affect medication adherence for tic disorder, and some influencing factors are controversial. The first-line treatment drugs, tiapride, risperidone, aripiprazole, and clonidine, have high medication adherence and are recommended for clinical use.

Citation： CHENG Xiao, YANG Chunsong, ZHANG Chuan, ZHANG Lingli. Systematic review of medication adherence in children with tic disorder. Chinese Journal of Evidence-Based Medicine, 2021, 21(5): 586-592. doi: 10.7507/1672-2531.202012024 Copy

1.	中華醫學會兒科學分會神經學組. 兒童抽動障礙診斷與治療專家共識(2017 實用版). 中華實用兒科臨床雜志, 2017, 32(15): 1137-1140.
2.	Sharma N, Mishra R, Mishra D. The fifth edition of diagnostic and statistical manual of mental disorders (DSM-5): what is new for the pediatrician? Indian Pediatr, 2015, 52(2): 141-143.
3.	Yang C, Zhang L, Zhu P, et al. The prevalence of tic disorders for children in China: a systematic review and meta-analysis. Medicine (Baltimore), 2016, 95(30): 4354.
4.	Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: prevalence, phenomenology, comorbidities, and coexistent psychopathologies. Lancet Psychiat, 2015, 2(1): 68-87.
5.	Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: assessment, investigations, and management. Lancet Psychiat, 2015, 2(1): 88-104.
6.	Pringsheim T, Doja A, Gorman D, et al. Canadian guidelines for the evidence-based treatment of tic disorders: pharmacotherapy. Can J Psychiatry, 2012, 57(3): 133-143.
7.	Hamamoto Y, Fujio M, Nonaka M, et al. Expert consensus on pharmacotherapy for tic disorders in Japan. Brain Dev, 2019, 41(6): 501-506.
8.	張冉, 田慶秀, 余麗君. 支氣管哮喘患者吸入糖皮質激素治療依從性的研究. 中華護理雜志, 2015, 50(1): 42-47.
9.	亓小燕, 戴俊明, 尉敏琦, 等. 高血壓患者社會支持, 藥物治療依從性與血壓控制的關系. 中華高血壓雜志, 2014, 22(1): 36-41.
10.	van Driel ML, Morledge MD, Ulep R, et al. Interventions to improve adherence to lipid-lowering medication. Cochrane Database Syst Rev, 2016, (12): CD004371.
11.	鄭亞兵, 宋雄. 泰必利和氟哌啶醇治療多發性抽動癥依從性比較. 廣西中醫學院學報, 2002, 5(2): 22-23.
12.	李耀東, 羅有年, 吳海珊, 等. 利培酮與氟哌啶醇治療兒童抽動障礙對照研究. 中國康復理論與實踐, 2006, 12(10): 844-845.
13.	劉艷艷, 陳燕惠, 陳輝, 等. 阿立哌唑與硫必利治療兒童抽動障礙的對照研究. 中國當代兒科雜志, 2010, 12(6): 421-424.
14.	秦劼. 阿立哌唑用于抽動障礙中對療效及患兒依從性的影響. 醫藥前沿, 2014, (27): 128-129.
15.	徐欣欣. 阿立哌唑用于抽動障礙中對療效和患兒依從性的影響. 世界最新醫學信息文摘(連續型電子期刊), 2015, (30): 77-78.
16.	陳穎萍, 陳燕惠. 系統化行為干預對抽動障礙患兒的療效. 中國兒童保健雜志, 2017, 25(5): 448-451.
17.	Gilbert DL, Murphy TK, Jankovic J, et al. Ecopipam, a D1 receptor antagonist, for treatment of tourette syndrome in children: A randomized, placebo-controlled crossover study. Mov Disord, 2018, 33(8): 1272-1280.
18.	Leckman JF, Detlor J, Harcherik DF, et al. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology, 1985, 35(3): 343-351.
19.	Silva RR, Mu?oz DM, Daniel W, et al. Causes of haloperidol discontinuation in patients with Tourette's disorder: management and alternatives. J Clin Psychiatry, 1996, 57(3): 129-135.
20.	吳紅波, 呂魏峰, 郭偉. 抽動障礙兒童就醫行為及藥物治療影響因素. 中華高血壓雜志社, 2015, 23(3): 636-637.
21.	楊春松, 俞丹, 許群芬, 等. 某院抽動障礙患兒用藥依從性及影響因素分析. 兒科藥學雜志, 2019, 25(3): 36-39.
22.	Yang C, Qin W, Yu D, et al. Medication adherence and associated factors for children with Tic disorders in western China: a cross-sectional survey. Front Neurol, 2019, 10: 1156.
23.	Yang C, Hao Z, Yu D, et al. The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: a systematic review and meta-analysis. Epilepsy Res, 2018, 142: 88-99.

1. 中華醫學會兒科學分會神經學組. 兒童抽動障礙診斷與治療專家共識(2017 實用版). 中華實用兒科臨床雜志, 2017, 32(15): 1137-1140.
2. Sharma N, Mishra R, Mishra D. The fifth edition of diagnostic and statistical manual of mental disorders (DSM-5): what is new for the pediatrician? Indian Pediatr, 2015, 52(2): 141-143.
3. Yang C, Zhang L, Zhu P, et al. The prevalence of tic disorders for children in China: a systematic review and meta-analysis. Medicine (Baltimore), 2016, 95(30): 4354.
4. Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: prevalence, phenomenology, comorbidities, and coexistent psychopathologies. Lancet Psychiat, 2015, 2(1): 68-87.
5. Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: assessment, investigations, and management. Lancet Psychiat, 2015, 2(1): 88-104.
6. Pringsheim T, Doja A, Gorman D, et al. Canadian guidelines for the evidence-based treatment of tic disorders: pharmacotherapy. Can J Psychiatry, 2012, 57(3): 133-143.
7. Hamamoto Y, Fujio M, Nonaka M, et al. Expert consensus on pharmacotherapy for tic disorders in Japan. Brain Dev, 2019, 41(6): 501-506.
8. 張冉, 田慶秀, 余麗君. 支氣管哮喘患者吸入糖皮質激素治療依從性的研究. 中華護理雜志, 2015, 50(1): 42-47.
9. 亓小燕, 戴俊明, 尉敏琦, 等. 高血壓患者社會支持, 藥物治療依從性與血壓控制的關系. 中華高血壓雜志, 2014, 22(1): 36-41.
10. van Driel ML, Morledge MD, Ulep R, et al. Interventions to improve adherence to lipid-lowering medication. Cochrane Database Syst Rev, 2016, (12): CD004371.
11. 鄭亞兵, 宋雄. 泰必利和氟哌啶醇治療多發性抽動癥依從性比較. 廣西中醫學院學報, 2002, 5(2): 22-23.
12. 李耀東, 羅有年, 吳海珊, 等. 利培酮與氟哌啶醇治療兒童抽動障礙對照研究. 中國康復理論與實踐, 2006, 12(10): 844-845.
13. 劉艷艷, 陳燕惠, 陳輝, 等. 阿立哌唑與硫必利治療兒童抽動障礙的對照研究. 中國當代兒科雜志, 2010, 12(6): 421-424.
14. 秦劼. 阿立哌唑用于抽動障礙中對療效及患兒依從性的影響. 醫藥前沿, 2014, (27): 128-129.
15. 徐欣欣. 阿立哌唑用于抽動障礙中對療效和患兒依從性的影響. 世界最新醫學信息文摘(連續型電子期刊), 2015, (30): 77-78.
16. 陳穎萍, 陳燕惠. 系統化行為干預對抽動障礙患兒的療效. 中國兒童保健雜志, 2017, 25(5): 448-451.
17. Gilbert DL, Murphy TK, Jankovic J, et al. Ecopipam, a D1 receptor antagonist, for treatment of tourette syndrome in children: A randomized, placebo-controlled crossover study. Mov Disord, 2018, 33(8): 1272-1280.
18. Leckman JF, Detlor J, Harcherik DF, et al. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology, 1985, 35(3): 343-351.
19. Silva RR, Mu?oz DM, Daniel W, et al. Causes of haloperidol discontinuation in patients with Tourette's disorder: management and alternatives. J Clin Psychiatry, 1996, 57(3): 129-135.
20. 吳紅波, 呂魏峰, 郭偉. 抽動障礙兒童就醫行為及藥物治療影響因素. 中華高血壓雜志社, 2015, 23(3): 636-637.
21. 楊春松, 俞丹, 許群芬, 等. 某院抽動障礙患兒用藥依從性及影響因素分析. 兒科藥學雜志, 2019, 25(3): 36-39.
22. Yang C, Qin W, Yu D, et al. Medication adherence and associated factors for children with Tic disorders in western China: a cross-sectional survey. Front Neurol, 2019, 10: 1156.
23. Yang C, Hao Z, Yu D, et al. The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: a systematic review and meta-analysis. Epilepsy Res, 2018, 142: 88-99.

Chinese Journal of Evidence-Based Medicine

Systematic review of medication adherence in children with tic disorder

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