Study on the service intervention of medication therapy management for outpatient children with epilepsy_Chinese Journal of Evidence-Based Medicine

Authors：

CHEN Zhe ^1,2,3,4 , LIN Mao ⁵ , NI Xiaofeng ^1,2,3,6 , GAN Jing ⁷ , LUO Rong ⁷ ,  HUANG Liang ^1,2,3 , ZHANG Lingli ^1,2,3

1. Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China;
2. Evidence-based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China;
3. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu 610041, P.R.China;
4. West China School of Pharmacy, Sichuan University, Chengdu 610041, P.R.China;
5. Department of Pharmacy, Sichuan Cancer Hospital & Institute, Chengdu 610041, P.R.China;
6. West China School of Medicine, Sichuan University, Chengdu 610041, P.R.China;
7. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China;

Corresponding?author：

HUANG Liang, Email: hliang_1022@163.com

Keywords：

Epilepsy; Children; Outpatient; Intervention; Medication therapy management

DOI：

10.7507/1672-2531.202107070

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the service contents of medication therapy management (MTM) for outpatient epileptic children by analyzing drug related problems (DRPs). Methods A cross-sectional study was adopted to analyze the status of DRPs in outpatient epileptic children in West China Second Hospital of Sichuan University. The focus group discussion method was adopted to formulate the specific service contents of MTM in outpatient epileptic children. Results A total of 2 754 cases of antiepileptic drug treatment were received in the pediatric clinic of West China Second Hospital of Sichuan University from October 1^st, 2018 to December 31^st, 2018, including 2 018 cases of monotherapy and 736 cases of combination therapy, involving 7 drugs and 10 specifications. The specifications in descending order of frequency of drug use were levetiracetam oral solution, levetiracetam tablets, sodium valproate oral solution, oxcarbazepine oral suspension, oxcarbazepine tablets, topiramate capsules, sodium valproate sustained-release tablets, lamotrigine tablets, magnesium valproate sustained-release tablets and carbamazepine tablets. We applied the Pharmaceutical Care Network Europe (PCNE) classification and found 718 DRPs, mainly focusing on drug selection and improper course of treatment. The specific service contents of MTM for children with epilepsy in the clinic included hospital pharmacy information services, medical teams established by pharmacists, doctors and nurses, child education and medication consultation, and medication follow-up for discharged children. In addition, specific measures to solve DRPs in outpatient epileptic children were designed from 2 aspects of disease management and medication education, and 3 aspects of drug prescription, dispensing, and usage. Conclusions There are various types of antiepileptic medications and treatment schemes for children, and DRPs are complicated. Therefore, MTM for children with epilepsy requires to be strengthened. In this study, the specific intervention contents of MTM for outpatient epileptic children are designed to carry out the follow-up empirical study to verify the effectiveness of MTM.

Citation： CHEN Zhe, LIN Mao, NI Xiaofeng, GAN Jing, LUO Rong, HUANG Liang, ZHANG Lingli. Study on the service intervention of medication therapy management for outpatient children with epilepsy. Chinese Journal of Evidence-Based Medicine, 2021, 21(11): 1241-1246. doi: 10.7507/1672-2531.202107070 Copy

1.	王可, 侯凱旋, 閆素英. 國內外藥物治療管理開展現狀. 中國藥房, 2018, 29(5): 580-586.
2.	Pellegrino AN, Martin MT, Tilton JJ, et al. Medication therapy management services: definitions and outcomes. Drugs, 2009, 69(4): 393-406.
3.	林茂, 陳哲, 曾力楠, 等. 國內, 外藥物治療管理文獻研究現狀分析. 中國藥房, 2019, 30(17): 2305-2310.
4.	McGivney MS, Meyer SM, Duncan-Hewitt W, et al. Medication therapy management: its relationship to patient counseling, disease management, and pharmaceutical care. J Am Pharm Assoc, 2007, 47(5): 620-628.
5.	U. S. government information. Affordable care act, 2010. Avaiable at: https://www.hhs.gov/healthcare/about-the-aca/index.html.
6.	彭敏, 章小雷. 慢性病兒童對父母、家庭的影響及相關干預的研究現狀和展望. 中國當代醫藥, 2019, 26(13): 30-33.
7.	楊陳, 張學兵. 慢性疾病兒童照顧者照護負荷研究進展. 護士進修雜志, 2018, 33(11): 992-996.
8.	Benavides S, Madzhidova S, Hernandez A, et al. Establishment of pediatric medication therapy management: a proposed model. Pharmacy (Basel), 2016, 4(1): 5.
9.	中國抗癲癇協會. 臨床診療指南: 癲癇病分冊. 北京: 人民軍醫出版社, 2015.
10.	楊春松, 宋虹漪, 張伶俐, 等. 中國兒童癲癇患者用藥依從性現狀和影響因素研究. 中國藥事, 2017, 31(12): 151-159.
11.	常琳, 王小姍. 中國癲癇流行病學調查研究進展. 國際神經病學神經外科學雜志, 2012, 39(2): 161-164.
12.	單曉光, 陳榮華, 鄧靜云, 等. 江蘇省0~14歲兒童癲癇流行病學調查. 南京醫學院學報, 1992, (2): 170-172.
13.	王家良. 臨床流行病學. 中華醫學雜志, 1998, 12: 930-932.
14.	Then KL, Rankin JA, Ali E. Focus group research: what is it and how can it be used. Can J Cardiovasc Nurs, 2014, 24(1): 16-22.
15.	Kidd PS, Parshall MB. Getting the focus and the group: enhancing analytical rigor in focus group research. Qual Health Res, 2000, 10(3): 293-308.
16.	Rabiee F. Focus-group interview and data analysis. Proc Nutr Soc, 2004, 63(4): 655-660.
17.	阮忠, 黃敬亨. 專題小組討論法. 中國健康教育, 1994, 9: 4-5.
18.	Marcus D. The epilepsies: diagnosis and management. Gen Pharmacol-vasc S, 1990, 22(4): 765.
19.	NICE. The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care. 2012. Available at: https://www.ncbi.nlm.nih.gov/books/NBK247130/.
20.	The committee for guidelines of the German society of neurology (DGN). Guideline first epileptic seizure and epilepsies in adulthood. Available at: http://www.nice.org.uk/guidance/QS26.
21.	曾晨欣, 王皓, 吳秋惠, 等. 藥學服務中藥物相關問題的研究進展. 中國藥房, 2018, 29(16): 2291-2295.
22.	張萍, 廖赟, 呂丹, 等. 運用PCNE分類體系對癌痛患者麻醉鎮痛藥物的處方分析. 中國藥師, 2018, 21(6): 1051-1054.
23.	《中國國家處方集》編委會. 中國國家處方集: 兒童版. 北京: 人民軍醫出版社, 2012.

1. 王可, 侯凱旋, 閆素英. 國內外藥物治療管理開展現狀. 中國藥房, 2018, 29(5): 580-586.
2. Pellegrino AN, Martin MT, Tilton JJ, et al. Medication therapy management services: definitions and outcomes. Drugs, 2009, 69(4): 393-406.
3. 林茂, 陳哲, 曾力楠, 等. 國內, 外藥物治療管理文獻研究現狀分析. 中國藥房, 2019, 30(17): 2305-2310.
4. McGivney MS, Meyer SM, Duncan-Hewitt W, et al. Medication therapy management: its relationship to patient counseling, disease management, and pharmaceutical care. J Am Pharm Assoc, 2007, 47(5): 620-628.
5. U. S. government information. Affordable care act, 2010. Avaiable at: https://www.hhs.gov/healthcare/about-the-aca/index.html.
6. 彭敏, 章小雷. 慢性病兒童對父母、家庭的影響及相關干預的研究現狀和展望. 中國當代醫藥, 2019, 26(13): 30-33.
7. 楊陳, 張學兵. 慢性疾病兒童照顧者照護負荷研究進展. 護士進修雜志, 2018, 33(11): 992-996.
8. Benavides S, Madzhidova S, Hernandez A, et al. Establishment of pediatric medication therapy management: a proposed model. Pharmacy (Basel), 2016, 4(1): 5.
9. 中國抗癲癇協會. 臨床診療指南: 癲癇病分冊. 北京: 人民軍醫出版社, 2015.
10. 楊春松, 宋虹漪, 張伶俐, 等. 中國兒童癲癇患者用藥依從性現狀和影響因素研究. 中國藥事, 2017, 31(12): 151-159.
11. 常琳, 王小姍. 中國癲癇流行病學調查研究進展. 國際神經病學神經外科學雜志, 2012, 39(2): 161-164.
12. 單曉光, 陳榮華, 鄧靜云, 等. 江蘇省0~14歲兒童癲癇流行病學調查. 南京醫學院學報, 1992, (2): 170-172.
13. 王家良. 臨床流行病學. 中華醫學雜志, 1998, 12: 930-932.
14. Then KL, Rankin JA, Ali E. Focus group research: what is it and how can it be used. Can J Cardiovasc Nurs, 2014, 24(1): 16-22.
15. Kidd PS, Parshall MB. Getting the focus and the group: enhancing analytical rigor in focus group research. Qual Health Res, 2000, 10(3): 293-308.
16. Rabiee F. Focus-group interview and data analysis. Proc Nutr Soc, 2004, 63(4): 655-660.
17. 阮忠, 黃敬亨. 專題小組討論法. 中國健康教育, 1994, 9: 4-5.
18. Marcus D. The epilepsies: diagnosis and management. Gen Pharmacol-vasc S, 1990, 22(4): 765.
19. NICE. The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care. 2012. Available at: https://www.ncbi.nlm.nih.gov/books/NBK247130/.
20. The committee for guidelines of the German society of neurology (DGN). Guideline first epileptic seizure and epilepsies in adulthood. Available at: http://www.nice.org.uk/guidance/QS26.
21. 曾晨欣, 王皓, 吳秋惠, 等. 藥學服務中藥物相關問題的研究進展. 中國藥房, 2018, 29(16): 2291-2295.
22. 張萍, 廖赟, 呂丹, 等. 運用PCNE分類體系對癌痛患者麻醉鎮痛藥物的處方分析. 中國藥師, 2018, 21(6): 1051-1054.
23. 《中國國家處方集》編委會. 中國國家處方集: 兒童版. 北京: 人民軍醫出版社, 2012.

Next Article
Investigation on AIDS knowledge and sexual behavior of middle school students in the key areas of HIV epidemic in Liangshan, Sichuan

Chinese Journal of Evidence-Based Medicine

Study on the service intervention of medication therapy management for outpatient children with epilepsy

Abstract Full text Figures/Tables Video References Cited by

Next Article

Format

Content