Changes in the disease burden of ischemic stroke in China from 1990 to 2019_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Le ^1,2 , YU Chao ³ , LIAO Yiwen ¹ , LI Jingjing ¹ , LIU Xingyu ^1,2 ,  KUANG Jie ^1,2

1. Department of Epidemiology, School of Public Health, Nanchang University, Nanchang 330006, P. R. China;
2. Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang 330006, P. R. China;
3. Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, P. R. China;

Corresponding?author：

KUANG Jie, Email: kuangjie@ncu.edu.cn

Keywords：

Ischemic stroke; Disease burden; Incidence; Mortality; Disability-adjusted life year (DALY)

DOI：

10.7507/1672-2531.202205112

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the epidemic trend and disease burden of ischemic stroke in the Chinese population and to provide references for formulating reasonable prevention and treatment measures and allocating health resources. Methods Based on Global Burden of Disease (GBD) data, we analyzed the morbidity, mortality, disability-adjusted life year (DALY) and normalized rates for ischemic stroke in China from 1990 to 2019 and evaluated the changes in the disease burden by sex and age group. Meanwhile, joinpoint regression model was constructed to analyze the time trend change in each stage during the study period. Results Compared with 1990, the incidence, mortality and DALY rate of ischemic stroke in China increased by 171.68%, 125.60% and 98.60% in 2019, among which the incidence, mortality and DALY rate of males increased by 184.29%, 148.96% and 115.16%, respectively; the morbidity, mortality and DALY rates of females increased by 160.9%, 101.32% and 81.44%, respectively. The age-standardized incidence increased by 34.70%, while the age-standardized mortality and age-standardized DALY rate decreased by 3.33% and 4.02%, respectively; the age-standardized incidence, mortality and DALY rates of males increased by 39.52%, 8.03% and 3.68%, respectively; the age-standardized incidence rate of females increased by 31.40%, while the age-standardized mortality rate and age-standardized DALY rate decreased by 14.02% and 11.53%, respectively. In 2019, both the mortality rate and DALY rate due to ischemic stroke increased with age, and the highest rate was found in the population over 85 years old. Males over 60 years old were significantly than females. In the 55-84 age group, the incidence of ischemic stroke in females was higher than that in males, while in the 85 and above age group, the incidence of ischemic stroke in females was lower than that in males. The AAPC of age-standardized incidence, age-standardized mortality, and age-standardized DALY rates due to ischemic stroke from 1990 to 2019 were 1.06% (95%CI 1.00% to 1.11%), 0.01% (95%CI ?0.45% to 0.48%) and ?0.16% (95%CI ?0.53% to 0.22%), respectively. All indicators of the AAPC for males were higher than those for females. Conclusion The curvent age-standardized mortality and DALY rate of ischemic stroke in China have decreased slightly compared with 1990. The crude mortality, morbidity and disease burden have significantly increased. All indicators of the AAPC for males were higher than those for females. To reduce the epidemic trend and disease burden of ischemic stroke, reasonable prevention and treatment measures and rational allocation of health resources should be made according to sex and age.

Citation： LIU Le, YU Chao, LIAO Yiwen, LI Jingjing, LIU Xingyu, KUANG Jie. Changes in the disease burden of ischemic stroke in China from 1990 to 2019. Chinese Journal of Evidence-Based Medicine, 2022, 22(9): 993-998. doi: 10.7507/1672-2531.202205112 Copy

1.	王隴德, 彭斌, 張鴻祺, 等. 《中國腦卒中防治報告2020》概要. 中國腦血管病雜志, 2022, 19(2): 136-144.
2.	宇傳華, 羅麗莎, 李梅, 等. 從全球視角看中國腦卒中疾病負擔的嚴峻性. 公共衛生與預防醫學, 2016, 27(1): 1-5.
3.	馬林, 巢寶華, 曹雷, 等. 2007—2017年中國腦卒中流行趨勢及特征分析. 中華腦血管病雜志(電子版), 2020, 14(5): 253-258.
4.	《中國腦卒中防治報告2018》編寫組. 我國腦卒中防治仍面臨巨大挑戰—《中國腦卒中防治報告2018》概要. 中國循環雜志, 2019, 34(2): 105-119.
5.	亓建羽, 王晨冉, 劉咪, 等. 1990—2017年中國與不同社會人口學指數地區腦卒中疾病負擔和危險因素的比較分析. 中華預防醫學雜志, 2021, 55(8): 958-964.
6.	劉咪, 王晨冉, 梁娟娟, 等. 中國1990—2017年腦卒中及其危險因素疾病負擔變化趨勢分析. 中國公共衛生, 2021, 37(10): 1501-1507.
7.	于洗河, 高尚, 賈歡歡, 等. 1999年、2009年、2019年我國與全球腦卒中疾病負擔研究. 中國衛生經濟, 2021, 40(6): 58-61.
8.	羅麗莎, 宇傳華, 孟潤堂, 等. 應用傷殘調整壽命年分析中國腦卒中疾病負擔與危險因素. 中國衛生統計, 2017, 34(4): 542-545.
9.	Wang YJ, Li ZX, Gu HQ, et al. China stroke statistics 2019: a report from the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations. Stroke Vasc Neurol, 2020, 5(3): 211-239.
10.	GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1223-1249.
11.	GBD 2017 Childhood Cancer Collaborators. The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017. Lancet Oncol, 2019, 20(9): 1211-1225.
12.	Zhou M, Wang H, Zhu J, et al. Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the global burden of disease study 2013. Lancet, 2016, 387(10015): 251-272.
13.	Lopez AD, Mathers CD, Ezzati M, et al. Global burden of disease and risk factors. New York: Oxford University Press, 2006.
14.	Roy-O'Reilly M, McCullough LD. Age and sex are critical factors in ischemic stroke pathology. Endocrinology, 2018, 159(8): 3120-3131.
15.	Diener HC, Hankey GJ. Primary and secondary prevention of ischemic stroke and cerebral hemorrhage: JACC focus seminar. J Am Coll Cardiol, 2020, 75(15): 1804-1818.
16.	劉明法, 周脈耕, 劉世煒, 等. 1990和2015年天津市腦卒中死亡率和疾病負擔分析. 中國現代神經疾病雜志, 2018, 18(7): 520-526.
17.	徐穎, 劉海韻, 于紹軼, 等. 煙臺市2015年腦卒中疾病負擔分析. 中國慢性病預防與控制, 2017, 25(11): 875-877.
18.	胡永勤. 人口性別和年齡變量對腦卒中發病的影響. 中國慢性病預防與控制, 2012, 20(4): 485-486.
19.	Worrall BB, Johnston KC, Kongable G, et al. Stroke risk factor profiles in African American women: an interim report from the African-American antiplatelet stroke prevention study. Stroke, 2002, 33(4): 913-919.
20.	周官恩, 安中平, 王景華, 等. 缺血性腦卒中分型, 危險因素和預后的性別差異研究. 中風與神經疾病雜志, 2014, 31(7): 625-627.
21.	李衛征, 劉鳴, 吳波, 等. 不同性別腦卒中危險因素類型及預后的比較研究. 中國實用內科雜志, 2009, 29(5): 444-446.
22.	王雷, 熊曉星. 年齡和性別因素對缺血性腦卒中的影響研究進展. 國際神經病學神經外科學雜志, 2017, 44(1): 106-109.

1. 王隴德, 彭斌, 張鴻祺, 等. 《中國腦卒中防治報告2020》概要. 中國腦血管病雜志, 2022, 19(2): 136-144.
2. 宇傳華, 羅麗莎, 李梅, 等. 從全球視角看中國腦卒中疾病負擔的嚴峻性. 公共衛生與預防醫學, 2016, 27(1): 1-5.
3. 馬林, 巢寶華, 曹雷, 等. 2007—2017年中國腦卒中流行趨勢及特征分析. 中華腦血管病雜志(電子版), 2020, 14(5): 253-258.
4. 《中國腦卒中防治報告2018》編寫組. 我國腦卒中防治仍面臨巨大挑戰—《中國腦卒中防治報告2018》概要. 中國循環雜志, 2019, 34(2): 105-119.
5. 亓建羽, 王晨冉, 劉咪, 等. 1990—2017年中國與不同社會人口學指數地區腦卒中疾病負擔和危險因素的比較分析. 中華預防醫學雜志, 2021, 55(8): 958-964.
6. 劉咪, 王晨冉, 梁娟娟, 等. 中國1990—2017年腦卒中及其危險因素疾病負擔變化趨勢分析. 中國公共衛生, 2021, 37(10): 1501-1507.
7. 于洗河, 高尚, 賈歡歡, 等. 1999年、2009年、2019年我國與全球腦卒中疾病負擔研究. 中國衛生經濟, 2021, 40(6): 58-61.
8. 羅麗莎, 宇傳華, 孟潤堂, 等. 應用傷殘調整壽命年分析中國腦卒中疾病負擔與危險因素. 中國衛生統計, 2017, 34(4): 542-545.
9. Wang YJ, Li ZX, Gu HQ, et al. China stroke statistics 2019: a report from the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations. Stroke Vasc Neurol, 2020, 5(3): 211-239.
10. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1223-1249.
11. GBD 2017 Childhood Cancer Collaborators. The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017. Lancet Oncol, 2019, 20(9): 1211-1225.
12. Zhou M, Wang H, Zhu J, et al. Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the global burden of disease study 2013. Lancet, 2016, 387(10015): 251-272.
13. Lopez AD, Mathers CD, Ezzati M, et al. Global burden of disease and risk factors. New York: Oxford University Press, 2006.
14. Roy-O'Reilly M, McCullough LD. Age and sex are critical factors in ischemic stroke pathology. Endocrinology, 2018, 159(8): 3120-3131.
15. Diener HC, Hankey GJ. Primary and secondary prevention of ischemic stroke and cerebral hemorrhage: JACC focus seminar. J Am Coll Cardiol, 2020, 75(15): 1804-1818.
16. 劉明法, 周脈耕, 劉世煒, 等. 1990和2015年天津市腦卒中死亡率和疾病負擔分析. 中國現代神經疾病雜志, 2018, 18(7): 520-526.
17. 徐穎, 劉海韻, 于紹軼, 等. 煙臺市2015年腦卒中疾病負擔分析. 中國慢性病預防與控制, 2017, 25(11): 875-877.
18. 胡永勤. 人口性別和年齡變量對腦卒中發病的影響. 中國慢性病預防與控制, 2012, 20(4): 485-486.
19. Worrall BB, Johnston KC, Kongable G, et al. Stroke risk factor profiles in African American women: an interim report from the African-American antiplatelet stroke prevention study. Stroke, 2002, 33(4): 913-919.
20. 周官恩, 安中平, 王景華, 等. 缺血性腦卒中分型, 危險因素和預后的性別差異研究. 中風與神經疾病雜志, 2014, 31(7): 625-627.
21. 李衛征, 劉鳴, 吳波, 等. 不同性別腦卒中危險因素類型及預后的比較研究. 中國實用內科雜志, 2009, 29(5): 444-446.
22. 王雷, 熊曉星. 年齡和性別因素對缺血性腦卒中的影響研究進展. 國際神經病學神經外科學雜志, 2017, 44(1): 106-109.

Chinese Journal of Evidence-Based Medicine

Changes in the disease burden of ischemic stroke in China from 1990 to 2019

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content