Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations: an evidence map analysis_Chinese Journal of Evidence-Based Medicine

Authors：

SHA Yinyin ^1,3 ,  XU Liran ² , WANG Xueting ¹ , SHAO Cancan ¹

1. Henan University of Chinese Medicine, Zhengzhou 450000, P. R. China;
2. The First Affiliated Hospital of Henan University of TCM, Zhengzhou 450008, P. R. China;
3. Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710000, P. R. China;

Corresponding?author：

XU Liran, Email: xuliran666@sina.com

Keywords：

Traditional Chinese medicine compound preparations; AIDS; Clinical research; Evidence map

DOI：

10.7507/1672-2531.202211038

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically search and sort out the clinical research literature on the treatment of AIDS by traditional Chinese medicine compound preparations by using the evidence map method, and to understand the distribution of evidence in this field. Methods The CNKI, WanFang Data, VIP, CBM, PubMed and Cochrane Library databases were electronically searched to collect studies on the treatment of AIDS with traditional Chinese medicine compound preparations from inception to August 2022. The distribution characteristics of evidence were analyzed and presented in the form of charts and words. Results A total of 337 articles were included, involving 268 intervention studies, 66 observational studies and 4 systematic reviews/meta-analysis. A total of 92 kinds of traditional Chinese medicine compound preparations were obtained, and the literature quantity of different preparations was obviously stratified, with Kangaibaosheng preparation being the most frequently reported. In recent years, the number of published literature has been declining, the quality of literature is generally low, and the level of evidence is not high. As for the intervention duration, this field tends to have a longer intervention observation period. As for the outcome indicators, the evaluation criteria of some indicators are not uniform, and the characteristics of TCM advantages are not reflected. The quantity and quality of systematic reviews/meta-analyses were insufficient. No normative consensus or guidelines for the treatment of AIDS with traditional Chinese medicine compound preparations had been formed. Conclusion studies on the effectiveness and safety of traditional Chinese medicine compound preparations in treating AIDS has initially formed a certain scale of evidence group. In the future, it is necessary to further improve the quality of studies, explore outcome indicators that can reflect the advantages of TCM efficacy, and formulate relevant guidelines in a standardized manner.

Citation： SHA Yinyin, XU Liran, WANG Xueting, SHAO Cancan. Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations: an evidence map analysis. Chinese Journal of Evidence-Based Medicine, 2023, 23(5): 583-587. doi: 10.7507/1672-2531.202211038 Copy

1.	許向前, 許前磊, 金艷濤, 等. 后HAART時期中醫藥調節HIV/AIDS患者免疫功能研究評述. 中華中醫藥雜志, 2018, 33(3): 829-832.
2.	Qian Z, Zhang Y, Xie X, et al. Efficacy and safety of traditional Chinese herbal medicine combined with HAART in the treatment of HIV/AIDS: a protocol for systematic review and meta-analysis. Medicine (Baltimore), 2021, 100(52): e28287.
3.	羅偉生, 王仕衍, 黃瑞, 等. 中藥復方制劑聯合HAART對HIV/AIDS病人免疫重建的系統評價. 中國艾滋病性病, 2017, 23(1): 28-32.
4.	張方圓, 沈傲梅, 強萬敏. AMSTAR使用過程中存在的問題及建議. 中國循證心血管醫學雜志, 2018, 10(2): 138-142.
5.	熊俊, 陳日新. 系統評價/Meta分析方法學質量的評價工具AMSTAR. 中國循證醫學雜志, 2011, 11(9): 1084-1089.
6.	李艷飛, 李秀霞, 李睿, 等. 證據圖譜的制作與報告. 中國循證醫學雜志, 2020, 20(9): 1098-1103.
7.	張情. 中西醫結合治療艾滋病對免疫功能的影響. 云南中醫中藥雜志, 2011, 32(10): 59-60.
8.	楊玉琪, 瞿廣城, 蒲亞萍, 等. 167例轉氨酶異常的老年艾滋病患者接受中西醫結合治療效果分析. 云南中醫中藥雜志, 2019, 40(1): 23-26.
9.	楊玉琪, 瞿廣城, 陸中云, 等. 扶正抗毒丸聯合HAART治療艾滋病免疫重建不全的臨床療效分析. 中醫藥導報, 2020, 26(10): 66-68.
10.	孫俊, 王莉, 賀錚錚, 等. 康愛保生丸對HAART后低CD4/CD8比值的HIV/AIDS患者療效分析. 云南中醫中藥雜志, 2020, 41(10): 16-19.
11.	孫俊, 汪林芬, 張祖英, 等. 人類免疫缺陷病毒/艾滋病患者接受高效抗逆轉錄病毒治療聯合中醫藥治療后血常規結果的臨床分析. 中醫臨床研究, 2020, 12(20): 10-13.
12.	趙競, 王莉, 柳陳堅, 等. 1373例HIV/AIDS患者中醫藥治療臨床療效分析. 云南中醫學院學報, 2017, 40(5): 34-39.
13.	楊玉琪, 瞿廣城, 蔡怡, 等. 中西醫結合治療對艾滋病免疫重建不全者CD4~+T淋巴細胞影響. 中國艾滋病性病, 2019, 25(7): 680-682,712.
14.	袁君, 金艷濤, 蔣自強, 等. 中醫藥治療對HIV/AIDS患者CD4~+淋巴細胞計數影響的回顧性分析. 中國中西醫結合雜志, 2018, 38(4): 407-409.
15.	李亮平, 徐立然, 扶偉, 等. 中醫藥綜合干預對艾滋病病毒感染者/艾滋病患者免疫功能和機會性感染的長期影響. 中醫學報, 2016, 31(1): 1-3.
16.	Wang D, Ma S, Ma Y, et al. Effect of traditional Chinese medicine therapy on the trend in CD4+ T-Cell counts among patients with HIV/AIDS treated with antiretroviral therapy: a retrospective cohort study. Evid Based Complement Alternat Med, 2021, 2021: 5576612.
17.	李靜茹, 馬秀蘭, 張穎, 等. 中西醫結合治療1250例艾滋病前瞻性隊列研究. 中國中西醫結合雜志, 2022, 42(4): 425-430.
18.	吳雪. 中醫藥調控腸道菌群改善艾滋病免疫重建不全作用的臨床觀察. 北京: 中國中醫科學院, 2021.
19.	Su QJ, Song C, Lu ZZ, et al. Impact of herbal preparations on outcomes of highly active antiretroviral therapy: a one-year prospective cohort study. Chin J Integr Med, 2020, 26(7): 497-501.
20.	魏葉葉, 馬建萍. 太芪培元顆粒治療HIV感染者臨床療效觀察. 中國醫藥導刊, 2017, 19(12): 1378-1381.
21.	李佩. 中藥艾可清膠囊對HIV感染者長期干預的研究. 廣州: 廣州中醫藥大學, 2010.
22.	宋夕元, 李寧, 崔偉鋒, 等. 隨機對照臨床評價中醫藥干預艾滋病療效存在的問題及對策. 中華中醫藥雜志, 2019, 34(12): 5774-5777.
23.	許向前, 馬玉青, 許前磊, 等. 中醫藥聯合高效聯合抗反轉錄病毒治療HIV/AIDS協同增效評價指標體系構建探討. 中華中醫藥雜志, 2020, 35(7): 3496-3498.
24.	趙少英, 張欣欣, 許前磊, 等. 后HAART時期艾滋病合并慢性病中醫藥防治. 中醫學報, 2022, 37(3): 524-528.
25.	許前磊, 李青雅, 金艷濤, 等. 后HAART時期中醫藥防治艾滋病的切入點. 中國中西醫結合雜志, 2016, 36(9): 1128-1131.
26.	王莉, 和麗生, 楊玉琪, 等. 康愛保生丸聯合HAART治療404例ⅡB期艾滋病患者: 隨機對照研究. 中國中西醫結合雜志, 2021, 41(11): 1307-1311.
27.	Wang J, Li Y, Tang YL, et al. Effect of immune No. 2 on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment:a randomized double blind placebo controlled clinical trial. Chin J Integr Med, 2013, 19(5): 340-346.
28.	咸慶飛. 從脾腎論治男男性接觸(MSM)AIDS患者抗病毒治療后免疫重建不全的研究. 北京: 中國中醫科學院, 2019.
29.	張揚武, 羅偉生, 黃瑞, 等. 益氣扶正法聯合高效抗逆轉錄病毒治療對艾滋病患者免疫重建的Meta分析. 遼寧中醫雜志, 2016, 43(10): 2042-2047.
30.	王映林, 劉建忠, 肖明中, 等. 健脾補腎法治療艾滋病患者的臨床效果. 中國醫藥導報, 2022, 19(2): 112-116.
31.	胡智平, 曹文欽, 陳小明, 等. 益氣養血、健脾祛濕方治療無癥狀HIV感染期臨床研究. 湖北中醫雜志, 2012, 34(3): 3-5.
32.	馬伯艷, 符林春, 蔡衛平, 等. 艾可清膠囊聯合高效抗病毒逆轉錄療法治療艾滋病臨床觀察. 廣州中醫藥大學學報, 2007, 24(6): 466-470.
33.	王階, 林洪生, 李勇, 等. 免疫2號方對艾滋病免疫重建不全患者臨床癥狀、體征的影響. 中醫雜志, 2012, 53(11): 923-926.
34.	吳廣偉, 朱克武, 李茂清, 等. 溫脾補腎法聯合高效抗逆轉錄病毒治療對HIV/AIDS患者免疫功能影響的研究. 國際醫藥衛生導報, 2014, 20(13): 1874-1878.
35.	劉明, 余花, 孟偉民, 等. 抗艾扶正膠囊聯合抗逆轉錄病毒(HAART)治療青海地區艾滋病的臨床療效觀察. 青海醫藥雜志, 2013, 43(9): 66-70.
36.	金艷濤, 許前磊, 蔣自強, 等. 中醫藥綜合治療對河南省農村地區HIV/AIDS患者生存質量的影響. 中醫雜志, 2016, 57(7): 579-583.

1. 許向前, 許前磊, 金艷濤, 等. 后HAART時期中醫藥調節HIV/AIDS患者免疫功能研究評述. 中華中醫藥雜志, 2018, 33(3): 829-832.
2. Qian Z, Zhang Y, Xie X, et al. Efficacy and safety of traditional Chinese herbal medicine combined with HAART in the treatment of HIV/AIDS: a protocol for systematic review and meta-analysis. Medicine (Baltimore), 2021, 100(52): e28287.
3. 羅偉生, 王仕衍, 黃瑞, 等. 中藥復方制劑聯合HAART對HIV/AIDS病人免疫重建的系統評價. 中國艾滋病性病, 2017, 23(1): 28-32.
4. 張方圓, 沈傲梅, 強萬敏. AMSTAR使用過程中存在的問題及建議. 中國循證心血管醫學雜志, 2018, 10(2): 138-142.
5. 熊俊, 陳日新. 系統評價/Meta分析方法學質量的評價工具AMSTAR. 中國循證醫學雜志, 2011, 11(9): 1084-1089.
6. 李艷飛, 李秀霞, 李睿, 等. 證據圖譜的制作與報告. 中國循證醫學雜志, 2020, 20(9): 1098-1103.
7. 張情. 中西醫結合治療艾滋病對免疫功能的影響. 云南中醫中藥雜志, 2011, 32(10): 59-60.
8. 楊玉琪, 瞿廣城, 蒲亞萍, 等. 167例轉氨酶異常的老年艾滋病患者接受中西醫結合治療效果分析. 云南中醫中藥雜志, 2019, 40(1): 23-26.
9. 楊玉琪, 瞿廣城, 陸中云, 等. 扶正抗毒丸聯合HAART治療艾滋病免疫重建不全的臨床療效分析. 中醫藥導報, 2020, 26(10): 66-68.
10. 孫俊, 王莉, 賀錚錚, 等. 康愛保生丸對HAART后低CD4/CD8比值的HIV/AIDS患者療效分析. 云南中醫中藥雜志, 2020, 41(10): 16-19.
11. 孫俊, 汪林芬, 張祖英, 等. 人類免疫缺陷病毒/艾滋病患者接受高效抗逆轉錄病毒治療聯合中醫藥治療后血常規結果的臨床分析. 中醫臨床研究, 2020, 12(20): 10-13.
12. 趙競, 王莉, 柳陳堅, 等. 1373例HIV/AIDS患者中醫藥治療臨床療效分析. 云南中醫學院學報, 2017, 40(5): 34-39.
13. 楊玉琪, 瞿廣城, 蔡怡, 等. 中西醫結合治療對艾滋病免疫重建不全者CD4~+T淋巴細胞影響. 中國艾滋病性病, 2019, 25(7): 680-682,712.
14. 袁君, 金艷濤, 蔣自強, 等. 中醫藥治療對HIV/AIDS患者CD4~+淋巴細胞計數影響的回顧性分析. 中國中西醫結合雜志, 2018, 38(4): 407-409.
15. 李亮平, 徐立然, 扶偉, 等. 中醫藥綜合干預對艾滋病病毒感染者/艾滋病患者免疫功能和機會性感染的長期影響. 中醫學報, 2016, 31(1): 1-3.
16. Wang D, Ma S, Ma Y, et al. Effect of traditional Chinese medicine therapy on the trend in CD4+ T-Cell counts among patients with HIV/AIDS treated with antiretroviral therapy: a retrospective cohort study. Evid Based Complement Alternat Med, 2021, 2021: 5576612.
17. 李靜茹, 馬秀蘭, 張穎, 等. 中西醫結合治療1250例艾滋病前瞻性隊列研究. 中國中西醫結合雜志, 2022, 42(4): 425-430.
18. 吳雪. 中醫藥調控腸道菌群改善艾滋病免疫重建不全作用的臨床觀察. 北京: 中國中醫科學院, 2021.
19. Su QJ, Song C, Lu ZZ, et al. Impact of herbal preparations on outcomes of highly active antiretroviral therapy: a one-year prospective cohort study. Chin J Integr Med, 2020, 26(7): 497-501.
20. 魏葉葉, 馬建萍. 太芪培元顆粒治療HIV感染者臨床療效觀察. 中國醫藥導刊, 2017, 19(12): 1378-1381.
21. 李佩. 中藥艾可清膠囊對HIV感染者長期干預的研究. 廣州: 廣州中醫藥大學, 2010.
22. 宋夕元, 李寧, 崔偉鋒, 等. 隨機對照臨床評價中醫藥干預艾滋病療效存在的問題及對策. 中華中醫藥雜志, 2019, 34(12): 5774-5777.
23. 許向前, 馬玉青, 許前磊, 等. 中醫藥聯合高效聯合抗反轉錄病毒治療HIV/AIDS協同增效評價指標體系構建探討. 中華中醫藥雜志, 2020, 35(7): 3496-3498.
24. 趙少英, 張欣欣, 許前磊, 等. 后HAART時期艾滋病合并慢性病中醫藥防治. 中醫學報, 2022, 37(3): 524-528.
25. 許前磊, 李青雅, 金艷濤, 等. 后HAART時期中醫藥防治艾滋病的切入點. 中國中西醫結合雜志, 2016, 36(9): 1128-1131.
26. 王莉, 和麗生, 楊玉琪, 等. 康愛保生丸聯合HAART治療404例ⅡB期艾滋病患者: 隨機對照研究. 中國中西醫結合雜志, 2021, 41(11): 1307-1311.
27. Wang J, Li Y, Tang YL, et al. Effect of immune No. 2 on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment:a randomized double blind placebo controlled clinical trial. Chin J Integr Med, 2013, 19(5): 340-346.
28. 咸慶飛. 從脾腎論治男男性接觸(MSM)AIDS患者抗病毒治療后免疫重建不全的研究. 北京: 中國中醫科學院, 2019.
29. 張揚武, 羅偉生, 黃瑞, 等. 益氣扶正法聯合高效抗逆轉錄病毒治療對艾滋病患者免疫重建的Meta分析. 遼寧中醫雜志, 2016, 43(10): 2042-2047.
30. 王映林, 劉建忠, 肖明中, 等. 健脾補腎法治療艾滋病患者的臨床效果. 中國醫藥導報, 2022, 19(2): 112-116.
31. 胡智平, 曹文欽, 陳小明, 等. 益氣養血、健脾祛濕方治療無癥狀HIV感染期臨床研究. 湖北中醫雜志, 2012, 34(3): 3-5.
32. 馬伯艷, 符林春, 蔡衛平, 等. 艾可清膠囊聯合高效抗病毒逆轉錄療法治療艾滋病臨床觀察. 廣州中醫藥大學學報, 2007, 24(6): 466-470.
33. 王階, 林洪生, 李勇, 等. 免疫2號方對艾滋病免疫重建不全患者臨床癥狀、體征的影響. 中醫雜志, 2012, 53(11): 923-926.
34. 吳廣偉, 朱克武, 李茂清, 等. 溫脾補腎法聯合高效抗逆轉錄病毒治療對HIV/AIDS患者免疫功能影響的研究. 國際醫藥衛生導報, 2014, 20(13): 1874-1878.
35. 劉明, 余花, 孟偉民, 等. 抗艾扶正膠囊聯合抗逆轉錄病毒(HAART)治療青海地區艾滋病的臨床療效觀察. 青海醫藥雜志, 2013, 43(9): 66-70.
36. 金艷濤, 許前磊, 蔣自強, 等. 中醫藥綜合治療對河南省農村地區HIV/AIDS患者生存質量的影響. 中醫雜志, 2016, 57(7): 579-583.

Chinese Journal of Evidence-Based Medicine

Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations: an evidence map analysis

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