Disease burden analysis of congenital birth defects in China from 1990 to 2019_Chinese Journal of Evidence-Based Medicine

Authors：

LENG Xue ¹ ,  XIAO Wenyan ² , ZHENG Juan ¹ , WANG Fengying ¹

1. The Second Department of Obstetrics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, P. R. China;
2. The Second Department of Intensive Care Unit, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P. R. China;

Corresponding?author：

XIAO Wenyan, Email: 516956335@qq.com

Keywords：

Birth defects; Morbidity; Mortality; Disease burden

DOI：

10.7507/1672-2531.202301060

Video：

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Objective To analyze the trend of disease burden changes in congenital birth defects in China from 1990 to 2019. Methods Using the global burden of disease study 2019 (GBD 2019), we analyzed the morbidity, mortality, and disability-adjusted life years (DALYs) of congenital birth defect diseases and their corresponding age-standardized rates and average annual percentage change (AAPC) to analyze the changes in the disease burden of congenital birth defects in China and compared them with global data from 1990 to 2019. Results In 2019, the age-standardized incidence, mortality, and DALY in China were 147.41/100 000, 4.62/100 000, 480.95/100 000, respectively. Compared with 1990, the age-standardized incidence rate, age-standardized mortality rate, and age-standardized DALY rate increased by 12.08% and decreased by 70.38% and 66.82%, respectively. In recent years, although the age-standardized incidence of congenital birth defect disease in China is on the rise and higher than the global level, the disease burden is roughly on the decline and lower than the global level, which is closely related to earlier intervention and treatment of the disease resulting in a lower standardized mortality rate. Conclusion The age-standardized mortality rate of children with congenital birth defects in China showed a decreasing trend from 1990 to 2019, and the burden of disease ranged from slightly higher than global to lower than global levels, but the age-standardized incidence rate was significantly higher, but the age-specific incidence rate has increased significantly.

Citation： LENG Xue, XIAO Wenyan, ZHENG Juan, WANG Fengying. Disease burden analysis of congenital birth defects in China from 1990 to 2019. Chinese Journal of Evidence-Based Medicine, 2023, 23(4): 386-390. doi: 10.7507/1672-2531.202301060 Copy

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1. 余靈輝, 李海燕, 曹登成. 圍產兒出生缺陷及相關危險因素分析. 醫學臨床研究, 2016, 33(7): 1307-1309.
2. 李淑妮, 許晨耘, 伍芳芳, 等. 海口市2016-2019年新生兒出生缺陷情況及相關影響因素分析. 實用預防醫學, 2021, 28(7): 881-884.
3. 黃歡, 孫麗洲. 出生缺陷的現狀、干預措施及分析. 中國產前診斷雜志(電子版), 2016, 8(3): 1-8.
4. 中華人民共和國衛生部. 中國出生缺陷防治報告(2012).
5. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1204-1222.
6. Li C, Jiang S, Zhang X. Intergenerational relationship, family social support, and depression among Chinese elderly: a structural equation modeling analysis. J Affect Disord, 2019, 248: 73-80.
7. Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2019, 394(10204): 1145-1158.
8. GBD 2019 Demographics Collaborators. Global, regional, and national age-sex-specific fertility, mortality, and population estimates, 1950-2019: a comprehensive demographic analysis for the global burden of disease study 2019. Lancet, 2020, 396(10258): 1160-1203.
9. 王莉, 吳愛惜, 李娟. 圍生兒發生出生缺陷的危險因素分析. 中國婦幼保健, 2021, 36(22): 5306-5308.
10. 陳愛軍, 任靜, 張美麗, 等. 高齡孕婦胎兒出生缺陷情況分析. 河北醫藥, 2017, 39(17): 2656-2658.
11. 王睜, 李利, 雷雪丫, 等. 產婦高齡對新生兒出生缺陷及生后并發癥的影響. 中國當代兒科雜志, 2016, 18(11): 1084-1089.
12. 袁麗, 夏榮明. 北京市朝陽區106370例圍產兒出生缺陷監測結果及相關因素分析. 中國婦幼保健, 2017, 32(1): 81-85.
13. 田曉勤, 姜紅. 武漢市新生兒出生缺陷情況調查及相關危險因素分析. 中國婦幼保健, 2016, 31(5): 1021-1023.
14. 張亞麗, 藍菊紅, 呂卓超, 等. 麗水市出生缺陷影響因素的病例對照研究. 溫州醫科大學學報, 2017, 47(1): 56-60.
15. 章玉霜, 金海華. 新生兒出生缺陷監測及相關危險因素分析. 中國婦幼保健, 2019, 34(9): 2069-2071.
16. 吳鳳妹, 林英, 謝真. 聯合切面掃查在胎兒先天性心臟病篩查中的現狀分析. 影像研究與醫學應用, 2019, 3(4): 206-209.
17. 闕敏, 孫巧玲, 計國平, 等. 安徽省圍生兒出生缺陷流行病學特征分析. 中國婦幼保健, 2021, 36(19): 4516-4519.
18. 汪桂艷, 鐘紅秀, 趙旭, 等. 廈門地區圍產兒出生缺陷監測情況分析. 中國婦幼保健, 2018, 33(22): 5050-5052.
19. 劉珍, 周陽文, 李小洪, 等. 出生缺陷防控健康教育專家共識. 中國婦幼保健, 2022, 37(5): 775-779.
20. 蔣夢可, 陸宗慶, 周伍明, 等. 1990—2019年中國胰腺炎疾病負擔分析. 中國循證醫學雜志, 2022, 22(8): 869-875.

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