Acupuncture for Alzheimer’s disease: a scoping review of clinical studies_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Xinyue ^1,2 , YIN Zihan ^1,2 , LI Yaqin ^1,2 , XIA Manze ^1,2 , CHEN Zhenghong ^1,2 , ZHAO Ling ^1,2 ,  LIANG Fanrong ^1,2

1. School of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, P. R. China;
2. Acupuncture Clinical Research Center of Sichuan Province, Chengdu 610075, P. R. China;

Corresponding?author：

LIANG Fanrong, Email: acuresearch@126.com

Keywords：

Acupuncture; Alzheimer' s disease; Clinical study; Scoping review

DOI：

10.7507/1672-2531.202302007

Video：

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Objective To provide a scoping review of the clinical studies of acupuncture on Alzheimer' s disease (AD). Methods The CNKI, WanFang Data, VIP, CBM, Web of Science, PubMed, EMbase, Cochrane Library databases, and ClinicalTrials.gov, ChiCTR clinical trial registration systems were searched to collect clinical studies on acupuncture treatment of AD from inception to May 14, 2022. Scope review method was used to summarize and analyze the publication year trend, type, degree of disease, traditional Chinese medicine (TCM) syndrome differentiation, sample size, treatment plan, intervention time, and outcome. Results A total of 226 clinical original research were included. This field emerged in 1995 and has been increasing. The main type of clinical research was randomized controlled trials. 56 studies paid attention to the severity of AD. Only 54 studies classified AD according to different criteria of TCM syndrome differentiation. There were only 4 studies with large sample size (>200 cases). Conventional acupuncture was the main intervention method in clinical research, with a total of 129 articles. Electroacupuncture was the main special acupuncture method, a total of 31 articles. More than 70 % of the studies had a course of intervention between 84 and 168 days. Among the 12 types of outcome indicators, cognitive function, clinical efficiency, activity function evaluation, cerebrospinal fluid and blood biomarkers, and adverse reactions were the most concerned outcomes. However, less attention was paid to neuropsychiatric symptoms and quality of life in AD patients. Acupuncture could improve the cognitive function of AD patients, but the current clinical related mechanism research was shallow, and the acupuncture point selection was also more diverse. Conclusion The clinical research of acupuncture in AD has formed a scale, but the current research type is single. The clinical research design schemes are various but not yet unified, and there is a lack of relevant authoritative TCM standards.

Citation： ZHANG Xinyue, YIN Zihan, LI Yaqin, XIA Manze, CHEN Zhenghong, ZHAO Ling, LIANG Fanrong. Acupuncture for Alzheimer’s disease: a scoping review of clinical studies. Chinese Journal of Evidence-Based Medicine, 2023, 23(7): 783-789. doi: 10.7507/1672-2531.202302007 Copy

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3. 中國老年醫學學會認知障礙分會, 認知障礙患者照料及管理專家共識撰寫組. 阿爾茨海默病患者日常生活能力和精神行為癥狀及認知功能全面管理中國專家共識(2019). 中華老年醫學雜志, 2020, 39(1): 1-8.
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5. 魏玉婷, 朱田田, 賈靜, 等. 針灸干預阿爾茨海默病作用機制的研究進展. 針刺研究, 2022, 47(4): 362-368.
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12. 鄒靖鋒, 郭培燕, 謝珂, 等. 針刺聯用中藥治療阿爾茨海默病療效Meta分析. 中醫學報, 2016, 31(1): 138-143.
13. 李姣, 劉進進. 針藥結合治療阿爾茨海默病療效的Meta分析. 阿爾茨海默病及相關病, 2019, 2(3): 431-436.
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18. Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med, 2018, 169(7): 467-473.
19. 梁繁榮, 王華. 針灸學. 第4版. 北京: 中國中醫藥出版社, 2016: 135-186.
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Chinese Journal of Evidence-Based Medicine

Acupuncture for Alzheimer’s disease: a scoping review of clinical studies

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