Efficacy of high-intensity interval training on weight loss and blood lipid metabolism with overweight or obesity: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Peiyuan ¹ , YANG Junchao ¹ , LU Zhihui ^1,2 ,  QIU Junqiang ^1,3

1. Exercise Science School, Beijing Sport University, Beijing 100084, P. R. China;
2. China Football College, Beijing Sport University, Beijing 100084, P. R. China;
3. Beijing Sports Nutrition Engineering Research Center, Beijing 100084, P. R. China;

Corresponding?author：

QIU Junqiang, Email: qiujunqiang@bsu.edu.cn

Keywords：

High intensity interval training; Overweight; Obesity; Blood lipid metabolism; Meta-analysis

DOI：

10.7507/1672-2531.202307110

Video：

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Objective To systematically review the intervention effects of high-intensity interval training (HIIT) on weight loss and blood lipid metabolism in overweight/obese populations. Methods The computer conducted searches in the PubMed, Embase, Cochrane Library, Web of Science, CNKI, and WanFang Data database to collect randomized controlled trials (RCTs) related to HIIT and weight loss, fat reduction, and blood lipid metabolism in overweight/obese populations. The search was conducted from the inception of the databases to March 31, 2023. Two researchers independently conducted literature screening and data extraction. After evaluating the risk of bias of the included studies, a meta-analysis was performed using RevMan 5.4 software. Results A total of 19 RCTs, involving 595 overweight/obese participants, were included. The meta-analysis results showed that compared wtih the control group, HIIT interventions effectively reduced body weight (MD=?2.63, 95%CI ?4.04 to ?1.23, P<0.05), BMI (MD=?1.21, 95%CI ?1.95 to ?0.48, P<0.05), Fat% (MD=?1.66, 95%CI ?2.28 to ?1.04, P<0.05), TG (MD=?0.13, 95%CI ?0.25 to ?0.01, P=0.04), HDL (MD=0.14, 95%CI 0.05 to 0.23, P<0.05), and LDL (MD=?0.26, 95%CI ?0.39 to ?0.13, P<0.05) levels but did not improve TC (MD=?0.15, 95%CI ?0.36 to 0.06, P=0.15) levels. Conclusion HIIT intervention can effectively improve body weight, BMI, Fat%, TG, HDL, and LDL levels in overweight/obese populations, particularly showing a more pronounced improvement in lipid profiles among overweight/obese adolescents, but it does not reduce TC levels. This study demonstrates that HIIT may be an effective strategy to assist in weight loss and prevent cardiovascular diseases in overweight/obese populations, with potential for broader application.

Citation： LI Peiyuan, YANG Junchao, LU Zhihui, QIU Junqiang. Efficacy of high-intensity interval training on weight loss and blood lipid metabolism with overweight or obesity: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2024, 24(3): 272-279. doi: 10.7507/1672-2531.202307110 Copy

1.	GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med, 2017, 377(1): 13-27.
2.	國家衛生健康委. 中國居民營養與慢性病狀況報告(2020年). 營養學報, 2020, 42(6): 521.
3.	Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol, 2021, 9(6): 373-392.
4.	Pi-Sunyer X. The medical risks of obesity. Postgrad Med, 2009, 121(6): 21-33.
5.	Visscher TL, Seidell JC. The public health impact of obesity. Annu Rev Public Health, 2001, 22: 355-375.
6.	Westerterp KR. Exercise, energy expenditure and energy balance, as measured with doubly labelled water. Proc Nutr Soc, 2018, 77(1): 4-10.
7.	邱俊強, 路明月, 張君, 等. 運動促進健康: 個性化精準解決方案. 北京體育大學學報, 2022, 45(10): 2-18.
8.	Trapp EG, Chisholm DJ, Freund J, et al. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond), 2008, 32(4): 684-691.
9.	Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med, 2012, 42(6): 489-509.
10.	Tj?nna AE, St?len TO, Bye A, et al. Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents. Clin Sci (Lond), 2009, 116(4): 317-326.
11.	黎涌明. 高強度間歇訓練對不同訓練人群的應用效果. 體育科學, 2015, 35(8): 59-75, 96.
12.	Cochrane Library. Cochrane handbook for systematic reviews of interventions (version 6.4). 2023.
13.	Cumpston M, Li T, Page MJ, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev, 2019, (10): ED000142.
14.	Racil G, Ben Ounis O, Hammouda O, et al. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol, 2013, 113(10): 2531-2540.
15.	韓涵. 高強度間歇和中強度持續訓練對青年肥胖女性體脂分布的影響. 石家莊: 河北師范大學, 2014.
16.	Smith-Ryan AE, Melvin MN, Wingfield HL. High-intensity interval training: modulating interval duration in overweight/obese men. Phys Sportsmed, 2015, 43(2): 107-113.
17.	Smith-Ryan AE, Trexler ET, Wingfield HL, et al. Effects of high-intensity interval training on cardiometabolic risk factors in overweight/obese women. J Sports Sci, 2016, 34(21): 2038-2046.
18.	林堅, 趙紅勤, 黃雄昂, 等. 高強度間歇訓練對肥胖女大學生體成分和血脂及空腹胰島素水平的影響. 中國全科醫學, 2016, 19(18): 2139-2144.
19.	王玲. 高強度間歇訓練對肥胖青年女性血清FGF21及糖脂代謝的影響. 石家莊: 河北師范大學, 2017.
20.	Khammassi M, Ouerghi N, Hadj-Taieb S, et al. Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth. J Exerc Rehabil, 2018, 14(1): 118-125.
21.	Sa?udo B, Mu?oz T, Davison GW, et al. High-intensity interval training combined with vibration and dietary restriction improves body composition and blood lipids in obese adults: a randomized trial. Dose Response, 2018, 16(3): 1559325818797015.
22.	Nazari M, Minasian V, Hovsepian S. Effects of two types of moderate- and high-intensity interval training on serum salusin-α and salusin-β levels and lipid profile in women with overweight/obesity. Diabetes Metab Syndr Obes, 2020, 13: 1385-1390.
23.	曹甍. 不同訓練方案對肥胖男生身體成分和糖脂代謝的干預效果研究. 上海: 上海體育學院, 2020.
24.	陳姍. 高強度間歇訓練與交叉點訓練對超重成年女性血脂代謝的影響. 北京: 北京體育大學, 2020.
25.	張立萌. 高強度間歇訓練對超重青年循環骨鈣素及其相關指標的影響. 北京: 首都體育學院, 2020.
26.	Saeidi A, Shishvan SR, Soltani M, et al. Differential effects of exercise programs on neuregulin 4, body composition and cardiometabolic risk factors in men with obesity. Front Physiol, 2022, 12: 797574.
27.	Sanayei M, Izadi A, Hajizadeh-Sharafabad F, et al. Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial. J Diabetes Metab Disord, 2021, 20(1): 781-792.
28.	阿迪力·尤努斯. 高強度間歇訓練對肥胖大學生身體成分和血脂代謝指標的影響研究. 烏魯木齊: 新疆師范大學, 2021.
29.	袁玲玲. 高強度間歇運動對超重或肥胖男性青少年心肺適能和身體成分及血脂水平的影響. 中華物理醫學與康復雜志, 2021, 43(3): 251-253.
30.	張立萌, 卜淑敏, 劉曉然. 6周高強度間歇訓練對超重/肥胖男青年循環骨鈣素水平的影響. 中國運動醫學雜志, 2021, 40(4): 270-275.
31.	Leite N, Pizzi J, De Menezes Junior FJ, et al. Effect of mict and hiit on cardiometabolic risk and body composition in obese boys. Revista Brasileira de Medicina do Esporte, 2022, 28(4): 274-280.
32.	蘭霄宇, 房國梁, 韓天雨, 等. 高強度有氧間歇運動對超重或肥胖老年人體成分、血脂及血糖的影響. 中國運動醫學雜志, 2022, 41(7): 510-517.
33.	Patton GC, Coffey C, Carlin JB, et al. Overweight and obesity between adolescence and young adulthood: a 10-year prospective cohort study. J Adolesc Health, 2011, 48(3): 275-280.
34.	O'Donovan G, Blazevich AJ, Boreham C, et al. The ABC of physical activity for health: a consensus statement from the British Association of Sport and Exercise Sciences. J Sports Sci, 2010, 28(6): 573-591.
35.	Santos VOA, Browne RAV, Souza DC, et al. Effects of high-intensity interval and moderate-intensity continuous exercise on physical activity and sedentary behavior levels in inactive obese males: a crossover trial. J Sports Sci Med. 2019, 18(3): 390-398.
36.	Thompson D, Karpe F, Lafontan M, et al. Physical activity and exercise in the regulation of human adipose tissue physiology. Physiol Rev, 2012, 92(1): 157-191.
37.	Ludzki AC, Schleh MW, Krueger EM, et al. Inflammation and metabolism gene sets in subcutaneous abdominal adipose tissue are altered 1 hour after exercise in adults with obesity. J Appl Physiol (1985), 2021, 131(4): 1380-1389.
38.	Trapp EG, Chisholm DJ, Boutcher SH. Metabolic response of trained and untrained women during high-intensity intermittent cycle exercise. Am J Physiol Regul Integr Comp Physiol, 2007, 293(6): R2370-R2375.
39.	Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Med, 2018, 48(2): 269-288.
40.	Vekic J, Zeljkovic A, Stefanovic A, et al. Obesity and dyslipidemia. Metabolism, 2019, 92: 71-81.
41.	中國成人血脂異常防治指南修訂聯合委員會. 中國成人血脂異常防治指南(2016年修訂版). 中國循環雜志, 2016, 31(10): 937-950.
42.	Chang KT, Chen CH, Chuang HH, et al. Which obesity index is the best predictor for high cardiovascular disease risk in middle-aged and elderly population. Arch Gerontol Geriatr, 2018, 78: 165-170.
43.	Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med, 2013, 43(10): 927-954.
44.	Laursen P. Science and application of high-intensity interval training: solutions to the programming puzzle. Human Kinetics, 2018.
45.	de Glisezinski I, Larrouy D, Bajzova M, et al. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol, 2009, 587(Pt 13): 3393-3404.
46.	朱顯貴, 石旅暢, 張海峰. 不同強度運動對脂解激素的影響及在減肥機制中的作用研究進展. 中國運動醫學雜志, 2020, 39(7): 569-576.

1. GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med, 2017, 377(1): 13-27.
2. 國家衛生健康委. 中國居民營養與慢性病狀況報告(2020年). 營養學報, 2020, 42(6): 521.
3. Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol, 2021, 9(6): 373-392.
4. Pi-Sunyer X. The medical risks of obesity. Postgrad Med, 2009, 121(6): 21-33.
5. Visscher TL, Seidell JC. The public health impact of obesity. Annu Rev Public Health, 2001, 22: 355-375.
6. Westerterp KR. Exercise, energy expenditure and energy balance, as measured with doubly labelled water. Proc Nutr Soc, 2018, 77(1): 4-10.
7. 邱俊強, 路明月, 張君, 等. 運動促進健康: 個性化精準解決方案. 北京體育大學學報, 2022, 45(10): 2-18.
8. Trapp EG, Chisholm DJ, Freund J, et al. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond), 2008, 32(4): 684-691.
9. Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med, 2012, 42(6): 489-509.
10. Tj?nna AE, St?len TO, Bye A, et al. Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents. Clin Sci (Lond), 2009, 116(4): 317-326.
11. 黎涌明. 高強度間歇訓練對不同訓練人群的應用效果. 體育科學, 2015, 35(8): 59-75, 96.
12. Cochrane Library. Cochrane handbook for systematic reviews of interventions (version 6.4). 2023.
13. Cumpston M, Li T, Page MJ, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev, 2019, (10): ED000142.
14. Racil G, Ben Ounis O, Hammouda O, et al. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol, 2013, 113(10): 2531-2540.
15. 韓涵. 高強度間歇和中強度持續訓練對青年肥胖女性體脂分布的影響. 石家莊: 河北師范大學, 2014.
16. Smith-Ryan AE, Melvin MN, Wingfield HL. High-intensity interval training: modulating interval duration in overweight/obese men. Phys Sportsmed, 2015, 43(2): 107-113.
17. Smith-Ryan AE, Trexler ET, Wingfield HL, et al. Effects of high-intensity interval training on cardiometabolic risk factors in overweight/obese women. J Sports Sci, 2016, 34(21): 2038-2046.
18. 林堅, 趙紅勤, 黃雄昂, 等. 高強度間歇訓練對肥胖女大學生體成分和血脂及空腹胰島素水平的影響. 中國全科醫學, 2016, 19(18): 2139-2144.
19. 王玲. 高強度間歇訓練對肥胖青年女性血清FGF21及糖脂代謝的影響. 石家莊: 河北師范大學, 2017.
20. Khammassi M, Ouerghi N, Hadj-Taieb S, et al. Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth. J Exerc Rehabil, 2018, 14(1): 118-125.
21. Sa?udo B, Mu?oz T, Davison GW, et al. High-intensity interval training combined with vibration and dietary restriction improves body composition and blood lipids in obese adults: a randomized trial. Dose Response, 2018, 16(3): 1559325818797015.
22. Nazari M, Minasian V, Hovsepian S. Effects of two types of moderate- and high-intensity interval training on serum salusin-α and salusin-β levels and lipid profile in women with overweight/obesity. Diabetes Metab Syndr Obes, 2020, 13: 1385-1390.
23. 曹甍. 不同訓練方案對肥胖男生身體成分和糖脂代謝的干預效果研究. 上海: 上海體育學院, 2020.
24. 陳姍. 高強度間歇訓練與交叉點訓練對超重成年女性血脂代謝的影響. 北京: 北京體育大學, 2020.
25. 張立萌. 高強度間歇訓練對超重青年循環骨鈣素及其相關指標的影響. 北京: 首都體育學院, 2020.
26. Saeidi A, Shishvan SR, Soltani M, et al. Differential effects of exercise programs on neuregulin 4, body composition and cardiometabolic risk factors in men with obesity. Front Physiol, 2022, 12: 797574.
27. Sanayei M, Izadi A, Hajizadeh-Sharafabad F, et al. Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial. J Diabetes Metab Disord, 2021, 20(1): 781-792.
28. 阿迪力·尤努斯. 高強度間歇訓練對肥胖大學生身體成分和血脂代謝指標的影響研究. 烏魯木齊: 新疆師范大學, 2021.
29. 袁玲玲. 高強度間歇運動對超重或肥胖男性青少年心肺適能和身體成分及血脂水平的影響. 中華物理醫學與康復雜志, 2021, 43(3): 251-253.
30. 張立萌, 卜淑敏, 劉曉然. 6周高強度間歇訓練對超重/肥胖男青年循環骨鈣素水平的影響. 中國運動醫學雜志, 2021, 40(4): 270-275.
31. Leite N, Pizzi J, De Menezes Junior FJ, et al. Effect of mict and hiit on cardiometabolic risk and body composition in obese boys. Revista Brasileira de Medicina do Esporte, 2022, 28(4): 274-280.
32. 蘭霄宇, 房國梁, 韓天雨, 等. 高強度有氧間歇運動對超重或肥胖老年人體成分、血脂及血糖的影響. 中國運動醫學雜志, 2022, 41(7): 510-517.
33. Patton GC, Coffey C, Carlin JB, et al. Overweight and obesity between adolescence and young adulthood: a 10-year prospective cohort study. J Adolesc Health, 2011, 48(3): 275-280.
34. O'Donovan G, Blazevich AJ, Boreham C, et al. The ABC of physical activity for health: a consensus statement from the British Association of Sport and Exercise Sciences. J Sports Sci, 2010, 28(6): 573-591.
35. Santos VOA, Browne RAV, Souza DC, et al. Effects of high-intensity interval and moderate-intensity continuous exercise on physical activity and sedentary behavior levels in inactive obese males: a crossover trial. J Sports Sci Med. 2019, 18(3): 390-398.
36. Thompson D, Karpe F, Lafontan M, et al. Physical activity and exercise in the regulation of human adipose tissue physiology. Physiol Rev, 2012, 92(1): 157-191.
37. Ludzki AC, Schleh MW, Krueger EM, et al. Inflammation and metabolism gene sets in subcutaneous abdominal adipose tissue are altered 1 hour after exercise in adults with obesity. J Appl Physiol (1985), 2021, 131(4): 1380-1389.
38. Trapp EG, Chisholm DJ, Boutcher SH. Metabolic response of trained and untrained women during high-intensity intermittent cycle exercise. Am J Physiol Regul Integr Comp Physiol, 2007, 293(6): R2370-R2375.
39. Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Med, 2018, 48(2): 269-288.
40. Vekic J, Zeljkovic A, Stefanovic A, et al. Obesity and dyslipidemia. Metabolism, 2019, 92: 71-81.
41. 中國成人血脂異常防治指南修訂聯合委員會. 中國成人血脂異常防治指南(2016年修訂版). 中國循環雜志, 2016, 31(10): 937-950.
42. Chang KT, Chen CH, Chuang HH, et al. Which obesity index is the best predictor for high cardiovascular disease risk in middle-aged and elderly population. Arch Gerontol Geriatr, 2018, 78: 165-170.
43. Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med, 2013, 43(10): 927-954.
44. Laursen P. Science and application of high-intensity interval training: solutions to the programming puzzle. Human Kinetics, 2018.
45. de Glisezinski I, Larrouy D, Bajzova M, et al. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol, 2009, 587(Pt 13): 3393-3404.
46. 朱顯貴, 石旅暢, 張海峰. 不同強度運動對脂解激素的影響及在減肥機制中的作用研究進展. 中國運動醫學雜志, 2020, 39(7): 569-576.

Chinese Journal of Evidence-Based Medicine

Efficacy of high-intensity interval training on weight loss and blood lipid metabolism with overweight or obesity: a meta-analysis

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