Prevalence of nocturnal enuresis among Chinese children and adolescents: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Wen ¹ , WANG Zhe ² , JIANG Haoran ³ , WANG Mingyue ⁴ ,  ZHENG Sanxia ⁴

1. The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, P. R. China;
2. Institute of Acumox and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, P. R. China;
3. College of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450046, P. R. China;
4. Department of Pediatrics, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, P. R. China;

Corresponding?author：

ZHENG Sanxia, Email: zhengsanxiasd@126.com

Keywords：

Nocturnal enuresis; Prevalence; Meta-analysis; Children; Adolescents

DOI：

10.7507/1672-2531.202310169

Video：

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Objective To systematically review the prevalence of enuresis in Chinese children and adolescents. Methods A computer search was conducted for epidemiological research on the prevalence of enuresis among Chinese children and adolescents in databases including CNKI, WanFang Data, VIP, SinoMed, PubMed, Embase, and Web of Science. Two researchers independently carried out literature screening, data extraction, and quality evaluation. Meta-analysis was executed using R language, with baujat plots and subgroup analysis to investigate heterogeneity sources, and leave-one-out for sensitivity analysis. Results A total of 38 papers were included, encompassing 327 065 participants, with 18 392 children suffering from enuresis. The aggregate prevalence rate was 5.59% (95%CI 4.58% to 6.81%). The prevalence rate showed a significant decreasing trend with increasing age, with rates at ages 5, 12, and 18 being 12.30% (95%CI 9.96% to 15.11%), 2.07% (95%CI 1.68% to 2.56%), and 1.95% (95%CI 0.90% to 4.20%), respectively. The incidence rate in male children was higher at 6.36% (95%CI 5.49% to 7.36%) than that in female children at 4.30% (95%CI 3.57% to 5.16%). Using DSM-IV as the diagnostic criteria, the prevalence rate was 3.78% (95%CI 2.58% to 5.52%), while it was 5.99% (95%CI 4.75% to 7.52%) using ICCS as the criteria. Conclusion The prevalence of enuresis among Chinese children and adolescents is affected by factors such as region, age, gender, and diagnostic standards. The prevalence is higher in South China, decreases with age, and is significantly higher in males than in females.

Citation： WANG Wen, WANG Zhe, JIANG Haoran, WANG Mingyue, ZHENG Sanxia. Prevalence of nocturnal enuresis among Chinese children and adolescents: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2024, 24(9): 1052-1060. doi: 10.7507/1672-2531.202310169 Copy

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4. Barone JG, Hanson C, DaJusta DG, et al. Nocturnal enuresis and overweight are associated with obstructive sleep apnea. Pediatrics, 2009, 124(1): e53-e59.
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Chinese Journal of Evidence-Based Medicine

Prevalence of nocturnal enuresis among Chinese children and adolescents: a meta-analysis

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