Guidelines for rehabilitation interventions in older adults with sarcopenia (2025 edition)_Chinese Journal of Evidence-Based Medicine

Authors：

 The Chinese Society of Physical Medicine and Rehabilitation

Rehabilitation Medicine Center of West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

The Chinese Society of Physical Medicine and Rehabilitation, Email: weiquan@scu.edu.cn

Keywords：

Age-related sarcopenia; Rehabilitation assessment; Rehabilitation therapy; Evidence-based medicine; Clinical practice guidelines

DOI：

10.7507/1672-2531.202512201

Video：

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Objective This guideline aims to address key challenges in the rehabilitation of sarcopenia in older adults in China, including the lack of standardized assessment systems, inconsistent intervention protocols, and insufficient multidisciplinary collaboration. Its goal is to promote the transformation toward an evidence-based, standardized, and individualized rehabilitation model, and to formulate a rehabilitation practice guideline tailored to the national context of China. Methods This guideline was initiated by the Chinese Society of Physical Medicine and Rehabilitation and West China Hospital of Sichuan University, and strictly followed the World Health Organization’s guideline development manual and the principles of clinical practice guideline development both domestically and internationally. A systematic search was conducted in relevant databases (from inception to November 30, 2025), and the PICO framework was used to structure clinical questions. Through a modified Delphi process, 23 core clinical questions were selected from 26 candidate questions. Methodological quality was assessed using internationally recognized tools, including the Cochrane Risk of Bias Tool, the Newcastle-Ottawa Scale, AMSTAR, and AGREE Ⅱ. The evidence grading system of the Oxford Centre for Evidence-Based Medicine and the GRADE system were applied to evaluate the quality of evidence and determine the strength of recommendations. After two rounds of external expert consultation, recommendations were formulated using the Evidence-to-Decision framework, and the guideline was drafted and reported in accordance with the RIGHT statement. Results This guideline addresses key areas in the rehabilitation of sarcopenia in older adults, including assessment, prevention, exercise interventions, nutritional support, rehabilitation technologies, and implementation strategies. It comprises 23 clinical questions and provides 58 recommendations, systematically integrating technical considerations for screening, assessment, and intervention, providing a scientific and operable practical basis for rehabilitation physicians, physiotherapists and relevant personnel. Conclusion This guideline is expected to standardize the clinical practice of rehabilitation for sarcopenia in older adults in China, improve the quality of rehabilitation services, enhance functional outcomes and quality of life in patients, and alleviate the individual, familial, and societal burden associated with the disease.

Citation： The Chinese Society of Physical Medicine and Rehabilitation. Guidelines for rehabilitation interventions in older adults with sarcopenia (2025 edition). Chinese Journal of Evidence-Based Medicine, 2026, 26(5): 497-519. doi: 10.7507/1672-2531.202512201 Copy

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