Clinical application of MRS combined with long-term VEEG on the surgical treatment of temporal lobe epilepsy_Journal of Epilepsy

Authors：

 WANGHuanming , HUFei , CHENJun , XIONGYubo , CHENYang

Department of Neurosurgery, Wuhan Brain Hospital & Changhang General Hospital, Wuhan, 430010, China;

Corresponding?author：

WANGHuanming, Email: 1808381741@qq.com

Keywords：

Temporal lobe epilepsy; MRS; VEEG

DOI：

10.7507/2096-0247.20150034

Video：

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Objective To explore the application value of MRS combined with VEEG on the surgical treatment of temporal lobe epilepsy. Methods There were 31 males and 20 females, age between 4 and 62 years.Their illness duration ranged from 4 to 10 years.The clinical manifestations showed complex partial seizure in 10 cases, secondary generalized seizure in 12 and generalized tonic-clonic seizure in 29. Based on their results of clinical manifestations, MRS and VEEG results, all the patients underwent anterior temporal lobectomy(including the most parts of the hippocampus and amydala). Results The follow-up of 1~3 years after the operation showed seizure free in 36 cases(Engle Ⅰ), and significant improvement in 11(Engle Ⅱ), no improvement in 4 cases(Engle Ⅳ). The overall effective rate was 92.16%. Conclusions MRS combined with VEEG has significant localization value for temporal lobe epilepsy. The prognosis of postoperative result is quiet good to the patient of typical temporal lobe epilepsy after anterior temporal lobectomy.

Citation： WANGHuanming, HUFei, CHENJun, XIONGYubo, CHENYang. Clinical application of MRS combined with long-term VEEG on the surgical treatment of temporal lobe epilepsy. Journal of Epilepsy, 2015, 1(3): 212-216. doi: 10.7507/2096-0247.20150034 Copy

1.	譚啟富, 李齡, 吳承遠.癲癇外科學.2版.北京:人民衛生出版社, 2012, 110-111.
2.	Kuzniecky R, dela Sayette V, Etheir R, et al. Magnetic resonance imaging in temporal lobe epilepsy:pathologic correlation.Ann Neurol, 1987, 22(8):341-347.
3.	羅超, 陳元媛, 趙林, 等. 1H-MRS磁共振波譜分析對海馬硬化診斷的評價.臨床軍醫雜志, 2011, 39(1):117-119.
4.	Connelly A, Van Paessehen W, Porter DA, et al. Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy. Neurology, 1998, 51(16):61-66.
5.	Ende GR, Laxer KD, Konwlton RC, et al. Temporal lobe epilepsy:bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging.Radiology, 1997, 202(45):809-817.
6.	Vernnathen P, Ende G, Laxer KD, et al. Temporal lobectomy for epilepsy:recovery of the contralateral hippocampus measured by 1H-MRS. Neurology, 2002, 59(10):633-636.
7.	高翔, 江澄川, 洪震, 等.海馬硬化與顳葉癲癇的關系.上海醫科大學學報, 2000, 27(2):115-116.
8.	Garcia PA, Laxer KD, Bartaro NM, et al. Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients underlying temporal lobectomy for medically refractory seizure. Epilepsia, 1994, 35(4):520-524.
9.	Kilpatrick C, Cook M, Kaye A, et al. Non-invasive investigations successfully select patients for temporal lobe surgery. J Neurol Neurosurg Psychiatry, 1997, 63(2):327-333.
10.	Jack CR, Cascino GD, Sharbrough FW, et al. Magnetic resonance image-based hippocampal volumetry:correlation with outcome after temporal lobectomy. Ann Neurol, 1992, 31(1):138-146.
11.	周健, 鮑民, 翟鋒, 等. MRI陰性的顳葉癲癇的外科治療.中華神經外科雜志, 2011, 27(12):1241-1243.
12.	許尚臣, 邢毅, 欒立明, 等.不同手術入路治療海馬硬化性顳葉內側癲癇的比較.中華神經外科雜志, 2012, 28(8):806-809.

1. 譚啟富, 李齡, 吳承遠.癲癇外科學.2版.北京:人民衛生出版社, 2012, 110-111.
2. Kuzniecky R, dela Sayette V, Etheir R, et al. Magnetic resonance imaging in temporal lobe epilepsy:pathologic correlation.Ann Neurol, 1987, 22(8):341-347.
3. 羅超, 陳元媛, 趙林, 等. 1H-MRS磁共振波譜分析對海馬硬化診斷的評價.臨床軍醫雜志, 2011, 39(1):117-119.
4. Connelly A, Van Paessehen W, Porter DA, et al. Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy. Neurology, 1998, 51(16):61-66.
5. Ende GR, Laxer KD, Konwlton RC, et al. Temporal lobe epilepsy:bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging.Radiology, 1997, 202(45):809-817.
6. Vernnathen P, Ende G, Laxer KD, et al. Temporal lobectomy for epilepsy:recovery of the contralateral hippocampus measured by 1H-MRS. Neurology, 2002, 59(10):633-636.
7. 高翔, 江澄川, 洪震, 等.海馬硬化與顳葉癲癇的關系.上海醫科大學學報, 2000, 27(2):115-116.
8. Garcia PA, Laxer KD, Bartaro NM, et al. Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients underlying temporal lobectomy for medically refractory seizure. Epilepsia, 1994, 35(4):520-524.
9. Kilpatrick C, Cook M, Kaye A, et al. Non-invasive investigations successfully select patients for temporal lobe surgery. J Neurol Neurosurg Psychiatry, 1997, 63(2):327-333.
10. Jack CR, Cascino GD, Sharbrough FW, et al. Magnetic resonance image-based hippocampal volumetry:correlation with outcome after temporal lobectomy. Ann Neurol, 1992, 31(1):138-146.
11. 周健, 鮑民, 翟鋒, 等. MRI陰性的顳葉癲癇的外科治療.中華神經外科雜志, 2011, 27(12):1241-1243.
12. 許尚臣, 邢毅, 欒立明, 等.不同手術入路治療海馬硬化性顳葉內側癲癇的比較.中華神經外科雜志, 2012, 28(8):806-809.

Journal of Epilepsy

Clinical application of MRS combined with long-term VEEG on the surgical treatment of temporal lobe epilepsy

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