未來癲癇領域的新療法——光基因神經調控技術_Journal of Epilepsy

Authors：

 高杰 ,  鄧艷

第四軍醫大學西京醫院神經內科(西安, 710032);

Corresponding?author：

鄧艷, Email: yanchundeng@yahoo.com

Keywords：

DOI：

10.7507/2096-0247.20150038

Video：

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Citation： 高杰, 鄧艷. 未來癲癇領域的新療法——光基因神經調控技術. Journal of Epilepsy, 2015, 1(3): 229-231. doi: 10.7507/2096-0247.20150038 Copy

1.	M Hausser, SL Smith. Controlling neural circuit with light. Nature, 2007, 446(7136):617-619.
2.	Fiala A, Suska A, Schlüter OM. Optogenetic approaches in neuroscience. Curr Biol, 2010, 20(20):897-903.
3.	Witten IB, Lin SC, Brodsky M, et al. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science, 2010, 330(6011):1677-1681.
4.	Petreanu L, Huber D, Sobczyk A, et al. Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci, 2007, 10(5):663-668.
5.	Wang J, Borton DA, Zhang J, et al. A neurophotonic device for stimulation and recording of neural microcircuits. Conf Proc IEEE Eng Med Biol Soc, 2010, 24(10):2935-2938.
6.	Sorensen AT, Kokaia M. Novel approaches to epilepsy treatment.Epilepsia 2013, 54(1):1-10.
7.	Ritter LM, Golshani P, Takahashi K, et al. Wonoep appraisal:optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis. Epilepsia 2014, 55(11):1693-1702.
8.	Mantoan L, Kullmann DM. Optogenetic treatment of epilepsy. ACNR, 2013, 13(20):12-15.
9.	Krook-Magnuson E, Armstrong C, Oijala M, et al. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. Nat Commun, 2013, 4(13):1376.
10.	Zhang F, Prigge M, Tsunoda SP, et al. Red-shifted optogenetic excitation:a tool for fast neural control derived from volvox carteri. Nat Neurosci, 2008, 11(22):631-633.
11.	Wykes RC, Heeroma JH, Mantoan L, et al. Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med, 2012, 4(161):161ra152.
12.	Zhang F, Gradinaru V, Adamantidis AR, et al. Optogenetic interrogation of neural circuits:technology for probing mammalian brain structures. Nat Protoc, 2010, 5(3):439-456.
13.	Kokaia M, Andersson M, Ledri M.An optogenetic approach in epilepsy. Neuropharmacology, 2013, 69(8):89-95.
14.	L?scher W, Klitgaard H, Twyman RE, et al. New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov, 2013, 12(10):757-776.
15.	Henderson KW, Gupta J, Tagliatela S, et al. Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons. Neurosci, 2014, 34(40):13492-13504.
16.	Kokaia M, Sorensen AT. The treatment of neurological diseases under a new light:the importance of optogenetics. Drugs Today (Barc), 2011, 47(1):53-62.
17.	Tonnesen J, Sorensen AT, Deisseroth K, et al. Optogenetic control of epileptiform activity. Proc Nat Acad Sci USA, 2009, 106(29):12162-12167.
18.	Somogyi P, Klausberger T. Defined types of cortical interneurone structure space and spike timing in the hippocampus. Physiol, 2005, 562(Pt 1):9-26.
19.	Zhao S, Ting JT, Atallah HE, et al. Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods, 2011, 8(9):745-752.
20.	Henderson KW, Gupta J, Tagliatela S, et al. Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons. Neurosci, 2014, 34(40):13492-13504.
21.	Zhang F, Wang LP, Brauner M, et al. Multimodal fast optical interrogation of neural circuitry. Nature, 2007, 446(12):633-639.
22.	張志成, 孫天勝, 李放, 等.光感基因調控技術——研究和治療神經系統疾病的新方法.中國微侵襲神經外科雜志, 2013, 16(6):280-282.
23.	Gnatkovsky V, Librizzi L, Trombin F, et al. Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro. Ann Neurol, 2008, 64(6):674-686.
24.	Ledri M, Madsen MG, Nikitidou L, et al. Global optogenetic activation of inhibitory interneurons during epileptiform activity. Neurosci, 2014, 34(9):3364-3377.
25.	G Miesenbock. The optpgenetic catechism. Science, 2009, 326(5951):395-399.
26.	Yizhar O, Fenno LE, Davidson TJ, et al. Optogenetics in neural systems. Neuron, 2011, 71(20):9-34.
27.	Peng Z, Zhang N, Wei W, et al. A reorganized GABAergic circuit in a model of epilepsy:evidence from optogenetic labeling and stimulation of somatostatin interneurons. J Neurosci, 2013, 33(36):14392-14405.
28.	Ladas TP, Chiang CC, Gonzalez-Reyes LE, et al. Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.Exp Neurol, 2015, 6(269):120-132.
29.	姚軍平, 侯文生, 陰正勤, 等.光基因技術在醫學研究中的進展.中華眼視光學與視覺科學雜志, 2011, 13(6):472-474.
30.	Boyden ES, Zhang F, Bamberg E, et al. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci, 2005, 8(4):1263-1268.
31.	Deisseroth K. Optogenetics. Nat Methods, 2011, 8(6):26-29.
32.	Moglich A, Hegemann P. Biotechnology:programming genomes with light. Nature, 2013, 500(7463):406-408.
33.	Mantoan L, Wykes RC, Schorge S, et al. Optogenetic suppression of high-frequency EEG activity in a model of focal epilepsy. Society For Neuroscience Meeting, 2011, 10:12-16.
34.	X Han, ES Boyden. Multiple-color optical activation, silencing and desynchronization of neural activity with single-spike temporal resolution. Plos One, 2007, 2(3):1-12.
35.	Gradinaru V, Thompson KR, Deisseroth. K. eNpHR:a natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biology, 2008, 36(1-4):129-139.
36.	Richner TJ, Thongpang S, Brodnick SK, et al. Optogenetic micro-electrocorticography for modulating and localizing cerebral cortex activity. Neural Eng, 2014, 11(1):016010.
37.	柳浦青, 竺可青.光敏感通道(Channelrhodopsin-2)——神經回路功能和神經系統疾病研究的新工具.中國生物化學與分子生物學報, 2010, 5(2):418-422.
38.	Smedemark-Margulies N, Trapani JG. Tools methods and applications for optophysiology in neuroscience. Front Mol Neurosci, 2013, 6(5):18.
39.	Gradinaru V, Mogri M, Thompson KR, et al. Optical deconstruction of parkinsonian neural circuitry. Science, 2009, 324(5925):354-359.
40.	Zhao M, Alleva R, Ma H, et al. Optogenetic tools for modulating and probing the epileptic network. Epilepsy Res, 2015, 10(116):15-26.

1. M Hausser, SL Smith. Controlling neural circuit with light. Nature, 2007, 446(7136):617-619.
2. Fiala A, Suska A, Schlüter OM. Optogenetic approaches in neuroscience. Curr Biol, 2010, 20(20):897-903.
3. Witten IB, Lin SC, Brodsky M, et al. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science, 2010, 330(6011):1677-1681.
4. Petreanu L, Huber D, Sobczyk A, et al. Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci, 2007, 10(5):663-668.
5. Wang J, Borton DA, Zhang J, et al. A neurophotonic device for stimulation and recording of neural microcircuits. Conf Proc IEEE Eng Med Biol Soc, 2010, 24(10):2935-2938.
6. Sorensen AT, Kokaia M. Novel approaches to epilepsy treatment.Epilepsia 2013, 54(1):1-10.
7. Ritter LM, Golshani P, Takahashi K, et al. Wonoep appraisal:optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis. Epilepsia 2014, 55(11):1693-1702.
8. Mantoan L, Kullmann DM. Optogenetic treatment of epilepsy. ACNR, 2013, 13(20):12-15.
9. Krook-Magnuson E, Armstrong C, Oijala M, et al. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. Nat Commun, 2013, 4(13):1376.
10. Zhang F, Prigge M, Tsunoda SP, et al. Red-shifted optogenetic excitation:a tool for fast neural control derived from volvox carteri. Nat Neurosci, 2008, 11(22):631-633.
11. Wykes RC, Heeroma JH, Mantoan L, et al. Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. Sci Transl Med, 2012, 4(161):161ra152.
12. Zhang F, Gradinaru V, Adamantidis AR, et al. Optogenetic interrogation of neural circuits:technology for probing mammalian brain structures. Nat Protoc, 2010, 5(3):439-456.
13. Kokaia M, Andersson M, Ledri M.An optogenetic approach in epilepsy. Neuropharmacology, 2013, 69(8):89-95.
14. L?scher W, Klitgaard H, Twyman RE, et al. New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov, 2013, 12(10):757-776.
15. Henderson KW, Gupta J, Tagliatela S, et al. Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons. Neurosci, 2014, 34(40):13492-13504.
16. Kokaia M, Sorensen AT. The treatment of neurological diseases under a new light:the importance of optogenetics. Drugs Today (Barc), 2011, 47(1):53-62.
17. Tonnesen J, Sorensen AT, Deisseroth K, et al. Optogenetic control of epileptiform activity. Proc Nat Acad Sci USA, 2009, 106(29):12162-12167.
18. Somogyi P, Klausberger T. Defined types of cortical interneurone structure space and spike timing in the hippocampus. Physiol, 2005, 562(Pt 1):9-26.
19. Zhao S, Ting JT, Atallah HE, et al. Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods, 2011, 8(9):745-752.
20. Henderson KW, Gupta J, Tagliatela S, et al. Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons. Neurosci, 2014, 34(40):13492-13504.
21. Zhang F, Wang LP, Brauner M, et al. Multimodal fast optical interrogation of neural circuitry. Nature, 2007, 446(12):633-639.
22. 張志成, 孫天勝, 李放, 等.光感基因調控技術——研究和治療神經系統疾病的新方法.中國微侵襲神經外科雜志, 2013, 16(6):280-282.
23. Gnatkovsky V, Librizzi L, Trombin F, et al. Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro. Ann Neurol, 2008, 64(6):674-686.
24. Ledri M, Madsen MG, Nikitidou L, et al. Global optogenetic activation of inhibitory interneurons during epileptiform activity. Neurosci, 2014, 34(9):3364-3377.
25. G Miesenbock. The optpgenetic catechism. Science, 2009, 326(5951):395-399.
26. Yizhar O, Fenno LE, Davidson TJ, et al. Optogenetics in neural systems. Neuron, 2011, 71(20):9-34.
27. Peng Z, Zhang N, Wei W, et al. A reorganized GABAergic circuit in a model of epilepsy:evidence from optogenetic labeling and stimulation of somatostatin interneurons. J Neurosci, 2013, 33(36):14392-14405.
28. Ladas TP, Chiang CC, Gonzalez-Reyes LE, et al. Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.Exp Neurol, 2015, 6(269):120-132.
29. 姚軍平, 侯文生, 陰正勤, 等.光基因技術在醫學研究中的進展.中華眼視光學與視覺科學雜志, 2011, 13(6):472-474.
30. Boyden ES, Zhang F, Bamberg E, et al. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci, 2005, 8(4):1263-1268.
31. Deisseroth K. Optogenetics. Nat Methods, 2011, 8(6):26-29.
32. Moglich A, Hegemann P. Biotechnology:programming genomes with light. Nature, 2013, 500(7463):406-408.
33. Mantoan L, Wykes RC, Schorge S, et al. Optogenetic suppression of high-frequency EEG activity in a model of focal epilepsy. Society For Neuroscience Meeting, 2011, 10:12-16.
34. X Han, ES Boyden. Multiple-color optical activation, silencing and desynchronization of neural activity with single-spike temporal resolution. Plos One, 2007, 2(3):1-12.
35. Gradinaru V, Thompson KR, Deisseroth. K. eNpHR:a natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biology, 2008, 36(1-4):129-139.
36. Richner TJ, Thongpang S, Brodnick SK, et al. Optogenetic micro-electrocorticography for modulating and localizing cerebral cortex activity. Neural Eng, 2014, 11(1):016010.
37. 柳浦青, 竺可青.光敏感通道(Channelrhodopsin-2)——神經回路功能和神經系統疾病研究的新工具.中國生物化學與分子生物學報, 2010, 5(2):418-422.
38. Smedemark-Margulies N, Trapani JG. Tools methods and applications for optophysiology in neuroscience. Front Mol Neurosci, 2013, 6(5):18.
39. Gradinaru V, Mogri M, Thompson KR, et al. Optical deconstruction of parkinsonian neural circuitry. Science, 2009, 324(5925):354-359.
40. Zhao M, Alleva R, Ma H, et al. Optogenetic tools for modulating and probing the epileptic network. Epilepsy Res, 2015, 10(116):15-26.

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