癲癇定義分類新觀念及個體化治療新進展_Journal of Epilepsy

Authors：

 郝南亞 , 吳夢倩 , 陳濤 ,  周東

四川大學華西醫院神經內科（成都，610041）;

Corresponding?author：

周東, Email: zhoudong66@yahoo.de

Keywords：

癲癇; 新定義; 個體化治療; 新進展

DOI：

10.7507/2096-0247.20160059

Video：

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作為一種高發病率的譜系疾病，癲癇受到國內外研究者的持續關注。隨著認識的深入，研究者們對癲癇的定義及分類提出了新的觀點。癲癇的個體化治療也面臨著新挑戰和機遇。基因檢測的進展、用藥時機的研究、高危及特殊人群用藥的新證據、神經調控術的發展都有助于醫生做出針對性更強的醫療決策。

Citation： 郝南亞, 吳夢倩, 陳濤, 周東. 癲癇定義分類新觀念及個體化治療新進展. Journal of Epilepsy, 2016, 2(4): 333-337. doi: 10.7507/2096-0247.20160059 Copy

1.	Sirven JI. Epilepsy:aspectrum disorder. Cold Spring Harbor Perspectives in Medicine, 2015, 5(9):a022848.
2.	Berg AT, Kabir AA, Liferidge AT, et al. Revised terminology and concepts for organization of seizures and epilepsies:report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 2010, 51(4):676-685.
3.	Fisher RS, Martello JP, Kanner AM, et al. ILAE Official Report:A practical clinical definition of epilepsy. Epilepsia, 2014, 55(4):475-482.
4.	中華醫學會, 臨床診療指南癲癇病分冊.北京:人民衛生出版社. 2015.
5.	Wang WZ, Shinnar S, Hopp JL, et al. The prevalence and treatment gap in epilepsy in China:an ILAE/IBE/WHO study. Neurology, 2003, 60(9):1544-1545.
6.	Gu L, French JA. Prevalence of epilepsy in the People's Republic of China:A systematic review. Epilepsy Research, 2013, 105(1-2):195-205.
7.	Neligan A, Hauser WA, Sander JW. The epidemiology of the epilepsies. Handbook of Clinical Neurology, 2012, 107(5):113-133.
8.	Phenome E, Epi KC. De novo mutations in epileptic encephalopathies. Nature, 2013, 501(7466):217-221.
9.	Truccolo W, Gloss DS, Sanchez AM, et al. Single-neuron dynamics in human focal epilepsy. Nat Neurosci, 2011, 14(5):635-641.
10.	Leach JP, Abassi H. Modern management of epilepsy. Clin Med, 2013, 13(1):84-86.
11.	Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ, 2014, 348(254):10.1136.
12.	Krumholz A, Wiebe S, Gronseth GS, et al. Evidence-based guideline:Management of an unprovoked first seizure in adults:Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2015, 84(16):1705.
13.	National Institute for Health and Clinical Excellence (NICE). The epilepsies:the diagnosis and management of the epilepsies in adults and children in primary and secondary care. London (UK):National Institute for Health and Clinical Excellence (NICE); 2012 Jan. 117 p. (Clinical guideline; no. 137).
14.	中華醫學會.臨床診療指南癲癇病分冊.北京:人民衛生出版社. 2007.
15.	Hesdorffer DC, Rossjohn J, Mc Cluskey J, et al. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia, 2009, 50(5):1102-1108.
16.	Illing PT, Vivian JP, Purcell AW, et al. Human leukocyte antigen-associated drug hypersensitivity. Current Opinion in Immunology, 2013, 25(1):81-89.
17.	Gilad R, Diaz-Arrastia R. Management of seizures following a stroke:what are the options?. Drugs Aging, 2012, 29(7):533-538.
18.	Guekht A, Bornstein NM. Seizures after stroke. Handb Clin Neurol, 2012, 10(8):569-583.
19.	Marigold R, Mickey B, D'Ambrosio R, et al. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database Syst Rev, 2013, 6(2):CD008710.
20.	Guo J, Li J, Zhou M, et al. Statin treatment reduces the risk of poststroke seizures. Neurology, 2015, 85(8):701-707.
21.	Annegers JF, Yablon S, Madden C, et al. A population-based study of seizures after traumatic brain injuries. New England Journal of Medicine, 1998, 338(1):20-24.
22.	Szaflarski JP, Nazzal Y, Dreer LE. Post-traumatic epilepsy:current and emerging treatment options. Neuropsychiatr Dis Treat, 2014, 10(2):1469-77.
23.	魏俊吉.神經外科重癥管理專家共識(2013版).中國腦血管病雜志, 2013, 10(8):1765-1779.
24.	Bhullar IS, Agostini MA, Van Ness PC, et al. More harm than good:antiseizure prophylaxis after traumatic brain injury does not decrease seizure rates but may inhibit functional recovery. Journal of Trauma and Acute Care Surgery, 2014, 76(1):54-61.
25.	Gupta PK, Sayed N, Ding K, et al. Subtypes of post-traumatic epilepsy:clinical, electrophysiological, and imaging features. J Neurotrauma, 2014, 31(16):1439-1443.
26.	Sayegh ET, Althouse SK, Miller JC, et al. Anticonvulsant prophylaxis for brain tumor surgery:determining the current best available evidence. J Neurosurg, 2014, 121(5):1139-1147.
27.	Ansari SF, Bohnstedt BN, Perkins SM, et al. Efficacy of postoperative seizure prophylaxis in intra-axial brain tumor resections. J Neurooncol, 2014, 118(1):117-122.
28.	Iuchi T, Eadie M, Roten A, et al. Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours:a phase Ⅱ prospective, randomised study. J Neurol Neurosurg Psychiatry, 2015, 86(10):1158-1162.
29.	Skardelly M, Lander CM, O'Brien TJ, et al. Predictors of preoperative and early postoperative seizures in patients with intra-axial primary and metastatic brain tumors:A retrospective observational single center study. Ann Neurol, 2015, 78(6):917-928.
30.	Vajda FJ, Graham J, Roten A, et al. Teratogenicity of the newer antiepileptic drugs——the Australian experience. J Clin Neurosci, 2012, 19(1):57-59.
31.	Hiilesmaa VK, Bardy A, Teramo K. Obstetric outcome in women with epilepsy. Am J Obstet Gynecol, 1985, 152(5):499-504.
32.	EURAP Study Group. Seizure control and treatment in pregnancy:observations from the EURAP epilepsy pregnancy registry. Neurology, 2006, 66(3):354-560.
33.	Meador KJ, Thompson L, Williams M, et al. Breastfeeding in children of women taking antiepileptic drugs:cognitive outcomes at age 6 years. JAMA Pediatr, 2014, 168(8):729-736.
34.	Go CY, Abdelmoity A, Buchhalter J, et al. Evidence-based guideline update:medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology, 2012, 78(24):1974-1980.
35.	Kayyali HR, Gustafson M, Myers T, et al. Ketogenic diet efficacy in the treatment of intractable epileptic spasms. Pediatr Neurol, 2014, 50(3):224-247.
36.	Morris GL, Buchhalter J, Gonzalez G, et al., Evidence-based guideline update:vagus nerve stimulation for the treatment of epilepsy:report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16):297-303.
37.	Sullivan R, Yao R, Jarrar R, et al. Text lassification towards detecting misdiagnosis of an epilepsy syndrome in a pediatric population. in annual symposium proceedings/AMIA symposium. AMIA Symposium, 2014, 14(11):1082-1087.
38.	Liu J, Liu Z, Chen T, et al. Treatment of epilepsy in China:Formal or informal. Neural Regen Res, 2013, 8(35):3316-3324.
39.	Hu J, Zhu S, Sander JW, et al. Prevalence and treatment gap of active convulsive epilepsy:a large community-based survey in rural west China. Seizure, 2014, 23(5):333-337.
40.	Huang DH, Ru X, Zheng J, et al. Treatment gaps of epilepsy and retention rates of sodium valproate in rural Guangxi, China. Genetics & Molecular Research Gmr, 2014, 13(3):6202-6212.
41.	Wang W, Wu J, Li S, et al. Sodium valproate for epilepsy in rural China:an efficacy and safety assessment in primary care. Epilepsy Res, 2012, 102(3):201-205.

1. Sirven JI. Epilepsy:aspectrum disorder. Cold Spring Harbor Perspectives in Medicine, 2015, 5(9):a022848.
2. Berg AT, Kabir AA, Liferidge AT, et al. Revised terminology and concepts for organization of seizures and epilepsies:report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 2010, 51(4):676-685.
3. Fisher RS, Martello JP, Kanner AM, et al. ILAE Official Report:A practical clinical definition of epilepsy. Epilepsia, 2014, 55(4):475-482.
4. 中華醫學會, 臨床診療指南癲癇病分冊.北京:人民衛生出版社. 2015.
5. Wang WZ, Shinnar S, Hopp JL, et al. The prevalence and treatment gap in epilepsy in China:an ILAE/IBE/WHO study. Neurology, 2003, 60(9):1544-1545.
6. Gu L, French JA. Prevalence of epilepsy in the People's Republic of China:A systematic review. Epilepsy Research, 2013, 105(1-2):195-205.
7. Neligan A, Hauser WA, Sander JW. The epidemiology of the epilepsies. Handbook of Clinical Neurology, 2012, 107(5):113-133.
8. Phenome E, Epi KC. De novo mutations in epileptic encephalopathies. Nature, 2013, 501(7466):217-221.
9. Truccolo W, Gloss DS, Sanchez AM, et al. Single-neuron dynamics in human focal epilepsy. Nat Neurosci, 2011, 14(5):635-641.
10. Leach JP, Abassi H. Modern management of epilepsy. Clin Med, 2013, 13(1):84-86.
11. Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ, 2014, 348(254):10.1136.
12. Krumholz A, Wiebe S, Gronseth GS, et al. Evidence-based guideline:Management of an unprovoked first seizure in adults:Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2015, 84(16):1705.
13. National Institute for Health and Clinical Excellence (NICE). The epilepsies:the diagnosis and management of the epilepsies in adults and children in primary and secondary care. London (UK):National Institute for Health and Clinical Excellence (NICE); 2012 Jan. 117 p. (Clinical guideline; no. 137).
14. 中華醫學會.臨床診療指南癲癇病分冊.北京:人民衛生出版社. 2007.
15. Hesdorffer DC, Rossjohn J, Mc Cluskey J, et al. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia, 2009, 50(5):1102-1108.
16. Illing PT, Vivian JP, Purcell AW, et al. Human leukocyte antigen-associated drug hypersensitivity. Current Opinion in Immunology, 2013, 25(1):81-89.
17. Gilad R, Diaz-Arrastia R. Management of seizures following a stroke:what are the options?. Drugs Aging, 2012, 29(7):533-538.
18. Guekht A, Bornstein NM. Seizures after stroke. Handb Clin Neurol, 2012, 10(8):569-583.
19. Marigold R, Mickey B, D'Ambrosio R, et al. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database Syst Rev, 2013, 6(2):CD008710.
20. Guo J, Li J, Zhou M, et al. Statin treatment reduces the risk of poststroke seizures. Neurology, 2015, 85(8):701-707.
21. Annegers JF, Yablon S, Madden C, et al. A population-based study of seizures after traumatic brain injuries. New England Journal of Medicine, 1998, 338(1):20-24.
22. Szaflarski JP, Nazzal Y, Dreer LE. Post-traumatic epilepsy:current and emerging treatment options. Neuropsychiatr Dis Treat, 2014, 10(2):1469-77.
23. 魏俊吉.神經外科重癥管理專家共識(2013版).中國腦血管病雜志, 2013, 10(8):1765-1779.
24. Bhullar IS, Agostini MA, Van Ness PC, et al. More harm than good:antiseizure prophylaxis after traumatic brain injury does not decrease seizure rates but may inhibit functional recovery. Journal of Trauma and Acute Care Surgery, 2014, 76(1):54-61.
25. Gupta PK, Sayed N, Ding K, et al. Subtypes of post-traumatic epilepsy:clinical, electrophysiological, and imaging features. J Neurotrauma, 2014, 31(16):1439-1443.
26. Sayegh ET, Althouse SK, Miller JC, et al. Anticonvulsant prophylaxis for brain tumor surgery:determining the current best available evidence. J Neurosurg, 2014, 121(5):1139-1147.
27. Ansari SF, Bohnstedt BN, Perkins SM, et al. Efficacy of postoperative seizure prophylaxis in intra-axial brain tumor resections. J Neurooncol, 2014, 118(1):117-122.
28. Iuchi T, Eadie M, Roten A, et al. Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours:a phase Ⅱ prospective, randomised study. J Neurol Neurosurg Psychiatry, 2015, 86(10):1158-1162.
29. Skardelly M, Lander CM, O'Brien TJ, et al. Predictors of preoperative and early postoperative seizures in patients with intra-axial primary and metastatic brain tumors:A retrospective observational single center study. Ann Neurol, 2015, 78(6):917-928.
30. Vajda FJ, Graham J, Roten A, et al. Teratogenicity of the newer antiepileptic drugs——the Australian experience. J Clin Neurosci, 2012, 19(1):57-59.
31. Hiilesmaa VK, Bardy A, Teramo K. Obstetric outcome in women with epilepsy. Am J Obstet Gynecol, 1985, 152(5):499-504.
32. EURAP Study Group. Seizure control and treatment in pregnancy:observations from the EURAP epilepsy pregnancy registry. Neurology, 2006, 66(3):354-560.
33. Meador KJ, Thompson L, Williams M, et al. Breastfeeding in children of women taking antiepileptic drugs:cognitive outcomes at age 6 years. JAMA Pediatr, 2014, 168(8):729-736.
34. Go CY, Abdelmoity A, Buchhalter J, et al. Evidence-based guideline update:medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology, 2012, 78(24):1974-1980.
35. Kayyali HR, Gustafson M, Myers T, et al. Ketogenic diet efficacy in the treatment of intractable epileptic spasms. Pediatr Neurol, 2014, 50(3):224-247.
36. Morris GL, Buchhalter J, Gonzalez G, et al., Evidence-based guideline update:vagus nerve stimulation for the treatment of epilepsy:report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16):297-303.
37. Sullivan R, Yao R, Jarrar R, et al. Text lassification towards detecting misdiagnosis of an epilepsy syndrome in a pediatric population. in annual symposium proceedings/AMIA symposium. AMIA Symposium, 2014, 14(11):1082-1087.
38. Liu J, Liu Z, Chen T, et al. Treatment of epilepsy in China:Formal or informal. Neural Regen Res, 2013, 8(35):3316-3324.
39. Hu J, Zhu S, Sander JW, et al. Prevalence and treatment gap of active convulsive epilepsy:a large community-based survey in rural west China. Seizure, 2014, 23(5):333-337.
40. Huang DH, Ru X, Zheng J, et al. Treatment gaps of epilepsy and retention rates of sodium valproate in rural Guangxi, China. Genetics & Molecular Research Gmr, 2014, 13(3):6202-6212.
41. Wang W, Wu J, Li S, et al. Sodium valproate for epilepsy in rural China:an efficacy and safety assessment in primary care. Epilepsy Res, 2012, 102(3):201-205.

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癲癇定義分類新觀念及個體化治療新進展

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