生酮飲食療法歷史淺談_Journal of Epilepsy

Authors：

 廖建湘 ¹ , 方科偉 ¹ ,  LanXiong ²

1. ;
2. ;

Corresponding?author：

LanXiong, Email: lan.xiong@umontreal.ca

Keywords：

生酮飲食; 癲癇; 辟谷; 歷史; 斷食

DOI：

10.7507/2096-0247.20160074

Video：

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生酮飲食是一種脂肪高比例, 碳水化合物低比例, 蛋白質和其他營養素合適的配方飲食。不僅治療癲癇, 近來治療其他疾病也在探索中。生酮飲食的前身是斷食治療, 斷食不是完全斷絕食物和水, 只是減少熱卡, 維持飲水。為了更長時間維持斷食的療效, 1921年美國梅奧診所出現了生酮飲食療法。現在約翰.霍普金斯醫院領導著全球的生酮飲食治療。2004年我國大陸生酮飲食療法臨床開始于深圳市兒童醫院。中國古老的辟谷療法, 目前主要用于西醫醫院以外的養生保健, 操作和西方的斷食療法非常類似, 辟谷大約在2 500多年前就開始存在了。

Citation： 廖建湘, 方科偉, LanXiong. 生酮飲食療法歷史淺談. Journal of Epilepsy, 2016, 2(5): 418-421. doi: 10.7507/2096-0247.20160074 Copy

1.	Freeman JM, Vining EPG. The efficacy of the ketogenic diet 1998:a prospective evaluation of intervention in 150 children. Pediatrics, 1998, 102(4):1358-1363.
2.	Kossoff EH, Freeman JM, Turner Z, et al. Ketogenic Diets:treatment for Epilepsy and Other Disorders, 5th edition:New York, DEMOS, 2011:39-48.
3.	廖建湘.生酮飲食療法的臨床方案.中華實用兒科臨床雜志, 2013, 28(12):881-883.
4.	Wheless JW. History of the ketogenic diet. Epilepsia, 2008, 49(Suppl 8):3-5.
5.	Freeman JM, Vining EP. Seizures decrease rapidly after fasting:preliminarystudies of the ketogenic diet. Arch Pediatr Adolesc Med, 1999, 153(9):946-949.
6.	馬王堆漢墓帛書整理小組.馬王堆漢墓出土醫書釋文(一), 文物, 1975, 6:1-5.
7.	Guelpa G, Marie A.Laluttecontrel epilepsieparlades in toxication etparl are educational imentaire. Rev Ther Medico-Chirurgicale, 1911, 78:8-13.
8.	Woodyatt RT. Objects and method of diet adjustment in diabetics. Arch Intern Med, 1921, 28:125-141.
9.	Peterman MG. The ketogenic diet in epilepsy. JAMA, 1925, 84:1979-1983.
10.	Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Charles C. Thomas, Springfield, IL, 1972:378-405.
11.	Huttenlocher PR. Ketonemia and seizures:metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976, 10(5):536-540.
12.	Liu YM. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia, 2008, 49 (Suppl 8):33-36.
13.	Kossoff EH, Cervenka MC, Henry BJ, et al.A decade of themodified Atkins diet (2003-2013):Results, insights, and future directions.Epilepsy Behav, 2013, 29(3):437-442.
14.	Kossoff EH, McGrogan JR, Bluml RM, et al. Amodified Atkins diet is effective for the treatment of intractable pediatricepilepsy. Epilepsia, 2006, 47(2):421-424.
15.	Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment:implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl8):42-45.
16.	Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy intuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2):180-182.
17.	Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet:recommendations of the International Ketogenic Diet Study Group.Epilepsia, 2009, 50(2):304-317.
18.	Kossoff EH, Al-Macki N, Cervenka MC, et al. What are theminimum requirements for ketogenic diet services in resource-limited regions?Recommendations from the International League Against Epilepsy Task Force forDietary Therapy. Epilepsia, 2015, 56(9):1337-1342.
19.	Kossoff EH, McGrogan JR. Worldwide use of the ketogenic diet. Epilepsia, 2015, 46(10):280-289.
20.	Pascual JM, Ronen GM. Glucose Transporter Type I Deficiency (G1D) at 25(1990-2015):presumptions, facts, and the lives of persons with this rare disease. Pediatr Neurol, 2015, 53(5):379-393.
21.	Roubergue A, Philibert B, Gautier A, et al. Excellentresponse to a ketogenic diet in a patient with alternating hemiplegia ofchildhood. JIMD Rep, 2015, 15(5):7-12.
22.	Allen BG, Bhatia SK, Anderson CM, et al. Ketogenic diets as anadjuvant cancer therapy:history and potential mechanism. Redox Biol, 2014, 2(5):963-970.
23.	Spilioti M, Evangeliou AE, Tramma D, et al. Evidence for treatable inborn errors ofmetabolism in a cohort of 187 Greek patients with autism spectrum disorder (ASD).Front Hum Neurosci, 2013, 7(8):858.
24.	Cheng CW, Adams GB, Perin L, et al. Prolonged fasting reduces IGF-1/PKA topromote hematopoietic-stem-cell-based regeneration and reverse immunesuppression.Cell Stem Cell, 2014, 14(6):810-823.Erratumin:Cell Stem Cell, 2016, 18(2):291-292.
25.	Valadao JM, Vigilante JA, DiGeorge NW, et al. Ketogenic diet for high partial pressure oxygendiving. Undersea Hyperb Med, 2014, 41(4):331-335.
26.	Freeman JM, Kossoff EH, Hartman AL.The ketogenic diet:one decade later.Pediatrics, 2007, 119(3):535-543.
27.	李德杏.道教醫學辟谷養生術淺析.中華中醫藥雜志, 2012, 25(5):1230-1232.
28.	王崗, 董調紅, 劉曉瑞, 等.從道教辟谷術論治糖尿病及其并發癥.湖南中醫藥大學學報, 2015, 22(12):43-45.
29.	黃巍, 何清湖, 姚勤.論馬王堆醫書中的飲食養生理念與方法.湖南中醫雜志, 2013, 20(7):6-8.
30.	陳紅梅.馬王堆醫書抄錄年代研究概況.中醫文獻雜志, 2009, 6:50-52.
31.	王娟娟.北京白云觀藏明《道藏》洞真部及太玄部醫藥文獻整理研究(研究生論文).北京中醫藥大學, 2016:1-215.
32.	劉曉瑞, 黃彬洋, 李凱, 等.服餌辟谷養生術防治2型糖尿病的理論初探.時珍國醫國藥, 2016, 4:907-908.
33.	趙江濱, 劉禹舟.從《傷寒論》陽明病篇看中醫養生觀.河南中醫, 2014, 1:6-7.
34.	劉先勇, 華衛國, 儲維忠, 等.辟谷食餌對S-180腹水癌小鼠的影響.山東中醫雜志, 2011, 11(5):806-808.
35.	燕曉雯, 郭建紅, 俞海虹, 等. 6名辟谷受試者體質量、血壓、血糖觀察及辟谷養生技術分析.中華中醫藥雜志, 2016, 29(2):627-629.
36.	洪斌, 王世其, 隴文菊, 等.辟食10天的實證體驗及思考.中國保健營養, 2012, 18(4):4187-4188.

1. Freeman JM, Vining EPG. The efficacy of the ketogenic diet 1998:a prospective evaluation of intervention in 150 children. Pediatrics, 1998, 102(4):1358-1363.
2. Kossoff EH, Freeman JM, Turner Z, et al. Ketogenic Diets:treatment for Epilepsy and Other Disorders, 5th edition:New York, DEMOS, 2011:39-48.
3. 廖建湘.生酮飲食療法的臨床方案.中華實用兒科臨床雜志, 2013, 28(12):881-883.
4. Wheless JW. History of the ketogenic diet. Epilepsia, 2008, 49(Suppl 8):3-5.
5. Freeman JM, Vining EP. Seizures decrease rapidly after fasting:preliminarystudies of the ketogenic diet. Arch Pediatr Adolesc Med, 1999, 153(9):946-949.
6. 馬王堆漢墓帛書整理小組.馬王堆漢墓出土醫書釋文(一), 文物, 1975, 6:1-5.
7. Guelpa G, Marie A.Laluttecontrel epilepsieparlades in toxication etparl are educational imentaire. Rev Ther Medico-Chirurgicale, 1911, 78:8-13.
8. Woodyatt RT. Objects and method of diet adjustment in diabetics. Arch Intern Med, 1921, 28:125-141.
9. Peterman MG. The ketogenic diet in epilepsy. JAMA, 1925, 84:1979-1983.
10. Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Charles C. Thomas, Springfield, IL, 1972:378-405.
11. Huttenlocher PR. Ketonemia and seizures:metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976, 10(5):536-540.
12. Liu YM. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia, 2008, 49 (Suppl 8):33-36.
13. Kossoff EH, Cervenka MC, Henry BJ, et al.A decade of themodified Atkins diet (2003-2013):Results, insights, and future directions.Epilepsy Behav, 2013, 29(3):437-442.
14. Kossoff EH, McGrogan JR, Bluml RM, et al. Amodified Atkins diet is effective for the treatment of intractable pediatricepilepsy. Epilepsia, 2006, 47(2):421-424.
15. Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment:implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl8):42-45.
16. Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy intuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2):180-182.
17. Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet:recommendations of the International Ketogenic Diet Study Group.Epilepsia, 2009, 50(2):304-317.
18. Kossoff EH, Al-Macki N, Cervenka MC, et al. What are theminimum requirements for ketogenic diet services in resource-limited regions?Recommendations from the International League Against Epilepsy Task Force forDietary Therapy. Epilepsia, 2015, 56(9):1337-1342.
19. Kossoff EH, McGrogan JR. Worldwide use of the ketogenic diet. Epilepsia, 2015, 46(10):280-289.
20. Pascual JM, Ronen GM. Glucose Transporter Type I Deficiency (G1D) at 25(1990-2015):presumptions, facts, and the lives of persons with this rare disease. Pediatr Neurol, 2015, 53(5):379-393.
21. Roubergue A, Philibert B, Gautier A, et al. Excellentresponse to a ketogenic diet in a patient with alternating hemiplegia ofchildhood. JIMD Rep, 2015, 15(5):7-12.
22. Allen BG, Bhatia SK, Anderson CM, et al. Ketogenic diets as anadjuvant cancer therapy:history and potential mechanism. Redox Biol, 2014, 2(5):963-970.
23. Spilioti M, Evangeliou AE, Tramma D, et al. Evidence for treatable inborn errors ofmetabolism in a cohort of 187 Greek patients with autism spectrum disorder (ASD).Front Hum Neurosci, 2013, 7(8):858.
24. Cheng CW, Adams GB, Perin L, et al. Prolonged fasting reduces IGF-1/PKA topromote hematopoietic-stem-cell-based regeneration and reverse immunesuppression.Cell Stem Cell, 2014, 14(6):810-823.Erratumin:Cell Stem Cell, 2016, 18(2):291-292.
25. Valadao JM, Vigilante JA, DiGeorge NW, et al. Ketogenic diet for high partial pressure oxygendiving. Undersea Hyperb Med, 2014, 41(4):331-335.
26. Freeman JM, Kossoff EH, Hartman AL.The ketogenic diet:one decade later.Pediatrics, 2007, 119(3):535-543.
27. 李德杏.道教醫學辟谷養生術淺析.中華中醫藥雜志, 2012, 25(5):1230-1232.
28. 王崗, 董調紅, 劉曉瑞, 等.從道教辟谷術論治糖尿病及其并發癥.湖南中醫藥大學學報, 2015, 22(12):43-45.
29. 黃巍, 何清湖, 姚勤.論馬王堆醫書中的飲食養生理念與方法.湖南中醫雜志, 2013, 20(7):6-8.
30. 陳紅梅.馬王堆醫書抄錄年代研究概況.中醫文獻雜志, 2009, 6:50-52.
31. 王娟娟.北京白云觀藏明《道藏》洞真部及太玄部醫藥文獻整理研究(研究生論文).北京中醫藥大學, 2016:1-215.
32. 劉曉瑞, 黃彬洋, 李凱, 等.服餌辟谷養生術防治2型糖尿病的理論初探.時珍國醫國藥, 2016, 4:907-908.
33. 趙江濱, 劉禹舟.從《傷寒論》陽明病篇看中醫養生觀.河南中醫, 2014, 1:6-7.
34. 劉先勇, 華衛國, 儲維忠, 等.辟谷食餌對S-180腹水癌小鼠的影響.山東中醫雜志, 2011, 11(5):806-808.
35. 燕曉雯, 郭建紅, 俞海虹, 等. 6名辟谷受試者體質量、血壓、血糖觀察及辟谷養生技術分析.中華中醫藥雜志, 2016, 29(2):627-629.
36. 洪斌, 王世其, 隴文菊, 等.辟食10天的實證體驗及思考.中國保健營養, 2012, 18(4):4187-4188.

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生酮飲食療法歷史淺談

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