Discussion on the distribution characteristics and preventive effects of EEG patterns in acute mountain sickness_Journal of Epilepsy

Authors：

 ZHAO Yuhua ¹ , ZHAXI Cuomu ² , YU Hao ¹ , ZHANG Yalong ² , ZHANG Tao ¹ , YANG Li ² , CIDAN Zhuoga ¹ , MIMA Dunzhu ¹ , DING Zhijie ¹

1. Department of Neurology, the People's Hospital of TAR, Lhasa 850000, China;
2. Department of Internal Medicine, Tibet Frontier Defence General Team Hospital, Lhasa 850000, China;

Corresponding?author：

ZHAO Yuhua, Email: drolyang@163.com

Keywords：

Electroencephalogram; Acute mountain sickness; Distribution characteristics; Early warning effect

DOI：

10.7507/2096-0247.20170044

Video：

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Objective The purpose of the research is to study the distribution and early warning of electroencephalogram (EEG) in acute mountain sickness (AMS). Methods A total of 280 healthy young men were recruited from September 2016 to October 2016. The basic data were collected by the centralized flow method, the general situation of the division of the investigators after the training, the Lewis Lake score, the computer self-rating anxiety scale and depression scale, and the collection of EEG. Follow up in three months. Results 94 of the patients with AMS, morbidity is 33%, 21 (22.34%) of the patients are moderate to severe, 73 (77.66%) are mild, morbidity is 26.67%. The abnormal detection rate of electrogram was 7.9% (22/280), which were mild EEG, normal EEG abnormal rate was 8.6% (16/186), abnormal detection rate of mild AMS was 4.1% (3/73), and the abnormal detection rate was 14.3% (3/21) in the medium / heavy AMS. The latter was significantly different from the previous (P < 0.05). Three months follow-up of this group of patients with 0 case of high altitude disease. Conclusions The EEG in AMS is mainly a rhythm irregular, unstable, poor amplitude modulation; or two hemisphere volatility difference of more than 50% or slightly increased activity. The result is statistically significant, suggesting that EEG distributions has possible early warning of AMS.

Citation： ZHAO Yuhua, ZHAXI Cuomu, YU Hao, ZHANG Yalong, ZHANG Tao, YANG Li, CIDAN Zhuoga, MIMA Dunzhu, DING Zhijie. Discussion on the distribution characteristics and preventive effects of EEG patterns in acute mountain sickness. Journal of Epilepsy, 2017, 3(4): 298-301. doi: 10.7507/2096-0247.20170044 Copy

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15.	李波, 戴維, 劉琨, 等.心理干預對新兵急行軍后焦慮-抑郁情緒的影響.沈陽醫學院學報, 2016, 18(1): 27-29.
16.	劉暢, 陳祉妍, 李丁川, 等.新兵焦慮-抑郁情緒測查及影響因素分析.中國臨床心理學雜志, 2006, 14(4):371-372.
17.	楊金生, 石向群, 谷有權等.急進高原部隊官兵抑郁和焦慮的評估.解放軍預防醫學雜志, 2006, 24(6): 355-356.
18.	趙瑾, 楊來啟, 吳興曲, 等.急進高原部隊官兵抑郁和焦慮的評估及相關干預.山東醫藥, 2012, 52(32): 54-55.
19.	胡軍, 李曉云, 王東紅, 等.急進高原官兵抑郁-焦慮及其影響因素的研究.西北國防醫學雜志. 2015, 36(6): 377-38.
20.	Sand T, Tygaard O. Quantitative EEG in acute mountain sickness. Acta Neurol Scand, 1998, 98(6):386-390.
21.	楊定周, 李素芝, 胡海燕, 等.腦電圖在高原腦水腫早期的表現及診斷價值.華南國防醫學雜志, 2010, 24(3): 171-173.
22.	Berend Feddersen, Horald Ausserer, Florian Thanbichler, et al.Right temproral cerebral dysfunction heralds symptoms of acute mountain sickness.J Neurol, 2007, 254(3): 359-363.
23.	Berend Feddersen, Pritam Neupane, Florian Thanbichler, et al. Reginal differences in the cerebral blood flow velocity response to hypobaric hypoxia at high altitudes. Journal of Cerebral Blood Flow and Metabolism, 2015, 35 (11): 1846-1851.

1. Hackett PH, Roach RC. High-altitude illness. N Engl J Med, 2001, 345(2): 107-114.
2. Roach RC, Bartsch P, Hackett PH, et al. The Lake Louise acute mountain sickness scoring system. Hypoxia and Molecular Medicine.In proceedings of the 8^th International Hypoxia symposium, Burlington, Canada, 1993: 272-274.https://www.researchgate.net/publication/277718910_The_Lake_Louise_Acute_Mountain_Sickness_Scoring_System.
3. 西藏自治區統計局, 國家統計局西藏調查總隊. 2015西藏統計年鑒.中國統計出版社, 北京, 2015: 9.
4. Martin J Macinnis, Eric A Carter, Michael G Freeman, et al. A prospective epidemiological study of acute mountain sickness in nepalese pilgrims ascending to high altitude (4380). PloS One, 2013, 8(10): 1-6.
5. Wu YI. Mountain rescue: the highest earthquake in Yushu. High Alt Med Biol, 2011, 12(1): 93-95.
6. WU Tian-yi, DING Shou-quan, LIU Jin-liang, et al. Who are more at risk for acute mountain sickness: a prospective study in Qinghai-Tibet railroad construction workers on Mt. Tanggula. Chinese Medical Journal, 2012, 125(8): 1393-1400.
7. 劉陽, 張繼航, 武曉靜, 等.平原動脈血壓對急性高原病易感性的預測.軍事醫學, 2014, 38(4): 252-259.
8. 邱友竹, 余潔, 王連友等.急進高原環境對血管內皮功能的影響及其與急性高原病的關系.解放軍醫學雜志, 2015, 40(5):415-419.
9. 鞏江, 倪士峰, 李文華, 等.高原疾病相關易感基因的研究進展.基礎醫學與臨床, 2012, 32(6):719-723.
10. 耿倩雯, 張繼航, 覃軍, 等. Nrf2基因單核苷酸多態性與急性高原病相關性研究.軍事醫學, 2015, 39(2): 105-107.
11. 劉曉燕, 吳遜.臨床腦電圖學.人民衛生出版社, 北京, 2006:214-215.
12. 王慎旭、何偉華、張明德.平原籍戰士急進高原后短期體質變化與急性高原病發病情況的調查.實用醫學雜志, 2015, 12(5):392-393.
13. 董建偉, 石自福, 李宇, 等.不同海拔駐地人群進駐高原急性高原反應發病情況比較.西北國防醫學雜志, 2015, 36(8):520-522.
14. 盧娟, 茍于強, 王濤, 等.高原駐訓部隊急性高原反應流行病學調查.西北國防醫學雜志, 2016, 37(4): 253-255.
15. 李波, 戴維, 劉琨, 等.心理干預對新兵急行軍后焦慮-抑郁情緒的影響.沈陽醫學院學報, 2016, 18(1): 27-29.
16. 劉暢, 陳祉妍, 李丁川, 等.新兵焦慮-抑郁情緒測查及影響因素分析.中國臨床心理學雜志, 2006, 14(4):371-372.
17. 楊金生, 石向群, 谷有權等.急進高原部隊官兵抑郁和焦慮的評估.解放軍預防醫學雜志, 2006, 24(6): 355-356.
18. 趙瑾, 楊來啟, 吳興曲, 等.急進高原部隊官兵抑郁和焦慮的評估及相關干預.山東醫藥, 2012, 52(32): 54-55.
19. 胡軍, 李曉云, 王東紅, 等.急進高原官兵抑郁-焦慮及其影響因素的研究.西北國防醫學雜志. 2015, 36(6): 377-38.
20. Sand T, Tygaard O. Quantitative EEG in acute mountain sickness. Acta Neurol Scand, 1998, 98(6):386-390.
21. 楊定周, 李素芝, 胡海燕, 等.腦電圖在高原腦水腫早期的表現及診斷價值.華南國防醫學雜志, 2010, 24(3): 171-173.
22. Berend Feddersen, Horald Ausserer, Florian Thanbichler, et al.Right temproral cerebral dysfunction heralds symptoms of acute mountain sickness.J Neurol, 2007, 254(3): 359-363.
23. Berend Feddersen, Pritam Neupane, Florian Thanbichler, et al. Reginal differences in the cerebral blood flow velocity response to hypobaric hypoxia at high altitudes. Journal of Cerebral Blood Flow and Metabolism, 2015, 35 (11): 1846-1851.

Journal of Epilepsy

Discussion on the distribution characteristics and preventive effects of EEG patterns in acute mountain sickness

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