低血糖生成指數飲食治療癲癇研究進展_Journal of Epilepsy

Authors：

尚麗 ¹ , 龔德山 ¹ , 郭輝 ¹ , 張翠榮 ¹ ,  王開顏 ²

1. ;
2. ;

Corresponding?author：

王開顏, Email: 13917806739@163.com

Keywords：

生酮飲食; 低血糖生成指數飲食; 難治性癲癇

DOI：

10.7507/2096-0247.20180014

Video：

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Abstract Full text Figures/Tables Video References Cited by

盡管生酮飲食（Ketogenic diet，KD）可有效治療難治性癲癇，但因其脂肪含量較高，口感油膩，且飲食限制過于嚴格，配餐制作繁瑣，很多患者常難以耐受及堅持。低血糖生成指數飲食（Low glycemic index treatment，LGIT）做為改良的 KD，降低了脂肪比例，改善了飲食口感，更容易操作和耐受，且有效率與 KD 接近。現就 LGIT 的機制、實施方法及不良反應等進行闡述，以讓更多的臨床工作者進一步了解 LGIT。

Citation： 尚麗, 龔德山, 郭輝, 張翠榮, 王開顏. 低血糖生成指數飲食治療癲癇研究進展. Journal of Epilepsy, 2018, 4(1): 56-58. doi: 10.7507/2096-0247.20180014 Copy

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5.	Kossoff EH, McGrogan JR, Bluml RM, et al. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia, 2006, 47(2): 421-424.
6.	Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment: implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl 8): 42-45.
7.	Pfeifer HH, Thiele EA. Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy. Neurology, 2005, 65(11): 1810-1812.
8.	Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr, 1981, 34(3): 362-366.
9.	Bell SJ, Sears B. Low-glycemic-load diets: impact on obesity and chronic diseases. Crit Rev Food Sci Nutr, 2003, 43(4): 357-377.
10.	Boison D. New insights into the mechanisms of theketogenic diet. Curr Opin Neurol, 2017, 30(2): 187-192.
11.	Schwechter EM, Veliskova J, Velisek L. Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol, 2003, 53(1): 91-101.
12.	Muzykewicz DA, Lyczkowski DA, Memon N, et al. Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy. Epilepsia, 2009, 50(5): 1118-1126.
13.	Karimzadeh P, Sedighi M, Beheshti M, et al. Low Glycemic Index Treatment in pediatric refractory epilepsy: the first Middle East report. Seizure, 2014, 23(7): 570-572.
14.	Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy in tuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2): 180-182.
15.	Coppola G, D'Aniello A, Messana T, et al. Low glycemic index diet in children and young adults with refractory epilepsy: first Italian experience. Seizure, 2011, 20(7): 526-528.
16.	Kim SH, Kang HC, Lee EJ, et al. Low glycemic index treatment in patients with drug-resistant epilepsy. Brain Dev, 2017, 39(8): 687-692.
17.	Kizirian NV, Kong Y, Muirhead R, et al. Effects of alow-glycemic indexdiet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial. Am J Clin Nutr, 2016, 103(4): 1073-1082.

1. Dhamija R, Eckert S, Wirrell E. Ketogenic diet. Can J Neurol Sci, 2013, 40(2): 158-167.
2. Gano LB, PatelM, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res, 2014, 55(11): 2211-2228.
3. Verrotti A, Iapadre G, Pisano S, et al.Ketogenic dietand childhood neurological disorders other than epilepsy: an overview. Expert Rev Neurother, 2017, 17(5): 461-473.
4. Sampaio LP. Ketogenic dietfor epilepsy treatment. Arq Neuropsiquiatr, 2016, 74(10): 842-848.
5. Kossoff EH, McGrogan JR, Bluml RM, et al. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia, 2006, 47(2): 421-424.
6. Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment: implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl 8): 42-45.
7. Pfeifer HH, Thiele EA. Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy. Neurology, 2005, 65(11): 1810-1812.
8. Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr, 1981, 34(3): 362-366.
9. Bell SJ, Sears B. Low-glycemic-load diets: impact on obesity and chronic diseases. Crit Rev Food Sci Nutr, 2003, 43(4): 357-377.
10. Boison D. New insights into the mechanisms of theketogenic diet. Curr Opin Neurol, 2017, 30(2): 187-192.
11. Schwechter EM, Veliskova J, Velisek L. Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol, 2003, 53(1): 91-101.
12. Muzykewicz DA, Lyczkowski DA, Memon N, et al. Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy. Epilepsia, 2009, 50(5): 1118-1126.
13. Karimzadeh P, Sedighi M, Beheshti M, et al. Low Glycemic Index Treatment in pediatric refractory epilepsy: the first Middle East report. Seizure, 2014, 23(7): 570-572.
14. Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy in tuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2): 180-182.
15. Coppola G, D'Aniello A, Messana T, et al. Low glycemic index diet in children and young adults with refractory epilepsy: first Italian experience. Seizure, 2011, 20(7): 526-528.
16. Kim SH, Kang HC, Lee EJ, et al. Low glycemic index treatment in patients with drug-resistant epilepsy. Brain Dev, 2017, 39(8): 687-692.
17. Kizirian NV, Kong Y, Muirhead R, et al. Effects of alow-glycemic indexdiet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial. Am J Clin Nutr, 2016, 103(4): 1073-1082.

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低血糖生成指數飲食治療癲癇研究進展

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