Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province_Journal of Epilepsy

Authors：

HE Weili ¹ , YAN Shichun ¹ , MA Guangyu ² , HE Yizhan ² , Xu Lili ¹ ,  ZHANG Yaxu ¹

1. Division of Chronic Disease Control and Prevention, Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China;
2. Mudanjiang Humanity Elderly Hospital, Mudanjiang 157003, China;

Corresponding?author：

ZHANG Yaxu, Email: Dorcas555@163.com

Keywords：

Rural epilepsy; Follow-up management; Tracking investigation

DOI：

10.7507/2096-0247.20190056

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Objective To understand the treatment status and economic burden of convulsive epilepsy patients in Hailin City, Heilongjiang Province, who had received an epilepsy management program that was terminated for 6 years, and to estimate the long-term effect of the epilepsy management program.Methods Follow up the 234 patients in the program of epilepsy prevention and management in rural areas at the end of December 2011 by standardized questionnaire and interview.Results Among the 234 patients who received antiepileptic drugs (AEDs) and follow-up management at the end of epilepsy prevention and management program in rural areas, 172 patients received Phenobarbitone (PB) and 62 patients received Sodium valproate (VPA). 86 patients completed the survey. Among them, 46 (53.49%) were still taking original drugs, 31 (36.05%) changed to other AEDs, 9(10.47%) gave up the treatment due to the closure of the program. The treatment costs of patients in adherence group were also lower than that of other patients, and the average cost was only 43.61% of that of the replace group. There were statistical significant differences in annual household income, drug costs, offset seizure frequency and current seizure frequency between the two groups.Conclusion The epilepsy management program had remarkable long-term effects and short-term effects, it had advantages in treatment effect and reducing drug costs. It could be recommended throughout rural China.

Citation： HE Weili, YAN Shichun, MA Guangyu, HE Yizhan, Xu Lili, ZHANG Yaxu. Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province. Journal of Epilepsy, 2019, 5(5): 351-355. doi: 10.7507/2096-0247.20190056 Copy

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13.	Wang Wz, Wu Jz, Li Sc, et al. Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care. Epilepsy Research, 2012, 102(3): 201-205.
14.	王文志, 吳建中, 李世綽, 等. 我國農村地區 607 例癲癇患者應用丙戊酸鈉治療效果評價. 中華神經科雜志, 2011, 44(1): 15-19.
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16.	Feksi AT, Kaamugisha J, Sander JW, et al. Comprehensive primary health care antiepileptic drug treatment programme in rural and semi-urban Kenya. (International Community-based Epilepsy Research Group). Lancet, 1991, 337(8738): 406-409.
17.	Mani KS, Rangan G, Srinivas HV, et al. Epilepsy control with phenobarbital or phenytoin in rural south india: the yelandur stud. Lancet, 2001, 357(9265): 1316-1320.
18.	Wang WZ, Wu JZ, Ma GY, et al. Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurology, 2006, 5(1): 46-52.
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20.	趙否曦, 劉濤, 張益霞, 等. 農村癲癇人群癲癇治療的成本-效果分析. 中國衛生經濟, 2015, 34(12): 82-84.

1. 常琳, 王小姍. 中國癲癇流行病學調查研究進展. 國際神經病學神經外科學雜志, 2012, 39(2): 161-164.
2. WHO. Epilepsy management at primary health level in rural China: WHO/ILAE/IBE. A Global Campaign Against Epilepsy Demonstration Project, 2009.
3. Liu L, Zhang Q, Yao Z, et al. The operational model of network for managing patients with convulsive epilepsy in rural West China. Epilepsy & Behavior, 2010, 17(1): 75-81.
4. Huang DH, Zheng JO, Chen J, et al. Treatment gaps of epilepsy and retention rates of sodium valproate in rural Guangxi, China. Genetics & Molecular Research Gmr, 2014, 13(3): 6202.
5. Kwan P, Wang W, Wu J, et al. Long-term outcome of phenobarbital treatment for epilepsy in rural China: a prospective cohort study. Epilepsia, 2013, 54(3): 537-542.
6. 李曉裔, 邵西倉, 陳佐俊, 等. 貴州農村驚厥性癲癇巴比妥治療依從性分析. 世界最新醫學信息文摘, 2016, (82): 11-12.
7. 王文志, 李滌, 茹曉娟, 等. 中國農村癲癇防治管理項目介紹. 癲癇雜志, 2016, 2(5): 414-417.
8. 王文志, 吳建忠, 戴秀英, 等. 應用苯巴比妥治療中國農村地區 2455 例癲癇患者效果評估. 中華醫學雜志, 2006, 86(19): 1297.
9. 王文志, 吳建忠, 戴秀英, 等. 中國六省農村地區 2455 例癲癇患者治療管理效果觀察. 中國現代神經疾病雜志, 2006, 6(5): 375-376.
10. 楊洪超, 王文志, 吳建中, 等. 世界衛生組織全球抗癲癇運動中國農村癲癇示范項目結束后四年隨訪結果. 中國現代神經疾病雜志, 2012, 12(5): 530-535.
11. Tracy G, Elinor BM, Blaise B, et al. ILAE treatment guidelines:evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Journal of Neurology & Neurorehabilitation, 2010, 47(7): 1094-1120.
12. Patrick K, Brodie MJ. Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia, 2010, 45(9): 1141-1149.
13. Wang Wz, Wu Jz, Li Sc, et al. Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care. Epilepsy Research, 2012, 102(3): 201-205.
14. 王文志, 吳建中, 李世綽, 等. 我國農村地區 607 例癲癇患者應用丙戊酸鈉治療效果評價. 中華神經科雜志, 2011, 44(1): 15-19.
15. Li LM, Fernandes PT, Noronha AL, et al. Demonstration project on epilepsy in Brazil: outcome assessment. Arquivos de Neuro-Psiquiatria, 2007, 65(28): 58.
16. Feksi AT, Kaamugisha J, Sander JW, et al. Comprehensive primary health care antiepileptic drug treatment programme in rural and semi-urban Kenya. (International Community-based Epilepsy Research Group). Lancet, 1991, 337(8738): 406-409.
17. Mani KS, Rangan G, Srinivas HV, et al. Epilepsy control with phenobarbital or phenytoin in rural south india: the yelandur stud. Lancet, 2001, 357(9265): 1316-1320.
18. Wang WZ, Wu JZ, Ma GY, et al. Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurology, 2006, 5(1): 46-52.
19. 國家統計局編. 《中國統計年鑒 2018》, 北京: 中國統計出版社: 1-949.
20. 趙否曦, 劉濤, 張益霞, 等. 農村癲癇人群癲癇治療的成本-效果分析. 中國衛生經濟, 2015, 34(12): 82-84.

Journal of Epilepsy

Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province

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