癲癇相關睡眠時相異常及認知障礙發病機制的研究進展_Journal of Epilepsy

Authors：

于凱 ¹ , 卜凡 ¹ , 邵欣東 ¹ , 孫雪 ¹ , 郝雷 ¹ , 夏蕾 ¹ ,  李鵬 ²

1. ;
2. ;

Corresponding?author：

李鵬, Email: hlp8079@163.com

Keywords：

睡眠異常; 癲癇; 發病機制; 認知障礙; 綜述

DOI：

10.7507/2096-0247.20210009

Video：

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癲癇是由腦內局部神經元興奮性過高而產生的陣發性異常高頻放電的病癥，其發病機制復雜多樣，可能因離子通道、神經膠質細胞、神經遞質等異常而導致。近年來，越來越多的學者關注到睡眠對于癲癇患者疾病進程的影響，且睡眠異常的癲癇患者常伴有認知功能障礙，對患者的生活質量造成不良影響。文章對近年來睡眠引起癲癇的發病機制和睡眠對于癲癇患者認知功能影響的研究進展作一綜述。

Citation： 于凱, 卜凡, 邵欣東, 孫雪, 郝雷, 夏蕾, 李鵬. 癲癇相關睡眠時相異常及認知障礙發病機制的研究進展. Journal of Epilepsy, 2021, 7(1): 54-57. doi: 10.7507/2096-0247.20210009 Copy

1.	Yuen AWC, Keezer MR, Sander JW. Epilepsy is a neurological and a systemic disorder. Epilepsy Behav, 2018, 78: 57-61.
2.	Musto E, Gardella E, M?ller RS. Recent advances in treatment of epilepsy-related sodium channelopathies. Eur J Paediatr Neurol, 2020, 24: 123-128.
3.	Han S, Yu FH, Schwartz MD, et al. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc Natl Acad Sci U S A, 2012, 109(6): E368-E377.
4.	張慧敏, 田歡, 張晶鈺. 鈉離子通道在神經性疾病發病機制的研究進展. 基因組學與應用生物學, 2020, 38(1): 1-13.
5.	Wallace E, Wright S, Schoenike B, et al. Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy. Epilepsia, 2018, 59(8): 1527-1539.
6.	Wei F, Yan LM, Su T, et al. Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci Bull, 2017, 33(4): 455-477.
7.	Deng Chen, Yang Si, Jun He, et al. Terminal seizure frequency and its relation to SUDEP. Epilepsy Behav, 2017, 70(Pt A): 173-176.
8.	K?hling R, Wolfart J. Potassium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(5): a022871.
9.	Rajakulendran S, Hanna MG. The role of calcium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(1): a022723.
10.	Cheong E, Shin HS. T-type Ca²⁺ channels in normal and abnormal brain functions. Physiol Rev, 2013, 93(3): 961-992.
11.	Tillman L, Zhang J. Crossing the chloride channel: the current and potential therapeutic value of the neuronal K⁺-Cl^- Cotransporter KCC2. Biomed Res Int, 2019, 25(12): 8941046.
12.	Murillo-Rodriguez E, Arias-Carrion O, Zavala-Garcia A, et al. Basic sleep mechanisms: an integrative review. Cent Nerv Syst Agents Med Chem, 2012, 12(1): 38-54.
13.	Brown RE, Basheer R, McKenna JT, et al. Control of sleep and wakefulness. Physiol Rev, 2012, 92(3): 1087-1187.
14.	Verkhratsky A, Ho MS, Zorec R, et al. The concept of neuroglia. Adv Exp Med Biol, 2019, 1175: 1-13.
15.	Filous AR, Silver J. Targeting astrocytes in CNS injury and disease: A translational research approach. Prog Neurobiol, 2016, 144: 173-187.
16.	Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab, 2012, 32(7): 1152-1166.
17.	陳忠, 孫紅柳. 星形膠質細胞在癲癇發病中的作用. 浙江大學學報(醫學版), 2013, 42(3): 245-252.
18.	Lazarus M, Chen JF, Huang ZL, et al. Adenosine and sleep. Handb Exp Pharmacol, 2019, 253: 359-381.
19.	Boison D, Steinh?user C. Epilepsy and astrocyte energy metabolism. Glia, 2018, 66(6): 1235-1243.
20.	Eid T, Gruenbaum SE., Dhaher R., et al The glutamate–glutamine cycle in epilepsy. Adv Neurobiol, 2016, 13: 351-400.
21.	彭毓棻, 宋治. NMDA受體在癲癇發病機制中的作用. 中國病理生理雜志, 2011, 27(06): 1230-1233+1239.
22.	于歡, 洪震. 癲癇患者的認知功能障礙. 中國臨床康復, 2004, 10(22): 4586-4588.
23.	Zhu S, Noviello CM, Teng J, et al. Structure of a human synaptic GABAA receptor. Nature, 2018, 559(7712): 67-72.
24.	Helmstaedter C, Witt JA. Epilepsy and cognition – A bidirectional relationship? Seizure, 2017, 49: 83-89.
25.	Janati AB, ALGhasab NS, Aldaife MY, et al. A typical interictal epileptiform discharges in electroencephalography. J Epilepsy Res, 2018, 8(2): 55-60.
26.	Braun KPJ. Preventing cognitive impairment in children with epilepsy. Current Opinion in Neurology, 2017, 30(2): 140-147.
27.	Liu XY., Shi T, Yin WN, et al Interictal epileptiform discharges were associated with poorer cognitive performance in adult epileptic patients. Epilepsy Research, 2016, 128: 1-5.
28.	Gelinas JN, Khodagholy D, Thesen T, et al. Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med, 2016, 22(6): 641-648.
29.	Horak PC, Meisenhelter S, Song Y, et al. Interictal epileptiform discharges impair word recall in multiple brain areas. Epilepsia, 2017, 58(3): 373-380.
30.	Becker AJ. Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis. Neuropathology and Applied Neurobiology, 2018, 44(1): 112-129.
31.	Eastman CL, D'Ambrosio R, Ganesh T. Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury. Neuropharmacology, 2020, 172: 107907.
32.	陳美麗, 白宇. 癲癇與認知功能關系的研究進展. 中國康復理論與實踐, 2012, 18(4): 341-343.
33.	L?scher W, Friedman A. Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: A cause, consequence, or both? Int J Mol Sci, 2020, 21(2): 591.
34.	Prager O, Kamintsky L, Hasam-Henderson LA, et al. Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction. Epilepsia, 2019, 60(2): 322-336.
35.	Wang L, Chen S, Liu C, et al. Factors for cognitive impairment in adult epileptic patients. Brain Behav, 2020, 10(1): e01475.
36.	Kataria, L., & Vaughn, B. V Sleep and epilepsy. Sleep Medicine Clinics, 2016, 11(1): 25-38.
37.	Bazil, C. Sleep and epilepsy. Seminars in Neurology, 2017, 37(04): 407-412.
38.	Wennberg AMV, Wu MN, Rosenberg PB, et al. Sleep disturbance, cognitive decline, and dementia: a review. Semin Neurol, 2017, 37(4): 395-406.
39.	Lanigar S, Bandyopadhyay S. Sleep and epilepsy: a complex interplay. Mo Med, 2017, 114(6): 453-457.

1. Yuen AWC, Keezer MR, Sander JW. Epilepsy is a neurological and a systemic disorder. Epilepsy Behav, 2018, 78: 57-61.
2. Musto E, Gardella E, M?ller RS. Recent advances in treatment of epilepsy-related sodium channelopathies. Eur J Paediatr Neurol, 2020, 24: 123-128.
3. Han S, Yu FH, Schwartz MD, et al. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc Natl Acad Sci U S A, 2012, 109(6): E368-E377.
4. 張慧敏, 田歡, 張晶鈺. 鈉離子通道在神經性疾病發病機制的研究進展. 基因組學與應用生物學, 2020, 38(1): 1-13.
5. Wallace E, Wright S, Schoenike B, et al. Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy. Epilepsia, 2018, 59(8): 1527-1539.
6. Wei F, Yan LM, Su T, et al. Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci Bull, 2017, 33(4): 455-477.
7. Deng Chen, Yang Si, Jun He, et al. Terminal seizure frequency and its relation to SUDEP. Epilepsy Behav, 2017, 70(Pt A): 173-176.
8. K?hling R, Wolfart J. Potassium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(5): a022871.
9. Rajakulendran S, Hanna MG. The role of calcium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(1): a022723.
10. Cheong E, Shin HS. T-type Ca²⁺ channels in normal and abnormal brain functions. Physiol Rev, 2013, 93(3): 961-992.
11. Tillman L, Zhang J. Crossing the chloride channel: the current and potential therapeutic value of the neuronal K⁺-Cl^- Cotransporter KCC2. Biomed Res Int, 2019, 25(12): 8941046.
12. Murillo-Rodriguez E, Arias-Carrion O, Zavala-Garcia A, et al. Basic sleep mechanisms: an integrative review. Cent Nerv Syst Agents Med Chem, 2012, 12(1): 38-54.
13. Brown RE, Basheer R, McKenna JT, et al. Control of sleep and wakefulness. Physiol Rev, 2012, 92(3): 1087-1187.
14. Verkhratsky A, Ho MS, Zorec R, et al. The concept of neuroglia. Adv Exp Med Biol, 2019, 1175: 1-13.
15. Filous AR, Silver J. Targeting astrocytes in CNS injury and disease: A translational research approach. Prog Neurobiol, 2016, 144: 173-187.
16. Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab, 2012, 32(7): 1152-1166.
17. 陳忠, 孫紅柳. 星形膠質細胞在癲癇發病中的作用. 浙江大學學報(醫學版), 2013, 42(3): 245-252.
18. Lazarus M, Chen JF, Huang ZL, et al. Adenosine and sleep. Handb Exp Pharmacol, 2019, 253: 359-381.
19. Boison D, Steinh?user C. Epilepsy and astrocyte energy metabolism. Glia, 2018, 66(6): 1235-1243.
20. Eid T, Gruenbaum SE., Dhaher R., et al The glutamate–glutamine cycle in epilepsy. Adv Neurobiol, 2016, 13: 351-400.
21. 彭毓棻, 宋治. NMDA受體在癲癇發病機制中的作用. 中國病理生理雜志, 2011, 27(06): 1230-1233+1239.
22. 于歡, 洪震. 癲癇患者的認知功能障礙. 中國臨床康復, 2004, 10(22): 4586-4588.
23. Zhu S, Noviello CM, Teng J, et al. Structure of a human synaptic GABAA receptor. Nature, 2018, 559(7712): 67-72.
24. Helmstaedter C, Witt JA. Epilepsy and cognition – A bidirectional relationship? Seizure, 2017, 49: 83-89.
25. Janati AB, ALGhasab NS, Aldaife MY, et al. A typical interictal epileptiform discharges in electroencephalography. J Epilepsy Res, 2018, 8(2): 55-60.
26. Braun KPJ. Preventing cognitive impairment in children with epilepsy. Current Opinion in Neurology, 2017, 30(2): 140-147.
27. Liu XY., Shi T, Yin WN, et al Interictal epileptiform discharges were associated with poorer cognitive performance in adult epileptic patients. Epilepsy Research, 2016, 128: 1-5.
28. Gelinas JN, Khodagholy D, Thesen T, et al. Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med, 2016, 22(6): 641-648.
29. Horak PC, Meisenhelter S, Song Y, et al. Interictal epileptiform discharges impair word recall in multiple brain areas. Epilepsia, 2017, 58(3): 373-380.
30. Becker AJ. Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis. Neuropathology and Applied Neurobiology, 2018, 44(1): 112-129.
31. Eastman CL, D'Ambrosio R, Ganesh T. Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury. Neuropharmacology, 2020, 172: 107907.
32. 陳美麗, 白宇. 癲癇與認知功能關系的研究進展. 中國康復理論與實踐, 2012, 18(4): 341-343.
33. L?scher W, Friedman A. Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: A cause, consequence, or both? Int J Mol Sci, 2020, 21(2): 591.
34. Prager O, Kamintsky L, Hasam-Henderson LA, et al. Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction. Epilepsia, 2019, 60(2): 322-336.
35. Wang L, Chen S, Liu C, et al. Factors for cognitive impairment in adult epileptic patients. Brain Behav, 2020, 10(1): e01475.
36. Kataria, L., & Vaughn, B. V Sleep and epilepsy. Sleep Medicine Clinics, 2016, 11(1): 25-38.
37. Bazil, C. Sleep and epilepsy. Seminars in Neurology, 2017, 37(04): 407-412.
38. Wennberg AMV, Wu MN, Rosenberg PB, et al. Sleep disturbance, cognitive decline, and dementia: a review. Semin Neurol, 2017, 37(4): 395-406.
39. Lanigar S, Bandyopadhyay S. Sleep and epilepsy: a complex interplay. Mo Med, 2017, 114(6): 453-457.

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Journal of Epilepsy

癲癇相關睡眠時相異常及認知障礙發病機制的研究進展

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