The effect of the mode of continuous guidance with wechat group on the ketogenic diet retention rate in children with infantile spasms_Journal of Epilepsy

Authors：

ZHA Jian , CAO Fangfang , XIONG Ling , FANG Juhua , YI Zhaoshi , YANG Qianqian , CHEN Yong ,  ZHONG Jianmin

Department of Neurology, Jiangxi Provincial Children's Hospital(The Affiliated Children's Hospital of Nanchang University), Nanchang 330006, China;

Corresponding?author：

ZHONG Jianmin, Email: zhongjm@126.com

Keywords：

Ketogenic diet; Infantile spasms; Wechat; Retention rate; Efficacy

DOI：

10.7507/2096-0247.20210020

Video：

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Objective To explore the impact on the retention and effective rate of the mode of continuous guidance with wechat group in children with infantile spasms (IS) treated by ketogenic diet (KD).Methods The clinical data of 40 children who received KD treatment in Jiangxi Children’s Hospital from January 2017 to June 2019 were retrospectively analyzed, including 23 males and 17 females, the average age was (19.90±13.10) months and the average course was (9.95±7.61) months. They were randomly divided into control group (20 cases) and observation group (wechat group continuity Guidance Group, 20 cases), and followed up one year to compare the retention rate and efficacy.Results There was no statistical difference between the general data of the observation group and the control group (P>0.05). After 9 and 12 months of KD treatment, the retention and effective rate of the observation group was significantly higher than the control group (P<0.05). And the seizure-free rate was higher than the control group (35% vs. 10%, 35% vs. 15%).Conclusion This model of continuous guidance with wechat group can increase the KD retention rate of IS children, And increase the effective rate.

Citation： ZHA Jian, CAO Fangfang, XIONG Ling, FANG Juhua, YI Zhaoshi, YANG Qianqian, CHEN Yong, ZHONG Jianmin. The effect of the mode of continuous guidance with wechat group on the ketogenic diet retention rate in children with infantile spasms. Journal of Epilepsy, 2021, 7(2): 122-126. doi: 10.7507/2096-0247.20210020 Copy

1.	甘靖, 屈藝, 羅蓉. 嬰兒痙攣癥治療進展. 中華實用兒科臨床雜志, 2014, 29(24): 1889-1892.
2.	Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
3.	Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
4.	Pires ME, Ilea A, Bourel E, et al. Ketogenic diet for infantile spasms refractory to first-line treatments: An open prospective study. Epilepsy Research, 2013, 105(1-2): 189-194.
5.	Numis AL, Yellen MB, Chu-Shore CJ, et al. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Research, 2011, 96(1-2): 172-175.
6.	中國醫師協會神經內科醫師分會兒童神經專業委員會, 中華醫學會兒科學分會神經學組. 生酮飲食治療兒童癲癇性腦病循證指南. 中華實用兒科臨床雜志, 2019, 34(12): 881-888.
7.	Hong AM, Turner Z, Hamdy RF, et al. Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants. Epilepsia, 2010, 51(8): 1403-1407.
8.	查劍, 易招師, 鐘建民, 等. 生酮飲食治療兒童難治性癲癇的臨床觀察. 江西醫藥, 2015, (5): 461-464.
9.	吳革菲, 胡家勝, 吳舒華, 等. 生酮飲食治療嬰兒痙攣癥的療效和保留率. 中華實用兒科臨床雜志, 2017, 32(10): 780-783.
10.	胡春輝, 王華. 生酮飲食治療嬰兒痙攣25例臨床分析. 中華實用兒科臨床雜志, 2015, 30(7): 532-534.
11.	石卉, 任翼, 石霖. 兒科微信公眾平臺的運行現狀調研. 科技情報開發與經濟, 2015, 25(20): 104-107.
12.	蔣鳳宣, 鄭幗. 生酮飲食治療嬰兒痙攣癥 31 例臨床分析. 南京醫科大學學報(自然科學版), 2018, 38(2): 257-259.
13.	Kossoff EH, Hedderick EF, Turner Z, et al. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia, 2010, 49(9): 1504-1509.
14.	Eun SH, Kang HC, Kim DW, et al. Ketogenic diet for treatment of infantile spasms. Brain & Development, 2006, 28(9): 566-571.
15.	Kayyali HR, Gustafson M, Myers T, et al. Ketogenic Diet Efficacy in the Treatment of Intractable Epileptic Spasms. Pediatric Neurology, 2014, 50(3): 224-227.

1. 甘靖, 屈藝, 羅蓉. 嬰兒痙攣癥治療進展. 中華實用兒科臨床雜志, 2014, 29(24): 1889-1892.
2. Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
3. Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
4. Pires ME, Ilea A, Bourel E, et al. Ketogenic diet for infantile spasms refractory to first-line treatments: An open prospective study. Epilepsy Research, 2013, 105(1-2): 189-194.
5. Numis AL, Yellen MB, Chu-Shore CJ, et al. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Research, 2011, 96(1-2): 172-175.
6. 中國醫師協會神經內科醫師分會兒童神經專業委員會, 中華醫學會兒科學分會神經學組. 生酮飲食治療兒童癲癇性腦病循證指南. 中華實用兒科臨床雜志, 2019, 34(12): 881-888.
7. Hong AM, Turner Z, Hamdy RF, et al. Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants. Epilepsia, 2010, 51(8): 1403-1407.
8. 查劍, 易招師, 鐘建民, 等. 生酮飲食治療兒童難治性癲癇的臨床觀察. 江西醫藥, 2015, (5): 461-464.
9. 吳革菲, 胡家勝, 吳舒華, 等. 生酮飲食治療嬰兒痙攣癥的療效和保留率. 中華實用兒科臨床雜志, 2017, 32(10): 780-783.
10. 胡春輝, 王華. 生酮飲食治療嬰兒痙攣25例臨床分析. 中華實用兒科臨床雜志, 2015, 30(7): 532-534.
11. 石卉, 任翼, 石霖. 兒科微信公眾平臺的運行現狀調研. 科技情報開發與經濟, 2015, 25(20): 104-107.
12. 蔣鳳宣, 鄭幗. 生酮飲食治療嬰兒痙攣癥 31 例臨床分析. 南京醫科大學學報(自然科學版), 2018, 38(2): 257-259.
13. Kossoff EH, Hedderick EF, Turner Z, et al. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia, 2010, 49(9): 1504-1509.
14. Eun SH, Kang HC, Kim DW, et al. Ketogenic diet for treatment of infantile spasms. Brain & Development, 2006, 28(9): 566-571.
15. Kayyali HR, Gustafson M, Myers T, et al. Ketogenic Diet Efficacy in the Treatment of Intractable Epileptic Spasms. Pediatric Neurology, 2014, 50(3): 224-227.

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