PET-CT 和 PET-MRI 在藥物難治性癲癇中的研究進展_Journal of Epilepsy

Authors：

王玲 ¹ ,  柳江燕 ^1,2 , 任婉娜 ³

1. ;
2. ;
3. ;

Corresponding?author：

柳江燕, Email: ery_liujy@lzu.edu.cn

Keywords：

難治性癲癇; PET-CT; PET-MRI; 術前評估; 療效評價; 受體顯像

DOI：

10.7507/2096-0247.20210040

Video：

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手術是藥物難治性癲癇的主要治療手段，手術成功的關鍵在于術前對致癇灶的精確定位。近年來神經影像技術迅速發展，在難治性癲癇患者術前評估及療效評價中發揮著重要的作用。本文對 PET-CT 和 PET-MRI 在藥物難治性癲癇患者術前評估、預后判斷以及 PET 腦受體顯像劑等方面作一綜述。

Citation： 王玲, 柳江燕, 任婉娜. PET-CT 和 PET-MRI 在藥物難治性癲癇中的研究進展. Journal of Epilepsy, 2021, 7(3): 257-261. doi: 10.7507/2096-0247.20210040 Copy

1.	沈雁文, 鄒麗萍. 從精準醫療的角度看藥物難治性癲癇解放軍醫學院學報, 2019, 40(3): 282-285.
2.	Sidhu MK, Duncan JS, Sander JW. Neuroimaging in epilepsy. Curr Opin Neurol, 2018, 31(4): 371-378.
3.	Hu ZH, Yang WD, Liu HX, et al. From PET-CT to PET-MRI: advances in instrumentation and clinical applications. Mol Pharm, 2014, 11(11): 3798-3809.
4.	劉鵬, 富麗萍. 一體化 PET/MR 技術研究進展. 中國醫療設備, 2019, 34(12): 160-164.
5.	von Oertzen TJ. PET and ictal SPECT can be helpful for localizing epileptic foci. Curr Opin Neurol, 2018, 31(2): 184-191.
6.	Chassoux F, Rodrigo S, Mellerio C, et al. Dysembryoplastic neuroepithelial tumors: an MRI-based scheme for epilepsy surgery. Neurology, 2012, 79(16): 1699-1707.
7.	Guedj E, Bonini F, Gavaret M, et al. 18FDG-PET in different subtypes of temporal lobe epilepsy: SEEG validation and predictive value. Epilepsia, 2015, 56(3): 414-421.
8.	Casse R, Rowe CC, Newton M, et al. Positron emission tomography and epilepsy. Mol Imaging Biol, 2002, 45(5): 338-351.
9.	Ding Y, Zhu YK, Jiang B, et al. F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging, 2018, 45(9): 1567-1572.
10.	Kojan M, Dole?alová I, Kori?áková E, et al. Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsy Behav, 2018, 79(2): 46-52.
11.	Chan TLH, Romsa J, Steven DA, et al. Refractory epilepsy: The role of positron emission tomography. Can J Neurol Sci, 2018, 45(1): 30-34.
12.	Gokdemir S, Halac M, Albayram S, et al. Contribution of FDG-PET in epilepsy surgery: consistency and postoperative results compared with magnetic resonance imaging and electroencephalography. Turk Neurosurg, 2015, 25(1): 53-57.
13.	Menon RN, Radhakrishnan A, Parameswaran R, et al. Does F-18 FDG-PET substantially alter the surgical decision-making in drug-resistant partial epilepsy? Epilepsy Behav, 2015, 51(10): 133-139.
14.	Morales-Chacon LM, Alfredo Sanchez Catasus C, Minou Baez Martin M, et al. Multimodal imaging in nonlesional medically intractable focal epilepsy. Front Biosci (Elite Ed), 2015, 7(1): 42-57.
15.	De Ciantis A, Barba C, Tassi L, et al. 7T MRI in focal epilepsy with unrevealing conventional field strength imaging. Epilepsia, 2016, 57(3): 445-454.
16.	Jones AL, Cascino GD. Evidence on uUse of neuroimaging for surgical treatment of temporal lobe epilepsy: A systematic review. JAMA Neurol, 2016, 73(4): 464-470.
17.	桑林, 張凱, 張建國, 等. PET-MRI 影像融合技術在藥物難治性癲癇術前評估中的價值. 中華神經外科雜志, 2017, 33(6): 559-563.
18.	Bisdas S, LáFougere C, Ernemann U. Hybrid MR-PET in neuroimaging. Clin Neuroradiol, 2015, 25(10): 275-281.
19.	Shin HW, Jewells V, Sheikh A, et al. Initial experience in hybrid PET-MRI for evaluation of refractory focal onset epilepsy. Seizure, 2015, 31(9): 1-4.
20.	張淼, 黃鵬, 占世坤, 等. 一體化 18F-FDG PET-MRI 多模態分子影像在癲癇精準定位中的應用價值. 診斷學理論與實踐, 2019, 18(3): 271-277.
21.	張桂霞, 盧倩, 黨浩丹, 等. PET-MRI 在兒童難治性癲癇定位診斷中的應用. 解放軍醫學院學報, 2018, 39(10): 833-837.
22.	Paldino MJ, Yang E, Jones JY, et al. Comparison of the diagnostic accuracy of PET-MRI to PET-CT-acquired FDG brain exams for seizure focus detection: a prospective study. Pediatr Radiol, 2017, 47(11): 1500-1507.
23.	Fernández S, Donaire A, Serès E, et al. PET-MRI and PET-MRI/SISCOM coregistration in the presurgical evaluation of refractory focal epilepsy. Epilepsy Res, 2015, 111(5): 1-9.
24.	Wang X, Zhang C, Wang Y, et al. Prognostic factors for seizure outcome in patients with MRI-negative temporal lobe epilepsy: A meta-analysis and systematic review. Seizure, 2016, 38(5): 54-62.
25.	Heiss WD. Hybrid PET/MR imaging in neurology: present applications and prospects for the future. J Nucl Med, 2016, 57(7): 993-995.
26.	Rubinger L, Chan C, D'Arco F, et al. Change in presurgical diagnostic imaging evaluation affects subsequent pediatric epilepsy surgery outcome. Epilepsia, 2016, 57(1): 32-40.
27.	Chassoux F, Artiges E, Semah F, et al. F-FDG-PET patterns of surgical success and failure in mesial temporal lobe epilepsy. Neurology, 2017, 88(11): 1045-1053.
28.	Willmann O, Wennberg R, May T, et al. The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis. Seizure, 2007, 16(6): 509-520.
29.	陸玲玲, 陳宇峰, 郭佳, 等. 成人顳葉癲癇患者發作間期 18F-FDG PET-CT 腦代謝顯像與術后療效的關系. 中國臨床醫學影像雜志, 2020, 31(2): 87-91.
30.	Nelissen N, Van Paesschen W, Baete K, et al. Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis. Neuroimage, 2006, 32(2): 684-695.
31.	劉遠梅. PET-CT 對 MRI 陰性的顳葉癲癇術前定位和療效的價值分析. 現代養生(下半月版), 2017, (1): 45.
32.	Kamm J, Boles Ponto LL, Manzel K, et al. Temporal lobe asymmetry in FDG-PET uptake predicts neuropsychological and seizure outcomes after temporal lobectomy. Epilepsy Behav, 2018, 78(1): 62-67.
33.	郝謙謙, 李迪彬, 李殿友, 等. PET-MRI 異機融合圖形對影像學陰性的難治性顳葉癲癇手術療效的價值. 中華神經外科雜志, 2014, 30(12): 1262-1265.
34.	Gok B, Jallo G, Hayeri R, et al. The evaluation of FDG-PET imaging for epileptogenic focus localization in patients with MRI positive and MRI negative temporal lobe epilepsy. Neuroradiology, 2013, 55(5): 541-550.
35.	Lin YC, Fang YH, Wu G, et al. Quantitative positron emission tomography-guided magnetic resonance imaging postprocessing in magnetic resonance imaging-negative epilepsies. Epilepsia, 2018, 59(8): 1583-1594.
36.	Mitterhauser M, Wadsak W, Wabnegger L, et al. Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET. Nucl Med Biol, 2004, 31(2): 291-295.
37.	林都, 王治國, 張國旭. MRI 與發作間期 18F-FDG 及 11 C-FMZ PET-CT 顯像對經典型海馬硬化性難治性癲癎的診斷價值. 中華核醫學與分子影像雜志, 2019, 39(12): 726-731.
38.	Hodolic M, Topakian R, Pichler R. (18)F-fluorodeoxyglucose and (18)F-flumazenil positron emission tomography in patients with refractory epilepsy. Radiol Oncol, 2016, 50(3): 247-253.
39.	Juhász C, Asano E, Shah A, et al. Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate? Epilepsia, 2009, 50(2): 240-250.
40.	MadarI, Lesser R P, Krauss G et al. Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography. Ann. Neurol, 1997, 41: 358-367.
41.	McGinnity CJ, Shidahara M, Feldmann M, et al. Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect. Neuroimage, 2013, 79(10): 72-80.
42.	Hammers A, Asselin MC, Hinz R, et al. Upregulation of opioid receptor binding following spontaneous epileptic seizures. Brain, 2007, 130(4): 1009-1016.
43.	Chugani HT, Luat AF, Kumar A, et al. α-[11C]-Methyl-L-tryptophan -PET in 191 patients with tuberous sclerosis complex. Neurology, 2013, 81(7): 674-680.
44.	Liew CJ, Lim YM, Bonwetsch R, et al. 18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy. Epilepsia, 2009, 50(2): 234-239.
45.	Didelot A, Mauguière F, Redouté J, et al. Voxel-based analysis of asymmetry index maps increases the specificity of 18F-MPPF PET abnormalities for localizing the epileptogenic zone in temporal lobe epilepsies. J Nucl Med, 2010, 51(11): 1732-1739.
46.	Didelot A, Ryvlin P, Lothe A, et al. PET imaging of brain 5-HT1A receptors in the preoperative evaluation of temporal lobe epilepsy. Brain, 2008, 131(10): 2751-2764.
47.	Leniger T, Kananura C, Hufnagel A, et al. A new Chrna4 mutation with low penetrance in nocturnal frontal lobe epilepsy. Epilepsia, 2003, 44(7): 981-985.
48.	Garibotto V, Wissmeyer M, Giavri Z, et al. Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy. Eur J Nucl Med Mol Imaging, 2019, 46(2): 385-395.
49.	Loddenkemper T, Wyllie E, Hirsch E. Epileptic syndromes with focal seizures of childhood and adolescence. Handb Clin Neurol, 2012, 107: 195-208.

1. 沈雁文, 鄒麗萍. 從精準醫療的角度看藥物難治性癲癇解放軍醫學院學報, 2019, 40(3): 282-285.
2. Sidhu MK, Duncan JS, Sander JW. Neuroimaging in epilepsy. Curr Opin Neurol, 2018, 31(4): 371-378.
3. Hu ZH, Yang WD, Liu HX, et al. From PET-CT to PET-MRI: advances in instrumentation and clinical applications. Mol Pharm, 2014, 11(11): 3798-3809.
4. 劉鵬, 富麗萍. 一體化 PET/MR 技術研究進展. 中國醫療設備, 2019, 34(12): 160-164.
5. von Oertzen TJ. PET and ictal SPECT can be helpful for localizing epileptic foci. Curr Opin Neurol, 2018, 31(2): 184-191.
6. Chassoux F, Rodrigo S, Mellerio C, et al. Dysembryoplastic neuroepithelial tumors: an MRI-based scheme for epilepsy surgery. Neurology, 2012, 79(16): 1699-1707.
7. Guedj E, Bonini F, Gavaret M, et al. 18FDG-PET in different subtypes of temporal lobe epilepsy: SEEG validation and predictive value. Epilepsia, 2015, 56(3): 414-421.
8. Casse R, Rowe CC, Newton M, et al. Positron emission tomography and epilepsy. Mol Imaging Biol, 2002, 45(5): 338-351.
9. Ding Y, Zhu YK, Jiang B, et al. F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging, 2018, 45(9): 1567-1572.
10. Kojan M, Dole?alová I, Kori?áková E, et al. Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsy Behav, 2018, 79(2): 46-52.
11. Chan TLH, Romsa J, Steven DA, et al. Refractory epilepsy: The role of positron emission tomography. Can J Neurol Sci, 2018, 45(1): 30-34.
12. Gokdemir S, Halac M, Albayram S, et al. Contribution of FDG-PET in epilepsy surgery: consistency and postoperative results compared with magnetic resonance imaging and electroencephalography. Turk Neurosurg, 2015, 25(1): 53-57.
13. Menon RN, Radhakrishnan A, Parameswaran R, et al. Does F-18 FDG-PET substantially alter the surgical decision-making in drug-resistant partial epilepsy? Epilepsy Behav, 2015, 51(10): 133-139.
14. Morales-Chacon LM, Alfredo Sanchez Catasus C, Minou Baez Martin M, et al. Multimodal imaging in nonlesional medically intractable focal epilepsy. Front Biosci (Elite Ed), 2015, 7(1): 42-57.
15. De Ciantis A, Barba C, Tassi L, et al. 7T MRI in focal epilepsy with unrevealing conventional field strength imaging. Epilepsia, 2016, 57(3): 445-454.
16. Jones AL, Cascino GD. Evidence on uUse of neuroimaging for surgical treatment of temporal lobe epilepsy: A systematic review. JAMA Neurol, 2016, 73(4): 464-470.
17. 桑林, 張凱, 張建國, 等. PET-MRI 影像融合技術在藥物難治性癲癇術前評估中的價值. 中華神經外科雜志, 2017, 33(6): 559-563.
18. Bisdas S, LáFougere C, Ernemann U. Hybrid MR-PET in neuroimaging. Clin Neuroradiol, 2015, 25(10): 275-281.
19. Shin HW, Jewells V, Sheikh A, et al. Initial experience in hybrid PET-MRI for evaluation of refractory focal onset epilepsy. Seizure, 2015, 31(9): 1-4.
20. 張淼, 黃鵬, 占世坤, 等. 一體化 18F-FDG PET-MRI 多模態分子影像在癲癇精準定位中的應用價值. 診斷學理論與實踐, 2019, 18(3): 271-277.
21. 張桂霞, 盧倩, 黨浩丹, 等. PET-MRI 在兒童難治性癲癇定位診斷中的應用. 解放軍醫學院學報, 2018, 39(10): 833-837.
22. Paldino MJ, Yang E, Jones JY, et al. Comparison of the diagnostic accuracy of PET-MRI to PET-CT-acquired FDG brain exams for seizure focus detection: a prospective study. Pediatr Radiol, 2017, 47(11): 1500-1507.
23. Fernández S, Donaire A, Serès E, et al. PET-MRI and PET-MRI/SISCOM coregistration in the presurgical evaluation of refractory focal epilepsy. Epilepsy Res, 2015, 111(5): 1-9.
24. Wang X, Zhang C, Wang Y, et al. Prognostic factors for seizure outcome in patients with MRI-negative temporal lobe epilepsy: A meta-analysis and systematic review. Seizure, 2016, 38(5): 54-62.
25. Heiss WD. Hybrid PET/MR imaging in neurology: present applications and prospects for the future. J Nucl Med, 2016, 57(7): 993-995.
26. Rubinger L, Chan C, D'Arco F, et al. Change in presurgical diagnostic imaging evaluation affects subsequent pediatric epilepsy surgery outcome. Epilepsia, 2016, 57(1): 32-40.
27. Chassoux F, Artiges E, Semah F, et al. F-FDG-PET patterns of surgical success and failure in mesial temporal lobe epilepsy. Neurology, 2017, 88(11): 1045-1053.
28. Willmann O, Wennberg R, May T, et al. The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis. Seizure, 2007, 16(6): 509-520.
29. 陸玲玲, 陳宇峰, 郭佳, 等. 成人顳葉癲癇患者發作間期 18F-FDG PET-CT 腦代謝顯像與術后療效的關系. 中國臨床醫學影像雜志, 2020, 31(2): 87-91.
30. Nelissen N, Van Paesschen W, Baete K, et al. Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis. Neuroimage, 2006, 32(2): 684-695.
31. 劉遠梅. PET-CT 對 MRI 陰性的顳葉癲癇術前定位和療效的價值分析. 現代養生(下半月版), 2017, (1): 45.
32. Kamm J, Boles Ponto LL, Manzel K, et al. Temporal lobe asymmetry in FDG-PET uptake predicts neuropsychological and seizure outcomes after temporal lobectomy. Epilepsy Behav, 2018, 78(1): 62-67.
33. 郝謙謙, 李迪彬, 李殿友, 等. PET-MRI 異機融合圖形對影像學陰性的難治性顳葉癲癇手術療效的價值. 中華神經外科雜志, 2014, 30(12): 1262-1265.
34. Gok B, Jallo G, Hayeri R, et al. The evaluation of FDG-PET imaging for epileptogenic focus localization in patients with MRI positive and MRI negative temporal lobe epilepsy. Neuroradiology, 2013, 55(5): 541-550.
35. Lin YC, Fang YH, Wu G, et al. Quantitative positron emission tomography-guided magnetic resonance imaging postprocessing in magnetic resonance imaging-negative epilepsies. Epilepsia, 2018, 59(8): 1583-1594.
36. Mitterhauser M, Wadsak W, Wabnegger L, et al. Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET. Nucl Med Biol, 2004, 31(2): 291-295.
37. 林都, 王治國, 張國旭. MRI 與發作間期 18F-FDG 及 11 C-FMZ PET-CT 顯像對經典型海馬硬化性難治性癲癎的診斷價值. 中華核醫學與分子影像雜志, 2019, 39(12): 726-731.
38. Hodolic M, Topakian R, Pichler R. (18)F-fluorodeoxyglucose and (18)F-flumazenil positron emission tomography in patients with refractory epilepsy. Radiol Oncol, 2016, 50(3): 247-253.
39. Juhász C, Asano E, Shah A, et al. Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate? Epilepsia, 2009, 50(2): 240-250.
40. MadarI, Lesser R P, Krauss G et al. Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography. Ann. Neurol, 1997, 41: 358-367.
41. McGinnity CJ, Shidahara M, Feldmann M, et al. Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect. Neuroimage, 2013, 79(10): 72-80.
42. Hammers A, Asselin MC, Hinz R, et al. Upregulation of opioid receptor binding following spontaneous epileptic seizures. Brain, 2007, 130(4): 1009-1016.
43. Chugani HT, Luat AF, Kumar A, et al. α-[11C]-Methyl-L-tryptophan -PET in 191 patients with tuberous sclerosis complex. Neurology, 2013, 81(7): 674-680.
44. Liew CJ, Lim YM, Bonwetsch R, et al. 18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy. Epilepsia, 2009, 50(2): 234-239.
45. Didelot A, Mauguière F, Redouté J, et al. Voxel-based analysis of asymmetry index maps increases the specificity of 18F-MPPF PET abnormalities for localizing the epileptogenic zone in temporal lobe epilepsies. J Nucl Med, 2010, 51(11): 1732-1739.
46. Didelot A, Ryvlin P, Lothe A, et al. PET imaging of brain 5-HT1A receptors in the preoperative evaluation of temporal lobe epilepsy. Brain, 2008, 131(10): 2751-2764.
47. Leniger T, Kananura C, Hufnagel A, et al. A new Chrna4 mutation with low penetrance in nocturnal frontal lobe epilepsy. Epilepsia, 2003, 44(7): 981-985.
48. Garibotto V, Wissmeyer M, Giavri Z, et al. Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy. Eur J Nucl Med Mol Imaging, 2019, 46(2): 385-395.
49. Loddenkemper T, Wyllie E, Hirsch E. Epileptic syndromes with focal seizures of childhood and adolescence. Handb Clin Neurol, 2012, 107: 195-208.

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PET-CT 和 PET-MRI 在藥物難治性癲癇中的研究進展

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