Analysis of correlation between epileptic seizure and lipid metabolism and nutritional indicators in patients with glioma_Journal of Epilepsy

Authors：

LI Xingchao ^1,2 , ZHANG Jinling ^1,2,3 , LI Mingzhu ¹ , WANG Youfang ⁴ , ZHOU Liangjian ¹ , SUN Xiangjun ⁵ , LI Jinkui ⁶ , CUI Yuanyuan ³ ,  CHE Fengyuan ²

1. Office of Academic Research of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
2. Brain Tumor Functional Imaging Engineering Research Center of Academic Research of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
3. Oncology Department of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
4. Intensive Care Unit of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
5. General Surgery of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
6. Internal medicine of People's Hospital of Lanshan district, Linyi 276002, China;

Corresponding?author：

CHE Fengyuan, Email: che1971@126.com

Keywords：

Glioma; Epilepsy; Lipid metabolism

DOI：

10.7507/2096-0247.20210051

Video：

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Objective To investigate the correlation between epileptic seizure and lipid metabolism and nutritional index in patients with glioma.Methods 380 patients with glioma admitted to Linyi People's Hospital Affiliated to Shandong University from January 2017 to December 2019 were selected. According to whether the first symptom is epilepsy or not, patients with glioma were divided into epileptic group (n=72) and control group (n=308). Combined with the basic demographic information, lipid metabolism and nutrition indicators in the medical records, the two groups of patients were analyzed retrospectively.Results The mean age of epileptic group was (39.38±13.40) years, and the sex ratio was 1.88∶1. The mean age of the control group was (46.25±15.97) years, and the sex ratio was 1.20∶1. Chi-square test results showed that there was a statistical correlation between gender, alcohol consumption, history of hypertension and seizures (χ²=0.813, P<0.05). The results of multiple logistic regression analysis showed that there were differences in age, weight, LDL-C and potassium between the epilepsy group and the control group (P<0.05).Conclusion Male, age, weight, LDL-C and abnormal potassium concentration are risk factors for epilepsy in patients with brain tumor, and effective prevention and treatment measures should be taken in time for patients with abnormal lipid metabolism and nutritional indicators.

Citation： LI Xingchao, ZHANG Jinling, LI Mingzhu, WANG Youfang, ZHOU Liangjian, SUN Xiangjun, LI Jinkui, CUI Yuanyuan, CHE Fengyuan. Analysis of correlation between epileptic seizure and lipid metabolism and nutritional indicators in patients with glioma. Journal of Epilepsy, 2021, 7(4): 318-322. doi: 10.7507/2096-0247.20210051 Copy

1.	Nowell M, Miserocchi A, McEvoy AW. Tumors in epilepsy. Semin Neurol, 2015, 35(3): 209-217.
2.	Giulioni M, Martinoni M, Marucci G. Challenges in epilepsyassociated tumors. J Neurooncol, 2016, 130(1): 239-240.
3.	梁錦平. 國際抗癲癇聯盟2017年版癲癇分類特點及其解讀. 中國實用兒科雜志, 2020, 35(1): 47-54.
4.	章殷希, 丁美萍. 癲癇相關腦腫瘤的臨床研究進展. 癲癇雜志, 2018, 4(1): 32-35.
5.	Ertürk ?etin ?, Isler C, Uzan M, et al. Epilepsy-related brain tumors. Seizure, 2017, 44: 93-97.
6.	明文杰, 章殷希, 沈春紅, 等. 膠質神經元腫瘤相關癲癇的臨床特點及影響手術療效的相關因素. 中華神經外科雜志, 2018, 34(12): 1202-1206.
7.	Blümcke I, Aronica E, Becker A, et al. Low-grade epilepsy associated neuroepithelial tumours - the 2016 WHO classification. Nat Rev Neurol, 2016, 12(12): 732-740.
8.	王冰, 胡世頡, 李兵, 等. 腦腫瘤相關性癲癇發生的影響因素分析及對癥處理. 中國腫瘤臨床與康復, 2012, 19(6): 542-544.
9.	楊虎, 陳陽美. 腦腫瘤相關性癲癇的簡介及目前研究進展. 癲癇與神經電生理學雜志, 2016, 253: 162-165.
10.	You G, Sha ZY, Yan W, et al. Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of lowgrade gliomas: a clinicopathological study. Neuro Oncol, 2012, 14(2): 230-241.
11.	郭毅. 酒精(乙醇)相關性癲癇發作的臨床特點及預防. 國際神經病學神經外科學雜志, 2015, 42(6): 534-538.
12.	曾軍, 洪震, 黃茂盛, 等. 人群癲癇危險因素及社會心理因素病例對照研究. 中華流行病學雜志, 2003, 24(2): 116-118.
13.	盧蕾, 王贊, 孟紅梅, 等. 以抽搐發作為首發癥狀的234例老年癲癇的病因及臨床特點分析. 中風與神經疾病雜志, 2010, 27(2): 164-166.
14.	謝清, 谷曉莉, 萬久香, 等. 老年人腦血管病并發癲癇的臨床特點. 中華老年醫學雜志, 2020, 39(09): 1025-1028.
15.	Cowie CJ, Cunningham MO. Peritumoral epilepsy: relating form and function for surgical success. Epilepsy Behav, 2014, 38: 53-61.
16.	Giulioni M, Marucci G, Martinoni M, et al. Epilepsy associated tumors: review article. World J Clin Cases, 2014, 2(11): 623-641.
17.	嚴金柱, 莊小鵬, 季曉林, 等. 成人癲癇患者夜間睡眠事件的多導睡眠圖分析. 福建醫科大學學報, 2018, 52(3): 40-44.
18.	陳婷, 陳婭, 張海清, 等. 腸道微生態與癲癇的相關性研究進展. 中華神經醫學雜志, 2019, 18(4): 413-416.
19.	陳潤真, 劉臣, 周鵬, 等. 急性心肌梗死經皮冠狀動脈介入治療術后D-二聚體、高敏C反應蛋白及LDL-C水平與預后的關系. 中華心血管病雜志, 2020, 48(5): 359-366.
20.	汪云, 賈小芳, 蘇暢, 等. 2015年中國15省(自治區、直轄市)60歲及以上居民膳食膽固醇攝入狀況及與血清膽固醇水平的關聯. 衛生研究, 2019, 13(1): 33-40.
21.	曾琦, 張月華. 良性癲癇與癲癇性腦病共享致病基因研究進展. 中華兒科雜志, 2019, 57(4): 309-312.
22.	吳靖, 常麗英, 續蕾. 194例成人癥狀性癲癇患者的病因分析. 卒中與神經疾病, 2018, 25(3): 78-79.

1. Nowell M, Miserocchi A, McEvoy AW. Tumors in epilepsy. Semin Neurol, 2015, 35(3): 209-217.
2. Giulioni M, Martinoni M, Marucci G. Challenges in epilepsyassociated tumors. J Neurooncol, 2016, 130(1): 239-240.
3. 梁錦平. 國際抗癲癇聯盟2017年版癲癇分類特點及其解讀. 中國實用兒科雜志, 2020, 35(1): 47-54.
4. 章殷希, 丁美萍. 癲癇相關腦腫瘤的臨床研究進展. 癲癇雜志, 2018, 4(1): 32-35.
5. Ertürk ?etin ?, Isler C, Uzan M, et al. Epilepsy-related brain tumors. Seizure, 2017, 44: 93-97.
6. 明文杰, 章殷希, 沈春紅, 等. 膠質神經元腫瘤相關癲癇的臨床特點及影響手術療效的相關因素. 中華神經外科雜志, 2018, 34(12): 1202-1206.
7. Blümcke I, Aronica E, Becker A, et al. Low-grade epilepsy associated neuroepithelial tumours - the 2016 WHO classification. Nat Rev Neurol, 2016, 12(12): 732-740.
8. 王冰, 胡世頡, 李兵, 等. 腦腫瘤相關性癲癇發生的影響因素分析及對癥處理. 中國腫瘤臨床與康復, 2012, 19(6): 542-544.
9. 楊虎, 陳陽美. 腦腫瘤相關性癲癇的簡介及目前研究進展. 癲癇與神經電生理學雜志, 2016, 253: 162-165.
10. You G, Sha ZY, Yan W, et al. Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of lowgrade gliomas: a clinicopathological study. Neuro Oncol, 2012, 14(2): 230-241.
11. 郭毅. 酒精(乙醇)相關性癲癇發作的臨床特點及預防. 國際神經病學神經外科學雜志, 2015, 42(6): 534-538.
12. 曾軍, 洪震, 黃茂盛, 等. 人群癲癇危險因素及社會心理因素病例對照研究. 中華流行病學雜志, 2003, 24(2): 116-118.
13. 盧蕾, 王贊, 孟紅梅, 等. 以抽搐發作為首發癥狀的234例老年癲癇的病因及臨床特點分析. 中風與神經疾病雜志, 2010, 27(2): 164-166.
14. 謝清, 谷曉莉, 萬久香, 等. 老年人腦血管病并發癲癇的臨床特點. 中華老年醫學雜志, 2020, 39(09): 1025-1028.
15. Cowie CJ, Cunningham MO. Peritumoral epilepsy: relating form and function for surgical success. Epilepsy Behav, 2014, 38: 53-61.
16. Giulioni M, Marucci G, Martinoni M, et al. Epilepsy associated tumors: review article. World J Clin Cases, 2014, 2(11): 623-641.
17. 嚴金柱, 莊小鵬, 季曉林, 等. 成人癲癇患者夜間睡眠事件的多導睡眠圖分析. 福建醫科大學學報, 2018, 52(3): 40-44.
18. 陳婷, 陳婭, 張海清, 等. 腸道微生態與癲癇的相關性研究進展. 中華神經醫學雜志, 2019, 18(4): 413-416.
19. 陳潤真, 劉臣, 周鵬, 等. 急性心肌梗死經皮冠狀動脈介入治療術后D-二聚體、高敏C反應蛋白及LDL-C水平與預后的關系. 中華心血管病雜志, 2020, 48(5): 359-366.
20. 汪云, 賈小芳, 蘇暢, 等. 2015年中國15省(自治區、直轄市)60歲及以上居民膳食膽固醇攝入狀況及與血清膽固醇水平的關聯. 衛生研究, 2019, 13(1): 33-40.
21. 曾琦, 張月華. 良性癲癇與癲癇性腦病共享致病基因研究進展. 中華兒科雜志, 2019, 57(4): 309-312.
22. 吳靖, 常麗英, 續蕾. 194例成人癥狀性癲癇患者的病因分析. 卒中與神經疾病, 2018, 25(3): 78-79.

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Analysis of correlation between epileptic seizure and lipid metabolism and nutritional indicators in patients with glioma

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