The significance of sleep deprivation electroencephalogram in the diagnosis of epilepsy: a Meta analysis_Journal of Epilepsy

Authors：

WU Yingying ¹ , CAO Li ² ,  ZHONG Ping ¹

1. Department of Neurology, Suzhou Hospital of Anhui Medical University, Suzhou 234000, China;
2. Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China;

Corresponding?author：

ZHONG Ping, Email: Drzp1966@163.com

Keywords：

Sleep deprivation EEG; Epilepsy; Meta-analysis

DOI：

10.7507/2096-0247.20210067

Video：

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Objectives To review the value of sleep deprivation EEG methodology in the diagnosis of epilepsy.Methods Such databases as Pubmed, MEDLINE, The Cochrane Library, Wanfang, VIP and CNKI Data are searched electronically and comprehensively for literature on the diagnosis of epilepsy by sleep deprivation EEG from inception to January 2021. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, meta-analysis was performed using Stata software.Results A total of 14studies involving 1221 patients were included in total. The results of meta-analysis showed that: Duration of sleep deprivation and effect value of positive rate [ r=0.670, 95%CI (0.664, 0.696), P<0.001 ], duration of the awake period records and effect value of positive rate [ r=0.659, 95%CI (0.596, 0.722), P<0.001 ], duration of sleep period records and effect value of positive rate [ r=0.67, 95%CI(0.619, 0.721), P<0.001 ], with significant differences.Conclusions The duration of sleep deprivation, the awake period records, and the sleep period records of sleep deprivation EEG examination, sleep deprivation time between 16 h to 24 h, the awake recording time ≥30 min, and the sleep recording time ≥ 60 min (≤ 3 h) can obviously improve the positive rate of sleep deprivation EEG.

Citation： WU Yingying, CAO Li, ZHONG Ping. The significance of sleep deprivation electroencephalogram in the diagnosis of epilepsy: a Meta analysis. Journal of Epilepsy, 2021, 7(5): 411-416. doi: 10.7507/2096-0247.20210067 Copy

1.	RD Thijs, R Surges, TJ O'Brien, et al. Epilepsy in adults. Lancet (London, England), 2019, 393(10172): 689-701.
2.	桂華. 兒童癲癇自然睡眠與藥物誘導睡眠的腦電圖分析. 實用醫技雜志, 2007, 14(7): 857-858.
3.	李榮. 癲癇診斷中睡眠剝奪和藥物誘導睡眠腦電圖的臨床價值. 深圳中西醫結合雜志, 2014, 24(03): 127-128.
4.	彭德強, 溫世斌, 景兆德. 部分睡眠剝奪聯合睡眠腦電圖在癲癇診斷中的價值. 蘭州醫學院學報. 2003, 29(2): 56-58.
5.	王惠琪, 余秀蘭, 魏亮. 自然睡眠與藥物誘導睡眠對腦電圖睡眠腦波的影響. 中國臨床康復, 2005, 9(21): 46-48.
6.	王璐, 盛敏. 剝奪性睡眠后自然睡眠腦電圖在癲癇診斷中的意義. 臨床和實驗醫學雜志, 2004, 3(3): 136-137.
7.	楊春清, 杜亞麗, 張素芳等. 睡眠剝奪和藥物誘導睡眠腦電圖在癲癇診斷中的應用價值. 中國全科醫學, 2010, 13(03): 305-306.
8.	楊麗. 癲癇診斷中睡眠剝奪和藥物誘導睡眠腦電圖的臨床應用價值探析. 臨床研究, 2018, 26(2): 85-87.
9.	朱艷. 癲癇診斷中睡眠剝奪和藥物誘導睡眠腦電圖的臨床價值, 影像研究與醫學應用, 2020, 4(10): 216-217.
10.	蔡少雅. 睡眠剝奪和藥物誘導睡眠腦電圖在癲癇診斷中的應用價值. 醫藥前沿, 2016, 22(06): 372-373.
11.	U Aguglia, A Gambardella, E Le Piane, et al. Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy. Journal of neurology, 1994, 241(10): 605-610.
12.	R Degen, HE Degen. The diagnostic value of the sleep EEG with and without sleep deprivation in patients with atypical absences. Epilepsia, 1983, 24(5): 557-566.
13.	R Degen. A study of the diagnostic value of waking and sleep EEGs after sleep deprivation in epileptic patients on anticonvulsive therapy. Electroencephalography and clinical neurophysiology, 1980, 49(5-6): 577-584.
14.	R Degen, HE Degen, M Reker. Sleep EEG with or without sleep deprivation? Does sleep deprivation activate more epileptic activity in patients suffering from different types of epilepsy? European neurology, 1987, 26(1): 51-59.
15.	I Geut, S Weenink, ILH Knottnerus, et al. Detecting interictal discharges in first seizure patients: ambulatory EEG or EEG after sleep deprivation? Seizure, 2017, 51: 52-54.

1. RD Thijs, R Surges, TJ O'Brien, et al. Epilepsy in adults. Lancet (London, England), 2019, 393(10172): 689-701.
2. 桂華. 兒童癲癇自然睡眠與藥物誘導睡眠的腦電圖分析. 實用醫技雜志, 2007, 14(7): 857-858.
3. 李榮. 癲癇診斷中睡眠剝奪和藥物誘導睡眠腦電圖的臨床價值. 深圳中西醫結合雜志, 2014, 24(03): 127-128.
4. 彭德強, 溫世斌, 景兆德. 部分睡眠剝奪聯合睡眠腦電圖在癲癇診斷中的價值. 蘭州醫學院學報. 2003, 29(2): 56-58.
5. 王惠琪, 余秀蘭, 魏亮. 自然睡眠與藥物誘導睡眠對腦電圖睡眠腦波的影響. 中國臨床康復, 2005, 9(21): 46-48.
6. 王璐, 盛敏. 剝奪性睡眠后自然睡眠腦電圖在癲癇診斷中的意義. 臨床和實驗醫學雜志, 2004, 3(3): 136-137.
7. 楊春清, 杜亞麗, 張素芳等. 睡眠剝奪和藥物誘導睡眠腦電圖在癲癇診斷中的應用價值. 中國全科醫學, 2010, 13(03): 305-306.
8. 楊麗. 癲癇診斷中睡眠剝奪和藥物誘導睡眠腦電圖的臨床應用價值探析. 臨床研究, 2018, 26(2): 85-87.
9. 朱艷. 癲癇診斷中睡眠剝奪和藥物誘導睡眠腦電圖的臨床價值, 影像研究與醫學應用, 2020, 4(10): 216-217.
10. 蔡少雅. 睡眠剝奪和藥物誘導睡眠腦電圖在癲癇診斷中的應用價值. 醫藥前沿, 2016, 22(06): 372-373.
11. U Aguglia, A Gambardella, E Le Piane, et al. Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy. Journal of neurology, 1994, 241(10): 605-610.
12. R Degen, HE Degen. The diagnostic value of the sleep EEG with and without sleep deprivation in patients with atypical absences. Epilepsia, 1983, 24(5): 557-566.
13. R Degen. A study of the diagnostic value of waking and sleep EEGs after sleep deprivation in epileptic patients on anticonvulsive therapy. Electroencephalography and clinical neurophysiology, 1980, 49(5-6): 577-584.
14. R Degen, HE Degen, M Reker. Sleep EEG with or without sleep deprivation? Does sleep deprivation activate more epileptic activity in patients suffering from different types of epilepsy? European neurology, 1987, 26(1): 51-59.
15. I Geut, S Weenink, ILH Knottnerus, et al. Detecting interictal discharges in first seizure patients: ambulatory EEG or EEG after sleep deprivation? Seizure, 2017, 51: 52-54.

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The significance of sleep deprivation electroencephalogram in the diagnosis of epilepsy: a Meta analysis

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