Clinical characteristics and prognostic factors of 33 children with status epilepticus_Journal of Epilepsy

Authors：

ZHAO Mingxue ^1,2 , LIU Shiguang ² ,  FAN Meili ³ , WANG Guangxin ^1,2

1. Department of Pediatrics, Jinan Central Hospital Affiliated of Shandong University, Jinan 250013, China;
2. Innovation Center of Intelligent Diagnosis, Jinan Central Hospital Affiliated of Shandong University, Jinan 250013, China;
3. Department of Massage, Qilu Children’s Hospital of Shandong University, Jinan 250022, China;

Corresponding?author：

FAN Meili, Email: fml679@126.com

Keywords：

Status epilepicus; Prognosis; Risk factors; Electroencephalogram

DOI：

10.7507/2096-0247.20220012

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Purpose To analyze the clinical characteristicsand prognostic factors of Status epilepticus (SE) in children. Methods The clinical data of 33 children with SE treated in Jinan Central Hospital Affiliated of Shandong University from January 2014 to June 2021 were collected, and their clinical characteristics were analyzed. Then, according to Glasgow prognosis scale, the children were divided into good prognosis group (n=20) and poor prognosis group (n=13). The age of first attack, duration of attack, type of attack and SE classification, EEG, cranial imaging and etiology were used to analyze the influencing factors of SE prognosis. Results 75.7% were 0 ~ 6 years old in the age of first attack, and 29 cases of convulsive status epilepticus accounted for 87.9% in the classification of seizure types. There were significant differences in age of first attack, duration of attack, EEG, history of mental retardation and etiology between the two groups (P<0.05); Logistic regression analysis showed that the age of first attack, duration of attack, history of mental retardation and EEG were independent factors affecting the prognosis. Conclusion Low age, especially ≤ 6 years old, is the high incidence of SE in children at first attack. Most children are symptomatic and have obvious incentives. Convulsive SE is the main type of SE in children. The age of first onset, duration of epilepsy, history of mental retardation, and EEG can affect the prognosis of SE.

Citation： ZHAO Mingxue, LIU Shiguang, FAN Meili, WANG Guangxin. Clinical characteristics and prognostic factors of 33 children with status epilepticus. Journal of Epilepsy, 2022, 8(1): 48-51. doi: 10.7507/2096-0247.20220012 Copy

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10.	方潤桃, 莊錦玲, 楊燕珍, 等. 兒童癲癇持續狀態的臨床特點及腦電圖分析. 中國衛生標準管理, 2020, 11(7): 62-66.
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1. 張敏, 蔣莉. 癲癇持續狀態的定義分類及藥物治療進展. 兒科藥學雜志, 2018, 24(10): 54-58.
2. 陸璐, 李勁梅, 周東. 癲癇持續狀態進展. 癲癇雜志, 2019, 5(4): 241-243.
3. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus - report of the ILAE task force on classification of status epilepticus. Epilepsia, 2015, 56(10): 1515-1523.
4. 夏毅, 張偉, 井曉蓉, 等. 兒童癲癇持續狀態的臨床特點、治療及預后分析. 中華神經外科雜志, 2021, 37(1): 16-20.
5. 中國抗癲癇協會. 臨床診療指南: 癲癇病分冊. 北京:人民衛生出版社, 2015: 67.
6. 朱海霞, 李小晶, 王秀英. 兒童驚厥性癲癇持續狀態的病因及其預后的影響因素. 廣西醫學, 2017, 39(8): 1160-1163.
7. 李慧. 兒童睡眠中癲癇性電持續狀態診療進展. 國際兒科學雜志, 2019, (03): 182-186.
8. Bektas G, Kipoglu O, Pembegul Yildiz E, et al. Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study. Brain Dev, 2019, 41(8): 699-705.
9. 張瓊香. 兒童癲癇持續狀態298例臨床分析. 蘇州:蘇州大學, 2018: 19-24.
10. 方潤桃, 莊錦玲, 楊燕珍, 等. 兒童癲癇持續狀態的臨床特點及腦電圖分析. 中國衛生標準管理, 2020, 11(7): 62-66.
11. Pujar SS, Martinos MM, Cortina-Borja M, et al. Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study. Lancet Child Adolesc Health, 2018, 2(2): 103-111.

Journal of Epilepsy

Clinical characteristics and prognostic factors of 33 children with status epilepticus

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