Study of correlation and status of compliance with ketogenic diet in children with refractory epilepsy_Journal of Epilepsy

Authors：

AI Lili ¹ ,  YU Lifei ¹ , GU Ying ² , Zhou Shuizhen ¹ , WANG Shuangyu ¹ , WU Min ¹

1. Department of Neurology, Children’s Hospital of Fudan University, Shanghai 201102, China;
2. Nursing Department , Children’s Hospital of Fudan University, Shanghai 201102, China;

Corresponding?author：

YU Lifei, Email: yulifei7711@163.com

Keywords：

Refractory epilepsy; Ketogenic diet; Compliance

DOI：

10.7507/2096-0247.202211006

Video：

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Objective To investigate the compliance of ketogenic diet in children with refractory epilepsy and its correlation with the curative effect, and to provide support and basis for the implementation and improvement of the long-term management of ketogenic diet in this patient population. Methods A total of 106 children and their families who were followed up on ketogenic diet in the Department of Pediatrics of Fudan University from March 2019 to January 2022 in the Department of Ketogenic Multidisciplinary Treatment (MDT) were selected by convenience sampling method. General data questionnaire and ketogenic compliance questionnaire were used for investigation and follow-up. Results The mean compliance of ketogenic diet in refractory epilepsy children was (13.27±3.68). The compliance scores of ketogenic children with different therapeutic effects and cognitive functions were significantly different. The compliance score was significantly correlated with the therapeutic effect and cognitive level, that is, the higher the therapeutic effect of ketogenic diet in children with higher compliance score, the better the cognitive improvement. Conclusion The compliance of ketogenic diet in children with refractory epilepsy needs to be further improved. Improving the compliance of ketogenic diet is of great significance for the efficacy of ketogenic diet. Medical staff should actively develop the corresponding intervention program and follow-up management mode to further improve the treatment compliance of children's families, improve the treatment effect and improve the quality of life of children's families.

Citation： AI Lili, YU Lifei, GU Ying, Zhou Shuizhen, WANG Shuangyu, WU Min. Study of correlation and status of compliance with ketogenic diet in children with refractory epilepsy. Journal of Epilepsy, 2023, 9(1): 16-21. doi: 10.7507/2096-0247.202211006 Copy

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5.	童麗麗, 呂明. 電話隨訪對生酮飲食治療難治性癲癇患兒的療效及依從性的影響. 齊魯護理雜志, 2016, 22(5): 116-118.
6.	喬紅麗, 劉曉鳴, 李瑋瑋. 全程個性化干預對難治性癲癎患兒生酮飲食治療依從性的改善效果. 中國醫藥, 2019, 14(6): 883-886.
7.	王娟, 郭藝, 程敏, 等. 兩種血酮儀對癲癇生酮飲食患兒的檢測結果對比分析. 癲癇雜志, 2018, 4(1): 6-9.
8.	van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol, 2016, 20(6): 1-12.
9.	黎振聲, 高曲文, 王偉, 等. 顳葉內側癲癇智力損害與發作間期癇樣放電擴散區域的相關性. 中國神經精神疾病雜志, 2018, 44(1): 6-10.
10.	Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
11.	Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
12.	梁麗麗, 賈珊珊, 李霞, 等. 生酮飲食添加治療兒童難治性癲癇的臨床效果. 臨床醫學研究與實踐, 鄭州大學, 2014, 碩士學位論文.

1. 武潔, 王荃, 錢素云, 等. 氯胺酮治療兒童難治性和超級難治性癲癇持續狀態的效果分析. 中華兒科雜志, 2020, (4): 295-300.
2. Zupec-Kania BA, Spellman E. An overview of the ketogenic diet for pediatric epilepsy. Nutr Clin Pract, 2008, 23(6): 589-596.
3. Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 2010, 51(6): 1069-1077.
4. 王紀文, 張娜娜. 生酮飲食療法的安全性. 中華實用兒科臨床雜志, 2013, 28(12): 886-887.
5. 童麗麗, 呂明. 電話隨訪對生酮飲食治療難治性癲癇患兒的療效及依從性的影響. 齊魯護理雜志, 2016, 22(5): 116-118.
6. 喬紅麗, 劉曉鳴, 李瑋瑋. 全程個性化干預對難治性癲癎患兒生酮飲食治療依從性的改善效果. 中國醫藥, 2019, 14(6): 883-886.
7. 王娟, 郭藝, 程敏, 等. 兩種血酮儀對癲癇生酮飲食患兒的檢測結果對比分析. 癲癇雜志, 2018, 4(1): 6-9.
8. van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol, 2016, 20(6): 1-12.
9. 黎振聲, 高曲文, 王偉, 等. 顳葉內側癲癇智力損害與發作間期癇樣放電擴散區域的相關性. 中國神經精神疾病雜志, 2018, 44(1): 6-10.
10. Dressler A, Benninger F, Trimme-Schwahofer P, et al. Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: a single-center parallel-cohort randomized controlled trial. Epilepsia, 2019, 60(3): 441-451.
11. Sharma S, Sankhyan N, Gulati S, et al. Use of the modified atkins diet in infantile spasms refractory to first-line treatment. Seizure, 2012, 21(1): 45-48.
12. 梁麗麗, 賈珊珊, 李霞, 等. 生酮飲食添加治療兒童難治性癲癇的臨床效果. 臨床醫學研究與實踐, 鄭州大學, 2014, 碩士學位論文.

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