Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy_Journal of Epilepsy

Authors：

 XIA Xinjian ¹ , LI Yaobin ¹ , WANG Hui ¹ , LI Xiang ² , LI Ning ¹

1. Shouguang people's Hospital Image Center, Shandong, Shouguang 262700 , China;
2. Shouguang people's Hospital Internal Medicine-Neurology, Shandong, Shouguang 262700, China;

Corresponding?author：

XIA Xinjian, Email: xxjxhm@163.com

Keywords：

Idiopathic Generalized Epilepsy; Magnetic Resonance Imaging; Cortical Thickness; Laterality

DOI：

10.7507/2096-0247.202212008

Video：

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Objective To construct a map of cerebral cortex thickness in Idiopathic Generalized Epilepsy (IGE) diagnosed at the first visit, using T1-weighted brain magnetic resonance imaging and advanced image analysis software. Methods High-resolution three-dimensional T1 images were obtained from 27 IGE patients diagnosed at the first visit and 29 normal controls in Shouguang People's Hospital from January 1, 2022 to December 31, 2021. The location recognition calculation system of the Freesurfer software was used to calculate the values of cortical thickness in each brain region, and the cortical thickness values were transformed into a brain atlas using the image analysis software. A differential brain atlas was generated using the two-sample t-test to analyze the difference in cortical thickness between IGE patients and normal controls. Paired t-test was used for within-group comparison to explore changes of cortical thickness laterality. Results In the IGE brain atlas, the brain regions with higher cortical thickness were the right left temporal pole, the right left entorhinal cortex, the head of the right anterior cingulate gyrus, the right and left insular lobe, the right and left middle temporal gyrus, the right inferior temporal gyrus, the head of the left anterior cingulate gyrus, the left tail of the anterior cingulate gyrus, the left inferior temporal gyrus, the left and right fusiform gyrus, and the left frontal pole. The areas with lower cortical thickness were the right and left paracalcaric gyrus, the right and left cuneiform lobe, the left and right lingual gyrus, the left and right posterior central gyrus, the left lateral occipital gyrus, and the right and left superior parietal gyrus. The distribution of cortical thickness of the IGE group was comparable to the cortical thickness atlas of the normal control. Compared with normal control, the areas with changes of cortical thickness in the IGE group were bilateral superior frontal gyrus, bilateral posterior central gyrus, bilateral anterior central gyri, bilateral lingual gyri, left cuneiform lobe, bilateral entorhinal cortex and temporal pole. The brain areas with laterality of cortical thickness between hemispheres in the IGE group were the tail of anterior cingulate gyrus, cuneiform lobe, inferior parietal gyrus, lateral occipital gyrus, posterior central gyrus, head of anterior cingulate gyrus, and superior marginal gyrus. Compared with normal control, the IGE group has decreased number of brain regions with laterality of cortical thickness. Conclusion The present study revealed the distribution and laterality of cerebral cortical thickness map in early idiopathic generalized epilepsy, which provides imaging structural basis for brain research in the future.

Citation： XIA Xinjian, LI Yaobin, WANG Hui, LI Xiang, LI Ning. Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy. Journal of Epilepsy, 2023, 9(2): 112-118. doi: 10.7507/2096-0247.202212008 Copy

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2.	吳嬌南, 呂心怡, 蔣玉寶, 等. 特發性全面性癲癇患者雙眼競爭的研究. 立體定向和功能性神經外科雜志, 2021, 34(4): 199-203.
3.	Gesche J, Hjalgrim H, Rubboli G, et al. The clinical spectrum of familial and sporadic idiopathic generalized epilepsy. Epilepsy Research, 2020, 165: 74-79.
4.	呂錦, 曲春生, 藍麗康. OTX1基因多態性與特發性癲癇的相關性研究. 浙江實用醫學, 2020, 25(1): 33-35.
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6.	陳濤, 賈文霄, 罕迦爾別克·庫錕, 等. 顳葉癲癇腦結構改變的MRI研究. 實用放射學雜志, 2022, 38(7): 1049-1052.
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8.	楊釩, 賈文霄, 罕迦爾別克·庫錕, 等. 基于體素的MRI陰性成人顳葉癲癇灰質結構研究. 影像診斷與介入放射學, 2021, 30(5): 330-336.
9.	Perani S, Tierney TM, Centeno M, et al. Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. Epilepsia, 2018, 59(1): 226-234.
10.	Kong XZ, Mathias SR, Guadalupe T, et al. Mapping cortical brain asymmetry in 17141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A, 2018, 115(22): E5154-63.
11.	Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(20): 11050-11055.
12.	王偉. 健康成人大腦灰質圖譜的建立研究. 中國微侵襲神經外科雜志, 2020, 25(10): 433-436.
13.	陳穎, 朱玉連, 胡瑞萍, 等. 經顱磁刺激抑制健康人初級運動皮質后雙側中央前回精細分區的腦有效連接變化. 中華物理醫學與康復雜志, 2021, 43(3): 211-214.
14.	Park K M, Kim T H, Han Y H, et al. Brain morphology in juvenile myoclonic epilepsy and absence seizures. Acta Neurologica Scandinavica, 2016, 133(2): 111-118.
15.	韓菊萍, 黃亞錦, 王小倩, 等. 兒童失神癲癇結構及功能磁共振成像研究進展. 中國醫藥, 2022, 017(001): 149-152.
16.	Overvliet GM, Besseling R, Jansen J, et al. Early onset of cortical thinning in children with rolandic epilepsy. Neuroimage Clinical, 2013, 2(Complete): 434-439.
17.	Pedreschi N, Bernard C, Clawson W, et al. Dynamic core-periphery structure of information sharing networks in entorhinal cortex and hippocampus. Network Neuroscience, 2020, 4(1): 1-42.
18.	張靜, 梁佩鵬, 趙瑩, 等. 高分辨MRI測量中國健康成人內嗅皮層體積. 中國醫學影像技術, 2021, 37(2): 165-168.
19.	Alhusaini S, Ronan L, Scanlon C, et al. Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy. Epilepsia, 2014, 54(9): e138-e141.
20.	Ronan L, Alhusaini S, Scanlon C, et al. Widespread cortical morphologic changes in juvenile myoclonic epilepsy: Evidence from structural MRI. Epilepsia, 2012, 53(4): 651-658.
21.	夏新建, 孫杉杉, 王輝, 等. 不同年齡段成人大腦皮質厚度偏側性的MRI研究. 中華解剖與臨床雜志, 2019, (6): 525-530.

1. Toga AW, Thompson PM, Mori S, et al. Towards multimodal atlases of the human brain. Nat Rev Neuro-sci, 2006, 7(12): 952-966.
2. 吳嬌南, 呂心怡, 蔣玉寶, 等. 特發性全面性癲癇患者雙眼競爭的研究. 立體定向和功能性神經外科雜志, 2021, 34(4): 199-203.
3. Gesche J, Hjalgrim H, Rubboli G, et al. The clinical spectrum of familial and sporadic idiopathic generalized epilepsy. Epilepsy Research, 2020, 165: 74-79.
4. 呂錦, 曲春生, 藍麗康. OTX1基因多態性與特發性癲癇的相關性研究. 浙江實用醫學, 2020, 25(1): 33-35.
5. Glahn DC, Thompson PM, Blangero J. Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function. Human Brain Mapping, 2010, 28(6): 488-501.
6. 陳濤, 賈文霄, 罕迦爾別克·庫錕, 等. 顳葉癲癇腦結構改變的MRI研究. 實用放射學雜志, 2022, 38(7): 1049-1052.
7. 郝競汝, 翁藝菲, 張其銳, 等. 內側顳葉癲癇患者丘腦核團表面形狀改變的結構MRI研究. 中華解剖與臨床雜志, 2021, 26(4): 373-378.
8. 楊釩, 賈文霄, 罕迦爾別克·庫錕, 等. 基于體素的MRI陰性成人顳葉癲癇灰質結構研究. 影像診斷與介入放射學, 2021, 30(5): 330-336.
9. Perani S, Tierney TM, Centeno M, et al. Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. Epilepsia, 2018, 59(1): 226-234.
10. Kong XZ, Mathias SR, Guadalupe T, et al. Mapping cortical brain asymmetry in 17141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A, 2018, 115(22): E5154-63.
11. Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(20): 11050-11055.
12. 王偉. 健康成人大腦灰質圖譜的建立研究. 中國微侵襲神經外科雜志, 2020, 25(10): 433-436.
13. 陳穎, 朱玉連, 胡瑞萍, 等. 經顱磁刺激抑制健康人初級運動皮質后雙側中央前回精細分區的腦有效連接變化. 中華物理醫學與康復雜志, 2021, 43(3): 211-214.
14. Park K M, Kim T H, Han Y H, et al. Brain morphology in juvenile myoclonic epilepsy and absence seizures. Acta Neurologica Scandinavica, 2016, 133(2): 111-118.
15. 韓菊萍, 黃亞錦, 王小倩, 等. 兒童失神癲癇結構及功能磁共振成像研究進展. 中國醫藥, 2022, 017(001): 149-152.
16. Overvliet GM, Besseling R, Jansen J, et al. Early onset of cortical thinning in children with rolandic epilepsy. Neuroimage Clinical, 2013, 2(Complete): 434-439.
17. Pedreschi N, Bernard C, Clawson W, et al. Dynamic core-periphery structure of information sharing networks in entorhinal cortex and hippocampus. Network Neuroscience, 2020, 4(1): 1-42.
18. 張靜, 梁佩鵬, 趙瑩, 等. 高分辨MRI測量中國健康成人內嗅皮層體積. 中國醫學影像技術, 2021, 37(2): 165-168.
19. Alhusaini S, Ronan L, Scanlon C, et al. Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy. Epilepsia, 2014, 54(9): e138-e141.
20. Ronan L, Alhusaini S, Scanlon C, et al. Widespread cortical morphologic changes in juvenile myoclonic epilepsy: Evidence from structural MRI. Epilepsia, 2012, 53(4): 651-658.
21. 夏新建, 孫杉杉, 王輝, 等. 不同年齡段成人大腦皮質厚度偏側性的MRI研究. 中華解剖與臨床雜志, 2019, (6): 525-530.

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Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy

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