Research progress on correlation between febrile seizure and trace elements in children_Journal of Epilepsy

Authors：

ZHONG Huiyong ¹ ,  ZHONG Jianmin ²

1. Department of Pediatrics, Jingdezhen First People’s Hospital, Jingdezhen 333000, China;
2. Department of Neurology, Jiangxi Children’s Hospital, Nanchang 330006, China;

Corresponding?author：

ZHONG Jianmin, Email: zhongjm@163.com

Keywords：

Febrile seizure; Trace elements; Children; Research progress

DOI：

10.7507/2096-0247.202308015

Video：

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Febrile seizure is one of the most common emergencies in children, accounting for about 30% of all types of children, and the most common among children aged 6 months to 5 years. At the same time, children in this age group are at the peak of growth and development, and the content of various trace elements in the body is prone to abnormalities. At present, there are few related studies on febrile seizure and trace elements in children. This paper summarizes the related studies on febrile seizure and trace elements in order to provide theoretical guidance for the prevention and treatment of febrile seizure

Citation： ZHONG Huiyong, ZHONG Jianmin. Research progress on correlation between febrile seizure and trace elements in children. Journal of Epilepsy, 2023, 9(6): 503-508. doi: 10.7507/2096-0247.202308015 Copy

1.	Lee SH, Byeon JH, Kim GH, et al. Epilepsy in children with a history of febrile seizures. Korean J Pediatr, 2016, 59 (2): 74-79.
2.	Smith DK, Sadler KP, Benedum M. Febrile Seizures: risks, evaluation, and prognosis. Am Fam Physician, 2019, 99 (7): 445-450.
3.	Laino D, Mencaroni E, Esposito S. Management of pediatric febrile seizures. Int J Environ Res Public Health, 2018, 15 (10): 2232.
4.	鐘建民. 熱性驚厥的臨床診治策略. 實用兒科臨床雜志, 2012, 27 (24): 1856-1859.
5.	Chung S. Febrile seizures. Korean J Pediatr, 2014, 57 (9): 384-395.
6.	Boillot M, Morin-Brureau M, Picard F, et al.Novel GABRG2 mutations cause familial febrile seizures. Neurol Genet, 2015, 1 (4): e35.
7.	華欣洋, 江震, 王志鋒, 等. 貴州省農村地區兒童微量元素補充現狀、影響因素及對生長發育遲緩效果預測研究. 中國兒童保健雜志, 2014, 22 (8): 791-794.
8.	Namakin K, Zardast M, Sharifzadeh G, et al. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol, 2016, 10 (3): 57-60.
9.	Shiva S, Barzegar M, Zokaie N, et al. Dose supplemental zinc prevents recurrence of febrile seizures? Iran J Child Neurol, 2011, 5 (4): 11-14.
10.	Pisacane A, Sansone R, Impagliazzo N, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ, 1996, 313 (7053): 343.
11.	Kobrinsky NL, Yager JY, Cheang MS, et al. Does iron deficiency raise the seizure threshold? J Child Neurol, 1995, 10 (2): 105-109.
12.	Vaswani RK, Dharaskar PG, Kulkarni S, et al. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr, 2010, 47 (5): 437-439.
13.	Jang HN, Yoon HS, Lee EH. Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr, 2019, 19 (1): 309.
14.	Kwak BO, Kim K, Kim SN, et al. Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and meta-analysis. Seizure, 2017, 52: 27-34.
15.	Sulviani R, Kamarullah W, Dermawan S, et al. Anemia and poor iron indices are associated with susceptibility to febrile seizures in children: a systematic review and meta-analysis. J Child Neurol, 2023, 38 (3-4): 186-197.
16.	李琴娜. 兒童熱性驚厥與血清離子及微量元素的相關性分析. 內蒙古醫科大學, 2019, 碩士學位論文.
17.	張前明. 兒童熱性驚厥與常見微量元素關系探討. 中外醫療, 2013, 32 (9): 47-49.
18.	Burhano?lu M, Tütüncüo?lu S, Coker C, et al. Hypozincaemia in febrile convulsion. Eur J Pediatr, 1996, 155 (6): 498-501.
19.	Salehiomran MR, Mahzari M. Zinc status in febrile seizure: a case-control study. Iran J Child Neurol, 2013, 7 (4): 20-23.
20.	Hosseini F, Nikkhah A, Afkhami Goli M. Serum zinc level in children with febrile seizure. Iran J Child Neurol, 2020, 14 (1): 43-47.
21.	???r? E, ?nan F?. Comparison of serum selenium, homocysteine, zinc, and vitamin d levels in febrile children with and without febrile seizures: a prospective single-center Study. Children (Basel), 2023, 10 (3): 528.
22.	張才軍. 熱性驚厥患兒的血清及腦脊液鋅水平的Meta分析. 重慶醫科大學, 2018, 碩士學位論文.
23.	Kannachamkandy L, Kamath SP, Mithra P, et al. Association between serum micronutrient levels and febrile seizures among febrile children in southern india: a case control study. Clinical Epidemiology and Global Health, 2020, 8 (4): 1366-1370.
24.	Saghazadeh A, Mahmoudi M, Meysamie A, et al. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev, 2015, 73 (11): 760-779.
25.	Prasad R, Singh A, Das B K, et al. Cerebrospinal fluid and serum zinc, copper, magnesium and calcium levels in children with Idiopathic seizure. Journal of Clinical and Diagnostic Research, 2009, 3 (6): 1841-1846.
26.	Salah ON, Abdelraouf ER, Abdelhameed MH, et al. Assessment of the level of GABA and some trace elements in blood in children who suffer from familial febrile convulsions. Open Access Maced J Med Sci, 2014, 2 (1): 68-73.
27.	Mahyar A, Ayazi P, Dalirani R, et al. A case- control study of the association between serum copper level and febrile seizures in children. Iran J Child Neurol, 2012, 6 (1): 23-28.
28.	Aly IA, Kmal HM, Soliman DR, et al. Iron profile parameters and serum zinc & copper levels in children with febrile convulsions in Banha. J Am Sci, 2014, 10 (7): 320-327.
29.	趙凱, 唐衛珍, 陳迎春. 兒童熱性驚厥與常見微量元素關系探討. 中國急救醫學, 2007, 27 (2): 121-123.
30.	孫運梅. 小兒熱性驚厥與常見微量元素鋅鐵銅的相關性探討. 中國現代藥物應用, 2017, 11 (6): 62-64.
31.	Mahyar A, Ayazi P, Fallahi M, et al. Correlation between serum selenium level and febrile seizures. Pediatr Neurol, 2010, 43 (5): 331-334.
32.	Amiri M, Farzin L, Moassesi ME, et al. Serum trace element levels in febrile convulsion. Biol Trace Elem Res, 2010, 135: 38-44.
33.	Bakhtiari E, Heydarian F, Khalesi M, et al. A comparison between serum selenium level in febrile children with or without seizure. Biol Trace Elem Res, 2022, 200 (7): 3103-3106.
34.	廖培成. 熱性驚厥患兒血清11種礦物質水平變化分析. 沈陽醫學院, 2021, 碩士學位論文.
35.	鄭柔, 祈樂, 白鳳芝, 等. 高熱驚厥患兒血鈉、鉀、鈣、鉛、糖變化的臨床意義. 中國實驗診學, 2008, 12 (3): 407-408.
36.	江志雄, 吳旅平, 邢旺興. 兒童腦性疾病血清痕量元素變化及其臨床意義. 杭州醫學高等專科學校學報, 2002, 23 (5): 209-210.
37.	Fallah R, Sabbaghzadegan S, Karbasi SA, et al. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: a randomised clinical trial. Nutrition, 2015, 31 (11-12): 1358-1361.
38.	Kumar M, Swarnim S, Khanam S. Zinc supplementation for prevention of febrile seizures recurrences in children: a systematic review and meta-analysis. Indian Pediatr, 2021, 58 (9): 857-860.
39.	Sharawat IK, Panda PK, Kumar V, et al. Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: a prospective study with comparison with historical controls. J Neurosci Rural Pract, 2022, 13 (4): 718-724.
40.	章靜靜, 鐘建民. 熱性驚厥發病機制的研究進展. 實用臨床醫學, 2019, 20 (09): 102-104+106.
41.	Daoud AS, Batieha A, Abu-Ekteish F, et al. Iron status: a possible risk factor for the first febrile seizure. Epilepsia, 2002, 43 (7): 740-743.
42.	Li Z, Liu Y, Wei R, et al. The important role of zinc in neurological diseases. biomolecules, 2022, 13 (1): 28.
43.	Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res, 2004, 102 (1-3): 1-10.
44.	Evens A, Hryhorczuk D, Lanphear BP, et al. The impact of low-level lead toxicity on school performance among children in the Chicago Public Schools: a population-based retrospective cohort study. Environ Health, 2015, 14: 21.
45.	黃躍海, 黃之抗. 復雜性高熱驚厥患兒血清鋅、鉛的測定及意義探討. 嶺南急診醫學雜志, 2008 (3): 197-198.
46.	Avery JC, Hoffmann PR. Selenium, selenoproteins, and immunity. Nutrients, 2018, 10 (9): 1203.
47.	Schweizer U, Schomburg L, Savaskan NE. The neurobiology of selenium: lessons from transgenic mice. J Nutr, 2004, 134 (4): 707-710.
48.	Turkdogan D, Toplan S, Karakoc Y. Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy. J Child Neurol, 2002, 17 (9): 673-676.
49.	El-Masry HMA, Sadek AA, Hassan MH, et al. Metabolic profile of oxidative stress and trace elements in febrile seizures among children. Metab Brain Dis, 2018, 33 (5): 1509-1515.
50.	Balachandran RC, Mukhopadhyay S, McBride D, et al. Brain manganese and the balance between essential roles and neurotoxicity. J Biol Chem, 2020, 295 (19): 6312-6329.
51.	張建裕, 龔華. 2094例兒童微量元素鉛、鎘、銅含量分析. 中國婦幼保健, 2012, 27 (1): 69-70.
52.	Malara P, Kwapuliński J, Drugacz J. Lead and cadmium occurrence in deciduous teeth of children exposed to cigarette smoke in apartments. Przegl Lek, 2004, 61 (10): 1122-1125.

1. Lee SH, Byeon JH, Kim GH, et al. Epilepsy in children with a history of febrile seizures. Korean J Pediatr, 2016, 59 (2): 74-79.
2. Smith DK, Sadler KP, Benedum M. Febrile Seizures: risks, evaluation, and prognosis. Am Fam Physician, 2019, 99 (7): 445-450.
3. Laino D, Mencaroni E, Esposito S. Management of pediatric febrile seizures. Int J Environ Res Public Health, 2018, 15 (10): 2232.
4. 鐘建民. 熱性驚厥的臨床診治策略. 實用兒科臨床雜志, 2012, 27 (24): 1856-1859.
5. Chung S. Febrile seizures. Korean J Pediatr, 2014, 57 (9): 384-395.
6. Boillot M, Morin-Brureau M, Picard F, et al.Novel GABRG2 mutations cause familial febrile seizures. Neurol Genet, 2015, 1 (4): e35.
7. 華欣洋, 江震, 王志鋒, 等. 貴州省農村地區兒童微量元素補充現狀、影響因素及對生長發育遲緩效果預測研究. 中國兒童保健雜志, 2014, 22 (8): 791-794.
8. Namakin K, Zardast M, Sharifzadeh G, et al. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol, 2016, 10 (3): 57-60.
9. Shiva S, Barzegar M, Zokaie N, et al. Dose supplemental zinc prevents recurrence of febrile seizures? Iran J Child Neurol, 2011, 5 (4): 11-14.
10. Pisacane A, Sansone R, Impagliazzo N, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ, 1996, 313 (7053): 343.
11. Kobrinsky NL, Yager JY, Cheang MS, et al. Does iron deficiency raise the seizure threshold? J Child Neurol, 1995, 10 (2): 105-109.
12. Vaswani RK, Dharaskar PG, Kulkarni S, et al. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr, 2010, 47 (5): 437-439.
13. Jang HN, Yoon HS, Lee EH. Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr, 2019, 19 (1): 309.
14. Kwak BO, Kim K, Kim SN, et al. Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and meta-analysis. Seizure, 2017, 52: 27-34.
15. Sulviani R, Kamarullah W, Dermawan S, et al. Anemia and poor iron indices are associated with susceptibility to febrile seizures in children: a systematic review and meta-analysis. J Child Neurol, 2023, 38 (3-4): 186-197.
16. 李琴娜. 兒童熱性驚厥與血清離子及微量元素的相關性分析. 內蒙古醫科大學, 2019, 碩士學位論文.
17. 張前明. 兒童熱性驚厥與常見微量元素關系探討. 中外醫療, 2013, 32 (9): 47-49.
18. Burhano?lu M, Tütüncüo?lu S, Coker C, et al. Hypozincaemia in febrile convulsion. Eur J Pediatr, 1996, 155 (6): 498-501.
19. Salehiomran MR, Mahzari M. Zinc status in febrile seizure: a case-control study. Iran J Child Neurol, 2013, 7 (4): 20-23.
20. Hosseini F, Nikkhah A, Afkhami Goli M. Serum zinc level in children with febrile seizure. Iran J Child Neurol, 2020, 14 (1): 43-47.
21. ???r? E, ?nan F?. Comparison of serum selenium, homocysteine, zinc, and vitamin d levels in febrile children with and without febrile seizures: a prospective single-center Study. Children (Basel), 2023, 10 (3): 528.
22. 張才軍. 熱性驚厥患兒的血清及腦脊液鋅水平的Meta分析. 重慶醫科大學, 2018, 碩士學位論文.
23. Kannachamkandy L, Kamath SP, Mithra P, et al. Association between serum micronutrient levels and febrile seizures among febrile children in southern india: a case control study. Clinical Epidemiology and Global Health, 2020, 8 (4): 1366-1370.
24. Saghazadeh A, Mahmoudi M, Meysamie A, et al. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev, 2015, 73 (11): 760-779.
25. Prasad R, Singh A, Das B K, et al. Cerebrospinal fluid and serum zinc, copper, magnesium and calcium levels in children with Idiopathic seizure. Journal of Clinical and Diagnostic Research, 2009, 3 (6): 1841-1846.
26. Salah ON, Abdelraouf ER, Abdelhameed MH, et al. Assessment of the level of GABA and some trace elements in blood in children who suffer from familial febrile convulsions. Open Access Maced J Med Sci, 2014, 2 (1): 68-73.
27. Mahyar A, Ayazi P, Dalirani R, et al. A case- control study of the association between serum copper level and febrile seizures in children. Iran J Child Neurol, 2012, 6 (1): 23-28.
28. Aly IA, Kmal HM, Soliman DR, et al. Iron profile parameters and serum zinc & copper levels in children with febrile convulsions in Banha. J Am Sci, 2014, 10 (7): 320-327.
29. 趙凱, 唐衛珍, 陳迎春. 兒童熱性驚厥與常見微量元素關系探討. 中國急救醫學, 2007, 27 (2): 121-123.
30. 孫運梅. 小兒熱性驚厥與常見微量元素鋅鐵銅的相關性探討. 中國現代藥物應用, 2017, 11 (6): 62-64.
31. Mahyar A, Ayazi P, Fallahi M, et al. Correlation between serum selenium level and febrile seizures. Pediatr Neurol, 2010, 43 (5): 331-334.
32. Amiri M, Farzin L, Moassesi ME, et al. Serum trace element levels in febrile convulsion. Biol Trace Elem Res, 2010, 135: 38-44.
33. Bakhtiari E, Heydarian F, Khalesi M, et al. A comparison between serum selenium level in febrile children with or without seizure. Biol Trace Elem Res, 2022, 200 (7): 3103-3106.
34. 廖培成. 熱性驚厥患兒血清11種礦物質水平變化分析. 沈陽醫學院, 2021, 碩士學位論文.
35. 鄭柔, 祈樂, 白鳳芝, 等. 高熱驚厥患兒血鈉、鉀、鈣、鉛、糖變化的臨床意義. 中國實驗診學, 2008, 12 (3): 407-408.
36. 江志雄, 吳旅平, 邢旺興. 兒童腦性疾病血清痕量元素變化及其臨床意義. 杭州醫學高等專科學校學報, 2002, 23 (5): 209-210.
37. Fallah R, Sabbaghzadegan S, Karbasi SA, et al. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: a randomised clinical trial. Nutrition, 2015, 31 (11-12): 1358-1361.
38. Kumar M, Swarnim S, Khanam S. Zinc supplementation for prevention of febrile seizures recurrences in children: a systematic review and meta-analysis. Indian Pediatr, 2021, 58 (9): 857-860.
39. Sharawat IK, Panda PK, Kumar V, et al. Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: a prospective study with comparison with historical controls. J Neurosci Rural Pract, 2022, 13 (4): 718-724.
40. 章靜靜, 鐘建民. 熱性驚厥發病機制的研究進展. 實用臨床醫學, 2019, 20 (09): 102-104+106.
41. Daoud AS, Batieha A, Abu-Ekteish F, et al. Iron status: a possible risk factor for the first febrile seizure. Epilepsia, 2002, 43 (7): 740-743.
42. Li Z, Liu Y, Wei R, et al. The important role of zinc in neurological diseases. biomolecules, 2022, 13 (1): 28.
43. Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res, 2004, 102 (1-3): 1-10.
44. Evens A, Hryhorczuk D, Lanphear BP, et al. The impact of low-level lead toxicity on school performance among children in the Chicago Public Schools: a population-based retrospective cohort study. Environ Health, 2015, 14: 21.
45. 黃躍海, 黃之抗. 復雜性高熱驚厥患兒血清鋅、鉛的測定及意義探討. 嶺南急診醫學雜志, 2008 (3): 197-198.
46. Avery JC, Hoffmann PR. Selenium, selenoproteins, and immunity. Nutrients, 2018, 10 (9): 1203.
47. Schweizer U, Schomburg L, Savaskan NE. The neurobiology of selenium: lessons from transgenic mice. J Nutr, 2004, 134 (4): 707-710.
48. Turkdogan D, Toplan S, Karakoc Y. Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy. J Child Neurol, 2002, 17 (9): 673-676.
49. El-Masry HMA, Sadek AA, Hassan MH, et al. Metabolic profile of oxidative stress and trace elements in febrile seizures among children. Metab Brain Dis, 2018, 33 (5): 1509-1515.
50. Balachandran RC, Mukhopadhyay S, McBride D, et al. Brain manganese and the balance between essential roles and neurotoxicity. J Biol Chem, 2020, 295 (19): 6312-6329.
51. 張建裕, 龔華. 2094例兒童微量元素鉛、鎘、銅含量分析. 中國婦幼保健, 2012, 27 (1): 69-70.
52. Malara P, Kwapuliński J, Drugacz J. Lead and cadmium occurrence in deciduous teeth of children exposed to cigarette smoke in apartments. Przegl Lek, 2004, 61 (10): 1122-1125.

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