癲癇外科手術技術專家共識—第二篇：腦皮質發育不良相關癲癇_Journal of Epilepsy

Authors：

 中國抗癲癇協會青年委員會 ,  譚啟富癲癇外科發展專項基金管理委員會 ,  北京神經科學學會腦功能疾病與認知發育專業委員會 , 國家兒科及小兒外科專業醫療質量控制中心 , 《癲癇雜志》編輯部

執筆張春青（陸軍軍醫大學第二附屬醫院）、孫曉琴（陸軍軍醫大學第二附屬醫院）、吳洵昳（復旦大學附屬華山醫院）、季濤云（北京大學第一醫院）、郭燕舞（南方醫科大學珠江醫院）、宋建平（陸軍軍醫大學第二附屬醫院）、王禮（陸軍軍醫大學第二附屬醫院）、石先俊（陸軍軍醫大學第二附屬醫院）、黃軍（陸軍軍醫大學第二附屬醫院）、張曉青（陸軍軍醫大學第二附屬醫院）;

Corresponding?author：

中國抗癲癇協會青年委員會, Email: cqzhang@tmmu.edu.cn; 譚啟富癲癇外科發展專項基金管理委員會, Email: zjguo73@126.com; 北京神經科學學會腦功能疾病與認知發育專業委員會, Email: 301_1sjwk@sina.cn

Keywords：

DOI：

10.7507/2096-0247.202403004

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Citation： 中國抗癲癇協會青年委員會, 譚啟富癲癇外科發展專項基金管理委員會, 北京神經科學學會腦功能疾病與認知發育專業委員會, 國家兒科及小兒外科專業醫療質量控制中心, 《癲癇雜志》編輯部. 癲癇外科手術技術專家共識—第二篇：腦皮質發育不良相關癲癇. Journal of Epilepsy, 2024, 10(3): 199-205. doi: 10.7507/2096-0247.202403004 Copy

1.	Blümcke I, Aronica E, Miyata H, et al. International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia, 2016, 57(3): 348-358.
2.	Blumcke I, Spreafico R, Haaker G, et al. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. N Engl J Med, 2017, 377(17): 1648-1656.
3.	Liu S, Yu T, Guan Y, et al. Resective epilepsy surgery in tuberous sclerosis complex: a nationwide multicentre retrospective study from China. Brain, 2020, 143(2): 570-581.
4.	Jayalakshmi S, Vooturi S, Vadapalli R, et al. Predictors of surgical outcome in focal cortical dysplasia and its subtypes. J Neurosurg, 2022, 136(2): 512-522.
5.	Licchetta L, Vignatelli L, Toni F, et al. Long-term Outcome of Epilepsy and Cortical Malformations Due to Abnormal Migration and Postmigrational Development: A Cohort Study. Neurology, 2022, 99(1): e23-e32.
6.	Balestrini S, Barba C, Thom M, et al. Focal cortical dysplasia: a practical guide for neurologists. Practical Neurology, 2023, 3(2): 256-261.
7.	Nguyen D, Singh S, Zaatreh M, et al. Hypothalamic hamartomas: seven cases and review of the literature. Epilepsy & Behavior, 2003, 4(3): 246-258.
8.	Curatolo, Paolo. Mechanistic Target of Rapamycin (mTOR) in Tuberous Sclerosis Complex-Associated Epilepsy. Pediatric Neurology, 2015, 52(3): 281-289.
9.	Paliotti K, Dassi C, Berrahmoune S, et al. The phenotypic spectrum of epilepsy associated with periventricular nodular heterotopia. J Neurol, 2023, 270(8): 3934-3945.
10.	Guerrini R, Carrozzo R. Epilepsy and genetic malformations of the cerebral cortex. American Journal of Medical Genetics, 2001, 106(2): 234-238.
11.	Maillard L, Ramantani G. Epilepsy surgery for polymicrogyria: a challenge to be undertaken. Epileptic Disord, 2018, 20(5): 319-338.
12.	Lamberink H J, Otte W M, Blümcke I, et al. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. The Lancet Neurology, 2020, 19(9): 748-757.
13.	Mathern G W. Challenges in the surgical treatment of epilepsy patients with cortical dysplasia. Epilepsia, 2009, 50(3): 689-693.
14.	Srour M, Rioux M F, Varga C, et al. The clinical spectrum of nodular heterotopias in children: report of 31 patients. Epilepsia, 2011, 52(4): 728-737.
15.	Valentin A, Lazaro M, Mullatti N, et al. Cingulate epileptogenesis in hypothalamic hamartoma. Epilepsia, 2011, 52(5): 901-905.
16.	Liu WY, Zhou D. Filamin A gene associated periventricular nodular heterotopia and epilepsy in a cohort of chinese patients. Chin Med J (Engl), 2017, 130(20): 2506-2507.
17.	Chu‐Shore C J, Major P, Camposano S, et al. The natural history of epilepsy in tuberous sclerosis complex. Epilepsia, 2010, 51(7): 1236-1241.
18.	Yoo SJ, Lee JY, Lee YJ, et al. Diffusion Tensor imaging and quantitative magnetic resonance volumetric assessment in the diagnosis of hemimegalencephaly: a case report. Journal of the Korean Society of Radiology, 2019, 80(1): 103-105.
19.	Koenig M, Dobyns W, Donato N D. Lissencephaly: Update on diagnostics and clinical management. European Journal of Paediatric Neurology, 2021, 35: 147-152.
20.	Tassi L, Colombo N, Garbelli R, et al. Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain, 2002, 125(Pt 8): 1719-1732.
21.	Brázdil M, Halámek J, Jurák P, et al. Interictal high-frequency oscillations indicate seizure onset zone in patients with focal cortical dysplasia. Epilepsy Research, 2010, 89(1-2): 28-32.
22.	Boonyapisit K, Najm I, Klem G, et al. Epileptogenicity of focal malformations due to abnormal cortical development: direct electrocorticographic-histopathologic correlations. Epilepsia, 2003, 44(1): 69-76.
23.	Mirandola L, Mai RF, Francione S, et al. Stereo-EEG: Diagnostic and therapeutic tool for periventricular nodular heterotopia epilepsies. Epilepsia, 2017, 58(11): 1962-71.
24.	Khoo HM, Ellenrieder NV, Zazubovits N, et al. Internodular functional connectivity in heterotopia‐related epilepsy. Annals of Clinical and Translational Neurology, 2019, 6(5): 851-853.
25.	Pitrik K, Leo T, Denese H. Crises dacrystiques et hamartome hypothalamique: a propos d'une observation video-stereo-EEG. Epilepsia, 1994, 6: 259-279.
26.	Kerrigan JF, Ng YT, Chung S, et al. The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Seminars in Pediatric Neurology, 2005, 12(2): 119-131.
27.	Benabid AL, Ryvlin P, Minotti L, et al. From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord, 2003, 5: 205-217.
28.	Neal A, Ostrowsky-Coste K, Jung J, et al. Epileptogenicity in tuberous sclerosis complex: a stereoelectroencephalographic study. Epilepsia, 2020, 61(1): 81-95.
29.	Stephenson SEM, Maixner WJ, Barton SM, et al. Resection of tuber centers only for seizure control in tuberous sclerosis complex. Epilepsy Res, 2021, 171: 106572.
30.	Zhang J, Yang Z, Yang Z, et al. Successful surgery for refractory seizures associated with bilateral schizencephaly: two case reports and literature review. Neurol Sci, 2016, 37(7): 1079-1088.
31.	Krsek P, Maton B, Jayakar P, et al. Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome. Neurology, 2009, 72(3): 217-223.
32.	Bourdillon P, Rheims S, Catenoix H, et al. Malformations of cortical development: New surgical advances. Rev Neurol (Paris), 2019, 175(3): 183-188.
33.	劉慶祝, 蔡立新, 劉曉燕, 等. 兒童后象限腦皮質發育障礙致難治性癲癇的手術治療. 中國當代兒科雜志, 2017, 19(3): 259-263.
34.	Macdonald-Laurs E, Maixner WJ, Bailey CA, et al. One-Stage, Limited-Resection Epilepsy Surgery for Bottom-of-Sulcus Dysplasia. Neurology, 2021, 97(2): e178-e190.
35.	Walger L, Adler S, Wagstyl K, et al. Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice. Epilepsia, 2023, 64(5): 1093-1112.
36.	Prada F, Gennari AG, Quaia E, et al. Advanced intraoperative ultrasound (ioUS) techniques in focal cortical dysplasia (FCD) surgery: a preliminary experience on a case series. Clin Neurol Neurosurg, 2020, 198: 106188.
37.	Kahane P, Ryvlin P, Hoffmann D, et al. From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord, 2003, 5(4): 205-217.
38.	Liu C, Zheng Z, Shao XQ, et al. Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis. Epilepsy Behav, 2021, 118: 107957.
39.	Scholly J, Staack AM, Kahane P, et al. Hypothalamic hamartoma: Epileptogenesis beyond the lesion? Epilepsia, 2017, 58(Suppl 2): 32-40.
40.	Lhatoo SD, Kahane P, Lüders HO. Invasive Studies of the Human Epileptic Brain: Principles and Practice. Oxford University Press, 2018.
41.	Khoo HM, Gotman J, Hall JA, et al. Treatment of Epilepsy Associated with Periventricular Nodular Heterotopia. Curr Neurol Neurosci Rep, 2020, 20(12): 59.
42.	中國醫師協會神經外科分會功能神經外科學組, 中國抗癲癇協會, 國家神經外科手術機器人應用示范項目專家指導委員會. 立體定向腦電圖引導射頻熱凝毀損治療藥物難治性癲癇的中國專家共識. 中華醫學雜志, 2021, 101(29): 1-7.
43.	Pizzo F, Roehri N, Catenoix H, et al. Epileptogenic networks in nodular heterotopia: a stereoelectroencephalography study. Epilepsia, 2017, 58(12): 2112-2123.
44.	Ladino LD, Dash C, Wu A, et al. Intracranial investigation of a patient with nodular heterotopia and hippocampal sclerosis: dealing with a dual pathology. Epileptic Disord, 2017, 19(2): 195-201.
45.	Agrawal M, Samala R, Doddamani RS, et al. Is surgery effective for treating hypothalamic hamartoma causing isolated central precocious puberty? A systematic review. Neurosurg Rev, 2021, 44(6): 3087-3105.
46.	Lehner KR, D'Amico RS, Rahme R, et al. Microsurgical management of complex hypothalamic hamartomas in the era of minimally invasive therapy: a case series and narrative review. World Neurosurg, 2022, 160: e388-e397.
47.	Kamida T, Maruyama T, Fujiki M, et al. Total callosotomy for a case of lissencephaly presenting with West syndrome and generalized seizures. Childs Nerv Syst, 2005, 21(12): 1056-1060.
48.	Lee YJ, Kang HC, Lee JS, et al. Resective pediatric epilepsy surgery in Lennox-Gastaut syndrome. Pediatrics, 2010, 125(1): e58-e66.
49.	Kim JY, Kang HC, Cho JH, et al. Combined use of multiple computational intracranial EEG analysis techniques for the localization of epileptogenic zones in Lennox-Gastaut syndrome. Clin EEG Neurosci, 2014, 45(3): 169-178.
50.	Jehi LE, O'Dwyer R, Najm I, et al. A longitudinal study of surgical outcome and its determinants following posterior cortex epilepsy surgery. Epilepsia, 2009, 50(9): 2040-2052.
51.	Koh S, Nguyen S, Asarnow RF, et al. Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy. Epilepsia, 2004, 45(5): 527-533.
52.	Di Gennaro G, D'Aniello A, De Risi M, et al. Prognostic significance of acute postoperative seizures in extra-temporal lobe epilepsy surgery. Clin Neurophysiol, 2013, 124(8): 1536-1540.
53.	中國抗癲癇協會. 臨床診療指南?癲癇病分冊(2023版). 北京: 人民衛生出版社, 2023.
54.	譚啟富. 癲癇外科學. 北京: 人民衛生出版社, 2012.

1. Blümcke I, Aronica E, Miyata H, et al. International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia, 2016, 57(3): 348-358.
2. Blumcke I, Spreafico R, Haaker G, et al. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. N Engl J Med, 2017, 377(17): 1648-1656.
3. Liu S, Yu T, Guan Y, et al. Resective epilepsy surgery in tuberous sclerosis complex: a nationwide multicentre retrospective study from China. Brain, 2020, 143(2): 570-581.
4. Jayalakshmi S, Vooturi S, Vadapalli R, et al. Predictors of surgical outcome in focal cortical dysplasia and its subtypes. J Neurosurg, 2022, 136(2): 512-522.
5. Licchetta L, Vignatelli L, Toni F, et al. Long-term Outcome of Epilepsy and Cortical Malformations Due to Abnormal Migration and Postmigrational Development: A Cohort Study. Neurology, 2022, 99(1): e23-e32.
6. Balestrini S, Barba C, Thom M, et al. Focal cortical dysplasia: a practical guide for neurologists. Practical Neurology, 2023, 3(2): 256-261.
7. Nguyen D, Singh S, Zaatreh M, et al. Hypothalamic hamartomas: seven cases and review of the literature. Epilepsy & Behavior, 2003, 4(3): 246-258.
8. Curatolo, Paolo. Mechanistic Target of Rapamycin (mTOR) in Tuberous Sclerosis Complex-Associated Epilepsy. Pediatric Neurology, 2015, 52(3): 281-289.
9. Paliotti K, Dassi C, Berrahmoune S, et al. The phenotypic spectrum of epilepsy associated with periventricular nodular heterotopia. J Neurol, 2023, 270(8): 3934-3945.
10. Guerrini R, Carrozzo R. Epilepsy and genetic malformations of the cerebral cortex. American Journal of Medical Genetics, 2001, 106(2): 234-238.
11. Maillard L, Ramantani G. Epilepsy surgery for polymicrogyria: a challenge to be undertaken. Epileptic Disord, 2018, 20(5): 319-338.
12. Lamberink H J, Otte W M, Blümcke I, et al. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. The Lancet Neurology, 2020, 19(9): 748-757.
13. Mathern G W. Challenges in the surgical treatment of epilepsy patients with cortical dysplasia. Epilepsia, 2009, 50(3): 689-693.
14. Srour M, Rioux M F, Varga C, et al. The clinical spectrum of nodular heterotopias in children: report of 31 patients. Epilepsia, 2011, 52(4): 728-737.
15. Valentin A, Lazaro M, Mullatti N, et al. Cingulate epileptogenesis in hypothalamic hamartoma. Epilepsia, 2011, 52(5): 901-905.
16. Liu WY, Zhou D. Filamin A gene associated periventricular nodular heterotopia and epilepsy in a cohort of chinese patients. Chin Med J (Engl), 2017, 130(20): 2506-2507.
17. Chu‐Shore C J, Major P, Camposano S, et al. The natural history of epilepsy in tuberous sclerosis complex. Epilepsia, 2010, 51(7): 1236-1241.
18. Yoo SJ, Lee JY, Lee YJ, et al. Diffusion Tensor imaging and quantitative magnetic resonance volumetric assessment in the diagnosis of hemimegalencephaly: a case report. Journal of the Korean Society of Radiology, 2019, 80(1): 103-105.
19. Koenig M, Dobyns W, Donato N D. Lissencephaly: Update on diagnostics and clinical management. European Journal of Paediatric Neurology, 2021, 35: 147-152.
20. Tassi L, Colombo N, Garbelli R, et al. Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain, 2002, 125(Pt 8): 1719-1732.
21. Brázdil M, Halámek J, Jurák P, et al. Interictal high-frequency oscillations indicate seizure onset zone in patients with focal cortical dysplasia. Epilepsy Research, 2010, 89(1-2): 28-32.
22. Boonyapisit K, Najm I, Klem G, et al. Epileptogenicity of focal malformations due to abnormal cortical development: direct electrocorticographic-histopathologic correlations. Epilepsia, 2003, 44(1): 69-76.
23. Mirandola L, Mai RF, Francione S, et al. Stereo-EEG: Diagnostic and therapeutic tool for periventricular nodular heterotopia epilepsies. Epilepsia, 2017, 58(11): 1962-71.
24. Khoo HM, Ellenrieder NV, Zazubovits N, et al. Internodular functional connectivity in heterotopia‐related epilepsy. Annals of Clinical and Translational Neurology, 2019, 6(5): 851-853.
25. Pitrik K, Leo T, Denese H. Crises dacrystiques et hamartome hypothalamique: a propos d'une observation video-stereo-EEG. Epilepsia, 1994, 6: 259-279.
26. Kerrigan JF, Ng YT, Chung S, et al. The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Seminars in Pediatric Neurology, 2005, 12(2): 119-131.
27. Benabid AL, Ryvlin P, Minotti L, et al. From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord, 2003, 5: 205-217.
28. Neal A, Ostrowsky-Coste K, Jung J, et al. Epileptogenicity in tuberous sclerosis complex: a stereoelectroencephalographic study. Epilepsia, 2020, 61(1): 81-95.
29. Stephenson SEM, Maixner WJ, Barton SM, et al. Resection of tuber centers only for seizure control in tuberous sclerosis complex. Epilepsy Res, 2021, 171: 106572.
30. Zhang J, Yang Z, Yang Z, et al. Successful surgery for refractory seizures associated with bilateral schizencephaly: two case reports and literature review. Neurol Sci, 2016, 37(7): 1079-1088.
31. Krsek P, Maton B, Jayakar P, et al. Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome. Neurology, 2009, 72(3): 217-223.
32. Bourdillon P, Rheims S, Catenoix H, et al. Malformations of cortical development: New surgical advances. Rev Neurol (Paris), 2019, 175(3): 183-188.
33. 劉慶祝, 蔡立新, 劉曉燕, 等. 兒童后象限腦皮質發育障礙致難治性癲癇的手術治療. 中國當代兒科雜志, 2017, 19(3): 259-263.
34. Macdonald-Laurs E, Maixner WJ, Bailey CA, et al. One-Stage, Limited-Resection Epilepsy Surgery for Bottom-of-Sulcus Dysplasia. Neurology, 2021, 97(2): e178-e190.
35. Walger L, Adler S, Wagstyl K, et al. Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice. Epilepsia, 2023, 64(5): 1093-1112.
36. Prada F, Gennari AG, Quaia E, et al. Advanced intraoperative ultrasound (ioUS) techniques in focal cortical dysplasia (FCD) surgery: a preliminary experience on a case series. Clin Neurol Neurosurg, 2020, 198: 106188.
37. Kahane P, Ryvlin P, Hoffmann D, et al. From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord, 2003, 5(4): 205-217.
38. Liu C, Zheng Z, Shao XQ, et al. Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis. Epilepsy Behav, 2021, 118: 107957.
39. Scholly J, Staack AM, Kahane P, et al. Hypothalamic hamartoma: Epileptogenesis beyond the lesion? Epilepsia, 2017, 58(Suppl 2): 32-40.
40. Lhatoo SD, Kahane P, Lüders HO. Invasive Studies of the Human Epileptic Brain: Principles and Practice. Oxford University Press, 2018.
41. Khoo HM, Gotman J, Hall JA, et al. Treatment of Epilepsy Associated with Periventricular Nodular Heterotopia. Curr Neurol Neurosci Rep, 2020, 20(12): 59.
42. 中國醫師協會神經外科分會功能神經外科學組, 中國抗癲癇協會, 國家神經外科手術機器人應用示范項目專家指導委員會. 立體定向腦電圖引導射頻熱凝毀損治療藥物難治性癲癇的中國專家共識. 中華醫學雜志, 2021, 101(29): 1-7.
43. Pizzo F, Roehri N, Catenoix H, et al. Epileptogenic networks in nodular heterotopia: a stereoelectroencephalography study. Epilepsia, 2017, 58(12): 2112-2123.
44. Ladino LD, Dash C, Wu A, et al. Intracranial investigation of a patient with nodular heterotopia and hippocampal sclerosis: dealing with a dual pathology. Epileptic Disord, 2017, 19(2): 195-201.
45. Agrawal M, Samala R, Doddamani RS, et al. Is surgery effective for treating hypothalamic hamartoma causing isolated central precocious puberty? A systematic review. Neurosurg Rev, 2021, 44(6): 3087-3105.
46. Lehner KR, D'Amico RS, Rahme R, et al. Microsurgical management of complex hypothalamic hamartomas in the era of minimally invasive therapy: a case series and narrative review. World Neurosurg, 2022, 160: e388-e397.
47. Kamida T, Maruyama T, Fujiki M, et al. Total callosotomy for a case of lissencephaly presenting with West syndrome and generalized seizures. Childs Nerv Syst, 2005, 21(12): 1056-1060.
48. Lee YJ, Kang HC, Lee JS, et al. Resective pediatric epilepsy surgery in Lennox-Gastaut syndrome. Pediatrics, 2010, 125(1): e58-e66.
49. Kim JY, Kang HC, Cho JH, et al. Combined use of multiple computational intracranial EEG analysis techniques for the localization of epileptogenic zones in Lennox-Gastaut syndrome. Clin EEG Neurosci, 2014, 45(3): 169-178.
50. Jehi LE, O'Dwyer R, Najm I, et al. A longitudinal study of surgical outcome and its determinants following posterior cortex epilepsy surgery. Epilepsia, 2009, 50(9): 2040-2052.
51. Koh S, Nguyen S, Asarnow RF, et al. Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy. Epilepsia, 2004, 45(5): 527-533.
52. Di Gennaro G, D'Aniello A, De Risi M, et al. Prognostic significance of acute postoperative seizures in extra-temporal lobe epilepsy surgery. Clin Neurophysiol, 2013, 124(8): 1536-1540.
53. 中國抗癲癇協會. 臨床診療指南?癲癇病分冊(2023版). 北京: 人民衛生出版社, 2023.
54. 譚啟富. 癲癇外科學. 北京: 人民衛生出版社, 2012.

Previous Article
癲癇外科手術技術專家共識—第一篇：腦內病變相關癲癇
Next Article
難治性癲癇（1歲以內）全營養配方食品臨床試驗技術指導原則（草案）

Journal of Epilepsy

癲癇外科手術技術專家共識—第二篇：腦皮質發育不良相關癲癇

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content