Therapeutic Effect of Arthroscopic Surgery Combined with Oral Glucosamine Hydrochloride on Osteoarthritis of the Knee_West China Medical Journal

Authors：

LIU Juncai ,  LI Zhong , ZUO Yinlong , WU Shaojun , CHEN Ge , YIN Yiran

Department of Bone and Joint Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding?author：

LI Zhong, Email: ljc125520@163.com

Keywords：

骨關節炎，膝; 關節鏡; 鹽酸氨基葡萄糖

Video：

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目的　探討關節鏡手術聯合口服鹽酸氨基葡萄糖治療膝骨關節炎（KOA）的近期臨床療效。方法　選取2011年1月－12月具有關節鏡手術指征的KOA患者86例，按手術順序單雙號分成兩組，試驗組（單號）行關節鏡手術聯合口服鹽酸氨基葡萄糖治療，對照組（雙號）行關節鏡手術治療。采用Lequesne指數對兩組患膝術前，術后第4、6周進行評分及療效分析。結果　兩組患膝術前與術后第4、6周Lequesne指數得分比較，差異有統計學意義（P＜0.05）；兩組術后近期療效比較，差異有統計學意義（P＜0.05）。結論　關節鏡手術聯合口服鹽酸氨基葡萄糖治療KOA具有良好的近期療效，優于單用關節鏡手術治療者。

Citation： LIU Juncai,LI Zhong,ZUO Yinlong,WU Shaojun,CHEN Ge,YIN Yiran. Therapeutic Effect of Arthroscopic Surgery Combined with Oral Glucosamine Hydrochloride on Osteoarthritis of the Knee. West China Medical Journal, 2012, 27(12): 1768-1771. doi: Copy

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6.	Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatoi Suppl, 1991, 27(1): 16-18.
7.	Sassi N, Laadhar L, Driss M, et al. The role of the Notch pathway in healthy and osteoarthritic articular cartilage:from experimental models to ex vivo studies. Arthritis Res Ther, 2011, 13(2): 208.
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9.	陳德生, 張志剛, 曹靖, 等. 鹽酸氨基葡萄糖對兔膝骨性關節炎的影響[J]. 中國修復重建外科雜志, 2010, 24(3): 287-291.
10.	康明, 胡建中, 郭漢明, 等. 關節鏡下清理術聯合透明質酸鈉注射對膝骨關節炎的療效分析[J].中國內鏡雜志, 2009, 15(7): 719-722.
11.	孫捷, 吳陽. 關節鏡治療中老年膝關節骨關節炎[J]. 中國微創外科雜志, 2009, 9(8): 733-734.
12.	李軍, 馬廣文, 周盛智, 等. 關節鏡診治膝關節骨關節炎臨床探討[J]. 安徽醫學, 2010, 31(8): 924-926.

1. 　劉俊才, 李忠, 王治, 等. 關節鏡手術與康復訓練聯合治療膝關節骨關節炎的療效分析[J]. 中國康復醫學雜志, 2012, 27(1): 66-68.
2. 　羅娟, 胡永善, 吳毅, 等. 鹽酸氨基葡萄糖改善膝骨性關節炎癥狀的效果評估[J]. 中國臨床康復, 2005, 9(38): 70-72.
3. 　Altman R, Asch E, Bloch D, et al. Development of criteria for theclassification and reporting of osteoarthritis. Classification of osteoarthritisof the knee[J]. Arthritis Rheum, 1986, 29(8): 1039-1049.
4. 　Outerbridge RE. The etiology of chondromalacia patellae[J]. J Bone Joint Surg Br, 1961, 43-B: 752-757.
5. 　Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis[J]. Ann Rheum Dis, 1957, 16(4): 494-502.
6. 　Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatoi Suppl, 1991, 27(1): 16-18.
7. 　Sassi N, Laadhar L, Driss M, et al. The role of the Notch pathway in healthy and osteoarthritic articular cartilage:from experimental models to ex vivo studies. Arthritis Res Ther, 2011, 13(2): 208.
8. 　Ivanovska N, Dimitrova P. Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine[J]. Arthritis Res Ther, 2011, 13(2): R44.
9. 　陳德生, 張志剛, 曹靖, 等. 鹽酸氨基葡萄糖對兔膝骨性關節炎的影響[J]. 中國修復重建外科雜志, 2010, 24(3): 287-291.
10. 　康明, 胡建中, 郭漢明, 等. 關節鏡下清理術聯合透明質酸鈉注射對膝骨關節炎的療效分析[J].中國內鏡雜志, 2009, 15(7): 719-722.
11. 　孫捷, 吳陽. 關節鏡治療中老年膝關節骨關節炎[J]. 中國微創外科雜志, 2009, 9(8): 733-734.
12. 　李軍, 馬廣文, 周盛智, 等. 關節鏡診治膝關節骨關節炎臨床探討[J]. 安徽醫學, 2010, 31(8): 924-926.

West China Medical Journal

Therapeutic Effect of Arthroscopic Surgery Combined with Oral Glucosamine Hydrochloride on Osteoarthritis of the Knee

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