Study on the Relationship between PvuⅡ，XbaⅠ and STR Polymorphism of the Estrogen Receptor α Gene and Primary Liver Cancer_West China Medical Journal

Authors：

ZHANG Wei ¹ , SHI De ² , DU Chengyou ² , et al. ²

1.Department of Hepatobiliary Surgery，Suining Central Hospital，Suining Sichuan 629000;2.The General Surgery Department，the First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China;

Corresponding?author：

Keywords：

原性肝癌; 雌激素受體; 等位基因; 短串聯重復序列

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目的:探討西南地區雌激素受體α（estrogen receptor α，ERα）基因多態性與原性肝癌關系。方法:選擇西南地區100名原發性肝癌患者為實驗組，100名非肝病人群作為對照組。應用分子生物學的方法分析PvuⅡ，XbaⅠ限制性片段長度多態性（restriction fragment length polymorphism，RFLP）。同時對人雌激素受體基因上游的短串聯重復序列（short tandem repeat，STR）進行純化、克隆和序列分析，觀察ERα基因多態性基因型在實驗組與對照組中的基因型分布。結果:PvuⅡ和XbaⅠ限制性片段長度多態性在兩組中均呈多態性分布。病例組TA13等位基因頻率高于對照組，差異有顯著性，TA15等位基因頻率低于對照組，差異有顯著性。結論:ERα基因多態性與原性肝癌有關，X等位基因可能是其危險因素，P等位基因可能是其保護因素，TA13等位基因可能是其危險因素，TA15等位基因可能是其保護因素。

Citation： ZHANG Wei,SHI De,DU Chengyou,et al.. Study on the Relationship between PvuⅡ，XbaⅠ and STR Polymorphism of the Estrogen Receptor α Gene and Primary Liver Cancer. West China Medical Journal, 2009, 24(1): 70-73. doi: Copy

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1. Jabbour HN，Kelly RW，Fraser HM，et al.Endocrine regulation of menstruation[J].Endocr Rew，2006，27（1）:17-46..
2. Giannitrapani L，Soresi M，La Spada E，et al.Sex hormones and risk of liver tumor[J].Ann N Y Acad Sci，2006，1089:228-236..
3. Hernandez J，Balic I，JohnsonPais TL，et al.Association between an estrogen receptor α gene polymorphism and the risk of prostate cancer in black men[J].Urol，2006，175（2）:523-527..
4. Grundberg E，Ribom EL，Brndstrm H，et al.A TArepeat polymorphism in the gene for the estrogen receptor ɑ does not correlate with muscle strength or body composition in young adult Swedish women[J].Maturitas，2005，50（3）:153-160..
5. Eagon PK，Francavilla A，Dileo A，et al.Quantitation of estrogen and androgen receptors in hepatocellular carcinoma and adjacent normal human liver[J].Dig Dis Sci，1991，36（9）∶1303..
6. Wang AG，Lee KY，Kim SY，et al.The expression of estrogen receptors in hepatocellular carcinoma in Korean patients[J].Yonsei Med J，2006，47（6）:811-816..
7. Nilsson M，Naessen S，Dahlman I，et al.Association of estrogen receptor β gene polymorphisms with bulimic disease in women[J].Molecular Psychiatry，2004，9（1）:28-34..
8. Chen WC，Wu HC，Lin WC，et al.The association of androgenand oestrogenreceptor gene polymorphisms with urolithiasis in men[J].BJU Int，2001，88（4）:432-436..
9. Pollake A，Rokach A，Blumennfeldt A，et al.Association of oestrogen receptor α gene polymorphism with the angiographic extent of coronary artery disease[J].Eur Heart，2004，25（3）:240-245.
10. Valdes AM，Slatkin M，Freimer NB.Allele frequencies at microsatellite loci:the tepwise mutation model revisited[J].Genetics，1993，133（3）:737-749.

West China Medical Journal

Study on the Relationship between PvuⅡ，XbaⅠ and STR Polymorphism of the Estrogen Receptor α Gene and Primary Liver Cancer

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