Effects of Artesunate on Apoptosis of Rat Glomerular Mesangial Cells_West China Medical Journal

Authors：

Department of Nephrology,West China Hospital of Sichuan University,Chengdu 610041,China;

Corresponding?author：

Keywords：

青蒿琥酯; 腎小球系膜細胞; 凋亡

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的：觀察青蒿琥酯對脂多糖誘導的大鼠腎小球系膜細胞(glomerular mesangial cells,GMC)凋亡的影響。方法：用不同濃度的青蒿琥酯刺激脂多糖誘導增殖的大鼠腎小球系膜細胞，HE染色觀察凋亡細胞形態，DAPI熒光染色觀察細胞核凋亡情況，用流式細胞儀檢測細胞凋亡率。結果：青蒿琥酯對系膜細胞凋亡有明顯誘導作用，呈一定劑量依賴性。結論：青蒿琥酯能夠劑量依賴性地誘導大鼠系膜細胞凋亡。

Citation： MA Xingyi,YANG Min,MI Xuhua,et al.. Effects of Artesunate on Apoptosis of Rat Glomerular Mesangial Cells. West China Medical Journal, 2008, 23(1): 92-93. doi: Copy

1.	Harrison DJ.Cell death in the diseased glomerulus[J].Histopathology，1988，12(6)：679-683..
2.	Baker AJ,Mooney A,Hughe-s J,et al.Mesangial cell apoptosis:the major mechanism for resolution of glomerular hypercellularity inexperimental mesangial proliferative nephritis[J].J Clin Invest,1994,94(5):2015-2116..
3.	謝彤，吳平,唐德炎，等.環磷酰胺在體外對大鼠腎小球系膜細胞增殖及凋亡的影響[J].中國病理生理雜志,2003,19(3):391-393..
4.	Amore A,Emancipator SN,Cirina P,et al.Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cell[J].Kidney Int,2000,57(4):1549-1559..
5.	孫田美，梅長林，葛守一，等.洛伐他汀對系膜細胞凋亡及Bcl-2和Bax基因表達的影響[J].中華腎臟病雜志，2003,19(1):38-42..
6.	Chen HH,Zhou HJ,Fang X.Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro[J].Pharmacol Res,2003,48(3):231-236..
7.	Posner GH,Northrop J,Paik IH,et al.New chemical and biological aspects of artemisinin－derived trioxanedimers[J].Bioorg Med Chem,2002,10(1)：227-232..
8.	Efferth T,Olbrich A,Bauer R，et al.mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate,arteether,and artemether[J].Biochem Pharmacol,2002,64(4):617-623..
9.	Singh NP,Lai H.Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells[J].Life Sci,2001,70(1)：49-56..
10.	方步武,來麗娜,林雅軍,等.青蒿琥酯抗四氯化碳致大鼠肝纖維化的作用[J].中國藥理學通報，2005，21（6）：762-763.

1. Harrison DJ.Cell death in the diseased glomerulus[J].Histopathology，1988，12(6)：679-683..
2. Baker AJ,Mooney A,Hughe-s J,et al.Mesangial cell apoptosis:the major mechanism for resolution of glomerular hypercellularity inexperimental mesangial proliferative nephritis[J].J Clin Invest,1994,94(5):2015-2116..
3. 謝彤，吳平,唐德炎，等.環磷酰胺在體外對大鼠腎小球系膜細胞增殖及凋亡的影響[J].中國病理生理雜志,2003,19(3):391-393..
4. Amore A,Emancipator SN,Cirina P,et al.Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cell[J].Kidney Int,2000,57(4):1549-1559..
5. 孫田美，梅長林，葛守一，等.洛伐他汀對系膜細胞凋亡及Bcl-2和Bax基因表達的影響[J].中華腎臟病雜志，2003,19(1):38-42..
6. Chen HH,Zhou HJ,Fang X.Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro[J].Pharmacol Res,2003,48(3):231-236..
7. Posner GH,Northrop J,Paik IH,et al.New chemical and biological aspects of artemisinin－derived trioxanedimers[J].Bioorg Med Chem,2002,10(1)：227-232..
8. Efferth T,Olbrich A,Bauer R，et al.mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate,arteether,and artemether[J].Biochem Pharmacol,2002,64(4):617-623..
9. Singh NP,Lai H.Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells[J].Life Sci,2001,70(1)：49-56..
10. 方步武,來麗娜,林雅軍,等.青蒿琥酯抗四氯化碳致大鼠肝纖維化的作用[J].中國藥理學通報，2005，21（6）：762-763.

West China Medical Journal

Effects of Artesunate on Apoptosis of Rat Glomerular Mesangial Cells

Abstract Full text Figures/Tables Video References Cited by

Format

Content