Tansplantation of Pancreas and Islet: State of the Art_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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徐澤寬 , 苗毅

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Keywords：

移植; 胰腺; 胰島

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糖尿病是臨床常見病，據推測至2010年全球糖尿病患者預計將超過3.5億，其中5%～10%的患者將因糖尿病晚期出現的糖尿病腎病、視網膜病變、微血管病變和神經末梢病變等并發癥而直接影響生命，因此糖尿病及其并發癥作為一項重要而艱巨的課題仍然困擾著廣大醫務工作者。胰腺移植和胰島移植能增加患者胰島素分泌細胞，從而有效地控制血糖，防止和改善糖尿病的并發癥，提高生活質量，是治療胰島素依賴性糖尿病（IDDM）的有效手段。

Citation： 徐澤寬,苗毅. Tansplantation of Pancreas and Islet: State of the Art. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 532-534. doi: Copy

1.	Odorico JS, Sollinger HW. Technical and immunosuppressive advances in transplantation for insulindependent diabetes mellitus [J]. World J Surg, 2002; 26(2)∶194.
2.	Miyamoto M. Current progress and perspectives in cell therapy for diabetes mellitus [J]. Hum Cell, 2001; 14(4)∶293.
3.	Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J]. Surgery, 1967; 61(6)∶827.
4.	Sollinger HW, Geffner SR. Pancreas transplantation [J]. Surg Clin North Am, 1994; 74(5)∶1183.
5.	West M, Gruessner AC, Sutherland DE, et al. Surgical complications after conversion from bladder to enteric drainage in pancreaticoduodenal transplantation [J]. Transplant Proc, 1998; 30(2)∶438.
6.	Gruessner AC, Sutherland DE. Report for the international pancreas transplant registry2000 [J]. Transplant Proc, 2001; 33(1-2)∶1643.
7.	Stratta RJ, Gaber AO, ShokouhAmiri MH, et al. Evolution in pancreas transplantation techniques: simultaneous kidneypancreas transplantation using portalenteric drainage without antilymphocyte induction [J]. Ann Surg, 1999; 229(5)∶701.
8.	Dawahra M, Petruzzo P, Lefrancois N, et al. Portal drainage of pancreas allograft: surgical complications and graft survival [J]. Transplant Proc, 2002; 34(3)∶817.
9.	Eubanks JW, ShokouhAmiri MH, Elmer D, et al. Solitary pancreas transplantation using the portalenteric technique [J]. Transplant Proc, 1998; 30(2)∶446.
10.	Kaufman DB, Leventhal JR, Koffron AJ, et al.A prospective study of rapid corticosteroid elimination in simultaneous pancreaskidney transplantation: comparison of two maintenance immunosuppression protocols: tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus [J]. Transplantation, 2002; 73(2)∶169.
11.	Berney T, Buhler L, Caulfield A, et al. Transplantation of islets of Langerhans: new developments [J]. Swiss Med Wkly, 2001; 131(47-48)∶671.
12.	Berney T, Ricordi C. Islet cell transplantation: the future? [J]. Langenbecks Arch Surg, 2000; 385(6)∶373.
13.	Morrison CP, WemyssHolden SA, Dennison AR, et al. Islet yield remains a problem in islet autotransplantation [J]. Arch Surg, 2002; 137(1)∶80.
14.	Docherty K. Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus [J]. Curr Opin Pharmacol, 2001; 1(6)∶641.
15.	Serup P, Madsen OD, MandrupPoulsen T. Islet and stem cell transplantation for treating diabetes [J]. BMJ, 2001; 322(7277)∶29.
16.	Zeng Y, Ricordi C, Lendoire J, et al. The effect of prednisone on pancreatic islet autografts in dogs [J]. Surgery, 1993; 113(1)∶98.
17.	Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoidfree immunosuppressive regimen [J]. N Engl J Med, 2000; 343(4)∶230.
18.	BonnerWeir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue [J]. Proc Natl Acad Sci USA, 2000; 97(14)∶7999.
19.	Ramiya VK, Maraist M, Arfors KE. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells [J]. Nat Med, 2000; 6(3)∶278.
20.	Soria B, Roche E, Berna G, et al. Insulinsecreting cells derived from embryonic stem cells normalize glycemia in streptozotocininduced diabetic mice [J]. Diabetes, 2000; 49(2)∶157.

1. Odorico JS, Sollinger HW. Technical and immunosuppressive advances in transplantation for insulindependent diabetes mellitus [J]. World J Surg, 2002; 26(2)∶194.
2. Miyamoto M. Current progress and perspectives in cell therapy for diabetes mellitus [J]. Hum Cell, 2001; 14(4)∶293.
3. Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J]. Surgery, 1967; 61(6)∶827.
4. Sollinger HW, Geffner SR. Pancreas transplantation [J]. Surg Clin North Am, 1994; 74(5)∶1183.
5. West M, Gruessner AC, Sutherland DE, et al. Surgical complications after conversion from bladder to enteric drainage in pancreaticoduodenal transplantation [J]. Transplant Proc, 1998; 30(2)∶438.
6. Gruessner AC, Sutherland DE. Report for the international pancreas transplant registry2000 [J]. Transplant Proc, 2001; 33(1-2)∶1643.
7. Stratta RJ, Gaber AO, ShokouhAmiri MH, et al. Evolution in pancreas transplantation techniques: simultaneous kidneypancreas transplantation using portalenteric drainage without antilymphocyte induction [J]. Ann Surg, 1999; 229(5)∶701.
8. Dawahra M, Petruzzo P, Lefrancois N, et al. Portal drainage of pancreas allograft: surgical complications and graft survival [J]. Transplant Proc, 2002; 34(3)∶817.
9. Eubanks JW, ShokouhAmiri MH, Elmer D, et al. Solitary pancreas transplantation using the portalenteric technique [J]. Transplant Proc, 1998; 30(2)∶446.
10. Kaufman DB, Leventhal JR, Koffron AJ, et al.A prospective study of rapid corticosteroid elimination in simultaneous pancreaskidney transplantation: comparison of two maintenance immunosuppression protocols: tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus [J]. Transplantation, 2002; 73(2)∶169.
11. Berney T, Buhler L, Caulfield A, et al. Transplantation of islets of Langerhans: new developments [J]. Swiss Med Wkly, 2001; 131(47-48)∶671.
12. Berney T, Ricordi C. Islet cell transplantation: the future? [J]. Langenbecks Arch Surg, 2000; 385(6)∶373.
13. Morrison CP, WemyssHolden SA, Dennison AR, et al. Islet yield remains a problem in islet autotransplantation [J]. Arch Surg, 2002; 137(1)∶80.
14. Docherty K. Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus [J]. Curr Opin Pharmacol, 2001; 1(6)∶641.
15. Serup P, Madsen OD, MandrupPoulsen T. Islet and stem cell transplantation for treating diabetes [J]. BMJ, 2001; 322(7277)∶29.
16. Zeng Y, Ricordi C, Lendoire J, et al. The effect of prednisone on pancreatic islet autografts in dogs [J]. Surgery, 1993; 113(1)∶98.
17. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoidfree immunosuppressive regimen [J]. N Engl J Med, 2000; 343(4)∶230.
18. BonnerWeir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue [J]. Proc Natl Acad Sci USA, 2000; 97(14)∶7999.
19. Ramiya VK, Maraist M, Arfors KE. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells [J]. Nat Med, 2000; 6(3)∶278.
20. Soria B, Roche E, Berna G, et al. Insulinsecreting cells derived from embryonic stem cells normalize glycemia in streptozotocininduced diabetic mice [J]. Diabetes, 2000; 49(2)∶157.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Tansplantation of Pancreas and Islet: State of the Art

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