Advances in Mechanism of Multiple Organs Dysfunction During Acute Obstructive Cholangitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GONG Jianping ¹ , HAN Benli ²

Department of General Surgery, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010;

Corresponding?author：

Keywords：

Acute obstructive cholangitis; Multiple organs dysfunction; Kupffer cells

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ObjectiveTo elucidate the mechanism of multiple organs dysfunction (MOD) during acute obstructive cholangitis (AOC). MethodsThe reports about MOD and AOC in recent 10 years were collected and reviewed.ResultsApplicable animal models of AOC were established. During AOC, the decrease of Kupffer cells (KCs) phagocytic function and clearance function, hepatocyte mitochondrion damage, the effect of KCs on protein synthesis of hepatocytes and activation of KCs by endotoxin played an important role in the pathogenesis of MOD. ConclusionThe mechanism of pathogenesis of MOD during AOC is complicated and the changes of KCs functions is one of major factors.

Citation： GONG Jianping,HAN Benli. Advances in Mechanism of Multiple Organs Dysfunction During Acute Obstructive Cholangitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 133-135. doi: Copy

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2.	Ou MC. Potential etiologic rule of PAF in two major septic complications: disseminated intravascular coagulation and multiple organ failure \[J\]. Thromb Res, 1994; 73(3-4)∶227.
3.	韓本立，龔建平，羅丁，等. 大鼠急性膽道感染動物模型的建立 \[J\]. 中華實驗外科雜志，1992； 9（1）∶9.
4.	董家鴻，黃志強，韓本立，等. 實驗性膽源性膿毒癥的臨床病理特征 \[J\]. 新消化病學雜志，1994； 2（3）∶140.
5.	Gong JP, Han BL, Luo D, et al. A study of Kupffer cell phagocytic function during acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1991; 6(3)∶222.
6.	龔建平，韓本立，羅丁，等. 急性膽道感染時腸粘膜屏障損傷的研究 \[J\]. 中華實驗外科雜志，1991； 8（3）∶115.
7.	龔建平，韓本立，李昆，等. 單核巨噬細胞在急性膽道感染所致肺損害中的作用 \[J\]. 第三軍醫大學學報，1993；15（1）∶1.
8.	陳平，韓本立，段恒春，等. 急性膽道感染時Kupffer細胞補體受體清除功能的研究 \[J\]. 中華實驗外科雜志，1993； 10（2）∶88.
9.	Sun WB, Han BL, Li K, et al. A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1992; 7(6)∶109.
10.	Luo D, Han BL, Gong JP, et al. An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis \[J\]. J Med Coll PLA, 1991; 6(4)∶319.
11.	楊一增，韓本立，段恒春.急性膽管炎時枯否細胞對肝細胞蛋白合成功能的影響 \[J\]. 中華實驗外科雜志， 1992； 9（增刊）∶139.
12.	李銳，韓本立，李昆，等. 急性膽管炎早期Kupffer細胞激活對肝細胞能量代謝的影響 \[J\]. 中華實驗外科雜志，1995；12（6）∶321.
13.	龔建平，韓本立，彭志明，等. 大鼠急性膽道感染時多臟器損傷的病理學觀察 \[J\]. 第三軍醫大學學報，1992； 14（2）∶107.
14.	李銳，韓本立. 巨噬細胞在嚴重膽道感染時肝肺損害發生機理中的作用 \[J\]. 第三軍醫大學學報，1994；16（4）∶309.
15.	Hasday JD, Dubin W, Mongovin S, et al. Bronchoalveolar macrophage CD14 expression: shift between membraneassociated and soluble pools \[J\]. Am J Physiol, 1997; 272(Lung Cell. Mol. Physiol. 16)∶L925.
16.	Liu S, Khemlani LS, Shapiro RA, et al. Expression of CD14 by hepatocytes: Upregulation by cytokines during endotoxemia \[J\]. Infection and Immunity, 1998; 66(11)∶5089.
17.	Bellezzo JM, Britton RS, Bacon BR, et al. LPSmediated NKkB activation in rat Kupffer cells can be induced independently of CD14 \[J\]. Am J Physiol, 1996; 270∶G956.
18.	Baldwin AS. The NFkB and IkB proteins: new discoveries and insights \[J\]. Ann Rev Immunol, 1996; 14∶649.
19.	May MJ, Ghosh S. Signal transduction through NFkB \[J\]. Immunology Today, 1998; 19(2)∶80.

1. Higure A, Okamoto K, Hirata K, et al. Macrophages and neutrophils infiltrating into the liver are responsible for tissue factor expression in a rabbit model of acute obstructive cholangitis \[J\]. Thromb Haemost, 1996; 75(5)∶ 791.
2. Ou MC. Potential etiologic rule of PAF in two major septic complications: disseminated intravascular coagulation and multiple organ failure \[J\]. Thromb Res, 1994; 73(3-4)∶227.
3. 韓本立，龔建平，羅丁，等. 大鼠急性膽道感染動物模型的建立 \[J\]. 中華實驗外科雜志，1992； 9（1）∶9.
4. 董家鴻，黃志強，韓本立，等. 實驗性膽源性膿毒癥的臨床病理特征 \[J\]. 新消化病學雜志，1994； 2（3）∶140.
5. Gong JP, Han BL, Luo D, et al. A study of Kupffer cell phagocytic function during acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1991; 6(3)∶222.
6. 龔建平，韓本立，羅丁，等. 急性膽道感染時腸粘膜屏障損傷的研究 \[J\]. 中華實驗外科雜志，1991； 8（3）∶115.
7. 龔建平，韓本立，李昆，等. 單核巨噬細胞在急性膽道感染所致肺損害中的作用 \[J\]. 第三軍醫大學學報，1993；15（1）∶1.
8. 陳平，韓本立，段恒春，等. 急性膽道感染時Kupffer細胞補體受體清除功能的研究 \[J\]. 中華實驗外科雜志，1993； 10（2）∶88.
9. Sun WB, Han BL, Li K, et al. A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1992; 7(6)∶109.
10. Luo D, Han BL, Gong JP, et al. An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis \[J\]. J Med Coll PLA, 1991; 6(4)∶319.
11. 楊一增，韓本立，段恒春.急性膽管炎時枯否細胞對肝細胞蛋白合成功能的影響 \[J\]. 中華實驗外科雜志， 1992； 9（增刊）∶139.
12. 李銳，韓本立，李昆，等. 急性膽管炎早期Kupffer細胞激活對肝細胞能量代謝的影響 \[J\]. 中華實驗外科雜志，1995；12（6）∶321.
13. 龔建平，韓本立，彭志明，等. 大鼠急性膽道感染時多臟器損傷的病理學觀察 \[J\]. 第三軍醫大學學報，1992； 14（2）∶107.
14. 李銳，韓本立. 巨噬細胞在嚴重膽道感染時肝肺損害發生機理中的作用 \[J\]. 第三軍醫大學學報，1994；16（4）∶309.
15. Hasday JD, Dubin W, Mongovin S, et al. Bronchoalveolar macrophage CD14 expression: shift between membraneassociated and soluble pools \[J\]. Am J Physiol, 1997; 272(Lung Cell. Mol. Physiol. 16)∶L925.
16. Liu S, Khemlani LS, Shapiro RA, et al. Expression of CD14 by hepatocytes: Upregulation by cytokines during endotoxemia \[J\]. Infection and Immunity, 1998; 66(11)∶5089.
17. Bellezzo JM, Britton RS, Bacon BR, et al. LPSmediated NKkB activation in rat Kupffer cells can be induced independently of CD14 \[J\]. Am J Physiol, 1996; 270∶G956.
18. Baldwin AS. The NFkB and IkB proteins: new discoveries and insights \[J\]. Ann Rev Immunol, 1996; 14∶649.
19. May MJ, Ghosh S. Signal transduction through NFkB \[J\]. Immunology Today, 1998; 19(2)∶80.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advances in Mechanism of Multiple Organs Dysfunction During Acute Obstructive Cholangitis

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