Interleukin-1 (IL-1), interleukin-2(IL-2) and interleukin-6(IL-6) activities and tumor necrosis factor (TNF) contents in plasma from patients with different sites of cancers as well as controls using bioassay technique were studied. The results showed that the levels of IL-1,IL-2,IL-6 s from patients with different sites of cancer were decreased remarkably in comparision with controls and the contents of TNF from patients with different sites of cancers increased significantly. But the difference between different sites of cancer was not statistically significant. The data suggest that the variations in the contents of TNF and the levels of interleukins may be related to the development of these caner patients.
Citation：
Meng Qingrun,Zhang Jun,Jin Hu,et al.. STUDY ON THE LEVELS OF INTERLEUKIN-1、2、6 AND THE CONTENTS OF TUMOR NECROSIS FACTOR IN THE PATIENTS WITH CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(3): 146-147. doi:
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- 1. Rovelli F, Lissoni P, Barni S, et al. Increased level of soluble IL2 receptor in advanced solid tumors: a preliminary study. Tumori, 1988; 74(3)∶633.
- 2. 張東吉. IL2的誘生與檢測.見：楊貴貞，主編.免疫生物工程綱要與技術. 第1版.長春：吉林科學技術出版社， 1991∶28～51.
- 3. 吳勇. IL6的誘生與檢測.見：楊貴貞，主編.免疫生物工程綱要與技術. 第1版.長春：吉林科學技術出版社， 1991∶129～142.
- 4. 李一. 白細胞介素1.見：楊貴貞，主編.免疫生物工程綱要與技術. 第1版.長春：吉林科學技術出版社， 1991∶ 12～13.
- 5. Rey A, Klein B, Zagury D, et al. Diminished interleukin2 activity production in cancer patients bearing solid tumors and its relationship withnatural killer cells. Immunol Lett, 1983; 6(3)∶175.
- 6. 王江濱，譚巖，葉維法.肝癌患者外周血LAK細胞活性測定及其影響因素的研究.臨床肝膽病雜志，1990； 6(4)∶183.
- 7. 曾勁楊，李卓婭，龔非力. 膜相關型腫瘤壞死因子α.國外醫學免疫學分冊， 1995； 2(1)∶26.
