Through dog models of common bile duct obstruction (BDO), the contents of liver superoxide dismutase (SOD) and malondialdehyde(MDA) were measured 2,3,4 and 5 weeks after BDO. Results indicated that the hepatic MDA content was increased 2 weeks after BDO as compared with control group (Ｐ＜0.01), the hepatic SOD content was decreased 3 weeks after BDO (Ｐ＜0.05). When bile duct obstructing, these changed were more serious. The results suggest that liver has little ability to eliminate the superoxide free radicals after BDO, whereas the lipid peroxidation products increase. It may be one of the mechanisms of liver damage after BDO.
Citation：
Li Jing,Chi Yanbang,Fang Xuejun.. CHANGES OF LIVER SUPEROXIDE DISMUTASE AND MALONDIALDEHYDE CONTENTS AFTER BILE DUCT OBSTRUCTION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(3): 148-149. doi:
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Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 2. 遲彥邦，黃志強，張建超等. 實驗性膽道阻塞性黃膽對肝、腎、肺的損害. 重慶醫藥， 1983； 11(6)∶53.
- 3. 李友元，何福清.自由基反應與肝損傷. 國外醫學生理病理科學與臨床分冊，1991； 11(3)∶136.
- 4. Tsai LY, Lee KT, Tsai SM, et al. Changes of lipid peroxide levels in blood and liver tissue of patients with obstructive jaundice. Chinica Chimica Acta, 1993; 215(1)∶41.
- 5. 程迅生，遲彥邦，祁佐元. 慢性膽道梗阻時肝臟血流量及微血管床的變化. 中華外科雜志， 1992；30 (12)∶ 751.
- 6. Parks DA. Oxygen radicals∶mediators of gastrointestinal pathophysiology. Gut, 1989; 30(3)∶293.
- 7. Slater IF. Free radical mechanisms in tissue injury. Biochem J, 1984; 222(1)∶1.
