為觀察高鉀低鈉HX液(HX液)和高鈉低鉀HX液(HXm液)保存鼠肝的效果，實驗用采60只Wistar大鼠制成大鼠肝臟離體灌注模型，關隨機分為HX組(HX液保存，n=30)和HXm組(HXm液保存，n=30)，測定其肝竇內皮細胞死亡率、Krebs-Henseleit液酮體比、肝臟糖釋放量及肝組織含水量。結果表明，保存鼠肝6小時，兩者保存效果無顯著性差異，但保存時間延至12小時或更長時間，HX液保存效果則明顯優于HXm液。
引用本文：
張銳敏,吳和光,沈文律,吳言濤,譚建三,陳玲莉,吳紅斌. HX液鈉、鉀含量對大鼠肝保存效果的影響. 中國普外基礎與臨床雜志, 1994, 1(2): 67-70. doi:
復制
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Howard TK, Goran B, Lintmalm G, et al. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation, 1990;49:103.
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Tashiro S, Kawamoto K, Hayashida N, et al. Evaluation of arly graft function in orthotopic liver transplants in dogs. Transplant Proc,1989;21:1344.
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- 1. 張銳敏，沈文律，吳言濤等.自制灌注液—HX液延長大鼠肝臟有效保存時間的初步研究.見：第二屆全國器官移植學術會議編.第二屆全國器官移植學術會議論文匯編.武漢：同濟醫科大學，1993：69.
- 2. Belinsky SA, Popp JA, Kauffman FC, et al. Trypan blue uptake ad a new method to study zonal hepatotoxicity in the perfused liver. J Pharmacol Exp Ther, 1984;230:755.
- 3. Collins GM, Bravo-Shugarman M, Teraski PI. Kidney preservation for transplatation-initial perfusion and 30 hours’ ice storage. Lancet, 1969;2:1229.
- 4. Moen J, Claesson K, Piennar H, et al. Preservation of dog liver, kidney, and pancreas using the Belzer-UW solution with high-sodium and low-potassium content. Transplantation,1989;47:940.
- 5. Rao PN, Walsh Makowka L, et al. Inbition of free radical generation and improved survival by protection of the hepatic mictocascular endothelium targeted erythrocytes in orthotoic rat liver transplantation. Transplantation,1990;49:1055.
- 6. Howard TK, Goran B, Lintmalm G, et al. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation, 1990;49:103.
- 7. Tashiro S, Kawamoto K, Hayashida N, et al. Evaluation of arly graft function in orthotopic liver transplants in dogs. Transplant Proc,1989;21:1344.
- 8. Kobayashi T, Sumimoto R, Shimada H, et al. Effect of sugars in the preservation solution on liver storage in rats. Cryobiology,1991;28:425.
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