Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

1. West China Medical School, Sichuan University, Chengdu 610041,China2. Department of Clinical Epidemiology & Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu 610041,China;

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Keywords：

Dengzhanhua Injection; Angina pectoris; Effectiveness; Systematic review

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Objective 　To assess the effect of Dengzhanhua Injection for angina pectoris.
Methods 　We performed an electronic search for MEDLINE (1966 to 2004), EMBASE (1974 to 2004), The Cochrane Library (Issue 4, 2004), CBM and CNKI (1980 to 2004). We included randomized controlled trials that met the inclusion and exclusion criteria and evaluated the quality of those trials and performed the meta-analysis by RevMan 4.2.7.
Results 　Eight trials were included involving 634 patients. However, they were of poor quality. The results of meta-analysis indicated that there were statistical difference on symptoms and electrocardiogram (ECG) improvements between Dengzhanhua and control group (Breviscarpine≥30 mg) with RR 1.26, 95%CI 1.11 to 1.44 and RR 1.30, 95%CI 1.14 to 1.49, respectively. However, Dengzhanhua Injection (Breviscarpine lt;30 mg) vs. basic therapy showed no statistical difference in either symptom improvement (RR 1.03, 95%CI was 0.90 to 1.18) or ECG improvement (RR 1.01, 95%CI 0.86 to 1.20). In addition, Dengzhanhua decreased the myocardial infarction attacks in one year following up (OR 0.06, 95%CI 0.01 to 0.29).
Conclusions 　Little evidence shows that Dengzhanhua is superior to simple basic therapy in the symptoms and ECG improvements as an auxiliary drug. However, this systematic review can not draw a conclusion about the effectiveness of Dengzhanhua Injection compared to simple basic therapy in the treatment of angina pectoris due to the poor quantity of included trials.

Citation： CAO Wenzhai,LAN De,ZHANG Ting,TANG Chao,WU Taixiang,LIU Guanjian. Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2005, 05(4): 317-322. doi: Copy

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21.	Cardiovascular Group of the First National Internal Medical Academic Conference. Proposition on Nomination and Diagnosis of Coronary Heart Disease[J]. Chinese Journal of Cardiology, 1981; 9(1): 75.
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27.	Yang J, Li Y, Shao GY. Clinical observation on Dengzhanhua for 62 cases coronary heart disease and angina pectoris[J]. Heinongjiang Medical Journal, 2001; 25(6): 447.
28.	Nie YW, Xing TG. Clinical observation on Dengzhanhua for coronary heart disease and angina pectoris[J]. Journal of Heze Medical College, 2002; 14(2): 36-37.
29.	Tang YP, Liu Y. Clinical observation on Dengzhanhua Injection and Danshen Injection for angina pectoris[J]. Journal of Guangxi Chinese Medical College, 2001; 18(1): 33-34.
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31.	Yu HW, Zhao L, Cao MR. Dengzhanhua Injection for UAP[J]. Chinese Herbal Medicine Information Journal, 2001; 8(9): 68.
32.	Wang LN, Cheng JL. Clinical observation on Dengzhanhua injection for angina pectoris[J]. Modern Combination of Chinese and Western Medicine Journal, 1999; 8(7): 1 072.
33.	Liu JP, Heather M, Lin H. Chinese medicinal herbs for chronic hepatitis B: a systematic review[J]. Chinese Journal of Evidence-Based Medicine, 2001; 1(1): 16-24.

1. 衛生部:2003年慢性疾病患病率[EB/OL]. 中國衛生統計年鑒2004, 2004.4; [引用日期2004.7.28]; 來源: URL http://61.49.18.68/statistics/digest04/s57.htm.
2. 陳一岳, 王勝濤, 曾文珊. 燈盞花素對大鼠主動脈肌環的松弛作用[J]. 中藥新藥與臨床藥理, 1994; 5(2): 15～19.
3. 第一屆全國內科學術會議心血管病組. 關于冠狀動脈性心臟病命名及診斷標準的建議[J]. 中華心血管雜志, 1981; 9(1): 75.
4. 國際心臟病學會和協會及世界衛生組織臨床命名標準化聯合專題組. 缺血性心臟病的命名及診斷標準[J]. 中華心血管雜志, 1981; 9(1): 75～76.
5. 朱效榮, 王燦東, 郭淑芬. 常規療法加燈盞花素治療不穩定性心絞痛療效觀察[J]. 山東醫藥, 2001; 41(1): 32.
6. 邢賽玲, 張小民, 劉春榮. 燈盞花素治療不穩定型心絞痛的療效分析[J]. 中國煤炭工業醫學雜志, 2000; 3(9): 934～934.
7. 楊晶, 李穎, 邵桂英. 燈盞花素治療冠心病心絞痛62 例臨床觀察[J]. 黑龍江醫學, 2001; 25(6): 447.
8. 聶元文, 邢同國. 燈盞花素治療冠心病心絞痛的療效觀察[J]. 菏澤醫專學報, 2002; 14(2): 36～37.
9. 唐耀平, 劉鷹. 燈盞花素注射液、復方丹參液治療冠心病的臨床觀察[J]. 廣西中醫學院學報, 2001; 18(1): 33～34.
10. 徐同文, 王立春. 燈盞花素注射液治療不穩定心絞痛17 例[J]. 山東醫藥, 2001(6); 8: 71.
11. 于紅偉, 趙亮, 曹茂榮. 燈盞花素注射液治療不穩定性心絞痛[J]. 中國中醫藥信息雜志, 2001; 8(9): 68.
12. 王麗娜, 程嘉倫. 燈盞花素注射液治療冠心病30例療效觀察. 現代中西醫結合雜志, 1999; 8(7): 1 072.
13. 劉建平, Heather McIntosh, 林輝. 中草藥治療慢性乙型肝炎隨機對照試驗的系統評價[J]. 中國循證醫學雜志, 2001; 1(1): 16～24.
14. AHA: Angina Pectoris [EB/OL]. Angina Pectoris[serial online]; [cited 2004, July 24]; Avaliable from: URL http://www.americanheart.org/presenter.jhtml?identifier=4472/.
15. Ford ES, Giles WH, Croft JB. Prevalence of nonfatal coronary heart disease among American adults[J]. Am Heart J, 2000; 139(3): 371-377.
16. Ministry of Health P.R. China: Morbidity Rate of Chronic Diseases in 2003[EB/OL]. China Health Statistics Yearbook 2004[serial online] 2004 April; [cited 2004, July 28]; Available from: URL http://61.49.18.68/statistics/digest04/s57.htm.
17. H, Shipley M, Britton A, Page M, Macfarlane P, Marmot M. Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall Ⅱ prospective cohort study Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall Ⅱ prospective cohort study[J]. BMJ, 2003; 10(327): 895.
18. SIGN. Drug Treatment[EB/OL]. in: Management of Stable Angina. [serial online] 2001 Dec[Cited 2004, August 2]. Available from: URL http://www.sign.ac.uk/guidelines/fulltext/32/.
19. Psaty BM, Koepsell TD, Wagner EH, LoGerfo JP, Inui TS. The relative risk of incident coronary heart disease associated wtih recently stopping the use of beta-blockers[J]. JAMA, 1990; 263(12): 1 653-1 657.
20. Chen YY, Wang ST, Zeng WS. Dengzhanhua Su relaxes the muscular ring of rat aorta[J]. New Chinese Herbal &Clinical Pharmacology,1994; 5(2): 15-19.
21. Cardiovascular Group of the First National Internal Medical Academic Conference. Proposition on Nomination and Diagnosis of Coronary Heart Disease[J]. Chinese Journal of Cardiology, 1981; 9(1): 75.
22. International Society and Association of Cardiology, WHO. Nomination and Diagnosis of Ishemic Heart Disease[J]. Chinese Journal of Cardiology, 1981; 9(1): 75-76.
23. International Conference on Harmonisation Expert Working Group: Internatioal conference on harmonization of technical requirements for registration of pharmaceuticals for human use. Guideline for good clinical practice[Z]. 1997 CFR&ICH Guidelines. 1997: Vol. 1,Barnett International/PAREXEL, PA 19063-2043, USA.
24. Aldeson P,Green S,Higgins JPT editors.Cochrane Reviews Handbook 4.2.2[Updated December 2003][M/CD].In:The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
25. Zhu XR, Wang CD, Guo SF. Study on Dengzhanhua with routine remedy for unstable angina[J]. Shandong Medicine, 2001; 41(1): 32.
26. Xing SL, Zhang XM, Liu CR. Analysis of Dengzhanhua curative effect on UAP[J]. Chinese Coal Industry Medicine Journal, 2000; 3(9): 934-934.
27. Yang J, Li Y, Shao GY. Clinical observation on Dengzhanhua for 62 cases coronary heart disease and angina pectoris[J]. Heinongjiang Medical Journal, 2001; 25(6): 447.
28. Nie YW, Xing TG. Clinical observation on Dengzhanhua for coronary heart disease and angina pectoris[J]. Journal of Heze Medical College, 2002; 14(2): 36-37.
29. Tang YP, Liu Y. Clinical observation on Dengzhanhua Injection and Danshen Injection for angina pectoris[J]. Journal of Guangxi Chinese Medical College, 2001; 18(1): 33-34.
30. Xu TW, Wang LC. Dengzhanhua Injection for UAP 17 cases[J]. Shangdong Medical Journal, 2001(6); 8: 71.
31. Yu HW, Zhao L, Cao MR. Dengzhanhua Injection for UAP[J]. Chinese Herbal Medicine Information Journal, 2001; 8(9): 68.
32. Wang LN, Cheng JL. Clinical observation on Dengzhanhua injection for angina pectoris[J]. Modern Combination of Chinese and Western Medicine Journal, 1999; 8(7): 1 072.
33. Liu JP, Heather M, Lin H. Chinese medicinal herbs for chronic hepatitis B: a systematic review[J]. Chinese Journal of Evidence-Based Medicine, 2001; 1(1): 16-24.

Chinese Journal of Evidence-Based Medicine

Effect of Dengzhanhua Injection for Angina Pectoris: A Systematic Review

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