Quality Assessement on the Studies of Traditional Chinese Medicine for Coronary Heart Disease Angina_Chinese Journal of Evidence-Based Medicine

Authors：

ZHOU Likun , DUAN Xin , AN Ning , WU Taixiang , LIU Guanjian

Department of Clinical Epidemiology; West China Hospital; Sichuan University; Chengdu 610041; China;

Corresponding?author：

Keywords：

Coronary heart disease angina; Randomized controlled trial; Quality assessment of study; Traditional Chinese medicine

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To assess the quality of randomised controlled trials on traditional Chinese medicine (TCM) for coronary heart disease (CHD) angina published from 1977 to 2002.
Method 　We did electronic search in Medline, Embase and hand searched 83 journals of traditional Chinese medicine (the earliest published in 1977 and the latest in June 2002). We assessed the quality of obstained studies.
Results 　Four hundred and forty articles met the criteria,of which 33 (7.5%) described randomization. None of them mentioned allocation concealment; 94.77% (417 studies) mentioned diagnosis criteria; only one mentioned the calculation basement of sample size; 84.09% (370 studies) mentioned comparability of baseline. Fifty three studies (12.05%) noted double-blind; 28 studies used single blind. Twenty-five studies used double-blind. Drop-outs were described in 7 cases without intention-to-treat (ITT); 159 studies applied statistical methods properly, while 4 did not. Ten studies never mentioned statistical methods; 73.18％ (322 studies) used forms to express their results.
Conclusions 　Till now, the quantity and quality of RCTs of traditional Chinese medicine for coronary heart disease angina were inadequate. Some well designed scientific methods were not adequately applied.

Citation： ZHOU Likun,DUAN Xin,AN Ning,WU Taixiang,LIU Guanjian. Quality Assessement on the Studies of Traditional Chinese Medicine for Coronary Heart Disease Angina. Chinese Journal of Evidence-Based Medicine, 2004, 04(4): 258-262. doi: Copy

1.	［1］Yan YH, Zhu CY. The effect observation of Integrated Traditional and Western Medicine for CHD angina[J]. Hebei Journal of Integrated Traditional and Western Medicine, 1998;7(11):1 809-1 810.
2.	閆韻洪,祝存英中西醫結合治療冠心病心絞痛的療效觀察[J].河北中西醫結合雜志,1998;7(11):1 809～1 810.
3.	［2］Fu Wei, Ding FZ, Lin Qing. Therapy of 50 cases about CHD angina by Fangxiangwentong method [ J ]. Acta Chinese Medicine and Pharmacology, 2000 ;2 ( 2 ) :9.
4.	付偉,丁鳳朱,林青.芳香溫通法治療冠心病心絞痛50例體會[J]中醫藥學報,2000;2(2):9.
5.	［3］Xu XM. The clinical observation of 160 cases about compound Danshendiwan for angina [ J ]. Chinese Traditional drugs,2000 ;31 ( 1 ) :44,72.
6.	徐象明復方丹參滴丸治療心絞痛160例臨床療效觀察[J]中草藥,2000;31(1):44,72.
7.	［4］Wang ZX. The experience of self-made Qingxinxiaotan soup for angina[J]. Journal ofBeijing TCM, 2000; (3) :14-15.
8.	王志祥.自擬清心消痰湯治療痰熱型胸痹心痛的體會[J].北京中醫,2000;(3):14～15.
9.	［5］Hu J, Huang XB. The clinical observation of Xinxuening for angina[J]. Beijing Journal of TCM , 1994;(4): 50-51.
10.	胡杰,黃小波心血寧治療胸痹的臨床觀察[J]北京中醫雜志,1994;(4):50～51.
11.	［6］WangJL. Clinicalepidemiology[M]. The 2nd edition. Shanghai:Shanghai science and technology publish house, 2001.
12.	王家良.臨床流行病學[M]第2版上海:上海科學技術出版社,2001年.
13.	［7］Shen SG, Han XJ. The clinical observation of Zhengxintai Capsule for CHD angina [ J]. Journal of Emergency in Traditional Chinese Medicine, 2001; 10 ( 2 ) :64-66.
14.	沈紹功,韓學杰.正心泰膠囊治療冠心病心絞痛臨床觀察[J].中國中醫急癥,2001;10(2):64～66.
15.	［8］Xiao B, Tang B, Guo JY. The assessment of Tetromethylpragin and Low molecular weight heparin for unstable CHD angina[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2001 ;10(22) :2 156-2 157.
16.	肖彬,湯蓓,郭靜蕓.川芎嗪與低分子肝素治療不穩定心絞痛評價[J].現代中西醫結合雜志,2001;10(22):2156～2157.
17.	［9］Yang HB. The clinical observation of Shexiangbaoxinwan for curing CHD angina[J]. Journal of Practical TCM, 2000; 16(10) :5-6.
18.	楊煥斌麝香保心丸治療冠心病心絞痛臨床觀察[J].實用中醫藥雜志,2000:16(10):5～6.
19.	［10］Zhang Y, Fan P. The clinical observation of 36 cases about compound Guanxintong for CHD angina [J ]. Journal of TCM, 2001 ;42(10) :602-603.
20.	張毅,范平.冠心通合劑治療冠心病心絞痛36例臨床觀察[J].中醫雜志,2001;42(10):602 603.
21.	［11］Li XZ, ShiJP, HuJX. The clinical effect observation of Tianbaoning and isosorbide dinitrate for curing CHD angina[J ]. Journal of Practical Integrated Emergency Chinese Traditional and Western Medicine, 1998 ;5 ( 3 ): 106-107.
22.	李秀芝,史建萍,胡錦霞聯用天保寧與消心痛治療心絞痛臨床療效觀察[J].中西醫結合實用臨床急救,1998;5(3):106～107.
23.	［12］Gao FJ, Zhang SJ. The comparison of Sini soup and isosorbide mononitrate for curing CHD angina [ J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2001 ;10(2) :128-129.
24.	高富杰,張淑君.四逆湯和單硝酸異山梨酯治療心絞痛的比較[J].現代中西醫結合雜志,2001;10(2):128～129.
25.	［13］Yuan JQ, Liu B, Guo WZ, Wang QX, Yang BJ, Yuan HW, Zhou YX. The clinical research of 116 cases about compound power made of Panax Sanqi and amber [ J ].Journal of TCM , 1992;33(9) :29-30.
26.	袁今奇,劉珀,郭文征,王慶憲,楊百景,袁洪文,周云霄人參三七琥珀末治療冠心病心絞痛116例臨床觀察[J].中醫雜志,1992;33(9):29～30.
27.	［14］Wang HG, Jiang F, Sun DX. The clinical research of Dalijiuxinwan for curing CHD angina[J]. Henan TCM, 1998;18(3) :150-151.
28.	王皓光,姜鳳,孫德喜.大力救心丸治療冠心病心絞痛的臨床研究[J].河南中醫,1998;18(3):150～151.
29.	［15］Wang ZH, Wang HJ. The effect observation of100 cases about Dalijiuxinwan for curing CHD angina [J ]. Journal of Emergency in Traditional Chinese Medicine, 2001 ;10( 1 ) :19-20.
30.	王振華,王慧杰.大力救心丸治療冠心病心絞痛100例療效觀察[J].中國中醫急診,2001;10(1):19～20.
31.	［16］Hu GH, Tan YS. The clinical and experimental research of Xintongling for CHD angina [ J ]. Chinese Journal of Traditional Medical Science and Technology, 1994; 1 ( 5 ) :6-8.
32.	胡國恒,譚元生.心痛靈治療冠心病心絞痛的臨床及試驗研究[J].中國中醫藥科技,1994;1(5):6～8.
33.	［17］Sun L, Dai PS, Shao J. Curing 40 cases of CHD angina by Fufangdanshendiwan [ J ]. Tianjin Journal of TraditionalChinese Medicine, 2000;17(3) :6-7.
34.	孫靈,戴培勝,邵杰.復方丹參滴丸治療冠心病心絞痛40例[J].天津中醫,2000;17(3):6～7.
35.	［18］Yan XH, Zhu GA. The effect observation of Xintongkoufuye and isosorbide dinitrate for coronary artherosclerosis CHD angina [ J ]. Chinese Tranditional and Morden Emergency Journal, 1999 ;6(8) :365-366.
36.	閻旭龍,朱國安.聯用心通口服液與硝酸異山梨醇酯治療冠狀動脈粥樣硬化性心臟病心絞痛療效觀察[J].中國中西醫結合急救雜志,1999;6(8):365～366.
37.	［19］Shang ZC, Liang HL, Zheng SZ. The clinical research of Yifukoufuye[J] . Journal of Beijing university of TCM, 1995;18(5) :56-57.
38.	尚熾昌,梁華龍,鄭紹周.薏附口服液治療寒濕型冠心病心絞痛的臨床研究[J].北京中醫藥大學學報,1995;18(5):56～57.

1. ［1］Yan YH, Zhu CY. The effect observation of Integrated Traditional and Western Medicine for CHD angina[J]. Hebei Journal of Integrated Traditional and Western Medicine, 1998;7(11):1 809-1 810.
2. 閆韻洪,祝存英中西醫結合治療冠心病心絞痛的療效觀察[J].河北中西醫結合雜志,1998;7(11):1 809～1 810.
3. ［2］Fu Wei, Ding FZ, Lin Qing. Therapy of 50 cases about CHD angina by Fangxiangwentong method [ J ]. Acta Chinese Medicine and Pharmacology, 2000 ;2 ( 2 ) :9.
4. 付偉,丁鳳朱,林青.芳香溫通法治療冠心病心絞痛50例體會[J]中醫藥學報,2000;2(2):9.
5. ［3］Xu XM. The clinical observation of 160 cases about compound Danshendiwan for angina [ J ]. Chinese Traditional drugs,2000 ;31 ( 1 ) :44,72.
6. 徐象明復方丹參滴丸治療心絞痛160例臨床療效觀察[J]中草藥,2000;31(1):44,72.
7. ［4］Wang ZX. The experience of self-made Qingxinxiaotan soup for angina[J]. Journal ofBeijing TCM, 2000; (3) :14-15.
8. 王志祥.自擬清心消痰湯治療痰熱型胸痹心痛的體會[J].北京中醫,2000;(3):14～15.
9. ［5］Hu J, Huang XB. The clinical observation of Xinxuening for angina[J]. Beijing Journal of TCM , 1994;(4): 50-51.
10. 胡杰,黃小波心血寧治療胸痹的臨床觀察[J]北京中醫雜志,1994;(4):50～51.
11. ［6］WangJL. Clinicalepidemiology[M]. The 2nd edition. Shanghai:Shanghai science and technology publish house, 2001.
12. 王家良.臨床流行病學[M]第2版上海:上海科學技術出版社,2001年.
13. ［7］Shen SG, Han XJ. The clinical observation of Zhengxintai Capsule for CHD angina [ J]. Journal of Emergency in Traditional Chinese Medicine, 2001; 10 ( 2 ) :64-66.
14. 沈紹功,韓學杰.正心泰膠囊治療冠心病心絞痛臨床觀察[J].中國中醫急癥,2001;10(2):64～66.
15. ［8］Xiao B, Tang B, Guo JY. The assessment of Tetromethylpragin and Low molecular weight heparin for unstable CHD angina[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2001 ;10(22) :2 156-2 157.
16. 肖彬,湯蓓,郭靜蕓.川芎嗪與低分子肝素治療不穩定心絞痛評價[J].現代中西醫結合雜志,2001;10(22):2156～2157.
17. ［9］Yang HB. The clinical observation of Shexiangbaoxinwan for curing CHD angina[J]. Journal of Practical TCM, 2000; 16(10) :5-6.
18. 楊煥斌麝香保心丸治療冠心病心絞痛臨床觀察[J].實用中醫藥雜志,2000:16(10):5～6.
19. ［10］Zhang Y, Fan P. The clinical observation of 36 cases about compound Guanxintong for CHD angina [J ]. Journal of TCM, 2001 ;42(10) :602-603.
20. 張毅,范平.冠心通合劑治療冠心病心絞痛36例臨床觀察[J].中醫雜志,2001;42(10):602 603.
21. ［11］Li XZ, ShiJP, HuJX. The clinical effect observation of Tianbaoning and isosorbide dinitrate for curing CHD angina[J ]. Journal of Practical Integrated Emergency Chinese Traditional and Western Medicine, 1998 ;5 ( 3 ): 106-107.
22. 李秀芝,史建萍,胡錦霞聯用天保寧與消心痛治療心絞痛臨床療效觀察[J].中西醫結合實用臨床急救,1998;5(3):106～107.
23. ［12］Gao FJ, Zhang SJ. The comparison of Sini soup and isosorbide mononitrate for curing CHD angina [ J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2001 ;10(2) :128-129.
24. 高富杰,張淑君.四逆湯和單硝酸異山梨酯治療心絞痛的比較[J].現代中西醫結合雜志,2001;10(2):128～129.
25. ［13］Yuan JQ, Liu B, Guo WZ, Wang QX, Yang BJ, Yuan HW, Zhou YX. The clinical research of 116 cases about compound power made of Panax Sanqi and amber [ J ].Journal of TCM , 1992;33(9) :29-30.
26. 袁今奇,劉珀,郭文征,王慶憲,楊百景,袁洪文,周云霄人參三七琥珀末治療冠心病心絞痛116例臨床觀察[J].中醫雜志,1992;33(9):29～30.
27. ［14］Wang HG, Jiang F, Sun DX. The clinical research of Dalijiuxinwan for curing CHD angina[J]. Henan TCM, 1998;18(3) :150-151.
28. 王皓光,姜鳳,孫德喜.大力救心丸治療冠心病心絞痛的臨床研究[J].河南中醫,1998;18(3):150～151.
29. ［15］Wang ZH, Wang HJ. The effect observation of100 cases about Dalijiuxinwan for curing CHD angina [J ]. Journal of Emergency in Traditional Chinese Medicine, 2001 ;10( 1 ) :19-20.
30. 王振華,王慧杰.大力救心丸治療冠心病心絞痛100例療效觀察[J].中國中醫急診,2001;10(1):19～20.
31. ［16］Hu GH, Tan YS. The clinical and experimental research of Xintongling for CHD angina [ J ]. Chinese Journal of Traditional Medical Science and Technology, 1994; 1 ( 5 ) :6-8.
32. 胡國恒,譚元生.心痛靈治療冠心病心絞痛的臨床及試驗研究[J].中國中醫藥科技,1994;1(5):6～8.
33. ［17］Sun L, Dai PS, Shao J. Curing 40 cases of CHD angina by Fufangdanshendiwan [ J ]. Tianjin Journal of TraditionalChinese Medicine, 2000;17(3) :6-7.
34. 孫靈,戴培勝,邵杰.復方丹參滴丸治療冠心病心絞痛40例[J].天津中醫,2000;17(3):6～7.
35. ［18］Yan XH, Zhu GA. The effect observation of Xintongkoufuye and isosorbide dinitrate for coronary artherosclerosis CHD angina [ J ]. Chinese Tranditional and Morden Emergency Journal, 1999 ;6(8) :365-366.
36. 閻旭龍,朱國安.聯用心通口服液與硝酸異山梨醇酯治療冠狀動脈粥樣硬化性心臟病心絞痛療效觀察[J].中國中西醫結合急救雜志,1999;6(8):365～366.
37. ［19］Shang ZC, Liang HL, Zheng SZ. The clinical research of Yifukoufuye[J] . Journal of Beijing university of TCM, 1995;18(5) :56-57.
38. 尚熾昌,梁華龍,鄭紹周.薏附口服液治療寒濕型冠心病心絞痛的臨床研究[J].北京中醫藥大學學報,1995;18(5):56～57.

Chinese Journal of Evidence-Based Medicine

Quality Assessement on the Studies of Traditional Chinese Medicine for Coronary Heart Disease Angina

Abstract Full text Figures/Tables Video References Cited by

Format

Content