補充維生素A對兒童感染性疾病發病率與死亡率的影響_《中國循證醫學雜志》

作者：

楊慧明 , 萬朝敏

四川大學華西醫院中國循證醫學中心；四川大學華西第二醫院兒科,成都,610041;

關鍵詞：

維生素A 感染性疾病發病率死亡率兒童臨床證據

視頻：

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目的　了解補充維生素A(維A)對兒童感染性疾病的發病率和死亡率的影響.
方法　計算機檢索Cochrane Library(2004年第1期)、MEDLINE(1966～2004.3)、The PedsCCM Evidence-Based Journal Club(1992～2002),收集補充維A與兒童感染性疾病的發病率與死亡率的系統評價和隨機對照試驗.
結果　共獲得107篇文獻,從中篩選出相關系統評價或隨機對照試驗13篇.所獲證據顯示,研究對象的基礎營養狀況與研究結果密切相關.補充維A能降低維A缺乏兒童腹瀉的發病率和麻疹的死亡率,而補充維A對兒童的呼吸道感染無影響,對營養充足的兒童補充大劑量維A反而使腹瀉和呼吸道感染的發病率增加.
結論　兒童的基礎營養狀況與一些感染性疾病的發病率和死亡率相關,兒童補充維A前應了解其營養狀況和血清維A水平.

引用本文： 楊慧明,萬朝敏. 補充維生素A對兒童感染性疾病發病率與死亡率的影響. 中國循證醫學雜志, 2004, 04(9): 644-647. doi: 復制

1.	［1］Chowdhury S, Kumar R, Ganguly NK, Kumar L, Walia BN. Effect of vitamin A supplementation on childhood morbidity and mortality[J]. Indian Journal of Medical Sciences, 2002; 56 (6): 259-264.
2.	［2］Sommer A, Tarwotjo I, Djunaedi E, West KP Jr, Loeden AA, Tilden R, Mele L. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial[J]. Lancet, 1986; 1 (8491): 1 169-1 173.
3.	［3］Rahmathullah L,Underwood BA,Thulasiraj RD, Milton RC, Ramaswamy K, Rahmathullah R, Babu G. Reduced mortality among children in Southern India receiving a small weekly dose of vitamin A[J]. The New England Journal of Medicine, 1990; 323 (14): 929-935.
4.	［4］Stansfield SK, Pierre-Louis M, Lerebours G,Augustin A. Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections[J]. Lancet, 1993; 342 (8871): 578-582.
5.	［5］Herrera MG, Nestel P, El Amin A, Fawzi WW, Mohamed KA, Weld L. Vitamin A supplementation and child survival[J]. Lancet, 1992; 340 (8814): 267-271.
6.	［6］Barreto ML, Santos LM, Assis AM, Araujo MP, Farenzena GG, Santos PA, Fiaccone RL. Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil[J]. Lancet, 1994; 344 (8917): 228-231.
7.	［7］Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children[J]. The Journal of Nutrition, 1996; 126 (2): 434-442.
8.	［8］Semba RD, Akib A, Beeler J, Munasir Z, Permaesih D, Muherdiyantiningsih, Komala, Martuti S, Muhilal. Effect of vitamin A supplementation on measles vaccination in nine-month-old infants[J]. Public Health, 1997; 111 (4): 245-247.
9.	［9］Coutsoudis A, Adhikari M, Pillay K, Kuhn L, Coovadia HM. Effect of vitamin A supplementation on morbidity of low-birth-weight neonates[J]. South African Medical Journal, 2000; 90 (7): 730-736.
10.	［10］D’Souza RM, D’Souza R. Vitamin A for treating measles in children (Cochrane Review) [M/CD]. In: The Cochrane Library, Issue 1, 2004.
11.	［11］Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection[J]. American Journal of Clinical Nutrition, 2004; 79 (3): 430-436.
12.	［12］West KP Jr, Pokhrel RP, Katz J, LeClerq SC, Khatry SK, Shrestha SR, Pradhan EK, Tielsch JM, Pandey MR, Sommer A. Efficacy of vitamin A in reducing preschool child mortality in Nepal[J]. Lancet, 1991; 338 (8759): 67-71.
13.	［13］Ghana VAST Study Team. Vitamin A supplementationin northern Ghana: effects on clinic attendances, hospital admissions, and child mortality[J]. Lancet, 1993; 342 (8 862): 7-12.

1. ［1］Chowdhury S, Kumar R, Ganguly NK, Kumar L, Walia BN. Effect of vitamin A supplementation on childhood morbidity and mortality[J]. Indian Journal of Medical Sciences, 2002; 56 (6): 259-264.
2. ［2］Sommer A, Tarwotjo I, Djunaedi E, West KP Jr, Loeden AA, Tilden R, Mele L. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial[J]. Lancet, 1986; 1 (8491): 1 169-1 173.
3. ［3］Rahmathullah L,Underwood BA,Thulasiraj RD, Milton RC, Ramaswamy K, Rahmathullah R, Babu G. Reduced mortality among children in Southern India receiving a small weekly dose of vitamin A[J]. The New England Journal of Medicine, 1990; 323 (14): 929-935.
4. ［4］Stansfield SK, Pierre-Louis M, Lerebours G,Augustin A. Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections[J]. Lancet, 1993; 342 (8871): 578-582.
5. ［5］Herrera MG, Nestel P, El Amin A, Fawzi WW, Mohamed KA, Weld L. Vitamin A supplementation and child survival[J]. Lancet, 1992; 340 (8814): 267-271.
6. ［6］Barreto ML, Santos LM, Assis AM, Araujo MP, Farenzena GG, Santos PA, Fiaccone RL. Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil[J]. Lancet, 1994; 344 (8917): 228-231.
7. ［7］Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children[J]. The Journal of Nutrition, 1996; 126 (2): 434-442.
8. ［8］Semba RD, Akib A, Beeler J, Munasir Z, Permaesih D, Muherdiyantiningsih, Komala, Martuti S, Muhilal. Effect of vitamin A supplementation on measles vaccination in nine-month-old infants[J]. Public Health, 1997; 111 (4): 245-247.
9. ［9］Coutsoudis A, Adhikari M, Pillay K, Kuhn L, Coovadia HM. Effect of vitamin A supplementation on morbidity of low-birth-weight neonates[J]. South African Medical Journal, 2000; 90 (7): 730-736.
10. ［10］D’Souza RM, D’Souza R. Vitamin A for treating measles in children (Cochrane Review) [M/CD]. In: The Cochrane Library, Issue 1, 2004.
11. ［11］Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection[J]. American Journal of Clinical Nutrition, 2004; 79 (3): 430-436.
12. ［12］West KP Jr, Pokhrel RP, Katz J, LeClerq SC, Khatry SK, Shrestha SR, Pradhan EK, Tielsch JM, Pandey MR, Sommer A. Efficacy of vitamin A in reducing preschool child mortality in Nepal[J]. Lancet, 1991; 338 (8759): 67-71.
13. ［13］Ghana VAST Study Team. Vitamin A supplementationin northern Ghana: effects on clinic attendances, hospital admissions, and child mortality[J]. Lancet, 1993; 342 (8 862): 7-12.

《中國循證醫學雜志》

補充維生素A對兒童感染性疾病發病率與死亡率的影響

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《中國循證醫學雜志》

補充維生素A對兒童感染性疾病發病率與死亡率的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料