An Analysis of the Relationship between Resting Heart Rate Controlling and Pulse Wave Velocity in Patients with Long-standing Persistent Atrial Fibrillation_West China Medical Journal

Authors：

WANG Junzhou ¹ , LIU Kai ² , LI Longxing ² , HUANG Rui ¹ , XIAO Li ¹ ,  CHEN Xiaoping ²

1. Jin Yang Community Health Center, Wuhou District, Chengdu, Sichuan 610041, P. R. China; 2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

CHEN Xiaoping, Email: qijing2788@163.com

Keywords：

心房顫動; 動脈僵硬度; 脈搏波傳導速度; 靜息心率

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目的　研究長期持續性心房顫動患者靜息心率控制與脈搏波傳導速度（PWV）的關系。方法　序貫收集于2011年12月－2012年3月在四川大學華西醫院心臟內科門診就診的長期持續性心房顫動患者84例，將人群按靜息心率是否低于80次/min，分為標準組（心率＜80次/min）和對照組（心率≥80次/min），采用Pearson相關及多元線性回歸分析方法，研究靜息心率控制與PWV的關系。結果　①標準組人群的PWV顯著低于對照組，而飲酒率顯著高于對照組，差異皆有統計學意義（P＜0.05）。②Pearson相關分析顯示靜息心率與PWV存在線性相關關系（r=0.355，P=0.001）；多元線性回歸分析顯示，在調整了年齡、性別、BMI、收縮壓、舒張壓、吸煙、飲酒、空腹血糖、總膽固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白等混雜因素影響后，心率與PWV仍獨立相關。結論　長期持續性心房顫動患者的靜息心率控制不良與PWV升高關系密切。

Citation： WANG Junzhou,LIU Kai,LI Longxing,HUANG Rui,XIAO Li,CHEN Xiaoping. An Analysis of the Relationship between Resting Heart Rate Controlling and Pulse Wave Velocity in Patients with Long-standing Persistent Atrial Fibrillation. West China Medical Journal, 2012, 27(11): 1606-1609. doi: Copy

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2.	Fuster V, Rydén LE, Cannom DS, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation：a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society[J]. Circulation, 2006, 114(7): 257-354.
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4.	O’Rourke MF, Gallagher DE. Pulse wave analysis[J]. J Hypertens Suppl, 1996, 14(5): S147-S157.
5.	European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm AJ, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2010, 31(19): 2369-2429.
6.	Wann LS, Curtis AB, January CT, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline): a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines[J]. Heart Rhythm, 2011, 8(1): 157-176.
7.	趙月香, 王玉堂. 心房顫動心室率控制的研究進展[J]. 軍醫進修學院學報, 2012, 33(7): 796-799.
8.	Cucherat M. Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials[J]. Eur Heart J, 2007, 28(24): 3012-3019.
9.	褚穩穩, 吳秀萍. 動脈僵硬度研究進展[J]. 中華臨床醫師雜志(電子版), 2012, 6(1): 168-170.
10.	Aronow WS, Fleg JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus documents developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension[J]. J Am Coll Cardiol, 2011, 57(20): 2037-2114.
11.	O’Rourke MF, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective [J]. JACC, 2007, 50(1): 1-13.
12.	Virmani R, Avolio AP, Mergner WJ, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis [J]. Am J Pathol, 1991, 139(5): 1119-1129.
13.	da Luz PL, Coimbra SR. Wine, Alcohol and atherosclerosis: clinical evidences and mechanisms [J]. Braz J Med Biol Res, 2004, 37(9): 1275-1295.
14.	Klatsky AL, Friedman GD, Armstrong MA, et al. Wine, liquor, beer, and mortality [J]. Am J Epidemiol, 2003, 158(6): 585-595.
15.	Opie LH, Lecour S. The red wine hypothesis: from concepts to protective signalling molecules[J]. Eur Heart J, 2007, 28(14): 1683-1693.

1. 　Prystowsky EN, Benson DW Jr, Fuster V, et a1. Management of patients with atrial fibrillation: a statement for heahhcare professionals from the subcommittee on electrocardiography and electrophysiology, American Heart Association[J]. Circulation, 1996, 93(6): 1262-1277.
2. 　Fuster V, Rydén LE, Cannom DS, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation：a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society[J]. Circulation, 2006, 114(7): 257-354.
3. 　van Gelder IG, Groenveld HF, Crijns HJ, et al. Lenient versus strict rate control in patients with atrial fibrillation[J]. N Engl J Med, 2010, 362(15): 1363-1373.
4. 　O’Rourke MF, Gallagher DE. Pulse wave analysis[J]. J Hypertens Suppl, 1996, 14(5): S147-S157.
5. 　European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm AJ, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2010, 31(19): 2369-2429.
6. 　Wann LS, Curtis AB, January CT, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline): a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines[J]. Heart Rhythm, 2011, 8(1): 157-176.
7. 　趙月香, 王玉堂. 心房顫動心室率控制的研究進展[J]. 軍醫進修學院學報, 2012, 33(7): 796-799.
8. 　Cucherat M. Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials[J]. Eur Heart J, 2007, 28(24): 3012-3019.
9. 　褚穩穩, 吳秀萍. 動脈僵硬度研究進展[J]. 中華臨床醫師雜志(電子版), 2012, 6(1): 168-170.
10. 　Aronow WS, Fleg JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus documents developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension[J]. J Am Coll Cardiol, 2011, 57(20): 2037-2114.
11. 　O’Rourke MF, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective [J]. JACC, 2007, 50(1): 1-13.
12. 　Virmani R, Avolio AP, Mergner WJ, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis [J]. Am J Pathol, 1991, 139(5): 1119-1129.
13. 　da Luz PL, Coimbra SR. Wine, Alcohol and atherosclerosis: clinical evidences and mechanisms [J]. Braz J Med Biol Res, 2004, 37(9): 1275-1295.
14. 　Klatsky AL, Friedman GD, Armstrong MA, et al. Wine, liquor, beer, and mortality [J]. Am J Epidemiol, 2003, 158(6): 585-595.
15. 　Opie LH, Lecour S. The red wine hypothesis: from concepts to protective signalling molecules[J]. Eur Heart J, 2007, 28(14): 1683-1693.

West China Medical Journal

An Analysis of the Relationship between Resting Heart Rate Controlling and Pulse Wave Velocity in Patients with Long-standing Persistent Atrial Fibrillation

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