Effect of Injection with Bradykinin in Atrium Dextrum on Respiration in Neonatal Rats_West China Medical Journal

Authors：

ZHANG Xiang ¹ , SUN Mingjie ² , JI Peng ¹ , LIU Bing ¹ ,  WANG Rurong ¹

West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China;

Corresponding?author：

WANG Rurong, Email: zhangxiang2000@163.com

Keywords：

緩激肽; 迷走神經; 呼吸暫停; 新生期

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目的　探討在Sprague-Dawley大鼠右心房注射緩激肽對呼吸的影響。方法　7～9 d和21～23 d大鼠在迷走神經完整和迷走神經切斷的情況下從右心房注射緩激肽，觀察呼吸指標的變化。結果　① 右心房注射緩激肽后，7～9 d大鼠出現呼吸暫停，而在21～23 d大鼠僅出現呼吸抑制（P＜0.05）；② 切斷迷走神經后，右心房注射緩激肽在兩組大鼠均不再出現呼吸暫停。結論　右心房注射緩激肽在7～9 d大鼠產生呼吸暫停，且依賴于迷走神經的完整性。

Citation： ZHANG Xiang,SUN Mingjie,JI Peng,LIU Bing,WANG Rurong. Effect of Injection with Bradykinin in Atrium Dextrum on Respiration in Neonatal Rats. West China Medical Journal, 2012, 27(4): 549-551. doi: Copy

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5.	Soukhova G, Wang Y, Ahmed M, et al. Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit[J]. J Appl Physiol, 2003, 95(1): 241-249.
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7.	Wang R, Xu F. Postnatal development of right atrial injection of capsaicin-induced apneic response in rats[J]. J Appl Physiol, 2006, 101(1): 60-67.
8.	Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers[J]. Respir Physiol, 2001, 125(1-2): 47-65.
9.	Hasan SU, Sarnat HB, Auer RN. Vagal nerve maturation in the fetal lamb: an ultrastructural and morphometric study[J]. Anat Rec, 1993, 237(4): 527-537.
10.	Nurmi L, Heikkilä HM, Vapaatalo H, et al. Downregulation of Bradykinin type 2 receptor expression in cardiac endothelial cells during senescence[J]. J Vasc Res, 2012, 49(1): 13-23.
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1. 　Dray A, Perkins M. Bradykinin and inflammatory pain[J]. Trends Neurosci, 1993, 16(3): 99-104.
2. 　Martin RJ, Abu-Shaweesh JM. Control of breathing and neonatal apnea[J]. Biol Neonate, 2005, 87(4): 288-295.
3. 　Jammes Y, Fornaris E, Mei N, et al. Afferent and efferent components of the bronchial vagal branches in Cats[J]. J Auton Nerv Syst, 1982, 5(2): 165-176.
4. 　Undem BJ, Carr MJ. Pharmacology of airway afferent nerve activity[J]. Respir Res, 2001, 2(4): 234-244.
5. 　Soukhova G, Wang Y, Ahmed M, et al. Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit[J]. J Appl Physiol, 2003, 95(1): 241-249.
6. 　Kollarik M, Undem BJ. Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice[J]. J Physiol, 2004, 555(pt 1): 115-123.
7. 　Wang R, Xu F. Postnatal development of right atrial injection of capsaicin-induced apneic response in rats[J]. J Appl Physiol, 2006, 101(1): 60-67.
8. 　Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers[J]. Respir Physiol, 2001, 125(1-2): 47-65.
9. 　Hasan SU, Sarnat HB, Auer RN. Vagal nerve maturation in the fetal lamb: an ultrastructural and morphometric study[J]. Anat Rec, 1993, 237(4): 527-537.
10. 　Nurmi L, Heikkilä HM, Vapaatalo H, et al. Downregulation of Bradykinin type 2 receptor expression in cardiac endothelial cells during senescence[J]. J Vasc Res, 2012, 49(1): 13-23.
11. 　Klintschar M, Heimbold C. Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome[J]. Pediatrics, 2012, 129(3): e756-e761.

West China Medical Journal

Effect of Injection with Bradykinin in Atrium Dextrum on Respiration in Neonatal Rats

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