體外超聲治療對血栓性疾病的防治作用_West China Medical Journal

Authors：

潘紅霞 ,  丁明甫

Corresponding?author：

丁明甫, Email: phxia1024@126.com

Keywords：

血栓性疾病; 體外超聲治療

Video：

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卒中后患者以及脊髓損傷患者均為康復科住院患者中深靜脈血栓（DVT）形成的高危人群。DVT的發生不僅影響患者肢體功能恢復，嚴重者還可引起肺栓塞，危及生命。靜脈血栓的治療包括藥物治療、介入治療和手術治療，但各種治療均存在一定的不足和限制。無創性新技術以及新型抗凝溶栓藥的開發顯得格外重要。近年超聲治療學的發展，推動了體外超聲治療對于血栓性疾病作用的研究，是一種安全、有效的血栓預防治療輔助方法。

Citation： 潘紅霞,丁明甫. 體外超聲治療對血栓性疾病的防治作用. West China Medical Journal, 2012, 27(6): 953-956. doi: Copy

1.	Kong KH, Chua SG, Earnest A. Deep vein thrombosis in stroke patients admitted to a rehabilitation unit in Singapore[J]. Int J Stroke, 2009, 4(3): 175-179.
2.	Turpie AG. Prophylaxis of venous thromboembolism in stroke patients [J]. Semin Thromb Hemost, 1997, 23(2): 155-157.
3.	宋舟鋒, 潘兵, 盧一生. 脊髓損傷后深靜脈血栓栓塞的研究進展[J]. 頸腰痛雜志, 2012, 33(1): 59-61.
4.	Australian and New Zealand Working Party on the Management and Prevention of Venous Thromboembolism. Prevention of venous thromboembolism: best practice guidelines for Australia and New Zealand[M]. 4th ed. Sydney: Health Education & Management Innovation, 2007.
5.	李藝, 王靜. 老年髖關節損傷患者深靜脈血栓預防的體會[J]. 新疆醫學, 2011, 4l(1): 48-49.
6.	周虹. 骨科高危患者深靜脈血栓的預防及護理[J]. 中國社區醫師:醫學專業, 2011, 13(7): 196-197.
7.	張錫平. 利伐沙班、低分子肝素、脈絡舒通預防下肢全髖置換術后靜脈血栓的療效比較[J]. 中外醫學研究, 2011, 9(18): 33-34.
8.	吳丹, 葛衛紅, 于鋒. 深靜脈血栓的藥物治療研究進展[J]. 中國藥房, 2011, 22(6): 560-562.
9.	任廣蘭. 防治血栓性疾病中的抗血小板藥和抗凝血藥[J]. 中國現代藥物應用, 2011, 5(2): 155.
10.	Lippi G, Favaloro EJ, Cervellin G. Prevention of venous thromboembolism: focus on mechanical prophylaxis[J]. Semin Thromb Hemost, 2011, 37(3): 237-251.
11.	黎華珍. 間歇性充氣壓力泵對老年髖關節置換術后下肢深靜脈血栓形成的影響[J]. 齊魯護理雜志, 2011, 17(3): 40-41.
12.	延雅青, 庫洪安. 氣壓式循環驅動器預防老年骨科術后下肢DVT效果觀察及護理[J]. 齊魯護理雜志, 2011, 17(5): 17-18.
13.	高金松, 袁立英, 王兵, 等. 循序減壓彈力襪在普外科術后預防深靜脈血栓形成的應用[J]. 中國實用醫刊, 2010, 37(13): 44-45.
14.	譚春華, 文哲, 魯道海. 足底動靜脈泵在下肢骨折患者術后的應用[J]. 局解手術學雜志, 2011, 20(1): 60-61.
15.	JCS Joint Working Group. Guidelines for the diagnosis, treatment and prevention of pulmonary thromboembolism and deep vein thrombosis (JCS 2009)[J]. Circ J, 2011, 75(5): 1258-1281.
16.	童嘉毅, Mrochek AG, Stelmashok VI. 超聲治療血栓栓塞性疾病的研究進展[J]. 中華物理醫學與康復雜志, 2006, 28(3): 208-210.
17.	嚴碧歌, 牛俊得. 醫學超聲治療原理及其臨床應用研究[J]. 現代生物醫學進展, 2007, 7(8): 1246-1248.
18.	Blinc A, Francis CW, Trudnowski JL, et al. Characterization of ultrasound-potentiated fibrinolysis in vitro[J]. Blood, 1993, 81(10): 2636-2643.
19.	Harpaz D, Chen X, Francis CW, et al. Ultrasound accelerates uroki-nase-induced thrombolysis and reperfusion[J]. Am Heart J, 1994, 127(5): 1211-1219.
20.	周小煦, 吳建國. 低頻超聲體外消溶血栓的研究[J]. 實用醫學雜志, 2007, 23(15): 2368-2370.
21.	Luo H, Steffen W, Cercek B, et al. Enhancement of thrombolysis by external ultrasound[J]. Am Heart J, 1993, 125(6): 1564-1569.
22.	賈如意, 沈學東, 李志善, 等. 超聲波對犬股動脈血栓助溶作用的觀察[J]. 中華物理醫學雜志, 1998, 20(3): 14-16,69.
23.	Saguchi T, Onoue H, Urashima M, et al. Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke model[J]. Stroke, 2008, 39(3): 1007-1011.
24.	Nilsson AM, Odselius R, Roijer A, et al. Pro- and antifibrinolytic effects of ultrasound on streptokinase-induced thrombolysis[J]. Ultrasound Med Biol, 1995, 21(6): 833-840.
25.	Michael D, Marc F. Therapeutic ultrasound in ischemic stroke treatment: experimental evidence[J]. Eur J Ultrasound, 2002, 16(1-2): 121-130.
26.	王海清, 曹林生, 蔣小燕, 等. 體外治療性超聲對大鼠纖溶系統的影響[J]. 心腦血管病防治, 2003, 3(2): 18-19.
27.	賈如意, 殷潔, 岳文偉, 等. 體外治療性超聲對冠心病患者纖溶性的影響[J]. 心臟雜志, 2008, 20(3): 334-336.
28.	王懷新, 梁浩, 趙吉梅, 等. 體外超聲助溶下肢深靜脈血栓的近期療效及其對凝血和纖溶的影響[J]. 中國醫學工程, 2010, 18(1): 24-25, 27.
29.	王愛國, 王從政, 楊淑玲. 體外治療性超聲聯合抗凝對左房內血栓的近期臨床療效觀察[J]. 中國現代醫生, 2010, 48(9): 153-155.
30.	董壯麗, 楊建國, 韓森楷, 等. 超聲波治療血栓性靜脈炎的療效觀察[J]. 中國超聲醫學雜志, 1996, l2(7): 58-59.
31.	高連生, 郝樹森, 陳稚麗, 等. 體外超聲波治療頸動脈粥樣硬化斑塊的臨床研究[J]. 河北醫藥, 2010, 32(11): 1418-1419.
32.	Hitchcock KE, Holland CK. Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles[J]. Stroke, 2010, 41(10 Suppl): S50-S53.
33.	Nedelmann M, Eicke BM, Lierke EG, et al. Low-Frequency ultrasound induces nonenzymatic thrombolysis in vitro[J]. J Ultrasound Med, 2002, 21(6): 649-656.
34.	Alexandrov AV. Ultrasound enhancement of fibrinolysis[J]. Stroke, 2009, 40(3 Suppl): S107-S110.
35.	Tsivgoulis G, Eggers J, Ribo M, et al. Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies[J]. Stroke, 2010, 41(2): 280-287.

1. 　Kong KH, Chua SG, Earnest A. Deep vein thrombosis in stroke patients admitted to a rehabilitation unit in Singapore[J]. Int J Stroke, 2009, 4(3): 175-179.
2. 　Turpie AG. Prophylaxis of venous thromboembolism in stroke patients [J]. Semin Thromb Hemost, 1997, 23(2): 155-157.
3. 　宋舟鋒, 潘兵, 盧一生. 脊髓損傷后深靜脈血栓栓塞的研究進展[J]. 頸腰痛雜志, 2012, 33(1): 59-61.
4. 　Australian and New Zealand Working Party on the Management and Prevention of Venous Thromboembolism. Prevention of venous thromboembolism: best practice guidelines for Australia and New Zealand[M]. 4th ed. Sydney: Health Education & Management Innovation, 2007.
5. 　李藝, 王靜. 老年髖關節損傷患者深靜脈血栓預防的體會[J]. 新疆醫學, 2011, 4l(1): 48-49.
6. 　周虹. 骨科高危患者深靜脈血栓的預防及護理[J]. 中國社區醫師:醫學專業, 2011, 13(7): 196-197.
7. 　張錫平. 利伐沙班、低分子肝素、脈絡舒通預防下肢全髖置換術后靜脈血栓的療效比較[J]. 中外醫學研究, 2011, 9(18): 33-34.
8. 　吳丹, 葛衛紅, 于鋒. 深靜脈血栓的藥物治療研究進展[J]. 中國藥房, 2011, 22(6): 560-562.
9. 　任廣蘭. 防治血栓性疾病中的抗血小板藥和抗凝血藥[J]. 中國現代藥物應用, 2011, 5(2): 155.
10. 　Lippi G, Favaloro EJ, Cervellin G. Prevention of venous thromboembolism: focus on mechanical prophylaxis[J]. Semin Thromb Hemost, 2011, 37(3): 237-251.
11. 　黎華珍. 間歇性充氣壓力泵對老年髖關節置換術后下肢深靜脈血栓形成的影響[J]. 齊魯護理雜志, 2011, 17(3): 40-41.
12. 　延雅青, 庫洪安. 氣壓式循環驅動器預防老年骨科術后下肢DVT效果觀察及護理[J]. 齊魯護理雜志, 2011, 17(5): 17-18.
13. 　高金松, 袁立英, 王兵, 等. 循序減壓彈力襪在普外科術后預防深靜脈血栓形成的應用[J]. 中國實用醫刊, 2010, 37(13): 44-45.
14. 　譚春華, 文哲, 魯道海. 足底動靜脈泵在下肢骨折患者術后的應用[J]. 局解手術學雜志, 2011, 20(1): 60-61.
15. 　JCS Joint Working Group. Guidelines for the diagnosis, treatment and prevention of pulmonary thromboembolism and deep vein thrombosis (JCS 2009)[J]. Circ J, 2011, 75(5): 1258-1281.
16. 　童嘉毅, Mrochek AG, Stelmashok VI. 超聲治療血栓栓塞性疾病的研究進展[J]. 中華物理醫學與康復雜志, 2006, 28(3): 208-210.
17. 　嚴碧歌, 牛俊得. 醫學超聲治療原理及其臨床應用研究[J]. 現代生物醫學進展, 2007, 7(8): 1246-1248.
18. 　Blinc A, Francis CW, Trudnowski JL, et al. Characterization of ultrasound-potentiated fibrinolysis in vitro[J]. Blood, 1993, 81(10): 2636-2643.
19. 　Harpaz D, Chen X, Francis CW, et al. Ultrasound accelerates uroki-nase-induced thrombolysis and reperfusion[J]. Am Heart J, 1994, 127(5): 1211-1219.
20. 　周小煦, 吳建國. 低頻超聲體外消溶血栓的研究[J]. 實用醫學雜志, 2007, 23(15): 2368-2370.
21. 　Luo H, Steffen W, Cercek B, et al. Enhancement of thrombolysis by external ultrasound[J]. Am Heart J, 1993, 125(6): 1564-1569.
22. 　賈如意, 沈學東, 李志善, 等. 超聲波對犬股動脈血栓助溶作用的觀察[J]. 中華物理醫學雜志, 1998, 20(3): 14-16,69.
23. 　Saguchi T, Onoue H, Urashima M, et al. Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke model[J]. Stroke, 2008, 39(3): 1007-1011.
24. 　Nilsson AM, Odselius R, Roijer A, et al. Pro- and antifibrinolytic effects of ultrasound on streptokinase-induced thrombolysis[J]. Ultrasound Med Biol, 1995, 21(6): 833-840.
25. 　Michael D, Marc F. Therapeutic ultrasound in ischemic stroke treatment: experimental evidence[J]. Eur J Ultrasound, 2002, 16(1-2): 121-130.
26. 　王海清, 曹林生, 蔣小燕, 等. 體外治療性超聲對大鼠纖溶系統的影響[J]. 心腦血管病防治, 2003, 3(2): 18-19.
27. 　賈如意, 殷潔, 岳文偉, 等. 體外治療性超聲對冠心病患者纖溶性的影響[J]. 心臟雜志, 2008, 20(3): 334-336.
28. 　王懷新, 梁浩, 趙吉梅, 等. 體外超聲助溶下肢深靜脈血栓的近期療效及其對凝血和纖溶的影響[J]. 中國醫學工程, 2010, 18(1): 24-25, 27.
29. 　王愛國, 王從政, 楊淑玲. 體外治療性超聲聯合抗凝對左房內血栓的近期臨床療效觀察[J]. 中國現代醫生, 2010, 48(9): 153-155.
30. 　董壯麗, 楊建國, 韓森楷, 等. 超聲波治療血栓性靜脈炎的療效觀察[J]. 中國超聲醫學雜志, 1996, l2(7): 58-59.
31. 　高連生, 郝樹森, 陳稚麗, 等. 體外超聲波治療頸動脈粥樣硬化斑塊的臨床研究[J]. 河北醫藥, 2010, 32(11): 1418-1419.
32. 　Hitchcock KE, Holland CK. Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles[J]. Stroke, 2010, 41(10 Suppl): S50-S53.
33. 　Nedelmann M, Eicke BM, Lierke EG, et al. Low-Frequency ultrasound induces nonenzymatic thrombolysis in vitro[J]. J Ultrasound Med, 2002, 21(6): 649-656.
34. 　Alexandrov AV. Ultrasound enhancement of fibrinolysis[J]. Stroke, 2009, 40(3 Suppl): S107-S110.
35. 　Tsivgoulis G, Eggers J, Ribo M, et al. Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies[J]. Stroke, 2010, 41(2): 280-287.

West China Medical Journal

體外超聲治療對血栓性疾病的防治作用

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