Research on Efficiency of H2 Receptor Antagonists and Proton Pump Inhibitors in Alleviating Gastric Mucosal Lesions Caused by Acute Alcohol Intoxication_West China Medical Journal

Authors：

ZHOU Luming ¹ , LAI Shichao ² , HU Hai ² ,  CAO Yu ²

1. Emergency Department, Chengdu 7th People’s Hospital, Chengdu, Sichuan 610021, P. R. China; 2. Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

CAO Yu, Email: 38565592@qq.com

Keywords：

H2受體拮抗劑; 質子泵抑制劑; 急性乙醇中毒急性胃黏膜損傷; 時效性

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目的　探討H2受體拮抗劑和質子泵抑制劑（PPI）緩解急性胃黏膜損傷的時效性研究。方法　對2008年1月－2010年1月在急診科就診的98例急性乙醇中毒后胃黏膜損傷患者，隨機分為對照組50例，治療組48例。常規給予休息、保暖，補液，維持水、電解質、酸堿平衡，維持循環功能等治療基礎上，對照組給予H2受體拮抗劑治療，治療組給予PPI治療。通過觀察急性胃黏膜損傷患者上消化道癥狀及體征，記錄不同飲酒及飲酒量，并根據患者就診時間及不同飲酒組治療后上消化道癥狀完全緩解時間進行比較。結果　治療組上消化道癥狀緩解所需時間與對照組比較差異有統計學意義（P＜0.001），不同飲酒組上消化道癥狀緩解時間上差異有統計學意義（P=0.000）。結論　PPI在緩解急性乙醇中毒所致胃黏膜損傷的時效上更明顯，具有臨床價值。

Citation： ZHOU Luming,LAI Shichao,HU Hai,CAO Yu. Research on Efficiency of H2 Receptor Antagonists and Proton Pump Inhibitors in Alleviating Gastric Mucosal Lesions Caused by Acute Alcohol Intoxication. West China Medical Journal, 2012, 27(9): 1319-1321. doi: Copy

1.	Knoll MR, Kolbel CB, Teyssen S, et al. Action of pureethanol and some alcoholic beverages on the gastric mucosain healthy humans: a descriptive endoscopic study[J]. Endoscopy, 1998, 30(3): 293-301.
2.	Yakabi K, Nakamura T. Acute gastroduodenal mucosal lesion[J]. Nihon Rinsho, 1998, 56(9): 2336-2342.
3.	陳曼彤, 崔西玉, 邱小蕾, 等. 上消化道出血病因及發病趨勢分析[J]. 實用臨床醫學, 2005, 6(10): 15-17.
4.	拓楠, 余宏宇. 酒精致胃黏膜損傷的研究進展[J]. 中國實用內科雜志, 2009, 29(12): 1145-1146.
5.	Brzozowski T, Konturek PC, Konturek SJ, et al. Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin[J]. Int J Colorectal Dis, 2003, 18(4): 320-329.
6.	Kwiecień S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury[J]. J Physiol Pharmacol, 2002, 53(1): 39-50.
7.	張宏亮, 徐楊, 范曉. 不同病因導致的應激性胃黏膜損傷中環氧化酶-2的改變[J]. 華西醫學, 2010, 25(5): 833-836.
8.	何紹珍, 任建林. 乙醇對胃黏膜作用機制的研究進展[J]. 世界華人消化雜志, 2005, 13(21): 2591-2596.
9.	吳燕燕, 郭勇, 鄒妤婕. 泮托拉唑治療急性酒精中毒后胃黏膜損傷的療效觀察[J]. 中國藥房, 2011, 22(28): 2650-2652.
10.	Sibilia V, Rindi G, Pagani F, et al. Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action[J]. Endocrinology, 2003, 144(1): 353-359.

1. 　Knoll MR, Kolbel CB, Teyssen S, et al. Action of pureethanol and some alcoholic beverages on the gastric mucosain healthy humans: a descriptive endoscopic study[J]. Endoscopy, 1998, 30(3): 293-301.
2. 　Yakabi K, Nakamura T. Acute gastroduodenal mucosal lesion[J]. Nihon Rinsho, 1998, 56(9): 2336-2342.
3. 　陳曼彤, 崔西玉, 邱小蕾, 等. 上消化道出血病因及發病趨勢分析[J]. 實用臨床醫學, 2005, 6(10): 15-17.
4. 　拓楠, 余宏宇. 酒精致胃黏膜損傷的研究進展[J]. 中國實用內科雜志, 2009, 29(12): 1145-1146.
5. 　Brzozowski T, Konturek PC, Konturek SJ, et al. Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin[J]. Int J Colorectal Dis, 2003, 18(4): 320-329.
6. 　Kwiecień S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury[J]. J Physiol Pharmacol, 2002, 53(1): 39-50.
7. 　張宏亮, 徐楊, 范曉. 不同病因導致的應激性胃黏膜損傷中環氧化酶-2的改變[J]. 華西醫學, 2010, 25(5): 833-836.
8. 　何紹珍, 任建林. 乙醇對胃黏膜作用機制的研究進展[J]. 世界華人消化雜志, 2005, 13(21): 2591-2596.
9. 　吳燕燕, 郭勇, 鄒妤婕. 泮托拉唑治療急性酒精中毒后胃黏膜損傷的療效觀察[J]. 中國藥房, 2011, 22(28): 2650-2652.
10. 　Sibilia V, Rindi G, Pagani F, et al. Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action[J]. Endocrinology, 2003, 144(1): 353-359.

West China Medical Journal

Research on Efficiency of H2 Receptor Antagonists and Proton Pump Inhibitors in Alleviating Gastric Mucosal Lesions Caused by Acute Alcohol Intoxication

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