The Effect of Dexmedetomidine on the Agitation Induced by Sevoflurane during the Recovery Period of General Anesthesia in Children_West China Medical Journal

Authors：

ZHAO Yanling ¹ , WANG Guanglei ²

1. Department of Anesthesiology, Tongshan Daxu Town Center Hospital, Xuzhou, Jiangsu 221124, P. R. China; 2. Department of Anesthesiology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P. R. China;

Corresponding?author：

Keywords：

右美托咪定; 七氟烷; 麻醉，吸入; 躁動

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目的　探討右美托咪定對小兒七氟烷吸入麻醉蘇醒期躁動的影響。方法　選擇2011年3月－2012年1月美國麻醉醫師協會分級Ⅰ～Ⅱ級、年齡2～8歲、擇期行疝囊高位結扎術和隱睪下降固定術患兒40例，隨機分為2組，右美托咪定組（A組）和對照組（B組），兩組患兒在年齡、體重、手術種類無明顯差異。兩組患兒均采用面罩8%七氟烷吸入麻醉誘導，開放靜脈，給予鹽酸戊乙奎醚0.1 mg/kg、順式阿曲庫銨0.15 mg/kg，插入喉罩，麻醉維持根據血壓、心率及腦電雙頻指數調節吸入麻醉藥濃度。A組靜脈給予1 μg/kg右美托咪定，B組給予同等容量的生理鹽水。入室至手術結束時連續觀察收縮壓、舒張壓、心率、血氧飽和度，記錄清醒時間、拔除喉罩時間，記錄蘇醒期并發癥的發生數。記錄入麻醉恢復室即刻（0 min）、15、30、60、90 min患兒疼痛和躁動評分。結果　兩組患兒在手術時間、清醒時間以及拔除喉罩時間差異無統計學意義（P＞0.05），A組術后入恢復室0、15、30 min疼痛評分和躁動評分均低于B組（P＜0.05），兩組患兒圍術期均未出現低血壓和心動過緩。結論　右美托咪定用于小兒七氟烷吸入麻醉能夠增強術后鎮痛，減少蘇醒期躁動。

Citation： ZHAO Yanling,WANG Guanglei. The Effect of Dexmedetomidine on the Agitation Induced by Sevoflurane during the Recovery Period of General Anesthesia in Children. West China Medical Journal, 2012, 27(9): 1366-1368. doi: Copy

1.	Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale[J]. Anesthesiology, 2004, 100(5): 1138-1145.
2.	Cole JW, Murray DJ, Mcallister JD, et al. Emergence behaviour in children: defining the incidence of excitement and agitation following anaesthesia[J]. Paediatr Anaesth, 2002, 12(5): 442-447.
3.	Weldon BC, Bell M, Craddock T. The effect of caudal analgesia on emergence agitation in children after sevoflurane versus halothane anesthesia[J]. Anesth Analg, 2004, 98(2): 321-326.
4.	郭繼龍, 張聯義, 王光磊, 等. 腹股溝斜疝修補術的臨床觀察[J]. 徐州醫學院學報, 2008, 28(1): 746-748.
5.	Veyckemans F. Excitation phenomena during sevoflurane anaesthesia in children[J]. Curr Opin Anaesthesiol, 2001, 14(3): 339-343.
6.	Okamoto T, Mori T, Takeda T, et al. Dexmedetomidine is an excellent sedative for voice monitoring surgery[J]. Masui, 2012, 61(5): 542-554.
7.	Bajwa SJ, Kaur J, Singh A, et al. Attenuation of pressor response and dose sparing of opioids and anaesthetics with pre-operative dexmedetomidine[J]. Indian J Anaesth, 2012, 56(2): 123-128.
8.	Blaudszun G, Lysakowski C, Elia N, et al. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials[J]. Anesthesiology, 2012, 116(6): 1312-1322.
9.	Santos LC, Ludders JW, Erb HN, et al. A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats[J]. Vet Anaesth Analg, 2011, 38(4): 320-327.
10.	Massad IM, Mohsen WA, Basha AS, et al. A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery[J]. Saudi Med J, 2009, 30(12): 1537-1541.
11.	Mizrak A, Erbagci I, Arici T, et al. Dexmedetomidine use during strabismus surgery in agitated children[J]. Med Princ Pract, 2011, 20(5): 427-432.
12.	Ozcengiz D, Gunes Y, Melatonin O. Dexmedetomidine and midazolam for prevention of postoperative agitation in children[J]. J Anesth, 2011, 25(2): 184-188.
13.	Isik B, Arslan M, Tunga AD, et al. Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery[J]. Paediatr Anaesth, 2006, 16(7): 748-753.
14.	Saadawy I, Boker A, Elshahawy MA, et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics[J]. Acta Anaesthesiol Scand, 2009, 53(2): 251-256.

1. 　Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale[J]. Anesthesiology, 2004, 100(5): 1138-1145.
2. 　Cole JW, Murray DJ, Mcallister JD, et al. Emergence behaviour in children: defining the incidence of excitement and agitation following anaesthesia[J]. Paediatr Anaesth, 2002, 12(5): 442-447.
3. 　Weldon BC, Bell M, Craddock T. The effect of caudal analgesia on emergence agitation in children after sevoflurane versus halothane anesthesia[J]. Anesth Analg, 2004, 98(2): 321-326.
4. 　郭繼龍, 張聯義, 王光磊, 等. 腹股溝斜疝修補術的臨床觀察[J]. 徐州醫學院學報, 2008, 28(1): 746-748.
5. 　Veyckemans F. Excitation phenomena during sevoflurane anaesthesia in children[J]. Curr Opin Anaesthesiol, 2001, 14(3): 339-343.
6. 　Okamoto T, Mori T, Takeda T, et al. Dexmedetomidine is an excellent sedative for voice monitoring surgery[J]. Masui, 2012, 61(5): 542-554.
7. 　Bajwa SJ, Kaur J, Singh A, et al. Attenuation of pressor response and dose sparing of opioids and anaesthetics with pre-operative dexmedetomidine[J]. Indian J Anaesth, 2012, 56(2): 123-128.
8. 　Blaudszun G, Lysakowski C, Elia N, et al. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials[J]. Anesthesiology, 2012, 116(6): 1312-1322.
9. 　Santos LC, Ludders JW, Erb HN, et al. A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats[J]. Vet Anaesth Analg, 2011, 38(4): 320-327.
10. 　Massad IM, Mohsen WA, Basha AS, et al. A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery[J]. Saudi Med J, 2009, 30(12): 1537-1541.
11. 　Mizrak A, Erbagci I, Arici T, et al. Dexmedetomidine use during strabismus surgery in agitated children[J]. Med Princ Pract, 2011, 20(5): 427-432.
12. 　Ozcengiz D, Gunes Y, Melatonin O. Dexmedetomidine and midazolam for prevention of postoperative agitation in children[J]. J Anesth, 2011, 25(2): 184-188.
13. 　Isik B, Arslan M, Tunga AD, et al. Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery[J]. Paediatr Anaesth, 2006, 16(7): 748-753.
14. 　Saadawy I, Boker A, Elshahawy MA, et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics[J]. Acta Anaesthesiol Scand, 2009, 53(2): 251-256.

West China Medical Journal

The Effect of Dexmedetomidine on the Agitation Induced by Sevoflurane during the Recovery Period of General Anesthesia in Children

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