黃芩及黃酮類成分防治腫瘤作用的研究進展_West China Medical Journal

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黃芩及黃酮類成分防治腫瘤作用的研究進展

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黃芩; 黃芩黃酮; 防治; 腫瘤

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【摘要】　黃芩為唇形科草本植物黃芩（scutellaria baicalensis georgi）的干燥根，已有二千余年的應用歷史。經現代醫學證明黃芩除了具有抗炎、抗病原微生物、降壓、利膽、鎮靜、抗過敏、抗氧化等作用，黃芩及其黃酮類成分還表現出調節多種腫瘤細胞的增殖、凋亡、運動、侵襲和血管生成等功效，使其有望成為防治腫瘤的一種理想藥物。

Citation： 黃芩及黃酮類成分防治腫瘤作用的研究進展. 黃芩及黃酮類成分防治腫瘤作用的研究進展. West China Medical Journal, 2011, 26(2): 297-300. doi: Copy

1.	陳發奎, 劉曉秋. 中藥有效成分含量測定[M]. 人民衛生出版社, 2008, 1844-1845.
2.	Lee JH, Li YC, Ip SW, et al. The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway[J]. Anticancer Res, 2008, 28(3A): 1701-1711.
3.	Lu HF, Hsueh SC, Ho YT, et al. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway[J]. Anticancer Res, 2007, 27(1A): 117-125.
4.	Baumann S, Fas SC, Giaisi M, et al. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCγ1- and Ca2+-dependent apoptosis[J]. Blood, 2008, 111(4): 2354-2363.
5.	Taniguchi H, Yoshida T, Horinaka M, et al. Baicalein overcomes tumor necrosis factor - related apoptosis inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells[J]. Cancer Res, 2008, 68(21): 8918-8927.
6.	Lee DH, Kim C, Zhang L, et al. Role of p53, PUMA and bax in wogonin- induced apoptosis in human cancer cells[J]. Biochem Pharmacol, 2008, 75(10): 2020-2033.
7.	Wang CZ, Li XL, Wang QF, et al. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells[J]. Phytomedicine, 2010, 17(1): 63-68.
8.	Chung H, Jung YM, Shin DH, et al. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts[J]. Int J Cancer, 2008, 122(4): 816-822.
9.	Pidgeon GP, Kandouz M, Meram A, et al. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibitionin prostate cancer cells[J]. Cancer Res, 2002, 62(9): 2721-2727.
10.	Chen CH, Huang TS, Wong CH, et al. Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 cells[J]. Food Chem Toxicol, 2009, 47(3): 638-644.
11.	Lee S, Jeong YJ, Yu MH. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells[J]. Biochem Biophys Res Commun, 2006, 351(1): 118-125.
12.	Miocinovic R, McCabe NP, Keck RW, et al. In vivo and in vitro effect of baicalein on human prosate cancer cell[J]. Int J Oncol, 2005, 26(1): 241-246.
13.	Gao Z, Huang K, Yang X, et al. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi[J]. Biochim Biophys Acta, 1999, 1472(3): 643-650.
14.	李越. 天然藥物抗氧化成分構效關系研究進展[J]. 天津藥學, 2006, 18 (2): 57-60.
15.	楊濱, 梁日欣, 周曉寧, 等. 黃芩脂質過氧化抑制率與有效成分含量的相關性研究[J]. 中國中藥雜志, 2008, 33(16): 2019-2022.
16.	Fas SC, Baumann S, Zhu JY, et al. Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis[J]. Blood, 2006, 108(12): 3700-3706.
17.	伍斌, 謝紅付, 李吉, 等. 黃芩素對A431細胞埃茲蛋白表達及侵襲力的影響[J]. 中華皮膚科雜志, 2010, 43(3): 168-173.
18.	王秀峰, 周錢梅, 蘇式兵. 黃芩素抑制人乳腺癌細胞侵襲和遷移的實驗研究[J]. 中國藥理學通報, 2010, 26(6): 745-750.
19.	Huang ST, Wang CY, Yang RC, et al. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells[J]. Phytomedicine, 2010, 17(1): 47-54.
20.	Tang NY, Yang JS, Chang YH, et al. Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in sprague-dawley rats[J]. In Vivo, 2006, 20(4): 527-532.
21.	Kaneko T, Chiba H, Horie N , et al. Effect of Scutellariae radix ingredients on prostaglandin E2 production and COX-2 expression by LPS-activated macrophage[J]. In Vivo, 2009, 23(4): 577-581.
22.	Huang RL, Chen CC, Huang HL, et al. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis[J]. Planta Med, 2000, 66(8): 694-698.
23.	Guo Q, Zhao L, You Q, et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo[J]. Antiviral Res, 2007, 74(1): 16-24.

1. 　陳發奎, 劉曉秋. 中藥有效成分含量測定[M]. 人民衛生出版社, 2008, 1844-1845.
2. 　Lee JH, Li YC, Ip SW, et al. The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway[J]. Anticancer Res, 2008, 28(3A): 1701-1711.
3. 　Lu HF, Hsueh SC, Ho YT, et al. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway[J]. Anticancer Res, 2007, 27(1A): 117-125.
4. 　Baumann S, Fas SC, Giaisi M, et al. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCγ1- and Ca2+-dependent apoptosis[J]. Blood, 2008, 111(4): 2354-2363.
5. 　Taniguchi H, Yoshida T, Horinaka M, et al. Baicalein overcomes tumor necrosis factor - related apoptosis inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells[J]. Cancer Res, 2008, 68(21): 8918-8927.
6. 　Lee DH, Kim C, Zhang L, et al. Role of p53, PUMA and bax in wogonin- induced apoptosis in human cancer cells[J]. Biochem Pharmacol, 2008, 75(10): 2020-2033.
7. 　Wang CZ, Li XL, Wang QF, et al. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells[J]. Phytomedicine, 2010, 17(1): 63-68.
8. 　Chung H, Jung YM, Shin DH, et al. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts[J]. Int J Cancer, 2008, 122(4): 816-822.
9. 　Pidgeon GP, Kandouz M, Meram A, et al. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibitionin prostate cancer cells[J]. Cancer Res, 2002, 62(9): 2721-2727.
10. 　Chen CH, Huang TS, Wong CH, et al. Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 cells[J]. Food Chem Toxicol, 2009, 47(3): 638-644.
11. 　Lee S, Jeong YJ, Yu MH. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells[J]. Biochem Biophys Res Commun, 2006, 351(1): 118-125.
12. 　Miocinovic R, McCabe NP, Keck RW, et al. In vivo and in vitro effect of baicalein on human prosate cancer cell[J]. Int J Oncol, 2005, 26(1): 241-246.
13. 　Gao Z, Huang K, Yang X, et al. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi[J]. Biochim Biophys Acta, 1999, 1472(3): 643-650.
14. 　李越. 天然藥物抗氧化成分構效關系研究進展[J]. 天津藥學, 2006, 18 (2): 57-60.
15. 　楊濱, 梁日欣, 周曉寧, 等. 黃芩脂質過氧化抑制率與有效成分含量的相關性研究[J]. 中國中藥雜志, 2008, 33(16): 2019-2022.
16. 　Fas SC, Baumann S, Zhu JY, et al. Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis[J]. Blood, 2006, 108(12): 3700-3706.
17. 　伍斌, 謝紅付, 李吉, 等. 黃芩素對A431細胞埃茲蛋白表達及侵襲力的影響[J]. 中華皮膚科雜志, 2010, 43(3): 168-173.
18. 　王秀峰, 周錢梅, 蘇式兵. 黃芩素抑制人乳腺癌細胞侵襲和遷移的實驗研究[J]. 中國藥理學通報, 2010, 26(6): 745-750.
19. 　Huang ST, Wang CY, Yang RC, et al. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells[J]. Phytomedicine, 2010, 17(1): 47-54.
20. 　Tang NY, Yang JS, Chang YH, et al. Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in sprague-dawley rats[J]. In Vivo, 2006, 20(4): 527-532.
21. 　Kaneko T, Chiba H, Horie N , et al. Effect of Scutellariae radix ingredients on prostaglandin E2 production and COX-2 expression by LPS-activated macrophage[J]. In Vivo, 2009, 23(4): 577-581.
22. 　Huang RL, Chen CC, Huang HL, et al. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis[J]. Planta Med, 2000, 66(8): 694-698.
23. 　Guo Q, Zhao L, You Q, et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo[J]. Antiviral Res, 2007, 74(1): 16-24.

West China Medical Journal

黃芩及黃酮類成分防治腫瘤作用的研究進展

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