Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy_West China Medical Journal

Authors：

YANG Chengbin ¹ ,  FENG Ping ² , CEN Yihu ¹ , LIANG Cheng ¹

1. The People’s Hospital of Butuo County, Butuo, Sichuan 616350, P. R. China; 2. Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

FENG Ping, Email: ycb20088@163.com

Keywords：

艾滋病; 耐藥性; 高效抗逆轉錄病毒療法; 病毒載量

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【摘要】　目的　評價高效抗逆轉錄病毒療法（highly active antiretroviral therapy，HAART）對艾滋病患者的療效，并觀察其耐藥情況。　方法　 2008年11月，對23例接受免費HAART治療1~3年的艾滋病患者的HIV-RNA病毒載量、HIV-1耐藥、CD4+T淋巴細胞絕對計數、常規生化檢測結果進行分析。　結果　 23例艾滋病患者在HAART治療1~3年后有6例（26.1%）患者HIV-RNA載量在水平線以下，17例（73.9%）HIV-RNA載量未達到檢測線以下。5例患者（21.7%）的HIV-1發生了耐藥，服藥依從性良好的患者僅9例（39.1%）。　結論　 HAART對艾滋病患者的療效較差、耐藥率高、服藥依從性差。
【Abstract】　Objective　 To evaluate the efficacy of highly active antiretroviral therapy (HAART) in treating HIV, and observe the resistance of HAART in AIDS patients.　Methods　 Twenty-three HIV patients receiving free HAART for one to three years were investigated. The plasma viral load, drug resistance to HIV-1, CD4+ T cell count were tested and routine laboratory examinations were performed in our study.　Results　 After one to fhnee-year HAART treatment, HIV viral load of six patients (26.1%) declined to the undetectable level, while the viral load of 17 patients (73.9%) kept at a high level. Resistance to HIV-1 occurred in five cases (21.7%). Only nine patients (39.1%) had good treatment compliance.　Conclusion　 HAART has a poor therapeutic effect on patients with HIV/AIDS with a high rate of drug resistance and poor treatment compliance.

Citation： YANG Chengbin,FENG Ping,CEN Yihu,LIANG Cheng. Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy. West China Medical Journal, 2011, 26(3): 424-426. doi: Copy

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1. 　張福杰, 文毅, 于蘭, 等. 艾滋病的抗病毒治療與我國的免費治療現狀[J]. 科技導報, 2005, 23(7): 24-29.
2. 　張福杰, 李太生, 王建, 等. 國家免費艾滋病抗病毒治療手冊[M]. 2版. 北京: 人民出版社, 2008: 12-16.
3. 　代麗麗, 楊瑞侃, 周舜泰. 抗反轉錄病毒治療[M]. 艾滋病診療學, 2009: 54-85.
4. 　Montaner JS, Reiss P, Cooper D, et al. A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS trial. Italy, The Netherlands, Canada and Australia Study[J]. JAMA, 1998, 279(2): 930-937.
5. 　Bangsbery DR, Hecht FM, Charlebois ED, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population[J]. AIDS, 2000, 14(1): 357-366.
6. 　Paterson DL, Swindells S, Mohr J, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection[J]. Ann Intern Med, 2000, 133(1): 21-30.
7. 　Shet A, Markowitz M. Transmitted multidrug resistant HIV-1; new and investigational therapeutic approaches[J]. Curr Opin Investig Drugs, 2006, 7(8): 709-720.
8. 　劉明斌, 熊志偉, 徐丹, 等. HIV耐藥的研究進展[J]. 中國艾滋病性病, 2007, 13(6): 588-590.
9. 　張福杰, 尚紅, 吳昊主. 艾滋病診療學(2007年版)[M]. 北京: 人民衛生出版社, 2009: 246-270.

West China Medical Journal

Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy

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