老年血清胱抑素C水平與急性心肌梗死相關性研究_《華西醫學》

作者：

韓幸 ¹ ,  吳錦暉 ² , 雷曉燕 ¹ , 張紹敏 ² , 趙艷萍 ²

1 四川省第四人民醫院急診內科（成都，610021）;2 四川大學華西醫院老年病科;

關鍵詞：

胱抑素C 急性心肌梗死老年

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【摘要】　目的　觀察70歲以上老年心肌梗死急性期血清胱抑素C（cystatin C，CysC）水平，探討急性心肌梗死后CysC水平變化的意義。　方法　順序入選2010年7月-2011年7月期間70歲以上急性心肌梗死患者58例及正常對照58例。入選對象均經冠狀動脈造影檢查確診或排除診斷，記錄急性心肌梗死患者梗死部位和梗死相關血管，并計算Gensini積分。所有入選對象采血，使用乳膠增強免疫透射比濁法測定急性期血清CysC水平。　結果　心肌梗死急性期，血清CysC水平低于正常對照組（P lt;0.05）；不同冠狀動脈病變評分與血清CysC水平呈負相關，Gensini積分越高，血清CysC水平越低。　結論　血清CysC與冠心病關系密切。檢測CysC，為冠心病的風險預測、老年患者危險分層和治療提供一條新的線索和途徑。

引用本文： 韓幸,吳錦暉,雷曉燕,張紹敏,趙艷萍. 老年血清胱抑素C水平與急性心肌梗死相關性研究. 華西醫學, 2011, 26(9): 1309-1311. doi: 復制

1.	Grubb A, Löfberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis[J]. Proc Natl Acad Sci USA, 1982, 79(9): 3024-3027.
2.	Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction[J]. Circulation, 2007, 116(22): 2634-2653.
3.	Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51(3): 606-606.
4.	Shi GP, Sukhova GK, Grubb A, et al. Cystatin c deficiency in human atherosclerosis and aortic aneurysms[J]. J Clin Invest, 1999, 104(9): 1191-1197.
5.	Cheng XW, Kuzuya M. Sasaki T, et al. Increased expression of elastolytic cysteine proteasesa,cathepsins S and K, in the neointima of balloon-injured rat carotid arteries[J]. Am J Pathol, 2004, 164(1): 243-251.
6.	Luc G, Bard JM, Lesueur C, et al. Plasma cystatin-C and development of coronary heart disease: the PRIME Study[J]. Atherosclersis, 2006, 85(2): 375-380.
7.	Koeni W, Twardella D, Brenner H, et al. Plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rat[J]. Clin Chem, 2005, 51 (2): 321-327.
8.	Noto D, Cefalu AB, Barbagallo CM, et al. Cystatin C levels are decreased in acute myocardial infarction: effect of cystatin C G73A gene polymorphism on plasma level[J]. Int J Cardiol, 2005, 101(2): 213-217.
9.	馮建芳, 汪淑榮, 李平, 等. 急性心肌梗死病人血清巰基蛋白酶抑制肽C的變化[J]. 基礎醫學與臨床, 1995, 15(4): 45-47.
10.	Sukhova GK, Wang B, Libby P, et al. Cystatin C deficiency increase elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice[J]. Circ Res, 2005, 96(3): 368-375.
11.	Eriksson P, DeguchiH, Samnegard A, et al. Human evidence that the cystatin C gene is imp licated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2004, 24(3): 551-557.
12.	Kilic T, Oner G, Ural E, et al. Comparison of the long-term prognostic value of cystatin C to other indicators of renal function, markers of inflammation and systolic dysfunction among patients with acute coronary syndrome[J]. Atherosclerosis, 2009, 207(2): 552-558.
13.	Ichimoto E, Jo K, Kobayashi Y, et al. Prognostic significance of cystatin C in patients with ST-elevation myocardial infarction[J]. Circ J, 2009, 73(9): 1669-1673.
14.	Frendéus KH, Wallin H, Janciauskiene S, et al. Macrophage responses to interferon-gamma are dependent on cystatin C levels[J]. Int J Biochem Cell Biol, 2009, 41(11): 2262-2269.
15.	Naruse H, Ishii J, Kawai T, et al. Cystatin C in acute heart failure without advanced renal impairment[J]. Am J Med, 2009, 122(6): 566-573.
16.	García Acuna JM, González-Babarro E, Grigorian Shamagian L, et al. Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome[J]. Rev Esp Cardiol, 2009, 62(5): 510-519.

1. 　Grubb A, Löfberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis[J]. Proc Natl Acad Sci USA, 1982, 79(9): 3024-3027.
2. 　Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction[J]. Circulation, 2007, 116(22): 2634-2653.
3. 　Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51(3): 606-606.
4. 　Shi GP, Sukhova GK, Grubb A, et al. Cystatin c deficiency in human atherosclerosis and aortic aneurysms[J]. J Clin Invest, 1999, 104(9): 1191-1197.
5. 　Cheng XW, Kuzuya M. Sasaki T, et al. Increased expression of elastolytic cysteine proteasesa,cathepsins S and K, in the neointima of balloon-injured rat carotid arteries[J]. Am J Pathol, 2004, 164(1): 243-251.
6. 　Luc G, Bard JM, Lesueur C, et al. Plasma cystatin-C and development of coronary heart disease: the PRIME Study[J]. Atherosclersis, 2006, 85(2): 375-380.
7. 　Koeni W, Twardella D, Brenner H, et al. Plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rat[J]. Clin Chem, 2005, 51 (2): 321-327.
8. 　Noto D, Cefalu AB, Barbagallo CM, et al. Cystatin C levels are decreased in acute myocardial infarction: effect of cystatin C G73A gene polymorphism on plasma level[J]. Int J Cardiol, 2005, 101(2): 213-217.
9. 　馮建芳, 汪淑榮, 李平, 等. 急性心肌梗死病人血清巰基蛋白酶抑制肽C的變化[J]. 基礎醫學與臨床, 1995, 15(4): 45-47.
10. 　Sukhova GK, Wang B, Libby P, et al. Cystatin C deficiency increase elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice[J]. Circ Res, 2005, 96(3): 368-375.
11. 　Eriksson P, DeguchiH, Samnegard A, et al. Human evidence that the cystatin C gene is imp licated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2004, 24(3): 551-557.
12. 　Kilic T, Oner G, Ural E, et al. Comparison of the long-term prognostic value of cystatin C to other indicators of renal function, markers of inflammation and systolic dysfunction among patients with acute coronary syndrome[J]. Atherosclerosis, 2009, 207(2): 552-558.
13. 　Ichimoto E, Jo K, Kobayashi Y, et al. Prognostic significance of cystatin C in patients with ST-elevation myocardial infarction[J]. Circ J, 2009, 73(9): 1669-1673.
14. 　Frendéus KH, Wallin H, Janciauskiene S, et al. Macrophage responses to interferon-gamma are dependent on cystatin C levels[J]. Int J Biochem Cell Biol, 2009, 41(11): 2262-2269.
15. 　Naruse H, Ishii J, Kawai T, et al. Cystatin C in acute heart failure without advanced renal impairment[J]. Am J Med, 2009, 122(6): 566-573.
16. 　García Acuna JM, González-Babarro E, Grigorian Shamagian L, et al. Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome[J]. Rev Esp Cardiol, 2009, 62(5): 510-519.

《華西醫學》

老年血清胱抑素C水平與急性心肌梗死相關性研究

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《華西醫學》

老年血清胱抑素C水平與急性心肌梗死相關性研究

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