新輔助化學療法在局部晚期宮頸癌中的研究進展_《華西醫學》

作者：

龔琳 ,  彭芝蘭

四川大學華西第二醫院婦產科（成都，610041）;

關鍵詞：

局部晚期宮頸癌新輔助化學療法同步放射化學療法研究進展

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

【摘要】　宮頸癌的傳統治療方式是根治性手術和放射治療。以往根據宮頸癌的演變過程，浸潤癌的高發年齡為50~55歲，且85%以上是鱗狀細胞癌，對放射治療敏感，放射治療可達到根治的效果。但近年來，宮頸癌發病有明顯年輕化趨勢，與其他年齡組比較，年輕宮頸癌患者具有顯著不同的臨床和病理特征，如非鱗癌比例高、淋巴結轉移率高和局部臨床期別晚等特點。對于這類患者，若單純手術或放射治療，不僅5年生存率低，而且術后易復發，放射治療者會嚴重影響其卵巢和陰道功能。為了提高局部晚期宮頸癌患者的生存率，減少復發，必須打破宮頸癌的傳統治療模式。如今，隨著化學療法藥物的開發利用和療效的提高，新輔助化學療法已成為局部晚期宮頸癌患者綜合治療中的重要組成部分，化學療法后首選手術，正成為治療中青年宮頸癌患者的發展趁勢。

引用本文： 龔琳,彭芝蘭. 新輔助化學療法在局部晚期宮頸癌中的研究進展. 華西醫學, 2011, 26(9): 1432-1436. doi: 復制

1.	王澤華. 重視和規范宮頸癌的新輔助化療[J]. 華中醫學雜志, 2007, 31 (6): 423-424.
2.	Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium[J]. Int J Gynaecol Obstet, 2009, 105(2): 103-104.
3.	Timotheadou E, Gore ME. Neoadjuvant chemotherapy for locally advanced cervical cancer[J]. Eur J Cancer, 2003, 39(17): 2419-2421.
4.	Tiersten AD, Selleck MJ, Hershman DL, et al. Phase Ⅱ study of topotecan and paclitaxel for persistent, or metastatic cervical cancer[J]. Gynecol Oncol, 2004, 92(2): 635-638.
5.	Eddy G, Bundy B, CreasmanW, et al. Treatment of (bulky)stage Ⅰb cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical surgery and pelvic/para-aortic lymphadenectomy: a phase Ⅲ trial of the gynecologic oncology group[J]. Gynecol Oncol, 2007, 106(2): 362-369.
6.	Han SC, 章青, 陸嘉德. 大腫塊ⅠB、ⅡA期及局部晚期宮頸癌的治療[J]. 中國癌癥雜志, 2006, 16(11): 890-895.
7.	Elit L, Fyles AW, Devries MC, et al. Follow-up for women after treatment for cervical cancer: a systematic review[J]. Gynecol Oncol, 2009, 114 (3): 528-535.
8.	Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01[J]. J Clin Oncol, 2004, 22(5): 872-880.
9.	劉成紅, 毛熙光, 伍宗惠. 近10年川南地區宮頸癌臨床特點變化趨勢分析[J]. 瀘州醫學院學報, 2008, 31(3): 312-315.
10.	Zhao EF, Bao L, Li C, et al. Changes in epidemiology and clinical characteristics of cervical cancer over the past 50 years[J]. J First Mil Med Univ, 2005, 25(6): 605-609.
11.	Frei E. Clinical cancer research: an embattled species[J]. Cancer, 1982, 50(10): 1979-1992.
12.	Ryu HS, Kang SB, Kim KT, et al. Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005)[J]. Int J Gynecol Cancer, 2007, 17(1): 132-136.
13.	趙虹, 王曉燕, 邵淑麗, 等. Ⅰb2-Ⅱb期宮頸鱗癌新輔助化療前后Bcl-2和Bax的表達差異[J]. 山西醫科大學學報, 2008, 39(11): 995-997.
14.	Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC[J]. Nature, 1999, 399(6735): 483-487.
15.	李莉, 李庭芳, 劉開江. 宮頸癌新輔助化療臨床病理、電鏡改變及作用機制的初步探討[J]. 中國婦產科臨床雜志, 2005, 9(9): 439-442.
16.	Robati M, Holtz D, Dunton CJ. A review of topotecan in combination chemotherapy for advanced cervical cancer[J]. Ther Clin Risk Manag, 2008, 4(1): 213-218.
17.	Souhami L, Gil RA, Allan SE, et al. A randomized trial of chemotherapy followed by pelvic radiation therapy in stage ⅢB carcinoma of the cervix[J]. J Clin Oncol, 1991, 9(6): 970-977.
18.	李慶水, 張錫芹, 李大鵬, 等. 子宮頸癌放療前新輔助化療的臨床研究[J]. 中華婦產科雜志, 2006, 41(2): 83-87.
19.	Tabata T, Takeshima N, Nishida H, et al. A randomized study of primary bleomycin, vincristine, mitomycin and cisplatin (BOMP) chemotherapy followed by radiotherapy versus radiotherapy alone in stage IIIB and IVA squamous cell carcinoma of the cervix[J]. Anticancer Res, 2003, 23(3C): 2885-2890.
20.	Tierney J. Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review andmeta-analysis of individual patient data from 21 randomized trials[J]. Eur J Cancer, 2003, 39 (17): 2470-2486.
21.	Bader HA, Winter R, Moinfar F, et al. Is intraoperative frozen section analysis of pelvic lymph nodes accurate after neoadjuvant chemotherapy in patients with cervical cancer?[J]. Gynecol Oncol, 2006, 103(1): 106-112.
22.	Chun M. Time for global efforts with clinical trials for advanced cervical cancer patients[J]. J Gynecol Oncol, 2009, 20(4): 201-202.
23.	Kumar JV, Doval DC, Rao R, et al. A retrospective study of patients with locally advanced cancer of the cervix treated with neoadjuvant chemotherapy followed by radical surgery[J]. Int J Gynecol Cancer, 2009, 19(3): 417- 422.
24.	邱俊源, 李莉, 雷箏. 宮頸癌新輔助化療近期療效觀察[J]. 中華全科醫學, 2009, 7(10): 1083-1084.
25.	Term rungruanglert W, Tresukosol D, Vasuratna A, et al. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in (bulky) squamous cell carcinoma of cervix stage IB2[J]. Gynecol Oncol, 2005, 97(2): 576-581.
26.	Benedetti-Panici P, Greggi S, Colombo A, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study[J]. J Clin Oncol, 2002, 20(1): 179-188.
27.	Cho YH, Kim DY, Kim JH, et al. Comparative study of neoadjuvant chemotherapy before radical hysterectomy and radical surgery alone in stage ⅠB2-ⅡA bulky cervical cancer[J]. J Gynecol Oncol, 2009, 20 (1): 22-27.
28.	Rydzewska L, Tierney J, Vale CL, et al. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer[J]. Cochrane DatabaseSyst Rev, 2010, 20(1): CD007406.
29.	Benedet JL, Pecorelli S, Hacker NF, et al. Staging classifications and clinical practice guidelines of gynaecologic cancer[M/OL]. http://www.figo.org/files/figo-corp/docs/staging_booklet.pdf.
30.	沈鏗, 郎景和. 婦科腫瘤面臨的問題和挑戰[M]. 北京: 人民衛生出版社, 2002: 237-238.
31.	Tierney JF, Vale C, Symonds P. Concomitant and neoadjuvant chemotherapy for cervical cancer[J]. Clin Oncol (R Coll Radiol), 2008, 20(6): 401-416.
32.	程曉東, 呂衛國, 葉楓, 等. 局部晚期子宮頸癌新輔助化療價值的評估[J]. 中華婦產科雜志, 2006, 41(1): 95-98.
33.	Saito T, Takehara M, Lee R, et al. Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma: a preliminary study[J]. Int J Gynecol Cancer, 2004, 14(3): 483-490.
34.	Loizzi V, Cormio G, Vicino M, et al. Neoadjuvant chemotherapy: an alternative option of treatment for locally advanced cervical cancer[J]. Gynecol Obstet Invest, 2008, 65(2): 96-103.
35.	Hwang YY, Moon H, Cho SH, et al. Ten-year survival of patients with locally advanced, stage ib-iib cervical cancer after neoadjuvant chemotherapy and radical hysterectomy[J]. Gynecol Oncol, 2001, 82(1): 88-93.
36.	Park DC, Suh MJ, Yeo SG. Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results[J]. Int J Gynecol Cancer, 2009, 19(5): 943-947.
37.	王平, 彭芝蘭, 張家文, 等. 子宮頸癌新輔助化療中不同化療途徑的療效比較[J]. 中華婦產科雜志, 2005, 40(4): 227-230.
38.	Bae JH, Lee SJ, Lee A. Neoadjuvant cisplatin and etoposide followed by radical hysterectomy for stage 1B-2B cervical cancer[J]. Gynecol Oncol, 2008, 111(3): 444-448.
39.	Chen H, Liang C, Zhang L, et al. Clinical efficacy of modified preoperative neoadjuvant chemotherapy in the treatment of locally advanced (stage ⅠB2 to ⅡB) cervical cancer: randomized study[J]. Gynecol Oncol, 2008, 110(3): 308-315.
40.	曹冬焱, 楊佳欣, 沈鏗, 等. 子宮頸癌患者子宮動脈插管與靜脈全身化療兩種途徑新輔助化療的效果對比[J]. 中華婦產科雜志, 2008, 43 (12): 888-891.
41.	Ki KD, Song DH, Tong SY, et al. Neoadjuvant chemotherapy in bulky stage ⅠB-ⅡA cervical cancer: results of a quick course with vincristine, bleomycin, and cisplatin[J]. Int J Gynecol Cancer, 2009, 19(1): 50-53.
42.	潘玫, 李隆玉, 羅兵, 等. 紫杉醇在宮頸癌術前新輔助化療中的應用[J]. 現代腫瘤醫學, 2009, 17(4): 711-712.
43.	Kuzuya K. Chemoradiotherapy for uterine cancer: current status and perspectives[J]. Int J Clin Oncol, 2004, 9(6): 458-470.
44.	Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage ⅠB cervical carcinoma[J]. N Engl J Med, 1999, 340(15): 1154-1161.
45.	Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer[J]. N Engl J Med, 1999, 340(15): 1137-1143.
46.	Peters WA III, Liu PY, Barrett RJ, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early stage cancer of the cervix[J]. J Clin Oncol, 2000, 18(8): 1606-1613.
47.	Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer[J]. N Engl J Med, 1999, 340(15): 1144-1153.
48.	Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study[J]. J Clin Oncol, 1999, 17(5): 1339-1348.
49.	魏毅利, 方建玲. 局部晚期宮頸癌綜合治療方法探討[J]. 實用腫瘤學雜志, 2008, 22(3): 224-228.
50.	Duenas-Gonzalez A, Lopez-graniel C, Gonzalez-Enciso A, et al. Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase Ⅱ studies[J]. Ann Oncol, 2002, 13(8): 1212-1219.
51.	Gonzalez-Martin A, Gonzalez-Cortijo L, Carballo N, et al. The current role of neoadjuvant chemotherapy in the management of cervical carcinoma[J]. Gynecol Oncol, 2008, 110(3 Suppl 2): S36-S40.

1. 　王澤華. 重視和規范宮頸癌的新輔助化療[J]. 華中醫學雜志, 2007, 31 (6): 423-424.
2. 　Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium[J]. Int J Gynaecol Obstet, 2009, 105(2): 103-104.
3. 　Timotheadou E, Gore ME. Neoadjuvant chemotherapy for locally advanced cervical cancer[J]. Eur J Cancer, 2003, 39(17): 2419-2421.
4. 　Tiersten AD, Selleck MJ, Hershman DL, et al. Phase Ⅱ study of topotecan and paclitaxel for persistent, or metastatic cervical cancer[J]. Gynecol Oncol, 2004, 92(2): 635-638.
5. 　Eddy G, Bundy B, CreasmanW, et al. Treatment of (bulky)stage Ⅰb cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical surgery and pelvic/para-aortic lymphadenectomy: a phase Ⅲ trial of the gynecologic oncology group[J]. Gynecol Oncol, 2007, 106(2): 362-369.
6. 　Han SC, 章青, 陸嘉德. 大腫塊ⅠB、ⅡA期及局部晚期宮頸癌的治療[J]. 中國癌癥雜志, 2006, 16(11): 890-895.
7. 　Elit L, Fyles AW, Devries MC, et al. Follow-up for women after treatment for cervical cancer: a systematic review[J]. Gynecol Oncol, 2009, 114 (3): 528-535.
8. 　Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01[J]. J Clin Oncol, 2004, 22(5): 872-880.
9. 　劉成紅, 毛熙光, 伍宗惠. 近10年川南地區宮頸癌臨床特點變化趨勢分析[J]. 瀘州醫學院學報, 2008, 31(3): 312-315.
10. 　Zhao EF, Bao L, Li C, et al. Changes in epidemiology and clinical characteristics of cervical cancer over the past 50 years[J]. J First Mil Med Univ, 2005, 25(6): 605-609.
11. 　Frei E. Clinical cancer research: an embattled species[J]. Cancer, 1982, 50(10): 1979-1992.
12. 　Ryu HS, Kang SB, Kim KT, et al. Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005)[J]. Int J Gynecol Cancer, 2007, 17(1): 132-136.
13. 　趙虹, 王曉燕, 邵淑麗, 等. Ⅰb2-Ⅱb期宮頸鱗癌新輔助化療前后Bcl-2和Bax的表達差異[J]. 山西醫科大學學報, 2008, 39(11): 995-997.
14. 　Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC[J]. Nature, 1999, 399(6735): 483-487.
15. 　李莉, 李庭芳, 劉開江. 宮頸癌新輔助化療臨床病理、電鏡改變及作用機制的初步探討[J]. 中國婦產科臨床雜志, 2005, 9(9): 439-442.
16. 　Robati M, Holtz D, Dunton CJ. A review of topotecan in combination chemotherapy for advanced cervical cancer[J]. Ther Clin Risk Manag, 2008, 4(1): 213-218.
17. 　Souhami L, Gil RA, Allan SE, et al. A randomized trial of chemotherapy followed by pelvic radiation therapy in stage ⅢB carcinoma of the cervix[J]. J Clin Oncol, 1991, 9(6): 970-977.
18. 　李慶水, 張錫芹, 李大鵬, 等. 子宮頸癌放療前新輔助化療的臨床研究[J]. 中華婦產科雜志, 2006, 41(2): 83-87.
19. 　Tabata T, Takeshima N, Nishida H, et al. A randomized study of primary bleomycin, vincristine, mitomycin and cisplatin (BOMP) chemotherapy followed by radiotherapy versus radiotherapy alone in stage IIIB and IVA squamous cell carcinoma of the cervix[J]. Anticancer Res, 2003, 23(3C): 2885-2890.
20. 　Tierney J. Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review andmeta-analysis of individual patient data from 21 randomized trials[J]. Eur J Cancer, 2003, 39 (17): 2470-2486.
21. 　Bader HA, Winter R, Moinfar F, et al. Is intraoperative frozen section analysis of pelvic lymph nodes accurate after neoadjuvant chemotherapy in patients with cervical cancer?[J]. Gynecol Oncol, 2006, 103(1): 106-112.
22. 　Chun M. Time for global efforts with clinical trials for advanced cervical cancer patients[J]. J Gynecol Oncol, 2009, 20(4): 201-202.
23. 　Kumar JV, Doval DC, Rao R, et al. A retrospective study of patients with locally advanced cancer of the cervix treated with neoadjuvant chemotherapy followed by radical surgery[J]. Int J Gynecol Cancer, 2009, 19(3): 417- 422.
24. 　邱俊源, 李莉, 雷箏. 宮頸癌新輔助化療近期療效觀察[J]. 中華全科醫學, 2009, 7(10): 1083-1084.
25. 　Term rungruanglert W, Tresukosol D, Vasuratna A, et al. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in (bulky) squamous cell carcinoma of cervix stage IB2[J]. Gynecol Oncol, 2005, 97(2): 576-581.
26. 　Benedetti-Panici P, Greggi S, Colombo A, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study[J]. J Clin Oncol, 2002, 20(1): 179-188.
27. 　Cho YH, Kim DY, Kim JH, et al. Comparative study of neoadjuvant chemotherapy before radical hysterectomy and radical surgery alone in stage ⅠB2-ⅡA bulky cervical cancer[J]. J Gynecol Oncol, 2009, 20 (1): 22-27.
28. 　Rydzewska L, Tierney J, Vale CL, et al. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer[J]. Cochrane DatabaseSyst Rev, 2010, 20(1): CD007406.
29. 　Benedet JL, Pecorelli S, Hacker NF, et al. Staging classifications and clinical practice guidelines of gynaecologic cancer[M/OL]. http://www.figo.org/files/figo-corp/docs/staging_booklet.pdf.
30. 　沈鏗, 郎景和. 婦科腫瘤面臨的問題和挑戰[M]. 北京: 人民衛生出版社, 2002: 237-238.
31. 　Tierney JF, Vale C, Symonds P. Concomitant and neoadjuvant chemotherapy for cervical cancer[J]. Clin Oncol (R Coll Radiol), 2008, 20(6): 401-416.
32. 　程曉東, 呂衛國, 葉楓, 等. 局部晚期子宮頸癌新輔助化療價值的評估[J]. 中華婦產科雜志, 2006, 41(1): 95-98.
33. 　Saito T, Takehara M, Lee R, et al. Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma: a preliminary study[J]. Int J Gynecol Cancer, 2004, 14(3): 483-490.
34. 　Loizzi V, Cormio G, Vicino M, et al. Neoadjuvant chemotherapy: an alternative option of treatment for locally advanced cervical cancer[J]. Gynecol Obstet Invest, 2008, 65(2): 96-103.
35. 　Hwang YY, Moon H, Cho SH, et al. Ten-year survival of patients with locally advanced, stage ib-iib cervical cancer after neoadjuvant chemotherapy and radical hysterectomy[J]. Gynecol Oncol, 2001, 82(1): 88-93.
36. 　Park DC, Suh MJ, Yeo SG. Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results[J]. Int J Gynecol Cancer, 2009, 19(5): 943-947.
37. 　王平, 彭芝蘭, 張家文, 等. 子宮頸癌新輔助化療中不同化療途徑的療效比較[J]. 中華婦產科雜志, 2005, 40(4): 227-230.
38. 　Bae JH, Lee SJ, Lee A. Neoadjuvant cisplatin and etoposide followed by radical hysterectomy for stage 1B-2B cervical cancer[J]. Gynecol Oncol, 2008, 111(3): 444-448.
39. 　Chen H, Liang C, Zhang L, et al. Clinical efficacy of modified preoperative neoadjuvant chemotherapy in the treatment of locally advanced (stage ⅠB2 to ⅡB) cervical cancer: randomized study[J]. Gynecol Oncol, 2008, 110(3): 308-315.
40. 　曹冬焱, 楊佳欣, 沈鏗, 等. 子宮頸癌患者子宮動脈插管與靜脈全身化療兩種途徑新輔助化療的效果對比[J]. 中華婦產科雜志, 2008, 43 (12): 888-891.
41. 　Ki KD, Song DH, Tong SY, et al. Neoadjuvant chemotherapy in bulky stage ⅠB-ⅡA cervical cancer: results of a quick course with vincristine, bleomycin, and cisplatin[J]. Int J Gynecol Cancer, 2009, 19(1): 50-53.
42. 　潘玫, 李隆玉, 羅兵, 等. 紫杉醇在宮頸癌術前新輔助化療中的應用[J]. 現代腫瘤醫學, 2009, 17(4): 711-712.
43. 　Kuzuya K. Chemoradiotherapy for uterine cancer: current status and perspectives[J]. Int J Clin Oncol, 2004, 9(6): 458-470.
44. 　Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage ⅠB cervical carcinoma[J]. N Engl J Med, 1999, 340(15): 1154-1161.
45. 　Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer[J]. N Engl J Med, 1999, 340(15): 1137-1143.
46. 　Peters WA III, Liu PY, Barrett RJ, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early stage cancer of the cervix[J]. J Clin Oncol, 2000, 18(8): 1606-1613.
47. 　Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer[J]. N Engl J Med, 1999, 340(15): 1144-1153.
48. 　Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study[J]. J Clin Oncol, 1999, 17(5): 1339-1348.
49. 　魏毅利, 方建玲. 局部晚期宮頸癌綜合治療方法探討[J]. 實用腫瘤學雜志, 2008, 22(3): 224-228.
50. 　Duenas-Gonzalez A, Lopez-graniel C, Gonzalez-Enciso A, et al. Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase Ⅱ studies[J]. Ann Oncol, 2002, 13(8): 1212-1219.
51. 　Gonzalez-Martin A, Gonzalez-Cortijo L, Carballo N, et al. The current role of neoadjuvant chemotherapy in the management of cervical carcinoma[J]. Gynecol Oncol, 2008, 110(3 Suppl 2): S36-S40.

《華西醫學》

新輔助化學療法在局部晚期宮頸癌中的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《華西醫學》

新輔助化學療法在局部晚期宮頸癌中的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料