Change of Cyclooxygenase-2 Expression in Different Stress-Related Gastric Mucosal Diseases_West China Medical Journal

West China Medical Journal

Supervisor：Ministry of Education of the People's Republic of China Sponsor：Sichuan University
Editor-in-chief：LUO Fengming
Publishing period： Monthly ISSN：1002-0179 CN：51-1356/R

Change of Cyclooxygenase-2 Expression in Different Stress-Related Gastric Mucosal Diseases

West China Medical Journal | 2010, 25(5): 833-836
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Authors：

ZHANG Hongliang ¹ ,  XU Yang ² , FAN Xiao ¹

1.Emergency Department, 2.The Department of Digestive Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R.China;

Corresponding?author：

XU Yang, Email: zhlzzj@163.com

Keywords：

應激; 胃黏膜; 潰瘍指數; 環氧化酶-2

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目的探討不同病因導致的應激性胃黏膜損傷時胃黏膜環氧化酶(cyclooxygenase,COX)-2表達強度的變化及二者的關系。方法通過建立急性甲胺磷中毒及急性心肌梗死動物模型,采用胃黏膜潰瘍指數評定是否發生胃黏膜損傷,采用免疫組化方法測定胃黏膜COX-2的表達強度變化。結果 ①成功建立大鼠急性甲胺磷中毒及急性心肌梗死動物模型；②在急性甲胺磷中毒及急性心肌梗死這兩種應激狀態下胃黏膜發生了損傷；③不同病因所致應激性胃黏膜損傷時胃黏膜COX-2表達增加。結論臨床危重疾病可產生應激狀態胃黏膜損傷,胃黏膜潰瘍指數增加。不同病因所致的應激性胃黏膜損傷時胃黏膜COX-2表達增加,可能為一種保護機制。

Citation： ZHANG Hongliang,XU Yang,FAN Xiao. Change of Cyclooxygenase-2 Expression in Different Stress-Related Gastric Mucosal Diseases. West China Medical Journal, 2010, 25(5): 833-836. doi: Copy

West China Medical Journal

Change of Cyclooxygenase-2 Expression in Different Stress-Related Gastric Mucosal Diseases

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