【摘要】 目的 觀察急性淋巴細胞白血病（ALL）患兒血清鐵蛋白（SF）及β2-微球蛋白（β2-MG）水平變化，探討SF和β2-MG水平變化對ALL患兒臨床治療效果的應用價值。 方法 對2008年7月-2010年4月期間血液病區住院確診為ALL的患兒53例，病情得到控制緩解后的ALL患兒28例，分別抽取空腹靜脈血進行SF和β2-MG測定，并選取正常健康兒童30例作為對照組。 結果 ALL患兒治療前血清SF和β2-MG水平均高于正常對照組（P lt;0.01），經治療緩解后ALL患兒的SF和β2-MG水平顯著降低，并隨著病情的轉歸而逐漸恢復至正常水平；與治療前比較，差異有統計學意義（P lt;0.01）。 結論 SF和β2-MG可作為ALL臨床治療效果的有效監測指標。
【Abstract】 Objective To observe the dynamic changes of Serum Ferritin(SF) and β2-MG levels in children with acute lymphoblastic leukemia(ALL) and to investigate its clinical significance on clinical curative effect. Methods Fifty-three in-patients with ALL, 28 relieved patients from July 2008 to April 2010 in our Hematology and 30 normal as control were selected in our study. The venousblood of patients and controls were extract in order to detect SF and β2-MG. Results Before the treatment, the level of SF and β2-MG in ALL group were significantly higher than those in the control group (P lt;0.01). After the treatment, the level of SF and β2-MG in ALL group decreased significantly (P lt;0.01), and they return to normal level gradually with the outcome; compared with before the treatment, the differences were statistically significant(P lt;0.01). Conclusion SF and β2-MG can be used as a helpful indicator to evaluate the therapeutic effect of ALL.
Citation： ZHAO Xiaoyuan,WU Dongyan,CAI Yanna,SHENG Huiying,PENG Minzhi. Clinical Significance of Serum Ferritin and β2-MG Detection in Children with Acute Lymphoblastic Leukemia. West China Medical Journal, 2010, 25(8): 1513-1514. doi: Copy
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