Changes of Neuron-specific Enolase and Myelin Basic Protein in the Serum and Cerebrospinal Fluid in Patients with Epilepsy after Single Episodes_West China Medical Journal

Authors：

YANG Xiaofang , YU Ming , NIE Bengang , XIONG Gaohua

Department of Neurology, Suining Central Hospital, Suining, Sichuan 629000, P.R.China;

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Keywords：

單次癲癇發作; 神經元特異性烯醇化酶; 髓鞘堿性蛋白; 腦損傷

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【摘要】　目的　探討單次癲癇發作是否會引起腦損傷。　方法　 2007年6月-2009年11月，采用電化學發光法檢測癲癇發作后24 h內40例和對照組40例患者血清和腦脊液中神經元特異性烯醇化酶（neuron-specific enolase，NSE）水平，采用ELISA法測定其血清和腦脊液中髓鞘堿性蛋白（myebin bosic protein，MBP）水平。　結果　癲癇組血清和腦脊液中NSE水平明顯高于對照組（P lt;0.01）；癲癇組血清MBP水平與對照組比較差異無統計學意義（P gt;0.05）；癲癇組腦脊液中MBP水平高于對照組（P lt;0.05）。　結論　單次癲癇患者血清和腦脊液中NSE明顯升高，腦脊液中MBP升高，提示單次癲癇發作可導致神經元損傷。
【Abstract】　Objective　 To detect the possibility of brain damage in the epileptic patients after single episodes.　Methods　 The levels of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) in 40 patients with single episodes within 24 hours after seizures from June 2007 to November 2009 were determined respectively by electrochemiluminescence. Another 40 healthy individuals were enrolled as the control. The levels of myelin basic protein (MBP) were determined by enzyme-linked immunosorbent assay.　Results　 The levels of NSE in the serum and CSF in epileptic group within 24 hours after seizures were significantly higher than those in the control group (P lt;0.01), and the levels of MBP in the serum in the two group didn′t differ much (P gt;0.05). The levels of MBP in CSF in epileptic group were significantly higher than those in the control group (P lt;0.05).　Conclusion　 After single episodes, the levels of NSE in serum and CSF and the levels of NSE in CSF increase,which suggests that single episodes may lead to neuronal damage.

Citation： YANG Xiaofang,YU Ming,NIE Bengang,XIONG Gaohua. Changes of Neuron-specific Enolase and Myelin Basic Protein in the Serum and Cerebrospinal Fluid in Patients with Epilepsy after Single Episodes. West China Medical Journal, 2010, 25(11): 2007-2008. doi: Copy

1.	李光乾, 林忠東, 葉秀云, 等. 熱性驚厥患兒血清和腦脊液神經元特異性烯醇化酶S-10013蛋白及髓鞘堿性蛋白的測定[J]. 中華神經科雜志, 2004, 37(4): 376-378.
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4.	周琴, 李光乾. 單次癲癇發作后患兒血清和腦脊液神經生化標志物的變化[J]. 實用臨床兒科雜志, 2006, 21(20): 1417-1418.
5.	Connolly AM, Chez M, Streif EM, et al. Brain derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy[J]. Biol Psychiatry, 2006, 59(4): 354-363.
6.	顧琴, 湯繼宏, 王浙東, 等. 實驗性癲癇發作后早期血清NSE、S-100β、MBP的變化[J]. 蘇州大學學報(醫學版), 2008, 28(2): 197-199.
7.	湯繼宏, 胡斯明, 顧琴, 等. 顳葉癲癇大鼠癇性發作后神經元特異性烯醇化酶、髓鞘堿性蛋白的變化及其意義[J]. 臨床神經病學雜志, 2007, 20(1): 64-65.

1. 　李光乾, 林忠東, 葉秀云, 等. 熱性驚厥患兒血清和腦脊液神經元特異性烯醇化酶S-10013蛋白及髓鞘堿性蛋白的測定[J]. 中華神經科雜志, 2004, 37(4): 376-378.
2. 　湯繼宏, 王浙東, 李巖, 等. 單純性與復雜性熱性驚厥患者神經特異性烯醇化酶水平變化的研究[J]. 中國當代兒科雜志, 2002, 18(4): 65-66.
3. 　Willert C, Spitzer C, Kusserow S, et al. Serum neuron-specific enolase, prolactin, and creatine kinase after epileptic and psychogenicnon-epileptic seizures[J]. Acta Neurol Scand, 2004, 109(5): 318-323.
4. 　周琴, 李光乾. 單次癲癇發作后患兒血清和腦脊液神經生化標志物的變化[J]. 實用臨床兒科雜志, 2006, 21(20): 1417-1418.
5. 　Connolly AM, Chez M, Streif EM, et al. Brain derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy[J]. Biol Psychiatry, 2006, 59(4): 354-363.
6. 　顧琴, 湯繼宏, 王浙東, 等. 實驗性癲癇發作后早期血清NSE、S-100β、MBP的變化[J]. 蘇州大學學報(醫學版), 2008, 28(2): 197-199.
7. 　湯繼宏, 胡斯明, 顧琴, 等. 顳葉癲癇大鼠癇性發作后神經元特異性烯醇化酶、髓鞘堿性蛋白的變化及其意義[J]. 臨床神經病學雜志, 2007, 20(1): 64-65.

West China Medical Journal

Changes of Neuron-specific Enolase and Myelin Basic Protein in the Serum and Cerebrospinal Fluid in Patients with Epilepsy after Single Episodes

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