Reference Intervals for Haematological Variables during Normal Pregnancy_West China Medical Journal

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Department of Laboratory Medicine，West China Second University Hospital，Sichuan University，Chengdu 610041，China;

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Keywords：

正常妊娠; 孕周相關; 血常規指標; 參考值范圍

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目的：了解正常妊娠婦女常用血常規指標的變化，建立其參考值范圍。方法:分別在早孕（孕10～14周）、中孕（孕20～24周）、晚孕（孕30～34周）及產后（產后12周）四個時期序貫性測定120例正常妊娠婦女血常規指標:紅細胞（RBC）、血紅蛋白（HB）、紅細胞壓積（HCT）、血小板（PLT）、白細胞（WBC），并建立參考值范圍。同期選取53例健康體檢非孕者為對照。結果：RBC、HCT早、中、晚孕相對于正常對照均降低（P lt;0.01）。HB在孕期降低，中、晚孕降低較明顯，相對于正常對照差異有統計學意義（P lt;0.01）。PLT早、中孕降低不明顯（P gt;0.05），到晚孕期相對于正常對照降低差異有統計學意義（P lt;0.05）。WBC在妊娠四期相對于正常對照均升高（P lt;0.01）。結論：血常規各項指標隨孕期發展均產生不同程度的變化，從該序慣性研究中得出了正常妊娠婦女的5個血常規指標水平的參考值范圍，該參考值范圍可以用于評估正常妊娠婦女的孕期健康水平。

Citation： YE Lei,CHEN Lan,DU Zeli,et al.. Reference Intervals for Haematological Variables during Normal Pregnancy. West China Medical Journal, 2009, 24(2): 403-405. doi: Copy

1.	The National Committee for Clinical Laboratory Standards.How to Define and Determine Reference Intervals in the Clinical Laboratory；Approved Guideline：Second Edition.NCCLS document C28A2（ISBN 1-56238-406-6）[S].NCCLS，940 West Valley Road，Suite 1400，Wayne，Pennsylvania 190871898，USA 2000，20（13）：14-21..
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1. The National Committee for Clinical Laboratory Standards.How to Define and Determine Reference Intervals in the Clinical Laboratory；Approved Guideline：Second Edition.NCCLS document C28A2（ISBN 1-56238-406-6）[S].NCCLS，940 West Valley Road，Suite 1400，Wayne，Pennsylvania 190871898，USA 2000，20（13）：14-21..
2. Milman N，Bergholt T，Byg KE，et al.Reference intervals for haematological variables during normal pregnancy and postpartum in 434 healthy Danish women[J].Eur J Haematol，2007，79（1）：39-46..
3. Cunningham FG，Leveno KJ，Bloom SL.Williams Obstetrics[M].第21版.北京：科學出版社，2002：79-85..
4. Piazze J，Gioia S，Cerekja A，et al.Doppler velocimetry alterations related to platelet changes in third trimester pregnancies[J].Platelets，2007，18（1）：11-15..
5. Cowans NJ，Spencer K.First and secondtrimester biochemical markers of chromosomal anomalies and their relationship to maternal haemoglobin levels[J].Prenat Diagn，2005，25（8）：693-699..
6. Marín GH，Fazio P，Rubbo S，et al.Prevalence of anaemia in pregnancy and analysis of the underlying factors[J].Aten Primaria，2002，29（3）：158-163..
7. van Buul EJ，Steegers EA，Jongsma HW，et al.Haematological and biochemical profile of uncomplicated pregnancy in nulliparous women；a longitudinal study[J].Neth J Med.1995，Feb，46（2）：73-85..
8. Williams MD，Wheby MS.Anemia in pregnancy[J].Med Clin North Am，1992，76：631-647..
9. Lund CJ，Donovan JC.Blood volume during pregnancy[J].Am J Obstet Gynecol，1967，98：394.
10. Campbell DM，MacGillivray I.Comparison of maternal response in first and second pregnancies in relation to baby weight[J].J Obstet Gynaecol Br Commonw，1972，79(8)：684-693..
11. Hytten F.Blood volume changes in normal pregnancy[J].Clin Haematol，1985，14：601-612.

West China Medical Journal

Reference Intervals for Haematological Variables during Normal Pregnancy

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